2,2',3,5',6-Pentachlorobiphenyl (BioDeep_00000173486)
human metabolite blood metabolite Industrial Pollutants
代谢物信息卡片
化学式: C12H5Cl5 (323.8834)
中文名称: 2,23,5,6-五氯联苯
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC(=C(C=C1Cl)C2=C(C=CC(=C2Cl)Cl)Cl)Cl
InChI: InChI=1S/C12H5Cl5/c13-6-1-2-8(14)7(5-6)11-9(15)3-4-10(16)12(11)17/h1-5H
描述信息
D004785 - Environmental Pollutants > D011078 - Polychlorinated Biphenyls
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代谢反应
0 个相关的代谢反应过程信息。
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1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Guangqin Liao, Xiao Song, Xinlu Wang, Wei Zhang, Lin Zhang, Jing Qiu, Ruyan Hou. Cytotoxicity of 2,2',3,5',6-Pentachlorobiphenyl (PCB95) and its metabolites in the chicken embryo liver cells of laying hens.
Ecotoxicology and environmental safety.
2020 May; 194(?):110338. doi:
10.1016/j.ecoenv.2020.110338. [PMID: 32135376] - Yoshihisa Kato, Aki Fujii, Koichi Haraguchi, Yukiko Fujii, Kazutaka Atobe, Tetsuya Endo, Osamu Kimura, Nobuyuki Koga, Chiho Ohta, Shizuo Yamada, Masakuni Degawa. Possible mechanism for the polychlorinated bipheny-linduced liver-selective accumulation of thyroxine in rats.
The Journal of toxicological sciences.
2017; 42(6):663-669. doi:
10.2131/jts.42.663. [PMID: 29142165] - Izabela Kania-Korwel, Christopher D Barnhart, Pamela J Lein, Hans-Joachim Lehmler. Effect of pregnancy on the disposition of 2,2',3,5',6-pentachlorobiphenyl (PCB 95) atropisomers and their hydroxylated metabolites in female mice.
Chemical research in toxicology.
2015 Sep; 28(9):1774-83. doi:
10.1021/acs.chemrestox.5b00241. [PMID: 26271003] - Guangshu Zhai, Sarah M Gutowski, Hans-Joachim Lehmler, Jerald L Schnoor. Enantioselective transport and biotransformation of chiral hydroxylated metabolites of polychlorinated biphenyls in whole poplar plants.
Environmental science & technology.
2014 Oct; 48(20):12213-20. doi:
10.1021/es503443e. [PMID: 25238141] - R G Ahmed. Early weaning PCB 95 exposure alters the neonatal endocrine system: thyroid adipokine dysfunction.
The Journal of endocrinology.
2013 Dec; 219(3):205-15. doi:
10.1530/joe-13-0302. [PMID: 24167152] - Viet D Dang, David M Walters, Cindy M Lee. Assessing ongoing sources of dissolved-phase polychlorinated biphenyls in a contaminated stream.
Environmental toxicology and chemistry.
2013 Mar; 32(3):535-40. doi:
10.1002/etc.2106. [PMID: 23258773] - Guangshu Zhai, Dingfei Hu, Hans-Joachim Lehmler, Jerald L Schnoor. Enantioselective biotransformation of chiral PCBs in whole poplar plants.
Environmental science & technology.
2011 Mar; 45(6):2308-16. doi:
10.1021/es1033662. [PMID: 21329345] - Lori Martin, Curtis D Klaassen. Differential effects of polychlorinated biphenyl congeners on serum thyroid hormone levels in rats.
Toxicological sciences : an official journal of the Society of Toxicology.
2010 Sep; 117(1):36-44. doi:
10.1093/toxsci/kfq187. [PMID: 20573785] - Moazzam A Khan, Larry G Hansen. Ortho-substituted polychlorinated biphenyl (PCB) congeners (95 or 101) decrease pituitary response to thyrotropin releasing hormone.
Toxicology letters.
2003 Sep; 144(2):173-82. doi:
10.1016/s0378-4274(03)00203-0. [PMID: 12927361] - Moazzam A Khan, Carol A Lichtensteiger, Obaid Faroon, Moiz Mumtaz, David J Schaeffer, Larry G Hansen. The hypothalamo-pituitary-thyroid (HPT) axis: a target of nonpersistent ortho-substituted PCB congeners.
Toxicological sciences : an official journal of the Society of Toxicology.
2002 Jan; 65(1):52-61. doi:
10.1093/toxsci/65.1.52. [PMID: 11752685]
