2,3-Dihydropyridine (BioDeep_00000173505)

   

human metabolite blood metabolite


代谢物信息卡片


2,3-Dihydropyridine

化学式: C5H7N (81.0578462)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1CN=CC=C1
InChI: InChI=1S/C5H7N/c1-2-4-6-5-3-1/h1-2,4H,3,5H2

描述信息

同义名列表

1 个代谢物同义名

2,3-Dihydropyridine



数据库引用编号

4 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Yoshihiro Uesawa, Takahiro Takeuchi, Kiminori Mohri. Integrated analysis on the physicochemical properties of dihydropyridine calcium channel blockers in grapefruit juice interactions. Current pharmaceutical biotechnology. 2012 Jul; 13(9):1705-17. doi: 10.2174/138920112800958878. [PMID: 22039822]
  • M Stowasser, A H Ahmed, E Pimenta, P J Taylor, R D Gordon. Factors affecting the aldosterone/renin ratio. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. 2012 Mar; 44(3):170-6. doi: 10.1055/s-0031-1295460. [PMID: 22147655]
  • Rebecca L Attridge, William D Linn, Laurajo Ryan, Jim Koeller, Christopher R Frei. Evaluation of the incidence and risk factors for development of fenofibrate-associated nephrotoxicity. Journal of clinical lipidology. 2012 Jan; 6(1):19-26. doi: 10.1016/j.jacl.2011.08.008. [PMID: 22264570]
  • Jin Young Sung, Hyoung Chul Choi. Nifedipine inhibits vascular smooth muscle cell proliferation and reactive oxygen species production through AMP-activated protein kinase signaling pathway. Vascular pharmacology. 2012 Jan; 56(1-2):1-8. doi: 10.1016/j.vph.2011.06.001. [PMID: 21708289]
  • Ilona Kurnatowska, Jerzy Królikowski, Kinga Jesionowska, Anna Marczak, Joanna Krajewska, Zbigniew Zbróg, Michał Nowicki. Prevalence of arterial hypertension and the number and classes of antihypertensive drugs prescribed for patients late after kidney transplantation. Annals of transplantation. 2012 Jan; 17(1):50-7. doi: 10.12659/aot.882636. [PMID: 22466909]
  • R Ram, G Swarnalatha, Bh Santhosh Pai, C Shyam Sunder Rao, K V Dakshinamurty. Cloudy peritoneal fluid attributable to non-dihydropyridine calcium channel blocker. Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis. 2012 Jan; 32(1):110-1. doi: 10.3747/pdi.2010.00277. [PMID: 22302929]
  • Pius S Fasinu, Patrick J Bouic, Bernd Rosenkranz. An overview of the evidence and mechanisms of herb-drug interactions. Frontiers in pharmacology. 2012; 3(?):69. doi: 10.3389/fphar.2012.00069. [PMID: 22557968]
  • Andreas S Kalogeropoulos, Sotirios Tsiodras, Angelos G Rigopoulos, Eleftherios A Sakadakis, Andreas Triantafyllis, Dimitrios Th Kremastinos, Ioannis Rizos. Novel association patterns of cardiac remodeling markers in patients with essential hypertension and atrial fibrillation. BMC cardiovascular disorders. 2011 Dec; 11(?):77. doi: 10.1186/1471-2261-11-77. [PMID: 22204652]
  • Vishal Gupta. Mineralocorticoid hypertension. Indian journal of endocrinology and metabolism. 2011 Oct; 15 Suppl 4(?):S298-312. doi: 10.4103/2230-8210.86972. [PMID: 22145132]
  • Francesco P Schena. Management of patients with chronic kidney disease. Internal and emergency medicine. 2011 Oct; 6 Suppl 1(?):77-83. doi: 10.1007/s11739-011-0688-2. [PMID: 22009616]
