2-Thenoyltrifluoroacetone (BioDeep_00000173442)

   

human metabolite blood metabolite Volatile Flavor Compounds


代谢物信息卡片


4,4,4-trifluoro-1-(thiophen-2-yl)butane-1,3-dione

化学式: C8H5F3O2S (221.9962346)
中文名称: 2-噻吩甲酰三氟丙酮
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CSC(=C1)C(=O)CC(=O)C(F)(F)F
InChI: InChI=1S/C8H5F3O2S/c9-8(10,11)7(13)4-5(12)6-2-1-3-14-6/h1-3H,4H2

描述信息

D064449 - Sequestering Agents > D002614 - Chelating Agents

同义名列表

7 个代谢物同义名

4,4,4-trifluoro-1-(thiophen-2-yl)butane-1,3-dione; 4,4,4-Trifluoro-1-(2-thienyl)-1,3-butanedione; 2-Thenoyltrifluoroacetone; Thenoyltrifluoroacetone; Trifluorothienylacetone; TTFA CPD; 2-Thenoyltrifluoroacetone



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Jingjing Zhao, Juntian Liu, Xiaoming Pang, Shuyue Wang, Di Wu, Xiaolu Zhang, Liuxin Feng. Angiotensin II induces C-reactive protein expression via AT1-ROS-MAPK-NF-κB signal pathway in hepatocytes. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 2013; 32(3):569-80. doi: 10.1159/000354461. [PMID: 24021937]
  • Naiyu Zheng, Eliza N Fung, Adela Buzescu, Mark E Arnold, Jianing Zeng. Esterase inhibitors as ester-containing drug stabilizers and their hydrolytic products: potential contributors to the matrix effects on bioanalysis by liquid chromatography/tandem mass spectrometry. Rapid communications in mass spectrometry : RCM. 2012 Jun; 26(11):1291-304. doi: 10.1002/rcm.6230. [PMID: 22555922]
  • Masoud Rohani Moghadam, Ali Mohammad Haji Shabani, Shayessteh Dadfarnia. Spectrophotometric determination of iron species using a combination of artificial neural networks and dispersive liquid-liquid microextraction based on solidification of floating organic drop. Journal of hazardous materials. 2011 Dec; 197(?):176-82. doi: 10.1016/j.jhazmat.2011.09.073. [PMID: 21999983]
  • Wing-Hang Tong, Carole Sourbier, Gennady Kovtunovych, Suh Young Jeong, Manish Vira, Manik Ghosh, Vladimir Valera Romero, Rachid Sougrat, Sophie Vaulont, Benoit Viollet, Yeong-Sang Kim, Sunmin Lee, Jane Trepel, Ramaprasad Srinivasan, Gennady Bratslavsky, Youfeng Yang, W Marston Linehan, Tracey A Rouault. The glycolytic shift in fumarate-hydratase-deficient kidney cancer lowers AMPK levels, increases anabolic propensities and lowers cellular iron levels. Cancer cell. 2011 Sep; 20(3):315-27. doi: 10.1016/j.ccr.2011.07.018. [PMID: 21907923]
  • Jong H Kim, Kathleen L Chan, Noreen Mahoney, Bruce C Campbell. Antifungal activity of redox-active benzaldehydes that target cellular antioxidation. Annals of clinical microbiology and antimicrobials. 2011 May; 10(?):23. doi: 10.1186/1476-0711-10-23. [PMID: 21627838]
  • Masoud Rohani Moghadam, Shayessteh Dadfarnia, Ali Mohammad Haji Shabani. Speciation and determination of ultra trace amounts of chromium by solidified floating organic drop microextraction (SFODME) and graphite furnace atomic absorption spectrometry. Journal of hazardous materials. 2011 Feb; 186(1):169-74. doi: 10.1016/j.jhazmat.2010.10.101. [PMID: 21112142]
