3-Biphenylacetic acid (BioDeep_00000173714)
human metabolite blood metabolite
代谢物信息卡片
Biphenylylacetic acid, 14C-labeled
化学式: C14H12O2 (212.0837252)
中文名称: 2-([1,1-联苯]-3-基)乙酸
谱图信息:
最多检出来源 Homo sapiens(blood) 89.47%
分子结构信息
SMILES: C1=CC=C(C=C1)C2=CC=CC(=C2)CC(=O)O
InChI: InChI=1S/C14H12O2/c15-14(16)10-11-5-4-8-13(9-11)12-6-2-1-3-7-12/h1-9H,10H2,(H,15,16)
描述信息
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
D000893 - Anti-Inflammatory Agents
D018501 - Antirheumatic Agents
同义名列表
数据库引用编号
5 个数据库交叉引用编号
- PubChem: 32153
- HMDB: HMDB0245651
- ChEMBL: CHEMBL142396
- chemspider: 29821
- CAS: 23948-77-8
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Mika Yoshimura Fujii, Yoko Asakawa, Toshiro Fukami. Potential application of novel liquid crystal nanoparticles of isostearyl glyceryl ether for transdermal delivery of 4-biphenyl acetic acid.
International journal of pharmaceutics.
2020 Feb; 575(?):118935. doi:
10.1016/j.ijpharm.2019.118935. [PMID: 31816353] - Jong Han Lee, Mithun Kumer Sarker, Hojung Choi, Dongyun Shin, Donghee Kim, Hee-Sook Jun. Lysophosphatidic acid receptor 1 inhibitor, AM095, attenuates diabetic nephropathy in mice by downregulation of TLR4/NF-κB signaling and NADPH oxidase.
Biochimica et biophysica acta. Molecular basis of disease.
2019 06; 1865(6):1332-1340. doi:
10.1016/j.bbadis.2019.02.001. [PMID: 30763641] - Qiuping Guo, Jianmin Guo, Guiying Chen, Zhong Han, Baiquan Xiao, Ruomin Jin, Chun Liang, Wei Yang. Biomarkers associated with binaprofen‑induced liver injury.
Molecular medicine reports.
2018 12; 18(6):5076-5086. doi:
10.3892/mmr.2018.9549. [PMID: 30320395] - Vincenzo Ferrone, Maura Carlucci, Paola Palumbo, Giuseppe Carlucci. Bioanalytical method development for quantification of ulifloxacin, fenbufen and felbinac in rat plasma by solid-phase extraction (SPE) and HPLC with PDA detection.
Journal of pharmaceutical and biomedical analysis.
2016 May; 123(?):205-12. doi:
10.1016/j.jpba.2016.01.062. [PMID: 26898973] - Yunliang Zheng, Xingjiang Hu, Jian Liu, Guolan Wu, You Zhai, Lihua Wu, Jianzhong Shentu. Qualitative and quantitative analysis of felbinac and its major metabolites in human plasma and urine by liquid chromatography tandem mass spectrometry and its application after intravenous administration of felbinac trometamol injection.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2015 Apr; 986-987(?):60-8. doi:
10.1016/j.jchromb.2015.01.042. [PMID: 25706568] - Suneela Dhaneshwar, Manisha Kusurkar, Subhash Bodhankar, Gopal Bihani. Carrier-linked mutual prodrugs of biphenylacetic acid as a promising alternative to bioprecursor fenbufen: design, kinetics, and pharmacological studies.
Inflammopharmacology.
2014 Aug; 22(4):235-50. doi:
10.1007/s10787-013-0194-4. [PMID: 24178955] - Yohei Sakaguchi, Hideyuki Yoshida, Tadashi Hayama, Makoto Yoshitake, Miki Itoyama, Kenichiro Todoroki, Masatoshi Yamaguchi, Hitoshi Nohta. Fluorous derivatization and fluorous-phase separation for fluorometric determination of naproxen and felbinac in human plasma.
Journal of pharmaceutical and biomedical analysis.
2011 Apr; 55(1):176-80. doi:
10.1016/j.jpba.2011.01.011. [PMID: 21310574] - Chao Zhang, Xiangyong Cui, Yan Yang, Feng Gao, Yantong Sun, Jingkai Gu, J Paul Fawcett, Wei Yang, Wei Wang. Pharmacokinetics of felbinac after intravenous administration of felbinac trometamol in rats.