  • Zied Zarai, Adel Kadri, Ines Ben Chobba, Riadh Ben Mansour, Ahmed Bekir, Hafedh Mejdoub, Néji Gharsallah. The in-vitro evaluation of antibacterial, antifungal and cytotoxic properties of Marrubium vulgare L. essential oil grown in Tunisia. Lipids in health and disease. 2011 Sep; 10(?):161. doi: 10.1186/1476-511x-10-161. [PMID: 21936887]
  • Conrad W Liang, Sarah J Diamond, Daniel S Hagg. Lipid rescue of massive verapamil overdose: a case report. Journal of medical case reports. 2011 Aug; 5(?):399. doi: 10.1186/1752-1947-5-399. [PMID: 21854635]
  • Göknur Aktay, Memet Hanifi Emre, Alaadin Polat. Influence of dihydropyridine calcium antagonist nitrendipine on benzo(a)pyrene-induced oxidative stress. Archives of pharmacal research. 2011 Jul; 34(7):1171-5. doi: 10.1007/s12272-011-0715-x. [PMID: 21811924]
  • Doreen M Rabi, Stella S Daskalopoulou, Raj S Padwal, Nadia A Khan, Steven A Grover, Daniel G Hackam, Martin G Myers, Donald W McKay, Robert R Quinn, Brenda R Hemmelgarn, Lyne Cloutier, Peter Bolli, Michael D Hill, Thomas Wilson, Brian Penner, Ellen Burgess, Maxime Lamarre-Cliché, Donna McLean, Ernesto L Schiffrin, George Honos, Karen Mann, Guy Tremblay, Alain Milot, Arun Chockalingam, Simon W Rabkin, Martin Dawes, Rhian M Touyz, Kevin D Burns, Marcel Ruzicka, Norman R C Campbell, Michel Vallée, G V Ramesh Prasad, Marcel Lebel, Tavis S Campbell, M Patrice Lindsay, Robert J Herman, Pierre Larochelle, Ross D Feldman, J Malcolm O Arnold, Gordon W Moe, Jonathan G Howlett, Luc Trudeau, Simon L Bacon, Robert J Petrella, Richard Lewanczuk, James A Stone, Denis Drouin, Jean-Martin Boulanger, Mukul Sharma, Pavel Hamet, George Fodor, George K Dresser, S George Carruthers, George Pylypchuk, Richard E Gilbert, Lawrence A Leiter, Charlotte Jones, Richard I Ogilvie, Vincent Woo, Philip A McFarlane, Robert A Hegele, Luc Poirier, Sheldon W Tobe. The 2011 Canadian Hypertension Education Program recommendations for the management of hypertension: blood pressure measurement, diagnosis, assessment of risk, and therapy. The Canadian journal of cardiology. 2011 Jul; 27(4):415-433.e1. doi: 10.1016/j.cjca.2011.03.015. [PMID: 21801975]
  • W Frank Peacock, Joseph Varon, Ramin Ebrahimi, Lala Dunbar, Charles V Pollack. Clevidipine for severe hypertension in patients with renal dysfunction: a VELOCITY trial analysis. Blood pressure. Supplement. 2011 Apr; 1(?):20-5. doi: 10.3109/08037051.2010.539317. [PMID: 21091269]
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  • Yi-Jing Sheen, Wayne Huey-Herng Sheu. Metabolic syndrome and renal injury. Cardiology research and practice. 2011 Mar; 2011(?):567389. doi: 10.4061/2011/567389. [PMID: 21461396]
  • K Manjunath, V Venkateswarlu, A Hussain. Preparation and characterization of nitrendipine solid lipid nanoparticles. Die Pharmazie. 2011 Mar; 66(3):178-86. doi: . [PMID: 21553647]
  • Shizuka Aritomi, Hirotaka Wagatsuma, Tomohiro Numata, Yoshitsugu Uriu, Yasuko Nogi, Akira Mitsui, Tomoyuki Konda, Yasuo Mori, Michihiro Yoshimura. Expression of N-type calcium channels in human adrenocortical cells and their contribution to corticosteroid synthesis. Hypertension research : official journal of the Japanese Society of Hypertension. 2011 Feb; 34(2):193-201. doi: 10.1038/hr.2010.191. [PMID: 20981032]
