trans-p-Menthane-1,8-diol (BioDeep_00000017336)

   

human metabolite PANOMIX_OTCML-2023 Endogenous


代谢物信息卡片


CYCLOHEXANEMETHANOL, 4-HYDROXY-.ALPHA.,.ALPHA.,4-TRIMETHYL-, TRANS-

化学式: C10H20O2 (172.14632200000003)
中文名称: 4-p-樟烷-1,8-二醇, 反式-萜二醇, 萜品, 4-P-樟烷-1,8-二醇
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 7.69%

分子结构信息

SMILES: CC(C)(O)C1CCC(C)(O)CC1
InChI: InChI=1S/C10H20O2/c1-9(2,11)8-4-6-10(3,12)7-5-8/h8,11-12H,4-7H2,1-3H3

描述信息

Cis-p-menthane-1,8-diol, also known as terpin, titanium (+4) salt or terpin hydrate, is a member of the class of compounds known as menthane monoterpenoids. Menthane monoterpenoids are monoterpenoids with a structure based on the o-, m-, or p-menthane backbone. P-menthane consists of the cyclohexane ring with a methyl group and a (2-methyl)-propyl group at the 1 and 4 ring position, respectively. The o- and m- menthanes are much rarer, and presumably arise by alkyl migration of p-menthanes. Cis-p-menthane-1,8-diol is slightly soluble (in water) and an extremely weak acidic compound (based on its pKa). Cis-p-menthane-1,8-diol is a bitter tasting compound found in herbs and spices, which makes cis-p-menthane-1,8-diol a potential biomarker for the consumption of this food product. Cis-p-menthane-1,8-diol exists in all eukaryotes, ranging from yeast to humans.
Terpin is a p-menthane monoterpenoid.
Terpin is a natural product found in Vitis vinifera with data available.
Terpin is a metabolite found in or produced by Saccharomyces cerevisiae.
cis-p-Menthane-1,8-diol is found in herbs and spices. cis-p-Menthane-1,8-diol is isolated from fruits of California peppertree (Schinus molle
D019141 - Respiratory System Agents > D005100 - Expectorants

同义名列表

57 个代谢物同义名

CYCLOHEXANEMETHANOL, 4-HYDROXY-.ALPHA.,.ALPHA.,4-TRIMETHYL-, TRANS-; CYCLOHEXANEMETHANOL, 4-HYDROXY-.ALPHA.,.ALPHA.,4-TRIMETHYL-, CIS-; Cyclohexanemethanol, 4-hydroxy-alpha,alpha,4-trimethyl-, trans-; Cyclohexanemethanol, 4-hydroxy-.alpha., .alpha.,4-trimethyl-; Cyclohexanemethanol, 4-hydroxy-.alpha.,.alpha.,4-trimethyl-; (1R,4R)-4-(2-HYDROXYPROPAN-2-YL)-1-METHYLCYCLOHEXAN-1-OL; cis-4-Hydroxy-alpha,alpha,4-trimethylcyclohexanemethanol; Cyclohexanemethanol, 4-hydroxy-alpha,alpha,4-trimethyl-; 2-hydroxy-alpha,alpha,4-trimethylcyclohexanemethanol; 4-Hydroxy-alpha,alpha,4-trimethylcyclohexanemethanol; cis-4-Hydroxy-|A,|A,4-trimethylcyclohexanemethanol; 4-(1-Hydroxy-1-methylethyl)-1-methylcyclohexanol #; 4-(1-Hydroxy-1-methylethyl)-1-methylcyclohexanol; 4-(2-hydroxypropan-2-yl)-1-methylcyclohexan-1-ol; 2-(2-hydroxypropan-2-yl)-5-methylcyclohexanol; 4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol; 4-(2-Hydroxy-2-propanyl)-1-methylcyclohexanol; TERPIN MONOHYDRATE IMPURITY D [EP IMPURITY]; trans-Terpin, analytical standard, for GC; Cyclohexanemethanol,.alpha.,4-trimethyl-; terpin, monohydrate(cis)-isomer; terpin, titanium (+4) salt; trans-p-Menthane-1,8-diol; trans-1,8-p-Menthanediol; trans-p-Menthan-1,8-diol; cis-p-Menthane-1,8-diol; cis-p-Menthan-1,8-diol; para-menthane-3,8-diol; cis-1,8-p-Menthanediol; Terpin trans-form [MI]; Emetine hydrochloride; 4-p-Menthan-1,8-diol; p-menthane-3,8-diol; p-menthane-1,8-diol; p-Mentha-1,8-diol; trans-1,8-Terpin; Dipenteneglycol; TERPIN [WHO-DD]; UNII-4HW1S44T5G; terpin hydrate; Terpin, trans-; trans_terpin; Tox21_111646; trans-Terpin; Terpin (VAN); Terpin [BAN]; Terpinhydrat; NCI60_003817; CAS-80-53-5; TERPIN [MI]; (Z)-terpin; 1,8-Terpin; 4HW1S44T5G; geranodyle; Terpinol; Terpene; Terpin



