2-Chloroethyl ethyl sulfide (BioDeep_00000173228)

   

human metabolite blood metabolite


代谢物信息卡片


1-Chloro-2-(ethylsulphanyl)ethane

化学式: C4H9ClS (124.01134640000001)
中文名称: 2-氯乙基乙基硫醚
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCSCCCl
InChI: InChI=1S/C4H9ClS/c1-2-6-4-3-5/h2-4H2,1H3

描述信息

同义名列表

5 个代谢物同义名

1-Chloro-2-(ethylsulphanyl)ethane; 1-chloro-2-(ethylsulfanyl)ethane; 2-CHLOROETHYL ethyl sulphide; 2-Chloroethyl ethyl sulfide; CEES



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Yang Li, Shitong Han, Zhanguo Li, Zhen Liu, Longhui Liang, Keping Yan, Anna Zhu. Decontamination of 2-Chloroethyl ethyl sulfide on the surface by atmospheric pressure plasma jet. Journal of hazardous materials. 2022 02; 424(Pt B):127536. doi: 10.1016/j.jhazmat.2021.127536. [PMID: 34879527]
  • Wolfgang Schmeißer, Robin Lüling, Dirk Steinritz, Horst Thiermann, Theo Rein, Harald John. Transthyretin as a target of alkylation and a potential biomarker for sulfur mustard poisoning: Electrophoretic and mass spectrometric identification and characterization. Drug testing and analysis. 2022 Jan; 14(1):80-91. doi: 10.1002/dta.3146. [PMID: 34397154]
  • Marie Gilardoni, Daniel Léonço, Fanny Caffin, Fanny Gros-Désormeaux, Camille Eldin, David Béal, Sadia Ouzia, Christophe Junot, François Fenaille, Christophe Piérard, Thierry Douki. Evidence for the systemic diffusion of (2-chloroethyl)-ethyl-sulfide, a sulfur mustard analog, and its deleterious effects in brain. Toxicology. 2021 10; 462(?):152950. doi: 10.1016/j.tox.2021.152950. [PMID: 34534560]
  • Marie Roser, David Béal, Camille Eldin, Leslie Gudimard, Fanny Caffin, Fanny Gros-Désormeaux, Daniel Léonço, François Fenaille, Christophe Junot, Christophe Piérard, Thierry Douki. Glutathione conjugates of the mercapturic acid pathway and guanine adduct as biomarkers of exposure to CEES, a sulfur mustard analog. Analytical and bioanalytical chemistry. 2021 Feb; 413(5):1337-1351. doi: 10.1007/s00216-020-03096-4. [PMID: 33410976]
  • Tapasi Rana, Aamir Ahmad, Iram Zafar, Nithya Mariappan, Darshan Shimoga Chandrashekar, Tariq Hamid, Maroof Husain, Sooryanarayana Varambally, Shama Ahmad, Aftab Ahmad. MicroRNA-mediated inflammation and coagulation effects in rats exposed to an inhaled analog of sulfur mustard. Annals of the New York Academy of Sciences. 2020 11; 1479(1):148-158. doi: 10.1111/nyas.14416. [PMID: 32602122]
  • Silpa Sabnam, Arttatrana Pal. Relevance of Erk1/2-PI3K/Akt signaling pathway in CEES-induced oxidative stress regulates inflammation and apoptosis in keratinocytes. Cell biology and toxicology. 2019 12; 35(6):541-564. doi: 10.1007/s10565-019-09467-7. [PMID: 30805762]
  • Satish Sagar, Soumya Ranjan Parida, Silpa Sabnam, Huma Rizwan, Sweta Pal, Mitali Madhusmita Swain, Arttatrana Pal. Increasing NO level regulates apoptosis and inflammation in macrophages after 2-chloroethyl ethyl sulphide challenge. The international journal of biochemistry & cell biology. 2017 02; 83(?):1-14. doi: 10.1016/j.biocel.2016.12.004. [PMID: 27939754]
  • Shekhar D Sawale, Pratul D Ambhore, Pallavi P Pawar, Uma Pathak, Utsab Deb, Ravindra M Satpute. Ameliorating effect of S-2(ω-aminoalkylamino) alkylaryl sulfide (DRDE-07) on sulfur mustard analogue, 2-chloroethyl ethyl sulfide-induced oxidative stress and inflammation. Toxicology mechanisms and methods. 2013 Nov; 23(9):702-10. doi: 10.3109/15376516.2013.843109. [PMID: 24024669]