  • Adriana Oliveira Dos Santos, Elizandra Aparecida Britta, Everson Miguel Bianco, Tania Ueda-Nakamura, Benedito Prado Dias Filho, Renato Crespo Pereira, Celso Vataru Nakamura. 4-Acetoxydolastane diterpene from the Brazilian brown alga Canistrocarpus cervicornis as antileishmanial agent. Marine drugs. 2011; 9(11):2369-2383. doi: 10.3390/md9112369. [PMID: 22163190]
  • Wei-Qiang Fan, Jing Feng, Shu-Yan Song, Yong-Qian Lei, Guo-Li Zheng, Hong-Jie Zhang. Synthesis and optical properties of europium-complex-doped inorganic/organic hybrid materials built from oxo-hydroxo organotin nano building blocks. Chemistry (Weinheim an der Bergstrasse, Germany). 2010 Feb; 16(6):1903-10. doi: 10.1002/chem.200902111. [PMID: 20029916]
  • Yufei Ma, Haiping Wang, Weisheng Liu, Qiong Wang, Jun Xu, Yu Tang. Microstructure, luminescence, and stability of a europium complex covalently bonded to an attapulgite clay. The journal of physical chemistry. B. 2009 Oct; 113(43):14139-45. doi: 10.1021/jp906848e. [PMID: 19807138]
  • Seiji Nakamura, Toshinari Takamura, Naoto Matsuzawa-Nagata, Hiroaki Takayama, Hirofumi Misu, Hiroyo Noda, Satoko Nabemoto, Seiichiro Kurita, Tsuguhito Ota, Hitoshi Ando, Ken-Ichi Miyamoto, Shuichi Kaneko. Palmitate induces insulin resistance in H4IIEC3 hepatocytes through reactive oxygen species produced by mitochondria. The Journal of biological chemistry. 2009 May; 284(22):14809-18. doi: 10.1074/jbc.m901488200. [PMID: 19332540]
  • Yadollah Yamini, Mohammad Faraji, Shahab Shariati, Rahim Hassani, Mahnaz Ghambarian. On-line metals preconcentration and simultaneous determination using cloud point extraction and inductively coupled plasma optical emission spectrometry in water samples. Analytica chimica acta. 2008 Apr; 612(2):144-51. doi: 10.1016/j.aca.2008.02.034. [PMID: 18358859]
  • Yongqiang Chen, Eileen McMillan-Ward, Jiming Kong, Sara J Israels, Spencer B Gibson. Mitochondrial electron-transport-chain inhibitors of complexes I and II induce autophagic cell death mediated by reactive oxygen species. Journal of cell science. 2007 Dec; 120(Pt 23):4155-66. doi: 10.1242/jcs.011163. [PMID: 18032788]
  • Xiaojing Zhu, Xiaolei Wang, Chongqiu Jiang. Spectrofluorimetric determination of 5-hydroxytryptamine using chlorosulphonylthenoyltrifluoroacetone-europium probe. Luminescence : the journal of biological and chemical luminescence. 2007 Sep; 22(5):487-92. doi: 10.1002/bio.989. [PMID: 17610298]
  • Nan Zhang, Bin Hu, Chaozhang Huang. A new ion-imprinted silica gel sorbent for on-line selective solid-phase extraction of dysprosium(III) with detection by inductively coupled plasma-atomic emission spectrometry. Analytica chimica acta. 2007 Jul; 597(1):12-8. doi: 10.1016/j.aca.2007.06.045. [PMID: 17658307]
  • Tanmoy Bera, Nilay Nandi, D Sudhahar, Md Ali Akbar, Abhik Sen, Pradeep Das. Preliminary evidence on existence of transplasma membrane electron transport in Entamoeba histolytica trophozoites: a key mechanism for maintaining optimal redox balance. Journal of bioenergetics and biomembranes. 2006 Dec; 38(5-6):299-308. doi: 10.1007/s10863-006-9047-9. [PMID: 17039394]