Xenobiotica; the fate of foreign compounds in biological systems.
2011 Apr; 41(4):340-8. doi:
10.3109/00498254.2010.544422. [PMID: 21182394] - Chao Zhang, Lu Wang, Wei Yang, Xisha Wang, J Paul Fawcett, Yantong Sun, Jingkai Gu. Validated LC-MS/MS assay for the determination of felbinac: Application to a preclinical pharmacokinetics study of felbinac trometamol injection in rat.
Journal of pharmaceutical and biomedical analysis.
2009 Aug; 50(1):41-5. doi:
10.1016/j.jpba.2009.03.019. [PMID: 19376665] - Jahye Kim, Hisakazu Ohtani, Masayuki Tsujimoto, Yasufumi Sawada. Quantitative comparison of the convulsive activity of combinations of twelve fluoroquinolones with five nonsteroidal antiinflammatory agents.
Drug metabolism and pharmacokinetics.
2009; 24(2):167-74. doi:
10.2133/dmpk.24.167. [PMID: 19430173] - S Marchand, C Pariat, A Boulanger, S Bouquet, W Couet. A pharmacokinetic/pharmacodynamic approach to show that not all fluoroquinolones exhibit similar sensitivity toward the proconvulsant effect of biphenyl acetic acid in rats.
The Journal of antimicrobial chemotherapy.
2001 Dec; 48(6):813-20. doi:
10.1093/jac/48.6.813. [PMID: 11733465] - S Marchand, C Pariat, S Bouquet, P Courtois, W Couet. Pharmacokinetic-pharmacodynamic modelling of the convulsant interaction between norfloxacin and biphenyl acetic acid in rats.
British journal of pharmacology.
2000 Apr; 129(8):1609-16. doi:
10.1038/sj.bjp.0703260. [PMID: 10780965] - G Carlucci, P Mazzeo, G Palumbo. Simultaneous determination of rufloxacin, fenbufen and felbinac in human plasma using high-performance liquid chromatography.
Journal of chromatography. B, Biomedical applications.
1996 Jul; 682(2):315-9. doi:
10.1016/0378-4347(96)00073-4. [PMID: 8844425] - H Ohtani, S Noma, J Kawakami, Y Sawada, T Iga. Lack of potentiation with felbinac patch on the convulsive toxicity of enoxacin in rats.
Biological & pharmaceutical bulletin.
1996 Jul; 19(7):995-7. doi:
10.1248/bpb.19.995. [PMID: 8839976] - K Akahane, S Ohkawara, M Nomura, M Kato. Effect of bile duct ligation and unilateral nephrectomy on brain concentration and convulsant potential of the quinolone antibacterial agent levofloxacin in rats.
Fundamental and applied toxicology : official journal of the Society of Toxicology.
1996 Feb; 29(2):280-6. doi:
10.1006/faat.1996.0032. [PMID: 8742326] - G Puglisi, C A Ventura, A Spadaro, G Campana, S Spampinato. Differential effects of modified beta-cyclodextrins on pharmacological activity and bioavailability of 4-biphenylacetic acid in rats after oral administration.
The Journal of pharmacy and pharmacology.
1995 Feb; 47(2):120-3. doi:
10.1111/j.2042-7158.1995.tb05762.x. [PMID: 7602465] - K Akahane, Y Kimura, Y Tsutomi, I Hayakawa. Possible intermolecular interaction between quinolones and biphenylacetic acid inhibits gamma-aminobutyric acid receptor sites.
Antimicrobial agents and chemotherapy.
1994 Oct; 38(10):2323-9. doi:
10.1128/aac.38.10.2323. [PMID: 7840564] - P G Davey, M Charter, S Kelly, T R Varma, I Jacobson, A Freeman, E Precious, J Lambert. Ciprofloxacin and sparfloxacin penetration into human brain tissue and their activity as antagonists of GABAA receptor of rat vagus nerve.
Antimicrobial agents and chemotherapy.
1994 Jun; 38(6):1356-62. doi:
10.1128/aac.38.6.1356. [PMID: 8092837] - H Arima, T Kondo, T Irie, F Hirayama, K Uekama, T Miyaji, Y Inoue. [Use of water-soluble beta-cyclodextrin derivatives as carriers of anti-inflammatory drug biphenylylacetic acid in rectal delivery].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.
