Polihexanide (BioDeep_00000173789)

   

human metabolite blood metabolite


代谢物信息卡片


Poly(iminocarbonimidoyliminocarbonimidoylimino-1,6-hexanediyl) hydrochloride

化学式: C8H19N5 (185.16403739999998)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 2.56%

分子结构信息

SMILES: CCCCCCN=C(N)N=C(N)N
InChI: InChI=1S/C8H19N5/c1-2-3-4-5-6-12-8(11)13-7(9)10/h2-6H2,1H3,(H6,9,10,11,12,13)

描述信息

D - Dermatologicals > D08 - Antiseptics and disinfectants > D08A - Antiseptics and disinfectants > D08AC - Biguanides and amidines
D007004 - Hypoglycemic Agents > D001645 - Biguanides
D000890 - Anti-Infective Agents
D004202 - Disinfectants

同义名列表

18 个代谢物同义名

Poly(iminocarbonimidoyliminocarbonimidoylimino-1,6-hexanediyl) hydrochloride; Poly(hexamethylenebiguanide) hydrochloride; Polyhexamethylene biguanide hydrochloride; 1-carbamimidamido-N-hexylmethanimidamide; Poly(hexamethylene biguanide); Polyhexamethylene biguanide; Polyhexamethylen-biguanide; Polihexanide hydrochloride; Polyhexamethylenbiguanide; Polyhexamethylenbiguanid; Vantocil ib OF vantocil; Polyhexanide; PHMB Polymer; Polihexanide; Baquacil; Lavasept; Vantocil; Cosmocil



