2,3-Bis(2,4-dichlorophenoxy)butanedioic acid (BioDeep_00000173493)
human metabolite blood metabolite
代谢物信息卡片
2,3-bis(2,4-dichlorophenoxy)butanedioic acid
化学式: C16H10Cl4O6 (437.9231)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 100%
分子结构信息
SMILES: C1=CC(=C(C=C1Cl)Cl)OC(C(C(=O)O)OC2=C(C=C(C=C2)Cl)Cl)C(=O)O
InChI: InChI=1S/C16H10Cl4O6/c17-7-1-3-11(9(19)5-7)25-13(15(21)22)14(16(23)24)26-12-4-2-8(18)6-10(12)20/h1-6,13-14H,(H,21,22)(H,23,24)
描述信息
同义名列表
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
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Environmental science & technology.
2011 May; 45(10):4609-15. doi:
10.1021/es200172q. [PMID: 21510672] - Asma Ahmed, Sambuddho Mukherjee, Mukta Deobagkar, Tanushree Naik, Dipankar Nandi. Rapid burst of H2O2 by plant growth regulators increases intracellular Ca2+ amounts and modulates CD4+ T cell activation.
International immunopharmacology.
2010 Nov; 10(11):1397-405. doi:
10.1016/j.intimp.2010.08.005. [PMID: 20728597] - Kent W Thomas, Mustafa Dosemeci, Joseph B Coble, Jane A Hoppin, Linda S Sheldon, Guadalupe Chapa, Carry W Croghan, Paul A Jones, Charles E Knott, Charles F Lynch, Dale P Sandler, Aaron E Blair, Michael C Alavanja. Assessment of a pesticide exposure intensity algorithm in the agricultural health study.
Journal of exposure science & environmental epidemiology.
2010 Sep; 20(6):559-69. doi:
10.1038/jes.2009.54. [PMID: 19888312] - Kent W Thomas, Mustafa Dosemeci, Jane A Hoppin, Linda S Sheldon, Carry W Croghan, Sydney M Gordon, Martin L Jones, Stephen J Reynolds, James H Raymer, Gerald G Akland, Charles F Lynch, Charles E Knott, Dale P Sandler, Aaron E Blair, Michael C Alavanja. Urinary biomarker, dermal, and air measurement results for 2,4-D and chlorpyrifos farm applicators in the Agricultural Health Study.
Journal of exposure science & environmental epidemiology.
2010 Mar; 20(2):119-34. doi:
10.1038/jes.2009.6. [PMID: 19240759] - Dina M Schreinemachers. Perturbation of lipids and glucose metabolism associated with previous 2,4-D exposure: a cross-sectional study of NHANES III data, 1988-1994.
Environmental health : a global access science source.
2010 Feb; 9(?):11. doi:
10.1186/1476-069x-9-11. [PMID: 20187939] - Tomoki Fukuyama, Yukari Tajima, Hideo Ueda, Koichi Hayashi, Yasufumi Shutoh, Takanori Harada, Tadashi Kosaka. Allergic reaction induced by dermal and/or respiratory exposure to low-dose phenoxyacetic acid, organophosphorus, and carbamate pesticides.
Toxicology.
2009 Jul; 261(3):152-61. doi:
10.1016/j.tox.2009.05.014. [PMID: 19467290] - Yun Ma, Chao Xu, Yuezhong Wen, Weiping Liu. Enantioselective separation and degradation of the herbicide dichlorprop methyl in sediment.
Chirality.
2009 Apr; 21(4):480-3. doi:
10.1002/chir.20624. [PMID: 18655160] - Sonia Soloneski, Norma V González, Miguel A Reigosa, Marcelo L Larramendy. Herbicide 2,4-dichlorophenoxyacetic acid (2,4-D)-induced cytogenetic damage in human lymphocytes in vitro in presence of erythrocytes.
Cell biology international.
2007 Nov; 31(11):1316-22. doi:
10.1016/j.cellbi.2007.05.003. [PMID: 17606385] - Bishnu P Chapagain, Zeev Wiesman. Phyto-saponins as a natural adjuvant for delivery of agromaterials through plant cuticle membranes.
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2006 Aug; 54(17):6277-85. doi:
10.1021/jf060591y. [PMID: 16910720] - N Stürtz, B Bongiovanni, M Rassetto, A Ferri, A M Evangelista de Duffard, R Duffard. Detection of 2,4-dichlorophenoxyacetic acid in rat milk of dams exposed during lactation and milk analysis of their major components.
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10.1016/j.fct.2005.03.012. [PMID: 16216402] - Ruo-Zhen Yu, Miao He, Han-Chang Shi, Ju Liu, Jie-Han Guo, Na Wang, Yi Qian. [Conjugation and immunogenic evaluation of complete immunogen for the small molecular environmental pollutants 2,4-D].
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NULL. [PMID: 16599138] - Tye E Arbuckle, Dana Bruce, Len Ritter, J Christopher Hall. Indirect sources of herbicide exposure for families on Ontario farms.
Journal of exposure science & environmental epidemiology.
