2,2-Dichloro-1,1,1-trifluoroethane (BioDeep_00000173448)
human metabolite blood metabolite
代谢物信息卡片
2,2-dichloro-1,1,1-trifluoroethane
化学式: C2HCl2F3 (151.9407)
中文名称: 2,2-二氯-1,1,1-三氟乙烷, 二氯三氟乙烷
谱图信息:
最多检出来源 Viridiplantae(blood) 5.76%
分子结构信息
SMILES: C(C(F)(F)F)(Cl)Cl
InChI: InChI=1S/C2HCl2F3/c3-1(4)2(5,6)7/h1H
数据库引用编号
分类词条
相关代谢途径
Reactome()
BioCyc()
PlantCyc()
代谢反应
个相关的代谢反应过程信息。
Reactome()
BioCyc()
WikiPathways()
Plant Reactome()
INOH()
PlantCyc()
COVID-19 Disease Map()
PathBank()
PharmGKB()
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Silvia Bortolato, Alberta Zanovello, Massimo Rugge, Maurizio Brotto, Sandra Marini, Pier Giovanni Gervasi, Maurizio Manno. Trifluoroacetylated proteins in liver and plasma of guinea pigs treated with HCFC-123 and halothane.
Toxicology letters.
2003 Sep; 144(1):35-47. doi:
10.1016/s0378-4274(03)00228-5. [PMID: 12919722] - Raymond Boucher, Constance Hanna, George M Rusch, Danny Stidham, Ellen Swan, Manny Vazquez. Hepatotoxicity associated with overexposure to 1,1-dichloro-2,2,2-trifluoroethane (HCFC-123).
AIHA journal : a journal for the science of occupational and environmental health and safety.
2003 Jan; 64(1):68-79. doi:
10.1080/15428110308984791. [PMID: 12570398] - Perrine Hoet, Jean-Pierre Buchet, Christine Sempoux, Vincent Haufroid, Jacques Rahier, Dominique Lison. Potentiation of 2,2-dichloro-1,1,1-trifluoroethane (HCFC-123)-induced liver toxicity by ethanol in guinea-pigs.
Archives of toxicology.
2002 Dec; 76(12):707-14. doi:
10.1007/s00204-002-0389-8. [PMID: 12451447] - G D Cappon, D A Keller, W J Brock, R W Slauter, M E Hurtt. Effects of HCFC-123 exposure to maternal and infant rhesus monkeys on hepatic biochemistry, lactational parameters and postnatal growth.
Drug and chemical toxicology.
2002 Nov; 25(4):481-96. doi:
10.1081/dct-120014798. [PMID: 12378954] - A Zanovello, R Ferrara, R Tolando, S Bortolato, I N White, M Manno. Bioactivation and toxicity in vitro of HCFC-123 and HCFC-141b: role of cytochrome P450.
Toxicology letters.
2001 Oct; 124(1-3):139-52. doi:
10.1016/s0378-4274(01)00385-x. [PMID: 11684366] - I N White, F De Matteis. The role of CYP forms in the metabolism and metabolic activation of HCFCs and other halocarbons.
Toxicology letters.
2001 Oct; 124(1-3):121-8. doi:
10.1016/s0378-4274(00)00288-5. [PMID: 11684364] - J Buschmann, W Bartsch, C Dasenbrock, R Fuhst, G Pohlmann, A Preiss, E Berger-Preiss. Cross-fostering inhalation toxicity study with HCFC-123 in lactating Sprague-Dawley rats.
Inhalation toxicology.
2001 Aug; 13(8):671-87. doi:
10.1080/08958370126866. [PMID: 11498800] - P Hoet, J P Buchet, C Sempoux, T Nomiyama, J Rahier, D Lison. Investigations on the liver toxicity of a blend of HCFC-123 (2,2-dichloro-1,1,1-trifluoroethane) and HCFC-124 (2-chloro-1,1,1,2-tetrafluoroethane) in guinea-pigs.
Archives of toxicology.
2001 Jul; 75(5):274-83. doi:
10.1007/s002040100237. [PMID: 11548120] - D A Keller, P H Lieder, W J Brock, J C Cook. 1,1,1-Trifluoro-2,2-dichloroethane (HCFC-123) and 1,1,1-trifluoro-2-bromo-2-chloroethane (halothane) cause similar biochemical effects in rats exposed by inhalation for five days.
Drug and chemical toxicology.
1998 Nov; 21(4):405-15. doi:
10.3109/01480549809002214. [PMID: 9839153] - P Hoet, M L Graf, M Bourdi, L R Pohl, P H Duray, W Chen, R M Peter, S D Nelson, N Verlinden, D Lison. Epidemic of liver disease caused by hydrochlorofluorocarbons used as ozone-sparing substitutes of chlorofluorocarbons.
Lancet (London, England).
1997 Aug; 350(9077):556-9. doi:
10.1016/s0140-6736(97)03094-8. [PMID: 9284778] - G Malinverno, G M Rusch, R J Millischer, E W Hughes, R E Schroeder, D W Coombs. Inhalation teratology and reproduction studies with 1,1-dichloro-2,2,2-trifluoroethane (HCFC-123).
Fundamental and applied toxicology : official journal of the Society of Toxicology.
