6-Hydroxy-5-methoxy-1h-indole-2-carboxylic acid (BioDeep_00000173766)
human metabolite blood metabolite
代谢物信息卡片
6-Hydroxy-5-methoxy-1h-indole-2-carboxylic acid
化学式: C10H9NO4 (207.05315539999998)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: COC1=C(C=C2C(=C1)C=C(N2)C(=O)O)O
InChI: InChI=1S/C10H9NO4/c1-15-9-3-5-2-7(10(13)14)11-6(5)4-8(9)12/h2-4,11-12H,1H3,(H,13,14)
描述信息
同义名列表
8 个代谢物同义名
6-Hydroxy-5-methoxy-1h-indole-2-carboxylic acid; 6-Hydroxy-5-methoxy-2-indolylcarboxylic acid; 6-Hydroxy-5-methoxy-2-indolecarboxylic acid; 6-Hydroxy-5-methoxyindole-2-carboxylic acid; 6-Hydroxy-5-methoxy-1H-indole-2-carboxylate; 5-Methoxy-6-hydroxyindole-2-carboxylic acid; 6-HMICA; 6H5MI2c
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
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Pigment cell research.
2006 Oct; 19(5):460-4. doi:
10.1111/j.1600-0749.2006.00324.x. [PMID: 16965276] - Kazumasa Wakamatsu, Akihiko Takasaki, Bertil Kågedal, Toshiro Kageshita, Shosuke Ito. Determination of eumelanin in human urine.
Pigment cell research.
2006 Apr; 19(2):163-9. doi:
10.1111/j.1600-0749.2006.00296.x. [PMID: 16524432] - J Hartleb, R Arndt. Cysteine and indole derivatives as markers for malignant melanoma.
Journal of chromatography. B, Biomedical sciences and applications.
2001 Nov; 764(1-2):409-43. doi:
10.1016/s0378-4347(01)00278-x. [PMID: 11817040] - R Kärnell, B Kågedal, C Lindholm, B Nilsson, K Arstrand, U Ringborg. The value of cysteinyldopa in the follow-up of disseminated malignant melanoma.
Melanoma research.
2000 Aug; 10(4):363-9. doi:
10.1097/00008390-200008000-00008. [PMID: 10985671] - R Kärnell, E von Schoultz, L O Hansson, B Nilsson, K Arstrand, B Kågedal. S100B protein, 5-S-cysteinyldopa and 6-hydroxy-5-methoxyindole-2-carboxylic acid as biochemical markers for survival prognosis in patients with malignant melanoma.
Melanoma research.
1997 Oct; 7(5):393-9. doi:
10.1097/00008390-199710000-00005. [PMID: 9429222] - K Wakamatsu, S Ito. Seasonal variation in serum concentration of 5-S-cysteinyldopa and 6-hydroxy-5-methoxyindole-2-carboxylic acid in healthy Japanese.
Pigment cell research.
1995 Jun; 8(3):132-4. doi:
10.1111/j.1600-0749.1995.tb00653.x. [PMID: 7567788] - H Hara, N Walsh, K Yamada, K Jimbow. High plasma level of a eumelanin precursor, 6-hydroxy-5-methoxyindole-2-carboxylic acid as a prognostic marker for malignant melanoma.
The Journal of investigative dermatology.
1994 Apr; 102(4):501-5. doi:
10.1111/1523-1747.ep12373153. [PMID: 8151128] - A Kammeyer, L A Oomen, S Pavel. Preparation of monoclonal mouse antibodies against two specific eu-melanin related compounds.
Journal of immunological methods.
1992 Nov; 156(1):61-7. doi:
10.1016/0022-1759(92)90011-h. [PMID: 1431163] - K Yamada, N Walsh, H Hara, K Jimbow, H Chen, S Ito. Measurement of eumelanin precursor metabolites in the urine as a new marker for melanoma metastases.
Archives of dermatology.
1992 Apr; 128(4):491-4. doi:
. [PMID: 1580656] - B Kågedal, L Lenner, K Arstrand, C Hansson. The stability of 5-S-cysteinyldopa and 6-hydroxy-5-methoxyindole-2-carboxylic acid in human urine.
Pigment cell research.
