3-Amino-2,2-dimethylpropanoic acid (BioDeep_00000173851)

   

human metabolite blood metabolite


代谢物信息卡片


3-Amino-2,2-dimethylpropanoic acid

化学式: C5H11NO2 (117.0789746)
中文名称: 3-氨基-2,2二甲基乙酸
谱图信息: 最多检出来源 Rattus norvegicus(blood) 1.69%

分子结构信息

SMILES: CC(C)(CN)C(=O)O
InChI: InChI=1S/C5H11NO2/c1-5(2,3-6)4(7)8/h3,6H2,1-2H3,(H,7,8)

描述信息

同义名列表

2 个代谢物同义名

3-Amino-2,2-dimethylpropanoic acid; 3-Amino-2,2-dimethylpropanoate



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Elena Dolgodilina, Stefan Imobersteg, Endre Laczko, Tobias Welt, Francois Verrey, Victoria Makrides. Brain interstitial fluid glutamine homeostasis is controlled by blood-brain barrier SLC7A5/LAT1 amino acid transporter. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2016 11; 36(11):1929-1941. doi: 10.1177/0271678x15609331. [PMID: 26661195]
  • Daniela Billups, Mari-Carmen Marx, Ioanna Mela, Brian Billups. Inducible presynaptic glutamine transport supports glutamatergic transmission at the calyx of Held synapse. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2013 Oct; 33(44):17429-34. doi: 10.1523/jneurosci.1466-13.2013. [PMID: 24174676]
  • L C Kusinski, M R Dilworth, P N Baker, C P Sibley, M Wareing, J D Glazier. System A activity and vascular function in the placental-specific Igf2 knockout mouse. Placenta. 2011 Nov; 32(11):871-6. doi: 10.1016/j.placenta.2011.07.086. [PMID: 21851977]
  • A Blot, D Billups, M Bjørkmo, A Z Quazi, N M Uwechue, F A Chaudhry, B Billups. Functional expression of two system A glutamine transporter isoforms in rat auditory brainstem neurons. Neuroscience. 2009 Dec; 164(3):998-1008. doi: 10.1016/j.neuroscience.2009.09.015. [PMID: 19751803]
  • Fiona E Baird, Kevin J Bett, Catherine MacLean, Andrew R Tee, Harinder S Hundal, Peter M Taylor. Tertiary active transport of amino acids reconstituted by coexpression of System A and L transporters in Xenopus oocytes. American journal of physiology. Endocrinology and metabolism. 2009 Sep; 297(3):E822-9. doi: 10.1152/ajpendo.00330.2009. [PMID: 19622785]
  • Danusa Menegaz, Angela Rosso, Carine Royer, Laura D Leite, Adair R S Santos, Fátima R M B Silva. Role of 1alpha,25(OH)2 vitamin D3 on alpha-[1-(14)C]MeAIB accumulation in immature rat testis. Steroids. 2009 Feb; 74(2):264-9. doi: 10.1016/j.steroids.2008.11.015. [PMID: 19073199]
  • M Desforges, K J Mynett, R L Jones, S L Greenwood, M Westwood, C P Sibley, J D Glazier. The SNAT4 isoform of the system A amino acid transporter is functional in human placental microvillous plasma membrane. The Journal of physiology. 2009 Jan; 587(1):61-72. doi: 10.1113/jphysiol.2008.161331. [PMID: 19015196]
  • Chen Yu Chiang, Zhaohui Li, Jonathan O Dostrovsky, James W Hu, Barry J Sessle. Glutamine uptake contributes to central sensitization in the medullary dorsal horn. Neuroreport. 2008 Jul; 19(11):1151-4. doi: 10.1097/wnr.0b013e3283086781. [PMID: 18596618]
  • Kate Evans, Zeerak Nasim, Jeremy Brown, Heather Butler, Samira Kauser, Hélène Varoqui, Jeffrey D Erickson, Terence P Herbert, Alan Bevington. Acidosis-sensing glutamine pump SNAT2 determines amino acid levels and mammalian target of rapamycin signalling to protein synthesis in L6 muscle cells. Journal of the American Society of Nephrology : JASN. 2007 May; 18(5):1426-36. doi: 10.1681/asn.2006091014. [PMID: 17429052]
  • Tuula Tolvanen, Kjell Någren, Meixiang Yu, Eija Sutinen, Katja Havu-Aurén, Sirkku Jyrkkiö, Markku Asola, Eira Kotoneva, Pirjo Nuutila, Heikki Minn. Human radiation dosimetry of [11C]MeAIB, a new tracer for imaging of system A amino acid transport. European journal of nuclear medicine and molecular imaging. 2006 Oct; 33(10):1178-84. doi: 10.1007/s00259-006-0096-4. [PMID: 16721566]
  • Kazunari Tanaka, Akira Yamamoto, Takuya Fujita. Functional expression and adaptive regulation of Na+ -dependent neutral amino acid transporter SNAT2/ATA2 in normal human astrocytes under amino acid starved condition. Neuroscience letters. 2005 Apr; 378(2):70-5. doi: 10.1016/j.neulet.2004.12.030. [PMID: 15774260]
