1-(Tert-Butyl)-3-(2-((4-(diethylamino)butyl)amino)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)urea (BioDeep_00000173692)

   

human metabolite blood metabolite


代谢物信息卡片


N-tert-butyl-N-(2-{[4-(diethylamino)butyl]imino}-6-(3,5-dimethoxyphenyl)-1H,2H-pyrido[2,3-d]pyrimidin-7-yl)carbamimidic acid

化学式: C28H41N7O3 (523.3270716000001)
中文名称: PD173074
谱图信息: 最多检出来源 Homo sapiens(blood) 98.51%

分子结构信息

SMILES: CCN(CC)CCCCN=C1NC2=NC(N=C(O)NC(C)(C)C)=C(C=C2C=N1)C1=CC(OC)=CC(OC)=C1
InChI: InChI=1S/C28H41N7O3/c1-8-35(9-2)13-11-10-12-29-26-30-18-20-16-23(19-14-21(37-6)17-22(15-19)38-7)25(31-24(20)32-26)33-27(36)34-28(3,4)5/h14-18H,8-13H2,1-7H3,(H3,29,30,31,32,33,34,36)

描述信息

同义名列表

7 个代谢物同义名

N-tert-butyl-N-(2-{[4-(diethylamino)butyl]imino}-6-(3,5-dimethoxyphenyl)-1H,2H-pyrido[2,3-d]pyrimidin-7-yl)carbamimidic acid; N-tert-butyl-N-(2-{[4-(diethylamino)butyl]imino}-6-(3,5-dimethoxyphenyl)-1H-pyrido[2,3-d]pyrimidin-7-yl)carbamimidic acid; 1-(Tert-Butyl)-3-(2-((4-(diethylamino)butyl)amino)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)urea; 1-Tert-butyl-3-(6-(3,5-dimethoxyphenyl)-2-(4-diethylaminobutylamino)pyrido(2,3-D)pyrimidin-7-yl)ureea; PD-173074; PD 173074; PD173074