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Anas Abdullah Hamad. In vitro Evaluation the Efficacy of Some Nnew Plant Extracts and Biocides on the Viability of Acanthamoeba castellanii. Protist. 2023 May; 174(3):125966. doi: 10.1016/j.protis.2023.125966. [PMID: 37229821]
  • Chul-Min Park, Hyeon-Young Kim, Doin Jeon, Young-Jun Shin, In-Hyeon Kim, Seong-Jin Choi, Ki Cheon Kim, Kyuhong Lee, Sung-Hwan Kim, Min-Seok Kim. Anti-fibrotic effect of pycnogenol® in a polyhexamethylene guanidine-treated mouse model. Respiratory physiology & neurobiology. 2022 02; 296(?):103802. doi: 10.1016/j.resp.2021.103802. [PMID: 34653662]
  • Yikelamu Alimu, Yoko Kusuya, Takako Yamamoto, Kana Arita, Naofumi Shigemune, Hiroki Takahashi, Takashi Yaguchi. Mechanism of Polyhexamethylene Biguanide Resistance in Purpureocillium lilacinum Strains. Biocontrol science. 2022; 27(3):117-130. doi: 10.4265/bio.27.117. [PMID: 36216563]
  • Maria Loose, Kurt G Naber, Larry Purcell, Manfred P Wirth, Florian M E Wagenlehner. Anti-Biofilm Effect of Octenidine and Polyhexanide on Uropathogenic Biofilm-Producing Bacteria. Urologia internationalis. 2021; 105(3-4):278-284. doi: 10.1159/000512370. [PMID: 33401282]
  • Jian-Ming Huang, Pin-Ju Ko, Chao-Li Huang, Po-Wei Wen, Chun-Hsien Chen, Min-Hsiu Shih, Wei-Chen Lin, Fu-Chin Huang. Cytochrome P450 monooxygenase of Acanthamoeba castellanii participates in resistance to polyhexamethylene biguanide treatment. Parasite (Paris, France). 2021; 28(?):77. doi: 10.1051/parasite/2021074. [PMID: 34762043]
  • Takako Yamamoto, Yikelamu Alimu, Hiroki Takahashi, Yoko Kusuya, Kouichi Hosoya, Naofumi Shigemune, Satoshi Nagai, Takashi Yaguchi. Isolation and Characterization of the Polyhexamethylene Biguanide Hydrochloride-Resistant Fungus, Purpureocillium lilacinum. Biocontrol science. 2021; 26(3):157-166. doi: 10.4265/bio.26.157. [PMID: 34556618]
  • Geetansh Sharma, Sonali K Kalra, Nidhi Tejan, Ujjala Ghoshal. Nanoparticles based therapeutic efficacy against Acanthamoeba: Updates and future prospect. Experimental parasitology. 2020 Nov; 218(?):108008. doi: 10.1016/j.exppara.2020.108008. [PMID: 32979343]
  • Melanie Hornschuh, Paula Zwicker, Thomas Schmidt, Birgit Finke, Axel Kramer, Gerald Müller. Poly (hexamethylene biguanide), adsorbed onto Ti-Al-V alloys, kills slime-producing Staphylococci and Pseudomonas aeruginosa without inhibiting SaOs-2 cell differentiation. Journal of biomedical materials research. Part B, Applied biomaterials. 2020 07; 108(5):1801-1813. doi: 10.1002/jbm.b.34522. [PMID: 31774237]
  • M Besser, M Dietrich, L Weber, J D Rembe, E K Stuermer. Efficacy of antiseptics in a novel 3-dimensional human plasma biofilm model (hpBIOM). Scientific reports. 2020 03; 10(1):4792. doi: 10.1038/s41598-020-61728-2. [PMID: 32179838]
  • Haonan Xing, Lin Cheng, Mei Lu, Hui Liu, Lang Lang, Tianzhi Yang, Xiaoyun Zhao, Hui Xu, Li Yang, Pingtian Ding. A biodegradable poly(amido amine) based on the antimicrobial polymer polyhexamethylene biguanide for efficient and safe gene delivery. Colloids and surfaces. B, Biointerfaces. 2019 Oct; 182(?):110355. doi: 10.1016/j.colsurfb.2019.110355. [PMID: 31306828]
  • Young-Suk Kim, Hyunju Cha, Hyo-Jin Kim, Joong-Myung Cho, Hak-Ryul Kim. The Anti-Fibrotic Effects of CG-745, an HDAC Inhibitor, in Bleomycin and PHMG-Induced Mouse Models. Molecules (Basel, Switzerland). 2019 Jul; 24(15):. doi: 10.3390/molecules24152792. [PMID: 31370295]
  • M C Nolff, S Winter, S Reese, A Meyer-Lindenberg. Comparison of polyhexanide, cold atmospheric plasma and saline in the treatment of canine bite wounds. The Journal of small animal practice. 2019 Jun; 60(6):348-355. doi: 10.1111/jsap.12971. [PMID: 30536970]