  • Lone Helboe, Jan Egebjerg, Morten Møller, Christian Thomsen. Distribution and pharmacology of alanine-serine-cysteine transporter 1 (asc-1) in rodent brain. The European journal of neuroscience. 2003 Oct; 18(8):2227-38. doi: 10.1046/j.1460-9568.2003.02966.x. [PMID: 14622183]
  • Eija Sutinen, Sirkku Jyrkkiö, Kalle Alanen, Kjell Någren, Heikki Minn. Uptake of [N-methyl-11C]alpha-methylaminoisobutyric acid in untreated head and neck cancer studied by PET. European journal of nuclear medicine and molecular imaging. 2003 Jan; 30(1):72-7. doi: 10.1007/s00259-002-1010-3. [PMID: 12483412]
  • Markku R Asola, Kirsi A Virtanen, Pauliina Peltoniemi, Kjell Någren, Meixiang Yu, Kari Mattila, Sirkku Jyrkkiö, Kaj Metsärinne, Pirjo Nuutila, Juhani Knuuti. Amino acid uptake in the skeletal muscle measured using [11C]methylaminoisobutyrate (MEAIB) and PET. European journal of nuclear medicine and molecular imaging. 2002 Nov; 29(11):1485-91. doi: 10.1007/s00259-002-0921-3. [PMID: 12397468]
  • Thomas L Freeman, Geoffrey M Thiele, Dean J Tuma, Tina K Machu, Mark E Mailliard. ATA2-mediated amino acid uptake following partial hepatectomy is regulated by redistribution to the plasma membrane. Archives of biochemistry and biophysics. 2002 Apr; 400(2):215-22. doi: 10.1016/s0003-9861(02)00006-1. [PMID: 12054432]
  • P Gomes, P Soares-da-Silva. Na+-independent transporters, LAT-2 and b0,+, exchange L-DOPA with neutral and basic amino acids in two clonal renal cell lines. The Journal of membrane biology. 2002 Mar; 186(2):63-80. doi: 10.1007/s00232-001-0136-8. [PMID: 11944084]
  • Stuart Cramer, Mark Beveridge, Michael Kilberg, Donald Novak. Physiological importance of system A-mediated amino acid transport to rat fetal development. American journal of physiology. Cell physiology. 2002 Jan; 282(1):C153-60. doi: 10.1152/ajpcell.2002.282.1.c153. [PMID: 11742808]
  • D Novak, F Quiggle, C Artime, M Beveridge. Regulation of glutamate transport and transport proteins in a placental cell line. American journal of physiology. Cell physiology. 2001 Sep; 281(3):C1014-22. doi: 10.1152/ajpcell.2001.281.3.c1014. [PMID: 11502579]
  • F R Silva, L D Leite, K P Barreto, C D'Agostini, A Zamoner. Effect of 3,5,3'-triiodo-L-thyronine on amino acid accumulation and membrane potential in Sertoli cells of the rat testis. Life sciences. 2001 Jul; 69(8):977-86. doi: 10.1016/s0024-3205(01)01186-9. [PMID: 11488410]
  • E Sutinen, S Jyrkkiö, T Grönroos, M Haaparanta, P Lehikoinen, K Någren. Biodistribution of [11C] methylaminoisobutyric acid, a tracer for PET studies on system A amino acid transport in vivo. European journal of nuclear medicine. 2001 Jul; 28(7):847-54. doi: 10.1007/s002590100548. [PMID: 11504081]
  • F Wu, B Cholewa, D L Mattson. Characterization of L-arginine transporters in rat renal inner medullary collecting duct. American journal of physiology. Regulatory, integrative and comparative physiology. 2000 Jun; 278(6):R1506-12. doi: 10.1152/ajpregu.2000.278.6.r1506. [PMID: 10848517]
  • T L Freeman, H Q Ngo, M E Mailliard. Inhibition of system A amino acid transport and hepatocyte proliferation following partial hepatectomy in the rat. Hepatology (Baltimore, Md.). 1999 Aug; 30(2):437-44. doi: 10.1002/hep.510300212. [PMID: 10421652]
  • K M Godfrey, N Matthews, J Glazier, A Jackson, C Wilman, C P Sibley. Neutral amino acid uptake by the microvillous plasma membrane of the human placenta is inversely related to fetal size at birth in normal pregnancy. The Journal of clinical endocrinology and metabolism. 1998 Sep; 83(9):3320-6. doi: 10.1210/jcem.83.9.5132. [PMID: 9745448]
  • D T Calvert, T G Kim, J J Choung, C Burns, D B Shennan. Characteristics of L-glutamine transport by lactating mammary tissue. The Journal of dairy research. 1998 May; 65(2):199-208. doi: 10.1017/s0022029997002756. [PMID: 9627839]