1992 Jan; 112(1):65-72. doi:
10.1248/yakushi1947.112.1_65. [PMID: 1578346] - G Puglisi, N A Santagati, C A Ventura, R Pignatello, A M Panico, S Spampinato. Enhancement of 4-biphenylacetic acid bioavailability in rats by its beta-cyclodextrin complex after oral administration.
The Journal of pharmacy and pharmacology.
1991 Jun; 43(6):430-2. doi:
10.1111/j.2042-7158.1991.tb03503.x. [PMID: 1681057] - W Bolten, E Waldorf-Bolten, D Sarfert, W Lehmann, W Miehlke. [Pharmacokinetic studies following 2 and 4-week Felbinac gel administration to the knee joint].
Zeitschrift fur Rheumatologie.
1990 Nov; 49(6):374-7. doi:
NULL. [PMID: 2085060] - K Naora, Y Katagiri, N Ichikawa, M Hayashibara, K Iwamoto. Simultaneous high-performance liquid chromatographic determination of ciprofloxacin, fenbufen and felbinac in rat plasma.
Journal of chromatography.
1990 Aug; 530(1):186-91. doi:
10.1016/s0378-4347(00)82320-8. [PMID: 2277110] - K Naora, Y Katagiri, N Ichikawa, M Hayashibara, K Iwamoto. A minor possibility of pharmacokinetic interaction between enoxacin and fenbufen in rats.
Journal of pharmacobio-dynamics.
1990 Feb; 13(2):90-6. doi:
10.1248/bpb1978.13.90. [PMID: 2384853] - W Bolten, G Salzmann, R Goldmann, K Miehlke. [Plasma and tissue concentrations of biphenylacetic acid following 1 week oral fenbufen medication and topical administration of Felbinac gel on the knee joint].
Zeitschrift fur Rheumatologie.
1989 Nov; 48(6):317-22. doi:
NULL. [PMID: 2696292] - Y Katagiri, K Naora, N Ichikawa, M Hayashibara, K Iwamoto. High-performance liquid chromatographic procedure for the simultaneous determination of norfloxacin, fenbufen and felbinac in rat plasma.
Chemical & pharmaceutical bulletin.
1989 Oct; 37(10):2858-60. doi:
10.1248/cpb.37.2858. [PMID: 2611947] - Y Katagiri, K Naora, N Ichikawa, M Hayashibara, K Iwamoto. Absence of pharmacokinetic interaction between ofloxacin and fenbufen in rats.
The Journal of pharmacy and pharmacology.
1989 Oct; 41(10):717-9. doi:
10.1111/j.2042-7158.1989.tb06349.x. [PMID: 2575153] - Y Katagiri, K Naora, N Ichikawa, M Hayashibara, K Iwamoto. Simultaneous determination of ofloxacin, fenbufen and felbinac in rat plasma by high-performance liquid chromatography.
Journal of chromatography.
1988 Sep; 431(1):135-42. doi:
10.1016/s0378-4347(00)83076-5. [PMID: 3235524] - M Dawson, C M McGee, J H Vine, P Nash, T R Watson, P M Brooks. The disposition of biphenylacetic acid following topical application.
European journal of clinical pharmacology.
1988; 33(6):639-42. doi:
10.1007/bf00542502. [PMID: 3366168] - M Dawson, C M McGee, P M Brooks, J H Vine, E Lacey, T R Watson. Quantitation of biphenylacetic acid in plasma and synovial fluid by gas chromatography-mass spectrometry-mass spectrometry.
Journal of chromatography.
1987 Sep; 420(1):129-34. doi:
10.1016/0378-4347(87)80162-7. [PMID: 3667813] - M J Jackson, A J Wagenmakers, R H Edwards. Effect of inhibitors of arachidonic acid metabolism on efflux of intracellular enzymes from skeletal muscle following experimental damage.
The Biochemical journal.
1987 Jan; 241(2):403-7. doi:
10.1042/bj2410403. [PMID: 3109374] - Y Shoji, Y Mizushima, A Yanagawa, T Shiba, H Takei, M Fujii, M Amino. Enhancement of anti-inflammatory effects of biphenylylacetic acid by its incorporation into lipid microspheres.
The Journal of pharmacy and pharmacology.
1986 Feb; 38(2):118-21. doi:
10.1111/j.2042-7158.1986.tb04523.x. [PMID: 2870154]
