Fludara (BioDeep_00000173277)

   

human metabolite blood metabolite


代谢物信息卡片


{[5-(6-amino-2-fluoro-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic acid

化学式: C10H13FN5O7P (365.05366100000003)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=NC2=C(N=C(N=C2N1C3C(C(C(O3)COP(=O)(O)O)O)O)F)N
InChI: InChI=1S/C10H13FN5O7P/c11-10-14-7(12)4-8(15-10)16(2-13-4)9-6(18)5(17)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,17-18H,1H2,(H2,12,14,15)(H2,19,20,21)



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Jianyuan Zhao, Qian Liu, Dongrong Yi, Quanjie Li, SaiSai Guo, Ling Ma, Yongxin Zhang, Dongxin Dong, Fei Guo, Zhenlong Liu, Tao Wei, Xiaoyu Li, Shan Cen. 5-Iodotubercidin inhibits SARS-CoV-2 RNA synthesis. Antiviral research. 2022 02; 198(?):105254. doi: 10.1016/j.antiviral.2022.105254. [PMID: 35101534]
  • Jeannine S McCune, Erica L Woodahl, Terry Furlong, Barry Storer, Joanne Wang, Shelly Heimfeld, H Joachim Deeg, Paul V O'Donnell. A pilot pharmacologic biomarker study of busulfan and fludarabine in hematopoietic cell transplant recipients. Cancer chemotherapy and pharmacology. 2012 Jan; 69(1):263-72. doi: 10.1007/s00280-011-1736-3. [PMID: 21909959]
  • J R Long-Boyle, K G Green, C G Brunstein, Q Cao, J Rogosheske, D J Weisdorf, J S Miller, J E Wagner, P B McGlave, P A Jacobson. High fludarabine exposure and relationship with treatment-related mortality after nonmyeloablative hematopoietic cell transplantation. Bone marrow transplantation. 2011 Jan; 46(1):20-6. doi: 10.1038/bmt.2010.53. [PMID: 20383215]
  • Wei Yin, Elena V Karyagina, Ante S Lundberg, David J Greenblatt, John Lister-James. Pharmacokinetics, bioavailability and effects on electrocardiographic parameters of oral fludarabine phosphate. Biopharmaceutics & drug disposition. 2010 Jan; 31(1):72-81. doi: 10.1002/bdd.690. [PMID: 19862681]
  • David H Salinger, David K Blough, Paolo Vicini, Claudio Anasetti, Paul V O'Donnell, Brenda M Sandmaier, Jeannine S McCune. A limited sampling schedule to estimate individual pharmacokinetic parameters of fludarabine in hematopoietic cell transplant patients. Clinical cancer research : an official journal of the American Association for Cancer Research. 2009 Aug; 15(16):5280-7. doi: 10.1158/1078-0432.ccr-09-0427. [PMID: 19671874]
  • Bruno Cazin, Marine Divine, Stéphane Leprêtre, Philippe Travade, Olivier Tournilhac, Alain Delmer, Jérôme Jaubert, Pierre Feugier, Brigitte Dreyfus, Béatrice Mahé, Bernard Grosbois, Frédéric Maloisel, Houchingue Eghbali, Charles Dumontet, Jacques Bénichou, Odile Guibon, Xavier Leleu, Michel Leporrier, Karim Maloum. High efficacy with five days schedule of oral fludarabine phosphate and cyclophosphamide in patients with previously untreated chronic lymphocytic leukaemia. British journal of haematology. 2008 Oct; 143(1):54-9. doi: 10.1111/j.1365-2141.2008.07309.x. [PMID: 18710390]
  • Ryuki Fukuda, Hiroshi Kawada, Yoshiaki Ogawa, Hidetaka Yanagi, Seiichiro Kojima, Tetsuya Urano, Ito Chie, Makoto Onizuka, Satomi Fukagawa, Masako Shimada, Rikio Suzuki, Atsushi Takagi, Tomomitsu Hotta. Pulmonary non-caseating granuloma in Waldenström macroglobulinemia. The Tokai journal of experimental and clinical medicine. 2005 Jul; 30(2):133-6. doi: NULL. [PMID: 16146205]
  • X Y Wang, R Martiniello-Wilks, J M Shaw, T Ho, N Coulston, C Cooke-Yarborough, P L Molloy, F Cameron, M Moghaddam, T J Lockett, L K Webster, I K Smith, G W Both, P J Russell. Preclinical evaluation of a prostate-targeted gene-directed enzyme prodrug therapy delivered by ovine atadenovirus. Gene therapy. 2004 Nov; 11(21):1559-67. doi: 10.1038/sj.gt.3302308. [PMID: 15343359]
  • Sonia C Maggio, Roberto R Rosato, Lora B Kramer, Yun Dai, Mohamed Rahmani, David S Paik, Ann C Czarnik, Shawn G Payne, Sarah Spiegel, Steven Grant. The histone deacetylase inhibitor MS-275 interacts synergistically with fludarabine to induce apoptosis in human leukemia cells. Cancer research. 2004 Apr; 64(7):2590-600. doi: 10.1158/0008-5472.can-03-2631. [PMID: 15059916]