  • F M Tedla, A Brar, R Browne, C Brown. Hypertension in chronic kidney disease: navigating the evidence. International journal of hypertension. 2011; 2011(?):132405. doi: 10.4061/2011/132405. [PMID: 21747971]
  • Rajiv Agarwal. Interdialytic hypertension-an update. Advances in chronic kidney disease. 2011 Jan; 18(1):11-6. doi: 10.1053/j.ackd.2010.10.001. [PMID: 21224025]
  • Wei-Chuan Tsai. Treatment options for hypertension in high-risk patients. Vascular health and risk management. 2011; 7(?):137-41. doi: 10.2147/vhrm.s11235. [PMID: 21468174]
  • Sule Ayla, Ismail Seckin, Gamze Tanriverdi, Mujgan Cengiz, Mediha Eser, B C Soner, Gulperi Oktem. Doxorubicin induced nephrotoxicity: protective effect of nicotinamide. International journal of cell biology. 2011; 2011(?):390238. doi: 10.1155/2011/390238. [PMID: 21789041]
  • Junichi Mukai, Hitoshi Tada, Masatomo Miura, Kiminori Mohri. [Meta-analysis-based examination regarding the efficacy of angiotensin II receptor blockers and calcium channel blockers in borderline diabetes and diabetes patients]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 2011; 131(8):1213-23. doi: 10.1248/yakushi.131.1213. [PMID: 21804326]
  • José Zamorano, Jonathan Edwards. Combining antihypertensive and antihyperlipidemic agents - optimizing cardiovascular risk factor management. Integrated blood pressure control. 2011; 4(?):55-71. doi: 10.2147/ibpc.s12215. [PMID: 22162939]
  • Konstantinos Tziomalos, Vasilios G Athyros, Asterios Karagiannis, Dimitri P Mikhailidis. Dyslipidemia induced by drugs used for the prevention and treatment of vascular diseases. The open cardiovascular medicine journal. 2011; 5(?):85-9. doi: 10.2174/1874192401105010085. [PMID: 21769302]
  • Xiao-Yan Bai, Xiao-Cheng Liu, Wen-Bin Jing, Qin Yang, Xiang-Dong Tang, Guo-Wei He. Effect of amlodipine in human internal mammary artery and clinical implications. The Annals of thoracic surgery. 2010 Dec; 90(6):1952-7. doi: 10.1016/j.athoracsur.2010.08.007. [PMID: 21095344]
  • Rajeev Gupta, Soneil Guptha. Strategies for initial management of hypertension. The Indian journal of medical research. 2010 Nov; 132(?):531-42. doi: ". [PMID: 21150005]
  • Carlos M Ferrario, Ronald D Smith. Role of olmesartan in combination therapy in blood pressure control and vascular function. Vascular health and risk management. 2010 Sep; 6(?):701-9. doi: 10.2147/vhrm.s6663. [PMID: 20859541]
  • Diana Hummel, Ulrike Raff, Thomas K Schwarz, Markus P Schneider, Roland E Schmieder, Bernhard M W Schmidt. Dihydropyridine calcium antagonists are associated with increased albuminuria in treatment-resistant hypertensives. Journal of nephrology. 2010 Sep; 23(5):563-8. doi: . [PMID: 20437398]
  • P-J Hsiao, H-W Lin, C-C Sung, C-W Wang, P Chu, S-H Lin. Incidence and clinical course of lercanidipine-associated cloudy effluent in continuous ambulatory peritoneal dialysis. Clinical nephrology. 2010 Sep; 74(3):217-22. doi: 10.5414/cnp74217. [PMID: 20860906]
  • Svein I Johannessen, Cecilie Johannessen Landmark. Antiepileptic drug interactions - principles and clinical implications. Current neuropharmacology. 2010 Sep; 8(3):254-67. doi: 10.2174/157015910792246254. [PMID: 21358975]