  • S D Maind, S A Kumar, N Chattopadhyay, Ch Gandhi, M Sudersanan. Analysis of Indian blue ballpoint pen inks tagged with rare-earth thenoyltrifluoroacetonates by inductively coupled plasma-mass spectrometry and instrumental neutron activation analysis. Forensic science international. 2006 May; 159(1):32-42. doi: 10.1016/j.forsciint.2005.05.037. [PMID: 16084680]
  • Amarjit S Sethi, Delphine M Lees, Julie A Douthwaite, Anne B Dawnay, Roger Corder. Homocysteine-induced endothelin-1 release is dependent on hyperglycaemia and reactive oxygen species production in bovine aortic endothelial cells. Journal of vascular research. 2006; 43(2):175-83. doi: 10.1159/000090947. [PMID: 16410680]
  • Tianxin Yang, Aihua Zhang, Matthew Honeggar, Donald E Kohan, Diane Mizel, Karl Sanders, John R Hoidal, Josephine P Briggs, Jurgen B Schnermann. Hypertonic induction of COX-2 in collecting duct cells by reactive oxygen species of mitochondrial origin. The Journal of biological chemistry. 2005 Oct; 280(41):34966-73. doi: 10.1074/jbc.m502430200. [PMID: 16024921]
  • James K Friel, Khalid Aziz, Wayne L Andrews, Robert E Serfass. Iron absorption and oxidant stress during erythropoietin therapy in very low birth weight premature infants: a cohort study. BMC pediatrics. 2005 Aug; 5(?):29. doi: 10.1186/1471-2431-5-29. [PMID: 16080798]
  • Zhefeng Fan, Bin Hu, Zucheng Jiang, Shengqing Li. Low-temperature electrothermal vaporization of thenoyltrifluoroacetone complex of Sc(III) and Y(III) for sample introduction in an inductively coupled plasma atomic emission spectrometry, and their determination in biological samples. Analytical and bioanalytical chemistry. 2004 Jan; 378(2):456-9. doi: 10.1007/s00216-003-2314-2. [PMID: 14658024]
  • Feng-Bo Wu, Shi-Quan Han, Chao Zhang, You-Feng He. Synthesis of a highly fluorescent beta-diketone-europium chelate and its utility in time-resolved fluoroimmunoassay of serum total thyroxine. Analytical chemistry. 2002 Nov; 74(22):5882-9. doi: 10.1021/ac025727f. [PMID: 12463376]
  • Tusty-Jiuan Hsieh, Shao-Ling Zhang, Janos G Filep, Shiow-Shih Tang, Julie R Ingelfinger, John S D Chan. High glucose stimulates angiotensinogen gene expression via reactive oxygen species generation in rat kidney proximal tubular cells. Endocrinology. 2002 Aug; 143(8):2975-85. doi: 10.1210/endo.143.8.8931. [PMID: 12130563]
  • A Asumendi, M C Morales, A Alvarez, J Aréchaga, G Pérez-Yarza. Implication of mitochondria-derived ROS and cardiolipin peroxidation in N-(4-hydroxyphenyl)retinamide-induced apoptosis. British journal of cancer. 2002 Jun; 86(12):1951-6. doi: 10.1038/sj.bjc.6600356. [PMID: 12085192]
  • Jin Gang Zhang, Marc W Fariss. Thenoyltrifluoroacetone, a potent inhibitor of carboxylesterase activity. Biochemical pharmacology. 2002 Feb; 63(4):751-4. doi: 10.1016/s0006-2952(01)00871-1. [PMID: 11992644]
  • J G Zhang, F A Nicholls-Grzemski, M A Tirmenstein, M W Fariss. Vitamin E succinate protects hepatocytes against the toxic effect of reactive oxygen species generated at mitochondrial complexes I and III by alkylating agents. Chemico-biological interactions. 2001 Dec; 138(3):267-84. doi: 10.1016/s0009-2797(01)00278-2. [PMID: 11714483]
