2-Fluoroadenine (BioDeep_00000173279)

   

human metabolite blood metabolite Antitumor activity


代谢物信息卡片


2-Fluoro-7(9)H-purin-6-ylamine

化学式: C5H4FN5 (153.0450716)
中文名称: 2-氟腺嘌呤
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=NC2=NC(=NC(=C2N1)N)F
InChI: InChI=1S/C5H4FN5/c6-5-10-3(7)2-4(11-5)9-1-8-2/h1H,(H3,7,8,9,10,11)

描述信息

2-Fluoroadenine is a toxic purine bases. 2-Fluoroadenine has toxicity in nonproliferating and proliferating tumor cells. 2-Fluoroadenine can be used for researching anticancer[1].

同义名列表

11 个代谢物同义名

2-Fluoro-7(9)H-purin-6-ylamine; 2-fluoro-3H-purin-6-amine; 2-Fluoro-1H-purin-6-amine; 2-Fluoro-6-aminopurine; 2-Fluoroadenine; TCMDC-124283; BRN 0610958; NSC 27364; SRI 774; 2-Fad; F-Ade



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

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代谢反应

0 个相关的代谢反应过程信息。

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Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

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1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Cécile Collonnier, Aline Epert, Kostlend Mara, François Maclot, Anouchka Guyon-Debast, Florence Charlot, Charles White, Didier G Schaefer, Fabien Nogué. CRISPR-Cas9-mediated efficient directed mutagenesis and RAD51-dependent and RAD51-independent gene targeting in the moss Physcomitrella patens. Plant biotechnology journal. 2017 01; 15(1):122-131. doi: 10.1111/pbi.12596. [PMID: 27368642]
  • Suman K Vodnala, Thomas Lundbäck, Esther Yeheskieli, Birger Sjöberg, Anna-Lena Gustavsson, Richard Svensson, Gabriela C Olivera, Anthonius A Eze, Harry P de Koning, Lars G J Hammarström, Martin E Rottenberg. Structure-activity relationships of synthetic cordycepin analogues as experimental therapeutics for African trypanosomiasis. Journal of medicinal chemistry. 2013 Dec; 56(24):9861-73. doi: 10.1021/jm401530a. [PMID: 24283924]
  • David H Salinger, David K Blough, Paolo Vicini, Claudio Anasetti, Paul V O'Donnell, Brenda M Sandmaier, Jeannine S McCune. A limited sampling schedule to estimate individual pharmacokinetic parameters of fludarabine in hematopoietic cell transplant patients. Clinical cancer research : an official journal of the American Association for Cancer Research. 2009 Aug; 15(16):5280-7. doi: 10.1158/1078-0432.ccr-09-0427. [PMID: 19671874]
  • Bénédicte Trouiller, Florence Charlot, Sandrine Choinard, Didier G Schaefer, Fabien Nogué. Comparison of gene targeting efficiencies in two mosses suggests that it is a conserved feature of Bryophyte transformation. Biotechnology letters. 2007 Oct; 29(10):1591-8. doi: 10.1007/s10529-007-9423-5. [PMID: 17565445]
  • X Y Wang, R Martiniello-Wilks, J M Shaw, T Ho, N Coulston, C Cooke-Yarborough, P L Molloy, F Cameron, M Moghaddam, T J Lockett, L K Webster, I K Smith, G W Both, P J Russell. Preclinical evaluation of a prostate-targeted gene-directed enzyme prodrug therapy delivered by ovine atadenovirus. Gene therapy. 2004 Nov; 11(21):1559-67. doi: 10.1038/sj.gt.3302308. [PMID: 15343359]
  • Song Ye, Martha M Rezende, Wei-Ping Deng, Brian Herbert, John W Daly, Roger A Johnson, Kenneth L Kirk. Synthesis of 2',5'-dideoxy-2-fluoroadenosine and 2',5'-dideoxy-2,5'-difluoroadenosine: potent P-site inhibitors of adenylyl cyclase. Journal of medicinal chemistry. 2004 Feb; 47(5):1207-13. doi: 10.1021/jm0303599. [PMID: 14971900]
  • Song Ye, Martha M Rezende, Wei-Ping Deng, Kenneth L Kirk. Convenient synthesis of 2'-deoxy-2-fluoroadenosine from 2-fluoroadenine. Nucleosides, nucleotides & nucleic acids. 2003 Oct; 22(10):1899-905. doi: 10.1081/ncn-120025237. [PMID: 14609229]
  • P Huang, W Plunkett. Phosphorolytic cleavage of 2-fluoroadenine from 9-beta-D-arabinofuranosyl-2-fluoroadenine by Escherichia coli. A pathway for 2-fluoro-ATP production. Biochemical pharmacology. 1987 Sep; 36(18):2945-50. doi: 10.1016/0006-2952(87)90207-3. [PMID: 3307790]