2,4-Dihydroxythiazole (BioDeep_00000173549)

   

human metabolite blood metabolite


代谢物信息卡片


4-hydroxy-2,3-dihydro-1,3-thiazol-2-one

化学式: C3H3NO2S (116.9884498)
中文名称: 2,4-二羟基噻唑
谱图信息: 最多检出来源 Homo sapiens(blood) 4.9%

分子结构信息

SMILES: C1=C(NC(=O)S1)O
InChI: InChI=1S/C3H3NO2S/c5-2-1-7-3(6)4-2/h1,5H,(H,4,6)



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • H S Chou, K E Truitt, J B Moberly, D Merante, Y Choi, Y Mun, A Pfützner. A 26-week, placebo- and pioglitazone-controlled monotherapy study of rivoglitazone in subjects with type 2 diabetes mellitus. Diabetes, obesity & metabolism. 2012 Nov; 14(11):1000-9. doi: 10.1111/j.1463-1326.2012.01631.x. [PMID: 22686944]
  • Khanh Vu, Naifa Busaidy, Maria E Cabanillas, Marina Konopleva, Stefan Faderl, Deborah A Thomas, Susan O'Brien, Kristine Broglio, Joe Ensor, Carmen Escalante, Michael Andreeff, Hagop Kantarjian, Victor Lavis, Sai-Ching Jim Yeung. A randomized controlled trial of an intensive insulin regimen in patients with hyperglycemic acute lymphoblastic leukemia. Clinical lymphoma, myeloma & leukemia. 2012 Oct; 12(5):355-62. doi: 10.1016/j.clml.2012.05.004. [PMID: 22658895]
  • M H Clark, M Hoenig, D C Ferguson, L Dirikolu. Pharmacokinetics of pioglitazone in lean and obese cats. Journal of veterinary pharmacology and therapeutics. 2012 Oct; 35(5):428-36. doi: 10.1111/j.1365-2885.2011.01341.x. [PMID: 22612529]
  • Janice V Huang, Clifford R Greyson, Gregory G Schwartz. PPAR-γ as a therapeutic target in cardiovascular disease: evidence and uncertainty. Journal of lipid research. 2012 Sep; 53(9):1738-54. doi: 10.1194/jlr.r024505. [PMID: 22685322]
  • Caroline Dart. Selective block of K(ATP) channels: why the anti-diabetic sulphonylureas and rosiglitazone have more in common than we thought. British journal of pharmacology. 2012 Sep; 167(1):23-5. doi: 10.1111/j.1476-5381.2012.01990.x. [PMID: 22506686]
  • Jessica R Singer, Walter Palmas, Jeanne Teresi, Ruth Weinstock, Steven Shea, José A Luchsinger. Adiponectin and all-cause mortality in elderly people with type 2 diabetes. Diabetes care. 2012 Sep; 35(9):1858-63. doi: 10.2337/dc11-2215. [PMID: 22773703]
  • Absalon D Gutierrez, Padma Sathyanarayana, Somasekhar Konduru, Yumei Ye, Yochai Birnbaum, Mandeep Bajaj. The effect of pioglitazone treatment on 15-epi-lipoxin A4 levels in patients with type 2 diabetes. Atherosclerosis. 2012 Jul; 223(1):204-8. doi: 10.1016/j.atherosclerosis.2012.04.016. [PMID: 22687642]
  • Neda Rasouli, Philip A Kern, Steven C Elbein, Neeraj K Sharma, Swapan K Das. Improved insulin sensitivity after treatment with PPARγ and PPARα ligands is mediated by genetically modulated transcripts. Pharmacogenetics and genomics. 2012 Jul; 22(7):484-97. doi: 10.1097/fpc.0b013e328352a72e. [PMID: 22437669]
  • D E Bonds, T E Craven, J Buse, J R Crouse, R Cuddihy, M Elam, H N Ginsberg, K Kirchner, S Marcovina, J C Mychaleckyj, P J O'Connor, J-A Sperl-Hillen. Fenofibrate-associated changes in renal function and relationship to clinical outcomes among individuals with type 2 diabetes: the Action to Control Cardiovascular Risk in Diabetes (ACCORD) experience. Diabetologia. 2012 Jun; 55(6):1641-50. doi: 10.1007/s00125-012-2524-2. [PMID: 22450889]
