2-Ethylhexyl 4-(dimethylamino)benzoate (BioDeep_00000173678)

   

human metabolite blood metabolite


代谢物信息卡片


4-N,N-dimethylamino-benzoic acid, 2-ethylhexyl ester

化学式: C17H27NO2 (277.20416819999997)
中文名称: 对二甲氨基苯甲酸异辛酯
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCCCC(CC)COC(=O)C1=CC=C(C=C1)N(C)C
InChI: InChI=1S/C17H27NO2/c1-5-7-8-14(6-2)13-20-17(19)15-9-11-16(12-10-15)18(3)4/h9-12,14H,5-8,13H2,1-4H3

描述信息

D020011 - Protective Agents > D011837 - Radiation-Protective Agents > D013473 - Sunscreening Agents
C1892 - Chemopreventive Agent > C851 - Sunscreen
D003879 - Dermatologic Agents
D003358 - Cosmetics

同义名列表

12 个代谢物同义名

4-N,N-dimethylamino-benzoic acid, 2-ethylhexyl ester; 2-Ethylhexyl 4-(dimethylamino)benzoic acid; 2-Ethylhexyl 4-(dimethylamino)benzoate; 2-Ethylhexyl 4-dimethylaminobenzoate; 2-Ethylhexyl-p-dimethylaminobenzoate; Padimic acid O; Arlatone 507; Arlatone uvb; Escalol 507; Padimate-O; Padimate O; Climacel



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Guanghua Lu, Ranran Zhou, Sheng Li, Tianjian Dang, Jianchao Liu. Bioaccumulation and Biomagnification of 2-Ethylhexyl-4-dimethylaminobenzoate in Aquatic Animals. International journal of environmental research and public health. 2018 10; 15(11):. doi: 10.3390/ijerph15112395. [PMID: 30380631]
  • Binni Ma, Guanghua Lu, Haohan Yang, Jianchao Liu, Zhenhua Yan, Matthew Nkoom. The effects of dissolved organic matter and feeding on bioconcentration and oxidative stress of ethylhexyl dimethyl p-aminobenzoate (OD-PABA) to crucian carp (Carassius auratus). Environmental science and pollution research international. 2018 Mar; 25(7):6558-6569. doi: 10.1007/s11356-017-1002-2. [PMID: 29255981]
  • Meltem Erol, Ismet Çok, Özlem Bostan Gayret, Pembegül Günes, Özgül Yigit, Elif Sayman, Aysegül Günes, Duygu Sultan Çelik, Sahin Hamilçikan, Serdar Altinay, Oya Ercan. Evaluation of the endocrine-disrupting effects of homosalate (HMS) and 2-ethylhexyl 4-dimethylaminobenzoate (OD-PABA) in rat pups during the prenatal, lactation, and early postnatal periods. Toxicology and industrial health. 2017 Oct; 33(10):775-791. doi: 10.1177/0748233717718974. [PMID: 28879804]
  • Binni Ma, Guanghua Lu, Jianchao Liu, Zhenhua Yan, Haohan Yang, Ting Pan. Bioconcentration and multi-biomarkers of organic UV filters (BM-DBM and OD-PABA) in crucian carp. Ecotoxicology and environmental safety. 2017 Jul; 141(?):178-187. doi: 10.1016/j.ecoenv.2017.03.034. [PMID: 28343007]
  • M Krause, A Klit, M Blomberg Jensen, T Søeborg, H Frederiksen, M Schlumpf, W Lichtensteiger, N E Skakkebaek, K T Drzewiecki. Sunscreens: are they beneficial for health? An overview of endocrine disrupting properties of UV-filters. International journal of andrology. 2012 Jun; 35(3):424-36. doi: 10.1111/j.1365-2605.2012.01280.x. [PMID: 22612478]
  • Zacarías León-González, Carlos Ferreiro-Vera, Feliciano Priego-Capote, María Dolores Luque de Castro. Targeting metabolomics analysis of the sunscreen agent 2-ethylhexyl 4-(N,N-dimethylamino)benzoate in human urine by automated on-line solid-phase extraction-liquid chromatography-tandem mass spectrometry with liquid chromatography-time-of-flight/mass spectrometry confirmation. Journal of chromatography. A. 2011 May; 1218(20):3013-21. doi: 10.1016/j.chroma.2011.03.045. [PMID: 21481400]
  • J G March, C Genestar, B M Simonet. Determination of 2-ethylhexyl 4-(dimethylamino) benzoate using membrane-assisted liquid-liquid extraction and gas chromatography-mass spectrometric detection. Analytical and bioanalytical chemistry. 2009 Jun; 394(3):883-91. doi: 10.1007/s00216-009-2770-4. [PMID: 19347661]
  • Gamal M M El Maghraby, Michael Campbell, Barrie C Finnin. Mechanisms of action of novel skin penetration enhancers: phospholipid versus skin lipid liposomes. International journal of pharmaceutics. 2005 Nov; 305(1-2):90-104. doi: 10.1016/j.ijpharm.2005.08.016. [PMID: 16199131]
  • T M Morgan, R A Parr, B L Reed, B C Finnin. Enhanced transdermal delivery of sex hormones in swine with a novel topical aerosol. Journal of pharmaceutical sciences. 1998 Oct; 87(10):1219-25. doi: 10.1021/js980026c. [PMID: 9758680]
  • T M Morgan, H M O'Sullivan, B L Reed, B C Finnin. Transdermal delivery of estradiol in postmenopausal women with a novel topical aerosol. Journal of pharmaceutical sciences. 1998 Oct; 87(10):1226-8. doi: 10.1021/js9800275. [PMID: 9758681]
  • R Jiang, C G Hayden, R J Prankerd, M S Roberts, H A Benson. High-performance liquid chromatographic assay for common sunscreening agents in cosmetic products, bovine serum albumin solution and human plasma. Journal of chromatography. B, Biomedical applications. 1996 Jun; 682(1):137-45. doi: 10.1016/0378-4347(96)00063-1. [PMID: 8832434]
  • M Yamada, J Takahashi. Effect of dietary DL-ethionine on postnatal growth, and activities of liver and kidney enzymes of male chickens, Gallus domesticus. Comparative biochemistry and physiology. C: Comparative pharmacology. 1977; 58(2C):177-81. doi: 10.1016/0306-4492(77)90101-0. [PMID: 23931]