1996 Dec; 34(2):276-87. doi:
10.1006/faat.1996.0197. [PMID: 8954757] - R J Williams, A Vinegar, J N McDougal, A M Jarabek, J W Fisher. Rat to human extrapolation of HCFC-123 kinetics deduced from halothane kinetics: a corollary approach to physiologically based pharmacokinetic modeling.
Fundamental and applied toxicology : official journal of the Society of Toxicology.
1996 Mar; 30(1):55-66. doi:
10.1006/faat.1996.0043. [PMID: 8812223] - W Dekant. Toxicology of chlorofluorocarbon replacements.
Environmental health perspectives.
1996 Mar; 104 Suppl 1(?):75-83. doi:
10.1289/ehp.96104s175. [PMID: 8722112] - R C Lind, A J Gandolfi, P D Hall. Biotransformation and hepatotoxicity of HCFC-123 in the guinea pig: potentiation of hepatic injury by prior glutathione depletion.
Toxicology and applied pharmacology.
1995 Sep; 134(1):175-81. doi:
10.1006/taap.1995.1182. [PMID: 7676453] - L A Malley, M Carakostas, J F Hansen, G M Rusch, D P Kelly, H J Trochimowicz. Two-year inhalation toxicity study in rats with hydrochlorofluorocarbon 123.
Fundamental and applied toxicology : official journal of the Society of Toxicology.
1995 Apr; 25(1):101-14. doi:
10.1006/faat.1995.1044. [PMID: 7601319] - A Vinegar, R J Williams, J W Fisher, J N McDougal. Dose-dependent metabolism of 2,2-dichloro-1,1,1-trifluoroethane: a physiologically based pharmacokinetic model in the male Fischer 344 rat.
Toxicology and applied pharmacology.
1994 Nov; 129(1):103-13. doi:
10.1006/taap.1994.1233. [PMID: 7974482] - G Urban, W Dekant. Metabolism of 1,1-dichloro-2,2,2-trifluoroethane in rats.
Xenobiotica; the fate of foreign compounds in biological systems.
1994 Sep; 24(9):881-92. doi:
10.3109/00498259409043287. [PMID: 7810170] - G M Rusch, H J Trochimowicz, L J Malley, D P Kelly, J Peckham, J Hansen, J B Charm. Subchronic inhalation toxicity studies with hydrochlorofluorocarbon 123 (HCFC 123).
Fundamental and applied toxicology : official journal of the Society of Toxicology.
1994 Aug; 23(2):169-78. doi:
10.1006/faat.1994.1095. [PMID: 7982525] - G B Marit, D E Dodd, M E George, A Vinegar. Hepatotoxicity in guinea pigs following acute inhalation exposure to 1,1-dichloro-2,2,2-trifluoroethane.
Toxicologic pathology.
1994 Jul; 22(4):404-14. doi:
10.1177/019262339402200406. [PMID: 7817129] - G D Loizou, G Urban, W Dekant, M W Anders. Gas-uptake pharmacokinetics of 2,2-dichloro-1,1,1-trifluoroethane (HCFC-123).
Drug metabolism and disposition: the biological fate of chemicals.
1994 Jul; 22(4):511-7. doi:
NULL. [PMID: 7956723] - Y Wang, M J Olson, M T Baker. Interaction of fluoroethane chlorofluorocarbon (CFC) substitutes with microsomal cytochrome P450. Stimulation of P450 activity and chlorodifluoroethene metabolism.
Biochemical pharmacology.
1993 Jul; 46(1):87-94. doi:
10.1016/0006-2952(93)90351-v. [PMID: 8347140] - D E Dodd, W T Brashear, A Vinegar. Metabolism and pharmacokinetics of selected halon replacement candidates.
Toxicology letters.
1993 May; 68(1-2):37-47. doi:
10.1016/0378-4274(93)90117-g. [PMID: 8516773] - J W Harris, J P Jones, J L Martin, A C LaRosa, M J Olson, L R Pohl, M W Anders. Pentahaloethane-based chlorofluorocarbon substitutes and halothane: correlation of in vivo hepatic protein trifluoroacetylation and urinary trifluoroacetic acid excretion with calculated enthalpies of activation.
Chemical research in toxicology.
1992 Sep; 5(5):720-5. doi:
10.1021/tx00029a020. [PMID: 1446014] - J Huwyler, D Aeschlimann, U Christen, J Gut. The kidney as a novel target tissue for protein adduct formation associated with metabolism of halothane and the candidate chlorofluorocarbon replacement 2,2-dichloro-1,1,1-trifluoroethane.
European journal of biochemistry.
1992 Jul; 207(1):229-38. doi:
10.1111/j.1432-1033.1992.tb17042.x. [PMID: 1628651] - J Huwyler, J Gut. Exposure to the chlorofluorocarbon substitute 2,2-dichloro-1,1,1- trifluoroethane and the anesthetic agent halothane is associated with transient protein adduct formation in the heart.
Biochemical and biophysical research communications.
1992 May; 184(3):1344-9. doi:
10.1016/s0006-291x(05)80030-0. [PMID: 1590796] - M Sano. Subcellular localizations of guanylate cyclase and 3',5'-cyclic nucleotide phosphodiesterase in sea urchin sperm.
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