  • J G Zhang, M A Tirmenstein, F A Nicholls-Grzemski, M W Fariss. Mitochondrial electron transport inhibitors cause lipid peroxidation-dependent and -independent cell death: protective role of antioxidants. Archives of biochemistry and biophysics. 2001 Sep; 393(1):87-96. doi: 10.1006/abbi.2001.2486. [PMID: 11516165]
  • S I Yamagishi , D Edelstein, X L Du, Y Kaneda, M Guzmán, M Brownlee. Leptin induces mitochondrial superoxide production and monocyte chemoattractant protein-1 expression in aortic endothelial cells by increasing fatty acid oxidation via protein kinase A. The Journal of biological chemistry. 2001 Jul; 276(27):25096-100. doi: 10.1074/jbc.m007383200. [PMID: 11342529]
  • O Döring, S Lüthje. Inhibition of trans-membrane hexacyanoferrate III reductase activity and proton secretion of maize (Zea mays L.) roots by thenoyltrifluoroacetone. Protoplasma. 2001; 217(1-3):3-8. doi: 10.1007/bf01289406. [PMID: 11732334]
  • A H Hamrahian, J Z Zhang, F S Elkhairi, R Prasad, F Ismail-Beigi. Activation of Glut1 glucose transporter in response to inhibition of oxidative phosphorylation. Archives of biochemistry and biophysics. 1999 Aug; 368(2):375-9. doi: 10.1006/abbi.1999.1320. [PMID: 10441390]
  • A Morales, C García-Ruiz, M Miranda, M Marí, A Colell, E Ardite, J C Fernández-Checa. Tumor necrosis factor increases hepatocellular glutathione by transcriptional regulation of the heavy subunit chain of gamma-glutamylcysteine synthetase. The Journal of biological chemistry. 1997 Nov; 272(48):30371-9. doi: 10.1074/jbc.272.48.30371. [PMID: 9374527]
  • S Gamen, A Anel, J Montoya, I Marzo, A Piñeiro, J Naval. mtDNA-depleted U937 cells are sensitive to TNF and Fas-mediated cytotoxicity. FEBS letters. 1995 Nov; 376(1-2):15-8. doi: 10.1016/0014-5793(95)01236-1. [PMID: 8521957]
  • V Gogvadze, A Zhukova. Thenoyltrifluoracetone induces lipid peroxidation in rat liver mitochondria. General physiology and biophysics. 1993 Jun; 12(3):303-8. doi: ". [PMID: 8224786]
  • Y Eto, D Kang, E Hasegawa, K Takeshige, S Minakami. Succinate-dependent lipid peroxidation and its prevention by reduced ubiquinone in beef heart submitochondrial particles. Archives of biochemistry and biophysics. 1992 May; 295(1):101-6. doi: 10.1016/0003-9861(92)90493-g. [PMID: 1575504]
  • M Glinn, L Ernster, C P Lee. Initiation of lipid peroxidation in submitochondrial particles: effect of respiratory inhibitors. Archives of biochemistry and biophysics. 1991 Oct; 290(1):57-65. doi: 10.1016/0003-9861(91)90591-6. [PMID: 1898100]
  • M Suno, A Nagaoka. Inhibition of lipid peroxidation by a novel compound (CV-2619) in brain mitochondria and mode of action of the inhibition. Biochemical and biophysical research communications. 1984 Dec; 125(3):1046-52. doi: 10.1016/0006-291x(84)91389-5. [PMID: 6517932]
  • A I Gagel'gans, A V Shkinevv, M V Zamaraeva, O V Krasil'nikov, V I Ternovskiĭ. [Effect of tenoyltrifluoroacetone on the functioning of mitochondria and other membrane structures]. Biokhimiia (Moscow, Russia). 1980 Dec; 45(12):2165-75. doi: ". [PMID: 7248351]
  • V K Subchinski, A A Konstantinov, E K Ruuge. [Interaction of paramagnetic probes with submitochondrial particle membranes]. Biofizika. 1978 Jan; 23(1):57-60. doi: ". [PMID: 623824]