  • Yong Joo Park, Mi Ho Jeong, In Jae Bang, Ha Ryong Kim, Kyu Hyuck Chung. Guanidine-based disinfectants, polyhexamethylene guanidine-phosphate (PHMG-P), polyhexamethylene biguanide (PHMB), and oligo(2-(2-ethoxy)ethoxyethyl guanidinium chloride (PGH) induced epithelial-mesenchymal transition in A549 alveolar epithelial cells. Inhalation toxicology. 2019 03; 31(4):161-166. doi: 10.1080/08958378.2019.1624896. [PMID: 31179775]
  • S Hafner, M Ehrenfeld, A-C Neumann, Andreas Wieser. Comparison of the bactericidal effect of cold atmospheric pressure plasma (CAPP), antimicrobial photodynamic therapy (aPDT), and polihexanide (PHX) in a novel wet surface model to mimic oral cavity application. Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery. 2018 Dec; 46(12):2197-2202. doi: 10.1016/j.jcms.2018.09.006. [PMID: 30316654]
  • Selina Winter, Mirja Christine Nolff, Sven Reese, Andrea Meyer-Lindenberg. [Comparison of the antibacterial efficacy of polyhexanide, cold atmospheric argon plasma and saline in the treatment of canine bite wounds]. Tierarztliche Praxis. Ausgabe K, Kleintiere/Heimtiere. 2018 04; 46(2):73-82. doi: 10.15654/tpk-170713. [PMID: 29727894]
  • Aparajita Chowdhury, Lora L Arnold, Zemin Wang, Karen L Pennington, Puttappa Dodmane, Ana Paula Farragut-Cardoso, James E Klaunig, Daniel Cros, Edmond E Creppy, Samuel M Cohen. Effect of polyhexamethylene biguanide on rat liver. Toxicology letters. 2018 Mar; 285(?):94-103. doi: 10.1016/j.toxlet.2017.12.032. [PMID: 29305328]
  • Verena Christen, Susanne Faltermann, Nadja Rebecca Brun, Petra Y Kunz, Karl Fent. Cytotoxicity and molecular effects of biocidal disinfectants (quaternary ammonia, glutaraldehyde, poly(hexamethylene biguanide) hydrochloride PHMB) and their mixtures in vitro and in zebrafish eleuthero-embryos. The Science of the total environment. 2017 May; 586(?):1204-1218. doi: 10.1016/j.scitotenv.2017.02.114. [PMID: 28236482]
  • Cornelia Wiegand, Thomas Eberlein, Anneke Andriessen. Antibacterial activity of polihexanide formulations in a co-culture of HaCaT keratinocytes and Staphylococcus aureus and at different pH levels. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. 2017 05; 25(3):423-431. doi: 10.1111/wrr.12528. [PMID: 28370821]
  • N Kapalschinski, H M Seipp, M Kückelhaus, K K Harati, J J Kolbenschlag, A Daigeler, F Jacobsen, M Lehnhardt, T Hirsch. Albumin reduces the antibacterial efficacy of wound antiseptics against Staphylococcus aureus. Journal of wound care. 2017 Apr; 26(4):184-187. doi: 10.12968/jowc.2017.26.4.184. [PMID: 28379100]
  • Daniela Knafl, Florian Thalhammer, Matthias G Vossen. In-vitro release pharmacokinetics of amikacin, teicoplanin and polyhexanide in a platelet rich fibrin-layer (PRF)-a laboratory evaluation of a modern, autologous wound treatment. PloS one. 2017; 12(7):e0181090. doi: 10.1371/journal.pone.0181090. [PMID: 28686663]
  • Alexander А Gusev, Alexey A Kudrinsky, Olga V Zakharova, Alexey I Klimov, Pavel M Zherebin, George V Lisichkin, Inna A Vasyukova, Albert N Denisov, Yurii A Krutyakov. Versatile synthesis of PHMB-stabilized silver nanoparticles and their significant stimulating effect on fodder beet (Beta vulgaris L.). Materials science & engineering. C, Materials for biological applications. 2016 May; 62(?):152-9. doi: 10.1016/j.msec.2016.01.040. [PMID: 26952409]
  • Satya Sree N Kolar, Joseph C Manarang, Alan R Burns, William L Miller, Alison M McDermott, Jan P G Bergmanson. Contact lens care solution killing efficacy against Acanthamoeba castellanii by in vitro testing and live-imaging. Contact lens & anterior eye : the journal of the British Contact Lens Association. 2015 Dec; 38(6):442-50. doi: 10.1016/j.clae.2015.06.006. [PMID: 26208952]