2006 Jan; 16(1):98-104. doi:
10.1038/sj.jea.7500441. [PMID: 16015277] - Handan Aydin, Nurullah Ozdemir, Nuray Uzunören. Investigation of the accumulation of 2,4-dichlorophenoxyacetic acid (2,4-D) in rat kidneys.
Forensic science international.
2005 Oct; 153(1):53-7. doi:
10.1016/j.forsciint.2005.04.018. [PMID: 15935583] - Eva Simánová, Tuansheng Shi, Jörg Schönherr, Lukas Schreiber. Sorption in reconstituted waxes of homologous series of alcohol ethoxylates and n-alkyl esters and their effects on the mobility of 2,4-dichlorophenoxybutyric acid.
Pest management science.
2005 Apr; 61(4):383-9. doi:
10.1002/ps.979. [PMID: 15751010] - Frantzeska Tsorteki, Kostas Bethanis, Nikos Pinotsis, Petros Giastas, Dimitris Mentzafos. Inclusion compounds of plant growth regulators in cyclodextrins. V. 4-Chlorophenoxyacetic acid encapsulated in beta-cyclodextrin and heptakis(2,3,6-tri-O-methyl)-beta-cyclodextrin.
Acta crystallographica. Section B, Structural science.
2005 Apr; 61(Pt 2):207-17. doi:
10.1107/s0108768105004106. [PMID: 15772454] - Tuansheng Shi, Eva Simanova, Jörg Schönherr, Lukas Schreiber. Effects of accelerators on mobility of 14C-2,4-dichlorophenoxy butyric acid in plant cuticles depends on type and concentration of accelerator.
Journal of agricultural and food chemistry.
2005 Mar; 53(6):2207-12. doi:
10.1021/jf048364o. [PMID: 15769158] - Elizabeth L Rylott, Caroline A Rogers, Alison D Gilday, Teresa Edgell, Tony R Larson, Ian A Graham. Arabidopsis mutants in short- and medium-chain acyl-CoA oxidase activities accumulate acyl-CoAs and reveal that fatty acid beta-oxidation is essential for embryo development.
The Journal of biological chemistry.
2003 Jun; 278(24):21370-7. doi:
10.1074/jbc.m300826200. [PMID: 12682048] - Devon J Sutherland, G Kim Stearman, Martha J M Wells. Development of an analytical scheme for simazine and 2,4-D in soil and water runoff from ornamental plant nursery plots.
Journal of agricultural and food chemistry.
2003 Jan; 51(1):14-20. doi:
10.1021/jf025661p. [PMID: 12502379] - Jan Petrásek, Miroslav Elckner, David A Morris, Eva Zazímalová. Auxin efflux carrier activity and auxin accumulation regulate cell division and polarity in tobacco cells.
Planta.
2002 Dec; 216(2):302-8. doi:
10.1007/s00425-002-0845-y. [PMID: 12447544] - Claudia E Balagué, Clara Silva de Ruiz, Rosario Rey, Ana María Evangelista de Duffard, María Elena Nader-Macías. Effect of the herbicide 2,4-dichlorophenoxyacetic acid on uropathogenic Escherichia coli virulence factors.
Toxicology.
2002 Aug; 177(2-3):143-55. doi:
10.1016/s0300-483x(02)00161-0. [PMID: 12135618] - D J Oakes, W S Webster, P D C Brown-Woodman, H E Ritchie. Testicular changes induced by chronic exposure to the herbicide formulation, Tordon 75D (2,4-dichlorophenoxyacetic acid and picloram) in rats.
Reproductive toxicology (Elmsford, N.Y.).
2002 May; 16(3):281-9. doi:
10.1016/s0890-6238(02)00015-1. [PMID: 12128102] - Marian Sulik, Artur Sulik, Małgorzata Barwijuk-Machała, Barbara Piłat-Marcinkiewicz. Fetotoxic action of 2,4-dichlorophenoxyacetic acid (2,4-D). III. Morphological changes in rat kidneys.
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2002; 47(?):175-85. doi:
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Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes.
2001 Nov; 36(6):755-64. doi:
10.1081/pfc-100107409. [PMID: 11757735] - V F Garry, R E Tarone, I R Kirsch, J M Abdallah, D P Lombardi, L K Long, B L Burroughs, D B Barr, J S Kesner. Biomarker correlations of urinary 2,4-D levels in foresters: genomic instability and endocrine disruption.
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2001 May; 109(5):495-500. doi:
10.1289/ehp.01109495. [PMID: 11401761] - J Schönherr, L Schreiber, A Buchholz. Effects of temperature and concentration of the accelerators ethoxylated alcohols, diethyl suberate and tributyl phosphate on the mobility of [14C]2,4-dichlorophenoxy butyric acid in plant cuticles.
Pest management science.
2001 Jan; 57(1):17-24. doi:
10.1002/1526-4998(200101)57:1<17::aid-ps266>3.0.co;2-8. [PMID: 11455627] - A Hamburg, V Puvanesarajah, T J Burnett, D E Barnekow, N D Premkumar, G A Smith. Comparative degradation of [14C]-2,4-dichlorophenoxyacetic acid in wheat and potato after Foliar application and in wheat, radish, lettuce, and apple after soil application.
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