  • M Horio, A Yamauchi, T Moriyama, E Imai, Y Orita. Osmotic regulation of amino acids and system A transport in Madin-Darby canine kidney cells. The American journal of physiology. 1997 Mar; 272(3 Pt 1):C804-9. doi: 10.1152/ajpcell.1997.272.3.c804. [PMID: 9124514]
  • Y Deguchi, K Nozawa, S Yamada, Y Yokoyama, R Kimura. Quantitative evaluation of brain distribution and blood-brain barrier efflux transport of probenecid in rats by microdialysis: possible involvement of the monocarboxylic acid transport system. The Journal of pharmacology and experimental therapeutics. 1997 Feb; 280(2):551-60. doi: NULL. [PMID: 9023263]
  • N Carbó, F J López-Soriano, J M Argilés. Neutral amino acid transport in placental plasma membrane vesicles in the late pregnant rat. Evidence for a B0-like transport system. European journal of obstetrics, gynecology, and reproductive biology. 1997 Jan; 71(1):85-90. doi: 10.1016/s0301-2115(96)02614-0. [PMID: 9031965]
  • J G Chen, A B Strawbridge, S A Kempson. Microtubule disruption stimulates system A transport in cultured vascular smooth muscle cells. The American journal of physiology. 1995 Jun; 268(6 Pt 1):C1512-9. doi: 10.1152/ajpcell.1995.268.6.c1512. [PMID: 7611372]
  • S K Lim, J P De Bandt, C Aussel, P Pernet, J Giboudeau, L Cynober. No evidence for a tumor necrosis factor alpha stimulated 2-methylaminoisobutyric acid uptake in hepatocyte monolayer. Journal of cellular physiology. 1995 Mar; 162(3):422-6. doi: 10.1002/jcp.1041620314. [PMID: 7860649]
  • D A Plumley, K Watkins, B P Bode, A J Pacitti, W W Souba. Cyclo-oxygenase blockade abrogates the endotoxin-induced increase in Na(+)-dependent hepatic amino acid transport. JPEN. Journal of parenteral and enteral nutrition. 1995 Jan; 19(1):9-14. doi: 10.1177/014860719501900109. [PMID: 7658609]
  • S Plakidou-Dymock, M J Tanner, J D McGivan. Regulation of System B0 amino-acid-transport activity in the renal epithelial cell line NBL-1 and concomitant changes in SAAT1 hybridizing transcripts. The Biochemical journal. 1994 Jul; 301 ( Pt 2)(?):399-405. doi: 10.1042/bj3010399. [PMID: 7519009]
  • P A King. Effects of insulin and exercise on amino acid transport in rat skeletal muscle. The American journal of physiology. 1994 Feb; 266(2 Pt 1):C524-30. doi: 10.1152/ajpcell.1994.266.2.c524. [PMID: 8141266]
  • A Felipe, D J Snyders, K K Deal, M M Tamkun. Influence of cloned voltage-gated K+ channel expression on alanine transport, Rb+ uptake, and cell volume. The American journal of physiology. 1993 Nov; 265(5 Pt 1):C1230-8. doi: 10.1152/ajpcell.1993.265.5.c1230. [PMID: 8238476]
  • J V Martínez-Mas, B Ruiz-Montasell, A Felipe, J Casado, M Pastor-Anglada. Up-regulation of system A activity in the regenerating rat liver. FEBS letters. 1993 Aug; 329(1-2):189-93. doi: 10.1016/0014-5793(93)80219-k. [PMID: 8354394]
  • R Muñíz, L Burguillo, J R del Castillo. Effect of starvation on neutral amino acid transport in isolated small-intestinal cells from guinea pigs. Pflugers Archiv : European journal of physiology. 1993 Apr; 423(1-2):59-66. doi: 10.1007/bf00374961. [PMID: 8488093]
  • A J Pacitti, Y Inoue, D A Plumley, E M Copeland, W W Souba. Growth hormone regulates amino acid transport in human and rat liver. Annals of surgery. 1992 Sep; 216(3):353-61; discussion 361. doi: 10.1097/00000658-199209000-00015. [PMID: 1329681]
  • S W Wilde, M S Kilberg. Glutamine transport by basolateral plasma-membrane vesicles prepared from rabbit intestine. The Biochemical journal. 1991 Aug; 277 ( Pt 3)(?):687-91. doi: 10.1042/bj2770687. [PMID: 1908221]
  • A Elgavish, E Meezan. Sulfation by human lung fibroblasts: SO4(2-) and sulfur-containing amino acids as sources for macromolecular sulfation. The American journal of physiology. 1991 Jun; 260(6 Pt 1):L450-6. doi: 10.1152/ajplung.1991.260.6.l450. [PMID: 1905488]
  • V Dall'Asta, O Bussolati, G G Guidotti, G C Gazzola. Energization of amino acid uptake by system A in cultured human fibroblasts. The Journal of biological chemistry. 1991 Jan; 266(3):1591-6. doi: 10.1016/s0021-9258(18)52335-8. [PMID: 1899091]