  • Mohammad Sarraf, Li Lu, Shuyu Ye, Michael J Reiter, Clifford R Greyson, Gregory G Schwartz. Thiazolidinedione drugs promote onset, alter characteristics, and increase mortality of ischemic ventricular fibrillation in pigs. Cardiovascular drugs and therapy. 2012 Jun; 26(3):195-204. doi: 10.1007/s10557-012-6384-2. [PMID: 22450779]
  • In-Hyuk Jung, You-Han Lee, Ji-Young Yoo, Se-Jin Jeong, Seong Keun Sonn, Jong-Gil Park, Keun Ho Ryu, Bong Yong Lee, Hye Young Han, So Young Lee, Dae-Yong Kim, Hang Lee, Goo Taeg Oh. Ginkgo biloba extract (GbE) enhances the anti-atherogenic effect of cilostazol by inhibiting ROS generation. Experimental & molecular medicine. 2012 May; 44(5):311-8. doi: 10.3858/emm.2012.44.5.035. [PMID: 22282402]
  • Jing-Quan Zheng, Kun Wang, Dee Pei, Yen-Lin Chen, Yen-Lin Chang, Chun-Hsien Hsu, Tsan-Ming Huang, Mei-Yu Lin, Pao-Ying Lin, Jiunn-Diann Lin. Improvement of abnormal liver enzymes after rosiglitazone treatment in Chinese type 2 diabetes. Indian journal of pharmacology. 2012 May; 44(3):372-6. doi: 10.4103/0253-7613.96340. [PMID: 22701249]
  • Arghya Biswas, Syed Imam Rabbani, Kshama Devi. Influence of pioglitazone on experimental heart failure and hyperlipidemia in rats. Indian journal of pharmacology. 2012 May; 44(3):333-9. doi: 10.4103/0253-7613.96305. [PMID: 22701242]
  • Areeba Ahmad, Riaz Ahmad. Understanding the mechanism of hepatic fibrosis and potential therapeutic approaches. Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association. 2012 May; 18(3):155-67. doi: 10.4103/1319-3767.96445. [PMID: 22626794]
  • Maria B Kadiiska, Marcelo G Bonini, Christine Ruggiero, Ellen Cleland, Shawna Wicks, Krisztian Stadler. Thiazolidinedione treatment decreases oxidative stress in spontaneously hypertensive heart failure rats through attenuation of inducible nitric oxide synthase-mediated lipid radical formation. Diabetes. 2012 Mar; 61(3):586-96. doi: 10.2337/db11-1091. [PMID: 22315311]
  • Meritxell Rosell, Elayne Hondares, Sadahiko Iwamoto, Frank J Gonzalez, Martin Wabitsch, Bart Staels, Yolanda Olmos, Maria Monsalve, Marta Giralt, Roser Iglesias, Francesc Villarroya. Peroxisome proliferator-activated receptors-α and -γ, and cAMP-mediated pathways, control retinol-binding protein-4 gene expression in brown adipose tissue. Endocrinology. 2012 Mar; 153(3):1162-73. doi: 10.1210/en.2011-1367. [PMID: 22253419]
  • Niti N Patel, Christine M Crincoli, Douglas M Frederick, Ruy Tchao, Peter J Harvison. Effect of structural modifications on 3-(3,5-dichlorophenyl)-2,4-thiazolidinedione-induced hepatotoxicity in Fischer 344 rats. Journal of applied toxicology : JAT. 2012 Feb; 32(2):108-17. doi: 10.1002/jat.1639. [PMID: 21337588]
  • Nahed M El-Enany, Amina A Abdelal, Fathalla F Belal, Yoshinori I Itoh, Mitsuhiro N Nakamura. Development and validation of a repharsed phase- HPLC method for simultaneous determination of rosiglitazone and glimepiride in combined dosage forms and human plasma. Chemistry Central journal. 2012 Jan; 6(1):9. doi: 10.1186/1752-153x-6-9. [PMID: 22277722]