  • George L Bakris. Dual RAAS blockade is desirable in kidney disease: con. Kidney international. 2010 Sep; 78(6):546-9. doi: 10.1038/ki.2010.226. [PMID: 20664560]
  • Ahmed S Awad, Michael E Goldberg. Role of clevidipine butyrate in the treatment of acute hypertension in the critical care setting: a review. Vascular health and risk management. 2010 Aug; 6(?):457-64. doi: 10.2147/vhrm.s5839. [PMID: 20730061]
  • Biff F Palmer, Andrew Z Fenves. Optimizing blood pressure control in patients with chronic kidney disease. Proceedings (Baylor University. Medical Center). 2010 Jul; 23(3):239-45. doi: 10.1080/08998280.2010.11928626. [PMID: 20671819]
  • Eiichiro Yamamoto, Keiichiro Kataoka, Yi-Fei Dong, Taishi Nakamura, Masaya Fukuda, Hisato Nako, Hisao Ogawa, Shokei Kim-Mitsuyama. Benidipine, a dihydropyridine L-type/T-type calcium channel blocker, affords additive benefits for prevention of cardiorenal injury in hypertensive rats. Journal of hypertension. 2010 Jun; 28(6):1321-9. doi: 10.1097/hjh.0b013e3283388045. [PMID: 20224431]
  • B B Matsubara, M Franco, J S Janicki, L S Matsubara. Effect of felodipine on myocardial and renal injury induced by aldosterone-high salt hypertension in uninephrectomized rats. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. 2010 May; 43(5):506-14. doi: 10.1590/s0100-879x2010007500037. [PMID: 20490436]
  • Abbie L Erickson, Jeremy R DeGrado, John R Fanikos. Clevidipine: a short-acting intravenous dihydropyridine calcium channel blocker for the management of hypertension. Pharmacotherapy. 2010 May; 30(5):515-28. doi: 10.1592/phco.30.5.515. [PMID: 20412001]
  • Darren M Allcock, James R Sowers. Best strategies for hypertension management in type 2 diabetes and obesity. Current diabetes reports. 2010 Apr; 10(2):139-44. doi: 10.1007/s11892-010-0100-z. [PMID: 20425573]
  • Pongsathorn Gojaseni, Angkana Phaopha, Worawon Chailimpamontree, Thaweepong Pajareya, Anutra Chittinandana. Prevalence and risk factors of microalbuminuria in Thai nondiabetic hypertensive patients. Vascular health and risk management. 2010 Mar; 6(?):157-65. doi: 10.2147/vhrm.s9739. [PMID: 20448800]
  • Kumiko Nakagawa, Toshikazu Goto. Effects of ingestion of grapefruit juice or grapefruit on the hypotensive effect and plasma concentrations of dihydropyridine calcium antagonists (amlodipine and nifedipine): a case study. Clinical and experimental hypertension (New York, N.Y. : 1993). 2010 Jan; 32(2):71-5. doi: 10.3109/10641960902960540. [PMID: 20374180]
  • Takehiro Ko, Yutaka Kakizoe, Naoki Wakida, Manabu Hayata, Kohei Uchimura, Naoki Shiraishi, Taku Miyoshi, Masataka Adachi, Shizuka Aritomi, Tomoyuki Konda, Kimio Tomita, Kenichiro Kitamura. Regulation of adrenal aldosterone production by serine protease prostasin. Journal of biomedicine & biotechnology. 2010; 2010(?):793843. doi: 10.1155/2010/793843. [PMID: 20204133]
  • Haroon-Ur Rashid. Renoprotection, renin inhibition, and blood pressure control: the impact of aliskiren on integrated blood pressure control. Integrated blood pressure control. 2010; 3(?):133-44. doi: 10.2147/ibpc.s12407. [PMID: 21949629]