  • Ioannis A Avramis, Walter E Laug, Edward A Sausville, Vassilios I Avramis. Determination of drug synergism between the tyrosine kinase inhibitors NSC 680410 (adaphostin) and/or STI571 (imatinib mesylate, Gleevec) with cytotoxic drugs against human leukemia cell lines. Cancer chemotherapy and pharmacology. 2003 Oct; 52(4):307-18. doi: 10.1007/s00280-003-0668-y. [PMID: 12827297]
  • Valérie Auzerie, Amin Chiali, Annette Bussel, Jean Claude Brouet, Jean Paul Fermand, Louis Dubertret, Patricia Senet. Leg ulcers associated with cryoglobulinemia: clinical study of 15 patients and response to treatment. Archives of dermatology. 2003 Mar; 139(3):391-3. doi: 10.1001/archderm.139.3.391. [PMID: 12622649]
  • Tao Wu, Brett Levay-Young, Neal Heuss, Hakan Sozen, Nicole Kirchhof, David E R Sutherland, Bernhard Hering, Zhiguang Guo. Inducing tolerance to MHC-matched allogeneic islet grafts in diabetic NOD mice by simultaneous islet and bone marrow transplantation under nonirradiative and nonmyeloablative conditioning therapy. Transplantation. 2002 Jul; 74(1):22-7. doi: 10.1097/00007890-200207150-00005. [PMID: 12134094]
  • Varsha Gandhi, William Plunkett. Cellular and clinical pharmacology of fludarabine. Clinical pharmacokinetics. 2002; 41(2):93-103. doi: 10.2165/00003088-200241020-00002. [PMID: 11888330]
  • Stuart M Lichtman, Erlinda Etcubanas, Daniel R Budman, Peter Eisenberg, George Zervos, Paul D'Amico, Vivian O'Mara, Kimberly Musgrave, Peter Cascella, Armen Melikian, Peter H Hinderling, Jorge M Ferrer, Gary J Williams. The pharmacokinetics and pharmacodynamics of fludarabine phosphate in patients with renal impairment: a prospective dose adjustment study. Cancer investigation. 2002; 20(7-8):904-13. doi: 10.1081/cnv-120005903. [PMID: 12449721]
  • D Oscier, J A Orchard, D Culligan, D Cunningham, S Johnson, A Parker, M Klein, H Gieschen. The bioavailability of oral fludarabine phosphate is unaffected by food. The hematology journal : the official journal of the European Haematology Association. 2001; 2(5):316-21. doi: 10.1038/sj.thj.6200113. [PMID: 11920267]
  • A Fraternale, A Casabianca, A Tonelli, G Vallanti, L Chiarantini, G Brandi, A G Celeste, M Magnani. Inhibition of murine AIDS by alternate administration of azidothymidine and fludarabine monophosphate. Journal of acquired immune deficiency syndromes (1999). 2000 Mar; 23(3):209-20. doi: 10.1097/00126334-200003010-00001. [PMID: 10839656]
  • P Coppo, C Scieux, F Ferchal, J Clauvel, K Lassoued. Astrovirus enteritis in a chronic lymphocytic leukemia patient treated with fludarabine monophosphate. Annals of hematology. 2000 Jan; 79(1):43-5. doi: 10.1007/s002770050008. [PMID: 10663621]
  • H Brachwitz, J Bergmann, Y Thomas, T Wollny, P Langen. Synthesis and antiproliferative potency of 9-beta-D-arabinofuranosyl-2-fluoroadenine phospholipid adducts. Bioorganic & medicinal chemistry. 1999 Jun; 7(6):1195-200. doi: 10.1016/s0968-0896(99)00027-9. [PMID: 10428391]
  • J M Foran, D Oscier, J Orchard, S A Johnson, M Tighe, M H Cullen, P G de Takats, C Kraus, M Klein, T A Lister. Pharmacokinetic study of single doses of oral fludarabine phosphate in patients with 'low-grade' non-Hodgkin's lymphoma and B-cell chronic lymphocytic leukemia. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 1999 May; 17(5):1574-9. doi: 10.1200/jco.1999.17.5.1574. [PMID: 10334546]
  • G Misztal, B Paw. Determination of fludarabine phosphate in human plasma using reversed phase high-performance liquid chromatography. Die Pharmazie. 1996 Oct; 51(10):733-4. doi: NULL. [PMID: 8941940]
  • F Nakhoul, J Green, Z A Abassi, A Carter. Tumor lysis syndrome induced by fludarabine monophosphate: a case report. European journal of haematology. 1996 Apr; 56(4):254-5. doi: 10.1111/j.1600-0609.1996.tb01939.x. [PMID: 8641396]
