3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione (BioDeep_00000173781)

   

human metabolite blood metabolite


代谢物信息卡片


3-(2,4-dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-2,5-dihydro-1H-pyrrole-2,5-dione

化学式: C19H12Cl2N2O2 (370.0275792)
中文名称: SB 216763
谱图信息: 最多检出来源 Homo sapiens(blood) 93.94%

分子结构信息

SMILES: CN1C=C(C2=CC=CC=C12)C1=C(C(=O)NC1=O)C1=C(Cl)C=C(Cl)C=C1
InChI: InChI=1S/C19H12Cl2N2O2/c1-23-9-13(11-4-2-3-5-15(11)23)17-16(18(24)22-19(17)25)12-7-6-10(20)8-14(12)21/h2-9H,1H3,(H,22,24,25)

描述信息

同义名列表

4 个代谢物同义名

3-(2,4-dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-2,5-dihydro-1H-pyrrole-2,5-dione; 3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione; 3-(2,4-dichlorophenyl)-4-(1-methylindol-3-yl)-1H-pyrrole-2,5-dione; SB216763



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Cheng Chang, Shu-Hui Wang, Li-Na Xu, Xue-Ling Su, Yi-Fan Zeng, Peng Wang, Li-Rong Zhang, Sheng-Na Han. Glycogen synthase kinase 3 beta inhibitor SB216763 improves Kir2.1 expression after myocardia infraction in rats. Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing. 2022 Mar; 63(2):239-248. doi: 10.1007/s10840-021-00963-7. [PMID: 33611692]
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  • Tingting Qin, Xinxin Fu, Jiayu Yu, Ruyi Zhang, Xueyang Deng, Qiang Fu, Zhanqiang Ma, Shiping Ma. Modification of GSK3β/β-catenin signaling on saikosaponins-d-induced inhibition of neural progenitor cell proliferation and adult neurogenesis. Toxicology. 2019 08; 424(?):152233. doi: 10.1016/j.tox.2019.06.004. [PMID: 31175886]
  • Su Myat Phyu, Chih-Chung Tseng, Tim Andrew Davies Smith. CDP-choline accumulation in breast and colorectal cancer cells treated with a GSK-3-targeting inhibitor. Magma (New York, N.Y.). 2019 Apr; 32(2):227-235. doi: 10.1007/s10334-018-0719-3. [PMID: 30446846]
  • Linjie Wang, Xueying Li, Zhe Chao, Tao Zhong, Jiazhong Guo, Yan Wang, Li Li, Hongping Zhang. Transcriptional Regulation of NAMPT Gene by Glycogen Synthase Kinase 3β in Goat Adipocytes. DNA and cell biology. 2019 Mar; 38(3):229-235. doi: 10.1089/dna.2018.4499. [PMID: 30615481]
  • Yi-De Zhang, Xiao-Jun Ding, Hou-Yong Dai, Wei-Sheng Peng, Nai-Feng Guo, Yuan Zhang, Qiao-Ling Zhou, Xiao-Lan Chen. SB-216763, a GSK-3β inhibitor, protects against aldosterone-induced cardiac, and renal injury by activating autophagy. Journal of cellular biochemistry. 2018 07; 119(7):5934-5943. doi: 10.1002/jcb.26788. [PMID: 29600538]
  • Fan Yang, Rongrong Wu, Zhi Jiang, Jinghai Chen, Jinliang Nan, Sheng'an Su, Na Zhang, Chen Wang, Jing Zhao, Cheng Ni, Yingchao Wang, Wangxing Hu, Zhiru Zeng, Keyang Zhu, Xianbao Liu, Xinyang Hu, Wei Zhu, Hong Yu, Jinyu Huang, Jian'an Wang. Leptin increases mitochondrial OPA1 via GSK3-mediated OMA1 ubiquitination to enhance therapeutic effects of mesenchymal stem cell transplantation. Cell death & disease. 2018 05; 9(5):556. doi: 10.1038/s41419-018-0579-9. [PMID: 29748581]
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  • Lihua Wang, Yifei Zhu, Lili Wang, Jingjing Hou, Yongning Gao, Lei Shen, Jingyu Zhang. Effects of chronic alcohol exposure on ischemia-reperfusion-induced acute kidney injury in mice: the role of β-arrestin 2 and glycogen synthase kinase 3. Experimental & molecular medicine. 2017 06; 49(6):e347. doi: 10.1038/emm.2017.76. [PMID: 28642577]
  • H B Shi, H L Shi, X Y Zhang, D X Chen, Z P Duan, F Ren. [Protective effect of glycogen synthase kinase 3β inhibition via peroxisome proliferator-activated receptor alpha activation in mice with acute liver failure]. Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology. 2017 Mar; 25(3):211-216. doi: 10.3760/cma.j.issn.1007-3418.2017.03.010. [PMID: 28482409]
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