  • Cornelia Wiegand, Sebastian Moritz, Nadine Hessler, Dana Kralisch, Falko Wesarg, Frank A Müller, Dagmar Fischer, Uta-Christina Hipler. Antimicrobial functionalization of bacterial nanocellulose by loading with polihexanide and povidone-iodine. Journal of materials science. Materials in medicine. 2015 Oct; 26(10):245. doi: 10.1007/s10856-015-5571-7. [PMID: 26411441]
  • Ian J Horner, Nadine D Kraut, Jerod J Hurst, Alyssa M Rook, Crystal M Collado, G Ekin Atilla-Gokcumen, E Peter Maziarz, X Michael Liu, Mohinder M Merchea, Frank V Bright. Effects of Polyhexamethylene Biguanide and Polyquaternium-1 on Phospholipid Bilayer Structure and Dynamics. The journal of physical chemistry. B. 2015 Aug; 119(33):10531-42. doi: 10.1021/acs.jpcb.5b07162. [PMID: 26239890]
  • Raimo Mikkola, Maria A Andersson, Maria Hautaniemi, Mirja S Salkinoja-Salonen. Toxic indole alkaloids avrainvillamide and stephacidin B produced by a biocide tolerant indoor mold Aspergillus westerdijkiae. Toxicon : official journal of the International Society on Toxinology. 2015 Jun; 99(?):58-67. doi: 10.1016/j.toxicon.2015.03.011. [PMID: 25804991]
  • Elena Llorens, Silvia Calderón, Luis J del Valle, Jordi Puiggalí. Polybiguanide (PHMB) loaded in PLA scaffolds displaying high hydrophobic, biocompatibility and antibacterial properties. Materials science & engineering. C, Materials for biological applications. 2015 May; 50(?):74-84. doi: 10.1016/j.msec.2015.01.100. [PMID: 25746248]
  • Gerald Müller, Hicham Benkhai, Rutger Matthes, Birgit Finke, Wenke Friedrichs, Norman Geist, Walter Langel, Axel Kramer. Poly (hexamethylene biguanide) adsorption on hydrogen peroxide treated Ti-Al-V alloys and effects on wettability, antimicrobial efficacy, and cytotoxicity. Biomaterials. 2014 Jul; 35(20):5261-5277. doi: 10.1016/j.biomaterials.2014.03.033. [PMID: 24703717]
  • M Núñez-Moral, E Sánchez-Álvarez, I González-Díaz, B Peláez-Requejo, A Fernández-Viña, A Quintana-Fernández, C Rodríguez-Suárez. Exit-site infection of peritoneal catheter is reduced by the use of polyhexanide. results of a prospective randomized trial. Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis. 2014 May; 34(3):271-7. doi: 10.3747/pdi.2012.00109. [PMID: 24497599]
  • Grit Baier, Alex Cavallaro, Krasimir Vasilev, Volker Mailänder, Anna Musyanovych, Katharina Landfester. Enzyme responsive hyaluronic acid nanocapsules containing polyhexanide and their exposure to bacteria to prevent infection. Biomacromolecules. 2013 Apr; 14(4):1103-12. doi: 10.1021/bm302003m. [PMID: 23448580]
  • Elise Chadeau, Emilie Dumas, Isabelle Adt, Pascal Degraeve, Claude Noël, Christophe Girodet, Nadia Oulahal. Assessment of the mode of action of polyhexamethylene biguanide against Listeria innocua by Fourier transformed infrared spectroscopy and fluorescence anisotropy analysis. Canadian journal of microbiology. 2012 Dec; 58(12):1353-61. doi: 10.1139/w2012-113. [PMID: 23210992]
  • Gerald Müller, Axel Kramer, Jürgen Schmitt, Daniela Harden, Torsten Koburger. Reduced cytotoxicity of polyhexamethylene biguanide hydrochloride (PHMB) by egg phosphatidylcholine while maintaining antimicrobial efficacy. Chemico-biological interactions. 2011 Apr; 190(2-3):171-8. doi: 10.1016/j.cbi.2011.02.024. [PMID: 21356204]
  • A Hammann, N-O Huebner, C Bender, A Ekkernkamp, B Hartmann, P Hinz, E Kindel, I Koban, S Koch, T Kohlmann, J Lademann, R Matthes, G Müller, R Titze, K-D Weltmann, A Kramer. Antiseptic efficacy and tolerance of tissue-tolerable plasma compared with two wound antiseptics on artificially bacterially contaminated eyes from commercially slaughtered pigs. Skin pharmacology and physiology. 2010; 23(6):328-32. doi: 10.1159/000314724. [PMID: 20588084]