  • A Kemena, M Fernandez, J Bauman, M Keating, W Plunkett. A sensitive fluorescence assay for quantitation of fludarabine and metabolites in biological fluids. Clinica chimica acta; international journal of clinical chemistry. 1991 Aug; 200(2-3):95-106. doi: 10.1016/0009-8981(91)90081-m. [PMID: 1723357]
  • H G Chun, B Leyland-Jones, B D Cheson. Fludarabine phosphate: a synthetic purine antimetabolite with significant activity against lymphoid malignancies. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 1991 Jan; 9(1):175-88. doi: 10.1200/jco.1991.9.1.175. [PMID: 1702143]
  • V I Avramis, J Champagne, J Sato, M Krailo, L J Ettinger, D G Poplack, J Finkelstein, G Reaman, G D Hammond, J S Holcenberg. Pharmacology of fludarabine phosphate after a phase I/II trial by a loading bolus and continuous infusion in pediatric patients. Cancer research. 1990 Nov; 50(22):7226-31. doi: NULL. [PMID: 1699658]
  • L Malspeis, M R Grever, A E Staubus, D Young. Pharmacokinetics of 2-F-ara-A (9-beta-D-arabinofuranosyl-2-fluoroadenine) in cancer patients during the phase I clinical investigation of fludarabine phosphate. Seminars in oncology. 1990 Oct; 17(5 Suppl 8):18-32. doi: NULL. [PMID: 1699279]
  • A F List, T D Kummet, J D Adams, H G Chun. Tumor lysis syndrome complicating treatment of chronic lymphocytic leukemia with fludarabine phosphate. The American journal of medicine. 1990 Sep; 89(3):388-90. doi: 10.1016/0002-9343(90)90358-k. [PMID: 1697447]
  • D H Shevrin, T E Lad, L J Kilton, M A Cobleigh, R R Blough, L L Weidner, N J Vogelzang. Phase II trial of fludarabine phosphate in advanced renal cell carcinoma: an Illinois Cancer Council Study. Investigational new drugs. 1989 Jul; 7(2-3):251-3. doi: 10.1007/bf00170869. [PMID: 2477345]
  • J M Leiby, M R Grever, A E Staubus, J A Neidhart, L Malspeis. Phase I clinical investigation of fludarabine phosphate by a loading-dose and continuous-infusion schedule. Journal of the National Cancer Institute. 1988 May; 80(6):447-9. doi: 10.1093/jnci/80.6.447. [PMID: 2452888]
  • M J Keating, H Kantarjian, M Talpaz, J Redman, K B McCredie. Fludarabine therapy in chronic lymphocytic leukemia (CLL). Nouvelle revue francaise d'hematologie. 1988; 30(5-6):461-6. doi: NULL. [PMID: 2464794]
  • L Balducci, B Blumenstein, D D Von Hoff, M Davis, H E Hynes, R M Bukowski, E D Crawford. Evaluation of fludarabine phosphate in renal cell carcinoma: a Southwest Oncology Group Study. Cancer treatment reports. 1987 May; 71(5):543-4. doi: NULL. [PMID: 2436773]
  • G R Weiss, H V Gaskill, J L Phillips. Pharmacologic analysis of the ip administration of fludarabine phosphate in the swine. Cancer treatment reports. 1986 Apr; 70(4):499-502. doi: NULL. [PMID: 2421893]
  • L Danhauser, W Plunkett, M Keating, F Cabanillas. 9-beta-D-arabinofuranosyl-2-fluoroadenine 5'-monophosphate pharmacokinetics in plasma and tumor cells of patients with relapsed leukemia and lymphoma. Cancer chemotherapy and pharmacology. 1986; 18(2):145-52. doi: 10.1007/bf00262285. [PMID: 2431803]
  • M R Hersh, J G Kuhn, J L Phillips, G Clark, T M Ludden, D D Von Hoff. Pharmacokinetic study of fludarabine phosphate (NSC 312887). Cancer chemotherapy and pharmacology. 1986; 17(3):277-80. doi: 10.1007/bf00256699. [PMID: 2427240]
  • J J Hutton, D D Von Hoff, J Kuhn, J Phillips, M Hersh, G Clark. Phase I clinical investigation of 9-beta-D-arabinofuranosyl-2-fluoroadenine 5'-monophosphate (NSC 312887), a new purine antimetabolite. Cancer research. 1984 Sep; 44(9):4183-6. doi: NULL. [PMID: 6204752]
  • V I Avramis, W Plunkett. Metabolism of 9-beta-D-arabinosyl-2-fluoroadenine-5'-phosphate by mice bearing P388 leukemia. Cancer drug delivery. 1983; 1(1):1-10. doi: 10.1089/cdd.1983.1.1. [PMID: 6085754]