数据库引用编号

19 个数据库交叉引用编号

分类词条

相关代谢途径

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PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Pingxi Xu, Fangfang Zeng, Robert H Bedoukian, Walter S Leal. DEET and other repellents are inhibitors of mosquito odorant receptors for oviposition attractants. Insect biochemistry and molecular biology. 2019 10; 113(?):103224. doi: 10.1016/j.ibmb.2019.103224. [PMID: 31446031]
  • Scott P Carroll, Jeffrey Venturino, John H Davies. A Milestone In Botanical Mosquito Repellents: Novel PMD-Based Formulation Protects More Than Twice As Long As High-Concentration Deet and Other Leading Products. Journal of the American Mosquito Control Association. 2019 09; 35(3):186-191. doi: 10.2987/19-6824.1. [PMID: 31647713]
  • John F Anderson, Francis J Ferrandino, Michael P Vasil, Robert H Bedoukian, Marie Maher, Karen McKenzie. Repellency of Naturally Occurring or Related Compounds, DEET, and Para-Menthane-3,8-Diol to Bed Bugs (Hemiptera: Cimicidae). Journal of medical entomology. 2018 05; 55(3):666-672. doi: 10.1093/jme/tjx253. [PMID: 29415167]
  • Cameron E Webb, Isabel Mr Hess. A review of recommendations on the safe and effective use of topical mosquito repellents. Public health research & practice. 2016 Dec; 26(5):. doi: 10.17061/phrp2651657. [PMID: 27997936]
  • A K Murchie, S Clawson, I Rea, I W N Forsythe, A W Gordon, S Jess. DEET (N,N-diethyl-meta-toluamide)/PMD (para-menthane-3,8-diol) repellent-treated mesh increases Culicoides catches in light traps. Parasitology research. 2016 Sep; 115(9):3543-9. doi: 10.1007/s00436-016-5119-x. [PMID: 27179956]
  • Cameron E Webb. Are we doing enough to promote the effective use of mosquito repellents?. The Medical journal of Australia. 2015 Feb; 202(3):128-9. doi: 10.5694/mja14.01237. [PMID: 25669466]
  • Pingxi Xu, Young-Moo Choo, Alyssa De La Rosa, Walter S Leal. Mosquito odorant receptor for DEET and methyl jasmonate. Proceedings of the National Academy of Sciences of the United States of America. 2014 Nov; 111(46):16592-7. doi: 10.1073/pnas.1417244111. [PMID: 25349401]
  • David J Menger, Bruno Otieno, Marjolein de Rijk, W Richard Mukabana, Joop J A van Loon, Willem Takken. A push-pull system to reduce house entry of malaria mosquitoes. Malaria journal. 2014 Mar; 13(?):119. doi: 10.1186/1475-2875-13-119. [PMID: 24674451]
  • Yunsung Nam, Eun-Joo Shin, Seung Woo Shin, Yong Kwang Lim, Jong Ho Jung, Jeong Hyun Lee, Jong Ryul Ha, Jong Seok Chae, Sung Kwon Ko, Ji Hoon Jeong, Choon-Gon Jang, Hyoung-Chun Kim. YY162 prevents ADHD-like behavioral side effects and cytotoxicity induced by Aroclor1254 via interactive signaling between antioxidant potential, BDNF/TrkB, DAT and NET. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2014 Mar; 65(?):280-92. doi: 10.1016/j.fct.2013.12.046. [PMID: 24394491]
  • M D Wilson, M Osei-Atweneboana, D A Boakye, I Osei-Akoto, E Obuobi, C Wiafe, A Kiszewski. Efficacy of DEET and non-DEET-based insect repellents against bites of Simulium damnosum vectors of onchocerciasis. Medical and veterinary entomology. 2013 Jun; 27(2):226-31. doi: 10.1111/j.1365-2915.2012.01054.x. [PMID: 23167529]
  • Erika Santamaría, Olga Lucía Cabrera, Yaneth Zipa, Raúl Hernando Pardo. [Field efficacy of repellent formulation containing para-menthane-3,8-diol and lemongrass against Culicoides pachymerus (Diptera: Ceratopogonidae) in Colombia]. Biomedica : revista del Instituto Nacional de Salud. 2012 Sep; 32(3):457-60. doi: 10.1590/s0120-41572012000300016. [PMID: 23715194]
  • Sarah J Moore, Samuel T Darling, Moisés Sihuincha, Norma Padilla, Gregor J Devine. A low-cost repellent for malaria vectors in the Americas: results of two field trials in Guatemala and Peru. Malaria journal. 2007 Aug; 6(?):101. doi: 10.1186/1475-2875-6-101. [PMID: 17678537]
  • Thomas G T Jaenson, Samira Garboui, Katinka Palsson. Repellency of oils of lemon eucalyptus, geranium, and lavender and the mosquito repellent MyggA natural to Ixodes ricinus (Acari: Ixodidae) in the laboratory and field. Journal of medical entomology. 2006 Jul; 43(4):731-6. doi: 10.1603/0022-2585(2006)43[731:rooole]2.0.co;2. [PMID: 16892632]
  • Stephen S Barasa, Isaiah O Ndiege, Wilber Lwande, Ahmed Hassanali. Repellent activities of stereoisomers of p-menthane-3,8-diols against Anopheles gambiae (Diptera: Culicidae). Journal of medical entomology. 2002 Sep; 39(5):736-41. doi: 10.1603/0022-2585-39.5.736. [PMID: 12349856]
  • Sarah J Moore, Annick Lenglet, Nigel Hill. Field evaluation of three plant-based insect repellents against malaria vectors in Vaca Diez Province, the Bolivian Amazon. Journal of the American Mosquito Control Association. 2002 Jun; 18(2):107-10. doi: ". [PMID: 12083351]
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