1992; Suppl 2(?):304-7. doi:
10.1111/j.1600-0749.1990.tb00390.x. [PMID: 1409435] - J M Duthel, J J Vallon. Indolic urinary melanogens: separation and identification by gas chromatography with selected-ion monitoring mass spectrometry of 5-hydroxy-6-methoxyindole-2-carboxylic and 5-methoxy-6-hydroxyindole-2- carboxylic acids.
Journal of chromatography.
1991 Sep; 570(1):166-72. doi:
10.1016/0378-4347(91)80211-t. [PMID: 1797822] - K Wakamatsu, S Ito. Identification of ester glucuronide and sulfate conjugates of 5-hydroxy-6-methoxyindole-2-carboxylic acid and 6-hydroxy-5-methoxyindole-2-carboxylic acid in melanoma urine.
Journal of dermatological science.
1990 Jul; 1(4):253-9. doi:
10.1016/0923-1811(90)90117-v. [PMID: 2095194] - S Ito, K Wakamatsu. Melanin chemistry and melanin precursors in melanoma.
The Journal of investigative dermatology.
1989 May; 92(5 Suppl):261S-265S. doi:
10.1111/1523-1747.ep13076587. [PMID: 2654299] - H Rorsman, E Tegner. Biochemical observations in UV-induced pigmentation.
Photo-dermatology.
1988 Feb; 5(1):30-8. doi:
. [PMID: 3281148] - C Hansson. Some indolic compounds as markers of the melanocyte activity.
Acta dermato-venereologica. Supplementum.
1988; 138(?):1-60. doi:
. [PMID: 3176811] - K Wakamatsu, S Ito, K Fujita. Melanin-related metabolites in urine of B16 melanoma-bearing mice.
Acta dermato-venereologica.
1988; 68(5):385-9. doi:
NULL. [PMID: 2461020] - H Rorsman, P Agrup, B Carlén, C Hansson, N Jonsson, E Rosengren, E Tegner. Trichochromuria in melanosis of melanoma.
Acta dermato-venereologica.
1986; 66(6):468-73. doi:
NULL. [PMID: 2433864] - C Hansson, L E Wirestrand, A Aronsson, H Rorsman, E Rosengren. Urinary excretion of 6-hydroxy-5-methoxyindole-2-carboxylic acid and 5-S-cysteinyldopa during PUVA treatment.
Photo-dermatology.
1985 Apr; 2(2):52-7. doi:
NULL. [PMID: 3929237] - R Carstam, C Hansson, G Krook, H Rorsman, E Rosengren, L E Wirestrand. Oxidation of dopa in human albinism.
Acta dermato-venereologica.
1985; 65(5):435-7. doi:
. [PMID: 2416170] - M C Ekelund, R Carstam, C Hansson, H Rorsman, E Rosengren. Urinary excretion of 5-S-cysteinyldopa and 6-hydroxy-5-methoxyindole-2-carboxylic acid: differences between pigmented and albino mice.
Acta dermato-venereologica.
1985; 65(5):437-9. doi:
NULL. [PMID: 2416171] - L E Wirestrand, C Hansson, E Rosengren, H Rorsman. Melanocyte metabolites in the urine of people of different skin colour.
Acta dermato-venereologica.
1985; 65(4):345-8. doi:
NULL. [PMID: 2413694] - R Carstam, C Hansson, H Rorsman, E Rosengren, N O Sjöberg, L E Wirestrand. Urinary excretion of melanocytic metabolites in fertile women.
Acta dermato-venereologica.
1985; 65(6):543-5. doi:
NULL. [PMID: 2420122] - C Hansson. 6-Hydroxy-5-methoxyindole-2-carboxylic acid in normal human urine.
Acta dermato-venereologica.
1984; 64(3):185-90. doi:
NULL. [PMID: 6204477] - S Pavel, F A Muskiet, G T Nagel, J Duchon. [Identification of some indolic acids in urine using mass fragmentography (author's transl)].
Sbornik lekarsky.
1981 May; 83(5):121-7. doi:
NULL. [PMID: 7256174] - S Pavel, B Matous, J Duchon, E Bubnová. 5-Hydroxy-6-methoxy-2-indolylcarboxylic and 6-hydroxy-5-methoxy-2-indolylcarboxylic acids in the urine of hamsters with melanotic melanoma.
Neoplasma.
1978; 25(3):343-7. doi:
NULL. [PMID: 683376]