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(2)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Sarah Justesen, Kirsten V Haugegaard, Jacob B Hansen, Harald S Hansen, Birgitte Andersen. The autocrine role of FGF21 in cultured adipocytes. The Biochemical journal. 2020 07; 477(13):2477-2487. doi: 10.1042/bcj20200220. [PMID: 32648929]
  • Satoshi Takasugi, Miho Shioyama, Masami Kitade, Masashi Nagata, Taketo Yamaji. Involvement of estrogen in phosphorus-induced nephrocalcinosis through fibroblast growth factor 23. Scientific reports. 2020 03; 10(1):4864. doi: 10.1038/s41598-020-61858-7. [PMID: 32184468]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Brian Czaya, Wacharee Seeherunvong, Saurav Singh, Christopher Yanucil, Phillip Ruiz, Yasmir Quiroz, Alexander Grabner, Chryso Katsoufis, Sethuraman Swaminathan, Carolyn Abitbol, Bernardo Rodriguez-Iturbe, Christian Faul, Michael Freundlich. Cardioprotective Effects of Paricalcitol Alone and in Combination With FGF23 Receptor Inhibition in Chronic Renal Failure: Experimental and Clinical Studies. American journal of hypertension. 2019 01; 32(1):34-44. doi: 10.1093/ajh/hpy154. [PMID: 30329020]
  • Maja Životić, Björn Tampe, Gerhard Müller, Claudia Müller, Aleksandar Lipkovski, Xingbo Xu, Gunsmaa Nyamsuren, Michael Zeisberg, Jasmina Marković-Lipkovski. Modulation of NCAM/FGFR1 signaling suppresses EMT program in human proximal tubular epithelial cells. PloS one. 2018; 13(11):e0206786. doi: 10.1371/journal.pone.0206786. [PMID: 30383875]
  • Alia Hassan, Karina Durlacher, Justin Silver, Tally Naveh-Many, Ronen Levi. The fibroblast growth factor receptor mediates the increased FGF23 expression in acute and chronic uremia. American journal of physiology. Renal physiology. 2016 Feb; 310(3):F217-21. doi: 10.1152/ajprenal.00332.2015. [PMID: 26311115]
  • Cheng-Hsiang Kuo, Meng-Chen Sung, Po-Ku Chen, Bi-Ing Chang, Fang-Tzu Lee, Chia-Fong Cho, Tai-Tzu Hsieh, Yu-Ching Huang, Yi-Heng Li, Guey-Yueh Shi, Chwan-Yau Luo, Hua-Lin Wu. FGFR1 mediates recombinant thrombomodulin domain-induced angiogenesis. Cardiovascular research. 2015 Jan; 105(1):107-17. doi: 10.1093/cvr/cvu239. [PMID: 25388665]
  • Giovana Seno Di Marco, Stefan Reuter, Dominik Kentrup, Alexander Grabner, Ansel Philip Amaral, Manfred Fobker, Jörg Stypmann, Hermann Pavenstädt, Myles Wolf, Christian Faul, Marcus Brand. Treatment of established left ventricular hypertrophy with fibroblast growth factor receptor blockade in an animal model of CKD. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2014 Nov; 29(11):2028-35. doi: 10.1093/ndt/gfu190. [PMID: 24875663]
  • Hui-Ping Lin, Li-Kuo Kuo, Chih-Pin Chuu. Combined treatment of curcumin and small molecule inhibitors suppresses proliferation of A549 and H1299 human non-small-cell lung cancer cells. Phytotherapy research : PTR. 2012 Jan; 26(1):122-6. doi: 10.1002/ptr.3523. [PMID: 21567511]
  • Luis R de Brito, Mike A Batey, Yan Zhao, Matt S Squires, Helen Maitland, Hing Y Leung, Andrew G Hall, Graham Jackson, David R Newell, Julie A E Irving. Comparative pre-clinical evaluation of receptor tyrosine kinase inhibitors for the treatment of multiple myeloma. Leukemia research. 2011 Sep; 35(9):1233-40. doi: 10.1016/j.leukres.2011.01.011. [PMID: 21316102]
  • C H Widberg, F S Newell, A W Bachmann, S N Ramnoruth, M C Spelta, J P Whitehead, L J Hutley, J B Prins. Fibroblast growth factor receptor 1 is a key regulator of early adipogenic events in human preadipocytes. American journal of physiology. Endocrinology and metabolism. 2009 Jan; 296(1):E121-31. doi: 10.1152/ajpendo.90602.2008. [PMID: 18940940]
  • Evgeni Ponimaskin, Galina Dityateva, Mika O Ruonala, Masaki Fukata, Yuko Fukata, Fritz Kobe, Fred S Wouters, Markus Delling, David S Bredt, Melitta Schachner, Alexander Dityatev. Fibroblast growth factor-regulated palmitoylation of the neural cell adhesion molecule determines neuronal morphogenesis. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2008 Sep; 28(36):8897-907. doi: 10.1523/jneurosci.2171-08.2008. [PMID: 18768683]
  • Shujiang Tu, Longji Cao, Yan Zhang, Qingqing Shao, Dianxiang Zhou, Chunmei Li. An efficient synthesis of pyrido[2,3-d]pyrimidine derivatives and related compounds under ultrasound irradiation without catalyst. Ultrasonics sonochemistry. 2008 Mar; 15(3):217-21. doi: 10.1016/j.ultsonch.2007.03.002. [PMID: 17466564]
  • Andrew M Thompson, Amy M Delaney, James M Hamby, Mel C Schroeder, Teresa A Spoon, Sheila M Crean, H D Hollis Showalter, William A Denny. Synthesis and structure-activity relationships of soluble 7-substituted 3-(3,5-dimethoxyphenyl)-1,6-naphthyridin-2-amines and related ureas as dual inhibitors of the fibroblast growth factor receptor-1 and vascular endothelial growth factor receptor-2 tyrosine kinases. Journal of medicinal chemistry. 2005 Jul; 48(14):4628-53. doi: 10.1021/jm0500931. [PMID: 16000000]
  • Suzanne Trudel, Scott Ely, Yildiz Farooqi, Maurizio Affer, Davide F Robbiani, Marta Chesi, P Leif Bergsagel. Inhibition of fibroblast growth factor receptor 3 induces differentiation and apoptosis in t(4;14) myeloma. Blood. 2004 May; 103(9):3521-8. doi: 10.1182/blood-2003-10-3650. [PMID: 14715624]
  • S D Skaper, W J Kee, L Facci, G Macdonald, P Doherty, F S Walsh. The FGFR1 inhibitor PD 173074 selectively and potently antagonizes FGF-2 neurotrophic and neurotropic effects. Journal of neurochemistry. 2000 Oct; 75(4):1520-7. doi: 10.1046/j.1471-4159.2000.0751520.x. [PMID: 10987832]
  • R P Wilson, P L Fowlkes. Activity of glutamine synthetase in channel catfish tissues determined by an improved tissue assay method. Comparative biochemistry and physiology. B, Comparative biochemistry. 1976; 54(3):365-8. doi: 10.1016/0305-0491(76)90258-3. [PMID: 6197]