2,2',4,4',5-Pentachlorobiphenyl (BioDeep_00000173487)

   

human metabolite blood metabolite Industrial Pollutants


代谢物信息卡片


1,2,4-trichloro-5-(2,4-dichlorophenyl)benzene

化学式: C12H5Cl5 (323.8834)
中文名称: 2,2,4,4,5-五氯联苯
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC(=C(C=C1Cl)Cl)C2=CC(=C(C=C2Cl)Cl)Cl
InChI: InChI=1S/C12H5Cl5/c13-6-1-2-7(9(14)3-6)8-4-11(16)12(17)5-10(8)15/h1-5H

描述信息

D004785 - Environmental Pollutants > D011078 - Polychlorinated Biphenyls

同义名列表

3 个代谢物同义名

1,2,4-trichloro-5-(2,4-dichlorophenyl)benzene; 2,2,4,4,5-Pentachlorobiphenyl; PCB99



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

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代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Maria Wielsøe, Peder Kern, Eva Cecilie Bonefeld-Jørgensen. Serum levels of environmental pollutants is a risk factor for breast cancer in Inuit: a case control study. Environmental health : a global access science source. 2017 06; 16(1):56. doi: 10.1186/s12940-017-0269-6. [PMID: 28610584]
  • Eveline Dirinck, Alin C Dirtu, Govindan Malarvannan, Adrian Covaci, Philippe G Jorens, Luc F Van Gaal. A Preliminary Link between Hydroxylated Metabolites of Polychlorinated Biphenyls and Free Thyroxin in Humans. International journal of environmental research and public health. 2016 Apr; 13(4):421. doi: 10.3390/ijerph13040421. [PMID: 27089353]
  • Esther Ng, Samira Salihovic, P Monica Lind, Anubha Mahajan, Anne-Christine Syvänen, Tomas Axelsson, Erik Ingelsson, Cecilia M Lindgren, Bert van Bavel, Andrew P Morris, Lars Lind. Genome-wide association study of plasma levels of polychlorinated biphenyls disclose an association with the CYP2B6 gene in a population-based sample. Environmental research. 2015 Jul; 140(?):95-101. doi: 10.1016/j.envres.2015.03.022. [PMID: 25839716]
  • Fadheela Al-Salman, Nick Plant. Non-coplanar polychlorinated biphenyls (PCBs) are direct agonists for the human pregnane-X receptor and constitutive androstane receptor, and activate target gene expression in a tissue-specific manner. Toxicology and applied pharmacology. 2012 Aug; 263(1):7-13. doi: 10.1016/j.taap.2012.05.016. [PMID: 22664347]
  • Barbara A Cohn, Piera M Cirillo, Robert I Sholtz, Assiamira Ferrara, June-Soo Park, Pamela J Schwingl. Polychlorinated biphenyl (PCB) exposure in mothers and time to pregnancy in daughters. Reproductive toxicology (Elmsford, N.Y.). 2011 Apr; 31(3):290-6. doi: 10.1016/j.reprotox.2011.01.004. [PMID: 21296657]
  • Lori Martin, Curtis D Klaassen. Differential effects of polychlorinated biphenyl congeners on serum thyroid hormone levels in rats. Toxicological sciences : an official journal of the Society of Toxicology. 2010 Sep; 117(1):36-44. doi: 10.1093/toxsci/kfq187. [PMID: 20573785]
  • Renée Dallaire, Eric Dewailly, Daria Pereg, Serge Dery, Pierre Ayotte. Thyroid function and plasma concentrations of polyhalogenated compounds in Inuit adults. Environmental health perspectives. 2009 Sep; 117(9):1380-6. doi: 10.1289/ehp.0900633. [PMID: 19750101]
  • James M Brady, Nathan J Cherrington, Dylan P Hartley, Susan C Buist, Ning Li, Curtis D Klaassen. Tissue distribution and chemical induction of multiple drug resistance genes in rats. Drug metabolism and disposition: the biological fate of chemicals. 2002 Jul; 30(7):838-44. doi: 10.1124/dmd.30.7.838. [PMID: 12065443]
  • M Chennaoui, D Gomez Merino, J Lesage, C Drogou, C Y Guezennec. Effects of moderate and intensive training on the hypothalamo-pituitary-adrenal axis in rats. Acta physiologica Scandinavica. 2002 Jun; 175(2):113-21. doi: 10.1046/j.1365-201x.2002.00971.x. [PMID: 12028131]
  • Nathan J Cherrington, Dylan P Hartley, Ning Li, David R Johnson, Curtis D Klaassen. Organ distribution of multidrug resistance proteins 1, 2, and 3 (Mrp1, 2, and 3) mRNA and hepatic induction of Mrp3 by constitutive androstane receptor activators in rats. The Journal of pharmacology and experimental therapeutics. 2002 Jan; 300(1):97-104. doi: 10.1124/jpet.300.1.97. [PMID: 11752103]