  • Ayumu Hirata, Ken Kishida, Hideaki Nakatsuji, Kana Inoue, Aki Hiuge-Shimizu, Tohru Funahashi, Iichiro Shimomura. High prevalence of gastroesophageal reflux symptoms in type 2 diabetics with hypoadiponectinemia and metabolic syndrome. Nutrition & metabolism. 2012 Jan; 9(1):4. doi: 10.1186/1743-7075-9-4. [PMID: 22277344]
  • Michael E Cobble, Robert Frederich. Saxagliptin for the treatment of type 2 diabetes mellitus: assessing cardiovascular data. Cardiovascular diabetology. 2012 Jan; 11(?):6. doi: 10.1186/1475-2840-11-6. [PMID: 22248301]
  • Tina Vilsbøll, Mikkel Christensen, Anders E Junker, Filip K Knop, Lise Lotte Gluud. Effects of glucagon-like peptide-1 receptor agonists on weight loss: systematic review and meta-analyses of randomised controlled trials. BMJ (Clinical research ed.). 2012 Jan; 344(?):d7771. doi: 10.1136/bmj.d7771. [PMID: 22236411]
  • Raghu R V Malapaka, SokKean Khoo, Jifeng Zhang, Jang H Choi, X Edward Zhou, Yong Xu, Yinhan Gong, Jun Li, Eu-Leong Yong, Michael J Chalmers, Lin Chang, James H Resau, Patrick R Griffin, Y Eugene Chen, H Eric Xu. Identification and mechanism of 10-carbon fatty acid as modulating ligand of peroxisome proliferator-activated receptors. The Journal of biological chemistry. 2012 Jan; 287(1):183-195. doi: 10.1074/jbc.m111.294785. [PMID: 22039047]
  • Latife Bozkurt, Christian S Göbl, Andrea Tura, Marek Chmelik, Thomas Prikoszovich, Lana Kosi, Oswald Wagner, Michael Roden, Giovanni Pacini, Amalia Gastaldelli, Alexandra Kautzky-Willer. Fatty liver index predicts further metabolic deteriorations in women with previous gestational diabetes. PloS one. 2012; 7(2):e32710. doi: 10.1371/journal.pone.0032710. [PMID: 22393439]
  • Richard J Wood, Elizabeth C O'Neill. Resistance Training in Type II Diabetes Mellitus: Impact on Areas of Metabolic Dysfunction in Skeletal Muscle and Potential Impact on Bone. Journal of nutrition and metabolism. 2012; 2012(?):268197. doi: 10.1155/2012/268197. [PMID: 22474580]
  • Wei-Chih Kan, Hsien-Yi Wang, Chih-Chiang Chien, Shun-Lai Li, Yu-Chun Chen, Liang-Hao Chang, Chia-Hui Cheng, Wan-Chen Tsai, Jyh-Chang Hwang, Shih-Bin Su, Li-Hsueh Huang, Jiunn-Jye Chuu. Effects of Extract from Solid-State Fermented Cordyceps sinensis on Type 2 Diabetes Mellitus. Evidence-based complementary and alternative medicine : eCAM. 2012; 2012(?):743107. doi: 10.1155/2012/743107. [PMID: 22474523]
  • M C Thomas, K A Jandeleit-Dahm, C Tikellis. The renoprotective actions of peroxisome proliferator-activated receptors agonists in diabetes. PPAR research. 2012; 2012(?):456529. doi: 10.1155/2012/456529. [PMID: 22448165]
  • Min-Tser Liao, Chih-Chien Sung, Kuo-Chin Hung, Chia-Chao Wu, Lan Lo, Kuo-Cheng Lu. Insulin resistance in patients with chronic kidney disease. Journal of biomedicine & biotechnology. 2012; 2012(?):691369. doi: 10.1155/2012/691369. [PMID: 22919275]
  • Eugenia Hovsepian, Federico Penas, Gerardo A Mirkin, Nora B Goren. Role of PPARs in Trypanosoma cruzi Infection: Implications for Chagas Disease Therapy. PPAR research. 2012; 2012(?):528435. doi: 10.1155/2012/528435. [PMID: 22448167]
  • Tamotsu Tsukahara. The Role of PPARγ in the Transcriptional Control by Agonists and Antagonists. PPAR research. 2012; 2012(?):362361. doi: 10.1155/2012/362361. [PMID: 22693486]