  • Toshiaki Ebina, Kazuo Kimura, Satoshi Umemura. [Calcium antagonists: current and future applications based on new evidence. Calcium channel blockers and JSH2009]. Clinical calcium. 2010 Jan; 20(1):16-22. doi: clica10011622. [PMID: 20048429]
  • Jin Li, Qi-Xiong Li, Xian-Fei Xie, Ying Ao, Chao-Rong Tie, Ren-Jie Song. Differential roles of dihydropyridine calcium antagonist nifedipine, nitrendipine and amlodipine on gentamicin-induced renal tubular toxicity in rats. European journal of pharmacology. 2009 Oct; 620(1-3):97-104. doi: 10.1016/j.ejphar.2009.08.021. [PMID: 19698708]
  • Joy M Weinberg, Lawrence J Appel, George Bakris, Jennifer J Gassman, Tom Greene, Cynthia A Kendrick, Xuelei Wang, James Lash, Julia A Lewis, Velvie Pogue, Denyse Thornley-Brown, Robert A Phillips. Risk of hyperkalemia in nondiabetic patients with chronic kidney disease receiving antihypertensive therapy. Archives of internal medicine. 2009 Sep; 169(17):1587-94. doi: 10.1001/archinternmed.2009.284. [PMID: 19786678]
  • Yu-Yan Fan, Masakazu Kohno, Daisuke Nakano, Hirofumi Hitomi, Yukiko Nagai, Yoshihide Fujisawa, Xiao-Mei Lu, Hua Fu, Jun Du, Koji Ohmori, Naohisa Hosomi, Shoji Kimura, Hideyasu Kiyomoto, Akira Nishiyama. Inhibitory effects of a dihydropyridine calcium channel blocker on renal injury in aldosterone-infused rats. Journal of hypertension. 2009 Sep; 27(9):1855-62. doi: 10.1097/hjh.0b013e32832dda6f. [PMID: 19633569]
  • Peter Bramlage, Isabelle Durand-Zaleski, Nisha Desai, Olaf Pirk, Caroline Hacker. The value of irbesartan in the management of hypertension. Expert opinion on pharmacotherapy. 2009 Aug; 10(11):1817-31. doi: 10.1517/14656560903103820. [PMID: 19601700]
  • Thomas Meyer, Joseph D Tobias. Perioperative blood pressure management with clevidipine during coiling of cerebral artery aneurysms. Saudi journal of anaesthesia. 2009 Jul; 3(2):83-6. doi: 10.4103/1658-354x.57880. [PMID: 20532109]
  • Makoto Takayama, Kozo Yao, Michihito Wada. The dihydropyridine calcium channel blocker benidipine prevents lysophosphatidylcholine-induced endothelial dysfunction in rat aorta. Journal of biomedical science. 2009 Jun; 16(?):57. doi: 10.1186/1423-0127-16-57. [PMID: 19558657]
  • W Frank Peacock, Jorge E Angeles, Karina M Soto, Philip D Lumb, Joseph Varon. Parenteral clevidipine for the acute control of blood pressure in the critically ill patient: a review. Therapeutics and clinical risk management. 2009 Jun; 5(3):627-34. doi: 10.2147/tcrm.s5312. [PMID: 19707278]
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  • Saeed Esmaeili-Mahani, Masoud Fereidoni, Mohammad Javan, Nader Maghsoudi, Fereshteh Motamedi, Abolhasan Ahmadiani. Nifedipine suppresses morphine-induced thermal hyperalgesia: evidence for the role of corticosterone. European journal of pharmacology. 2007 Jul; 567(1-2):95-101. doi: 10.1016/j.ejphar.2007.03.042. [PMID: 17466971]
  • Makoto Takayama, Masahiro Matsubara, Emi Arakawa, Chie Takada, Yasuhiro Ina, Kazuhide Hasegawa, Kozo Yao. Comparison of the antiatherosclerotic effects of dihydropyridine calcium channel blocker and HMG-CoA reductase inhibitor on hypercholesterolemic rabbits. Vascular pharmacology. 2007 Apr; 46(4):302-8. doi: 10.1016/j.vph.2006.11.004. [PMID: 17197250]
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