  • N-O Hübner, R Matthes, I Koban, C Rändler, G Müller, C Bender, E Kindel, T Kocher, A Kramer. Efficacy of chlorhexidine, polihexanide and tissue-tolerable plasma against Pseudomonas aeruginosa biofilms grown on polystyrene and silicone materials. Skin pharmacology and physiology. 2010; 23 Suppl(?):28-34. doi: 10.1159/000318265. [PMID: 20829659]
  • Ying-Hua Xuan, Byung-Suk Chung, Yeon-Chul Hong, Hyun-Hee Kong, Tae-Won Hahn, Dong-Il Chung. Keratitis by Acanthamoeba triangularis: report of cases and characterization of isolates. The Korean journal of parasitology. 2008 Sep; 46(3):157-64. doi: 10.3347/kjp.2008.46.3.157. [PMID: 18830055]
  • Helge Frieling, Kai-Steffen Lauer, Matthias Gründling, Taras Usichenko, Konrad Meissner, Theoni Kanellopoulou, Christian Lehmann, Michael Wendt, Dragan Pavlovic. Peritoneal instillation of taurolidine or polihexanide modulates intestinal microcirculation in experimental endotoxemia. International journal of colorectal disease. 2007 Jul; 22(7):807-17. doi: 10.1007/s00384-006-0239-x. [PMID: 17119983]
  • M Werthén, M Davoudi, A Sonesson, D P Nitsche, M Mörgelin, K Blom, A Schmidtchen. Pseudomonas aeruginosa-induced infection and degradation of human wound fluid and skin proteins ex vivo are eradicated by a synthetic cationic polymer. The Journal of antimicrobial chemotherapy. 2004 Oct; 54(4):772-9. doi: 10.1093/jac/dkh407. [PMID: 15355938]
  • H H Kong, D I Chung. Ultrastructural changes of Acanthamoeba cyst of clinical isolates after treatment with minimal cysticidal concentration of polyhexamethylene biguanide. The Korean journal of parasitology. 1998 Mar; 36(1):7-13. doi: 10.3347/kjp.1998.36.1.7. [PMID: 9529858]
  • W Khunkitti, A C Hann, D Lloyd, J R Furr, A D Russell. Biguanide-induced changes in Acanthamoeba castellanii: an electron microscopic study. Journal of applied microbiology. 1998 Jan; 84(1):53-62. doi: 10.1046/j.1365-2672.1997.00305.x. [PMID: 15244057]
  • D Michel, G A Zäch. Antiseptic efficacy of disinfecting solutions in suspension test in vitro against methicillin-resistant Staphylococcus aureus, Pseudomonas aeruginosa and Escherichia coli in pressure sore wounds after spinal cord injury. Dermatology (Basel, Switzerland). 1997; 195 Suppl 2(?):36-41. doi: 10.1159/000246028. [PMID: 9403253]
  • D Kumar, P K Khan, S P Sinha. Cytogenetic toxicity and no-effect limit dose of pesticides. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 1995 Apr; 33(4):309-14. doi: 10.1016/0278-6915(94)00147-g. [PMID: 7537710]
  • J A Chawner, P Gilbert. Interaction of the bisbiguanides chlorhexidine and alexidine with phospholipid vesicles: evidence for separate modes of action. The Journal of applied bacteriology. 1989 Mar; 66(3):253-8. doi: 10.1111/j.1365-2672.1989.tb02476.x. [PMID: 2663802]
  • P Broxton, P M Woodcock, F Heatley, P Gilbert. Interaction of some polyhexamethylene biguanides and membrane phospholipids in Escherichia coli. The Journal of applied bacteriology. 1984 Aug; 57(1):115-24. doi: 10.1111/j.1365-2672.1984.tb02363.x. [PMID: 6386785]
  • T Ikeda, A Ledwith, C H Bamford, R A Hann. Interaction of a polymeric biguanide biocide with phospholipid membranes. Biochimica et biophysica acta. 1984 Jan; 769(1):57-66. doi: 10.1016/0005-2736(84)90009-9. [PMID: 6691980]
  • T Ikeda, S Tazuke, M Watanabe. Interaction of biologically active molecules with phospholipid membranes. I. Fluorescence depolarization studies on the effect of polymeric biocide bearing biguanide groups in the main chain. Biochimica et biophysica acta. 1983 Nov; 735(3):380-6. doi: 10.1016/0005-2736(83)90152-9. [PMID: 6639946]