  • Edward C Chao. Dapagliflozin: an evidence-based review of its potential in the treatment of type-2 diabetes. Core evidence. 2012; 7(?):21-8. doi: 10.2147/ce.s16359. [PMID: 22701099]
  • Simeon-Pierre Choukem, Anastase Dzudie, Mesmin Dehayem, Marie-Patrice Halle, Marie-Solange Doualla, Henry Luma, Andre-Pascal Kengne. Comparison of different blood pressure indices for the prediction of prevalent diabetic nephropathy in a sub-Saharan African population with type 2 diabetes. The Pan African medical journal. 2012; 11(?):67. doi: NULL. [PMID: 22655101]
  • Jothydev Kesavadev, Arun Shankar, Gopika Krishnan, Sunitha Jothydev. Liraglutide therapy beyond glycemic control: an observational study in Indian patients with type 2 diabetes in real world setting. International journal of general medicine. 2012; 5(?):317-22. doi: 10.2147/ijgm.s27886. [PMID: 22536087]
  • Angela Passaro, Edoardo Dalla Nora, Caterina Marcello, Francesca Di Vece, Mario Luca Morieri, Juana M Sanz, Cristina Bosi, Renato Fellin, Giovanni Zuliani. PPARγ Pro12Ala and ACE ID polymorphisms are associated with BMI and fat distribution, but not metabolic syndrome. Cardiovascular diabetology. 2011 Dec; 10(?):112. doi: 10.1186/1475-2840-10-112. [PMID: 22168210]
  • Bianka Bojková, Miroslava Garajová, Martin Péč, Peter Kubatka, Karol Kajo, Marián Mokáň, Monika Kassayová, Peter Orendáš, Terézia Kisková, Eva Ahlersová, Ivan Ahlers. Metabolic effects of pioglitazone in chemically-induced mammary carcinogenesis in rats. Pathology oncology research : POR. 2011 Dec; 17(4):887-92. doi: 10.1007/s12253-011-9399-2. [PMID: 21647779]
  • Elisa Benetti, Nimesh S A Patel, Massimo Collino. The role of PPARβ/δ in the management of metabolic syndrome and its associated cardiovascular complications. Endocrine, metabolic & immune disorders drug targets. 2011 Dec; 11(4):273-84. doi: 10.2174/187153011797881175. [PMID: 21696362]
  • K M Schoenberg, T R Overton. Effects of plane of nutrition and 2,4-thiazolidinedione on insulin responses and adipose tissue gene expression in dairy cattle during late gestation. Journal of dairy science. 2011 Dec; 94(12):6021-35. doi: 10.3168/jds.2011-4533. [PMID: 22118090]
  • D R Owens, S D Luzio, C Sert-Langeron, M C Riddle. Effects of initiation and titration of a single pre-prandial dose of insulin glulisine while continuing titrated insulin glargine in type 2 diabetes: a 6-month 'proof-of-concept' study. Diabetes, obesity & metabolism. 2011 Nov; 13(11):1020-7. doi: 10.1111/j.1463-1326.2011.01459.x. [PMID: 21679291]
  • K M Schoenberg, K L Perfield, J K Farney, B J Bradford, Y R Boisclair, T R Overton. Effects of prepartum 2,4-thiazolidinedione on insulin sensitivity, plasma concentrations of tumor necrosis factor-α and leptin, and adipose tissue gene expression. Journal of dairy science. 2011 Nov; 94(11):5523-32. doi: 10.3168/jds.2011-4501. [PMID: 22032375]
  • Hironori Waki, Masahiro Nakamura, Toshimasa Yamauchi, Ken-ichi Wakabayashi, Jing Yu, Lisa Hirose-Yotsuya, Kazumi Take, Wei Sun, Masato Iwabu, Miki Okada-Iwabu, Takanori Fujita, Tomohisa Aoyama, Shuichi Tsutsumi, Kohjiro Ueki, Tatsuhiko Kodama, Juro Sakai, Hiroyuki Aburatani, Takashi Kadowaki. Global mapping of cell type-specific open chromatin by FAIRE-seq reveals the regulatory role of the NFI family in adipocyte differentiation. PLoS genetics. 2011 Oct; 7(10):e1002311. doi: 10.1371/journal.pgen.1002311. [PMID: 22028663]
  • V Pandit, R Gorantla, K Devi, Rs Pai, S Sarasija. Preparation and characterization of pioglitazone cyclodextrin inclusion complexes. Journal of young pharmacists : JYP. 2011 Oct; 3(4):267-74. doi: 10.4103/0975-1483.90234. [PMID: 22224032]
  • Hyun Jeong Jeon, Tae Keun Oh. Comparison of vildagliptin-metformin and glimepiride-metformin treatments in type 2 diabetic patients. Diabetes & metabolism journal. 2011 Oct; 35(5):529-35. doi: 10.4093/dmj.2011.35.5.529. [PMID: 22111045]
  • Rishi Shukla, Sanjay Kalra. Pioglitazone: Indian perspective. Indian journal of endocrinology and metabolism. 2011 Oct; 15(4):294-7. doi: 10.4103/2230-8210.85581. [PMID: 22029000]
  • Nazri Mustaffa, Suhairi Ibrahim, Wan Zaidah Abdullah, Zurkurnai Yusof. Add-on rosiglitazone therapy improves plasminogen activity and high-density lipoprotein cholesterol in type 2 diabetes mellitus. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis. 2011 Sep; 22(6):512-20. doi: 10.1097/mbc.0b013e32834740ba. [PMID: 21537159]
  • A P S Kong, A Yamasaki, R Ozaki, H Saito, T Asami, S Ohwada, G T C Ko, C K Wong, G T C Leung, K F Lee, C Y Yeung, J C N Chan. A randomized-controlled trial to investigate the effects of rivoglitazone, a novel PPAR gamma agonist on glucose-lipid control in type 2 diabetes. Diabetes, obesity & metabolism. 2011 Sep; 13(9):806-13. doi: 10.1111/j.1463-1326.2011.01411.x. [PMID: 21492364]
  • Jae-Hoon Choi, Jong-Gil Park, Hyung Jun Jeon, Mi-Sun Kim, Mi-Ran Lee, Mi-Ni Lee, SeongKeun Sonn, Jae-Hong Kim, Mun Han Lee, Myung-Sook Choi, Yong Bok Park, Oh-Seung Kwon, Tae-Sook Jeong, Woo Song Lee, Hyun Bo Shim, Dong Hae Shin, Goo Taeg Oh. 5-(4-Hydroxy-2,3,5-trimethylbenzylidene) thiazolidine-2,4-dione attenuates atherosclerosis possibly by reducing monocyte recruitment to the lesion. Experimental & molecular medicine. 2011 Aug; 43(8):471-8. doi: 10.3858/emm.2011.43.8.053. [PMID: 21691142]
  • Tsuyoshi Goto, Hiroyuki Nagai, Kahori Egawa, Young-Il Kim, Sota Kato, Aki Taimatsu, Tomoya Sakamoto, Shogo Ebisu, Takahiro Hohsaka, Hiroh Miyagawa, Shigeru Murakami, Nobuyuki Takahashi, Teruo Kawada. Farnesyl pyrophosphate regulates adipocyte functions as an endogenous PPARγ agonist. The Biochemical journal. 2011 Aug; 438(1):111-9. doi: 10.1042/bj20101939. [PMID: 21605082]
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  • Tamas Varga, Zsolt Czimmerer, Laszlo Nagy. PPARs are a unique set of fatty acid regulated transcription factors controlling both lipid metabolism and inflammation. Biochimica et biophysica acta. 2011 Aug; 1812(8):1007-22. doi: 10.1016/j.bbadis.2011.02.014. [PMID: 21382489]
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  • Katherine Robinson, John Prins, Bala Venkatesh. Clinical review: adiponectin biology and its role in inflammation and critical illness. Critical care (London, England). 2011 Apr; 15(2):221. doi: 10.1186/cc10021. [PMID: 21586104]
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