  • Raymond C Rancourt, Livia A Veress, Aftab Ahmad, Tara B Hendry-Hofer, Jacqueline S Rioux, Rhonda B Garlick, Carl W White. Tissue factor pathway inhibitor prevents airway obstruction, respiratory failure and death due to sulfur mustard analog inhalation. Toxicology and applied pharmacology. 2013 Oct; 272(1):86-95. doi: 10.1016/j.taap.2013.05.020. [PMID: 23727623]
  • Sherri C Young, Karine M Fabio, Mou-Tuan Huang, Jaya Saxena, Meredith P Harman, Christophe D Guillon, Anna M Vetrano, Diane E Heck, Robert A Flowers, Ned D Heindel, Jeffrey D Laskin. Investigation of anticholinergic and non-steroidal anti-inflammatory prodrugs which reduce chemically induced skin inflammation. Journal of applied toxicology : JAT. 2012 Feb; 32(2):135-41. doi: 10.1002/jat.1645. [PMID: 21319177]
  • Raymond C Rancourt, Livia A Veress, Xiaoling Guo, Tara N Jones, Tara B Hendry-Hofer, Carl W White. Airway tissue factor-dependent coagulation activity in response to sulfur mustard analog 2-chloroethyl ethyl sulfide. American journal of physiology. Lung cellular and molecular physiology. 2012 Jan; 302(1):L82-92. doi: 10.1152/ajplung.00306.2010. [PMID: 21964405]
  • Jessica Gadsden-Gray, Shyamali Mukherjee, Olugbemiga Ogunkua, Salil K Das. Induction of neuronal damage in guinea pig brain by intratracheal infusion of 2-chloroethyl ethyl sulfide, a mustard gas analog. Journal of biochemical and molecular toxicology. 2012 Jan; 26(1):23-30. doi: 10.1002/jbt.20409. [PMID: 21898719]
  • Masanori Kidera, Yasuo Seto, Kazuya Takahashi, Shuichi Enomoto, Shintaro Kishi, Mika Makita, Tsuyoshi Nagamatsu, Tatsuhiko Tanaka, Masayoshi Toda. New method for comprehensive detection of chemical warfare agents using an electron-cyclotron-resonance ion-source mass spectrometer. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2011 Mar; 78(3):1215-9. doi: 10.1016/j.saa.2010.12.052. [PMID: 21242103]
  • Victor Paromov, Sudha Kumari, Marianne Brannon, Naga S Kanaparthy, Hongsong Yang, Milton G Smith, William L Stone. Protective effect of liposome-encapsulated glutathione in a human epidermal model exposed to a mustard gas analog. Journal of toxicology. 2011; 2011(?):109516. doi: 10.1155/2011/109516. [PMID: 21776256]
  • Livia A Veress, Heidi C O'Neill, Tara B Hendry-Hofer, Joan E Loader, Raymond C Rancourt, Carl W White. Airway obstruction due to bronchial vascular injury after sulfur mustard analog inhalation. American journal of respiratory and critical care medicine. 2010 Dec; 182(11):1352-61. doi: 10.1164/rccm.200910-1618oc. [PMID: 20639443]
  • Sutapa Mukhopadhyay, Shyamali Mukherjee, Bimal K Ray, Alpana Ray, William L Stone, Salil K Das. Antioxidant liposomes protect against CEES-induced lung injury by decreasing SAF-1/MAZ-mediated inflammation in the guinea pig lung. Journal of biochemical and molecular toxicology. 2010 May; 24(3):187-94. doi: 10.1002/jbt.20329. [PMID: 20583300]
  • Shyamali Mukherjee, William L Stone, Hongsong Yang, Milton G Smith, Salil K Das. Protection of half sulfur mustard gas-induced lung injury in guinea pigs by antioxidant liposomes. Journal of biochemical and molecular toxicology. 2009 Mar; 23(2):143-53. doi: 10.1002/jbt.20279. [PMID: 19367648]
  • Syeda M Kabir, Shyamali Mukherjee, Veera Rajaratnam, Milton G Smith, Salil K Das. Desensitization of beta-adrenergic receptors in lung injury induced by 2-chloroethyl ethyl sulfide, a mustard analog. Journal of biochemical and molecular toxicology. 2009 Jan; 23(1):59-70. doi: 10.1002/jbt.20265. [PMID: 19202564]
  • Maria A Pino, Blase Billack. Reduction of vesicant toxicity by butylated hydroxyanisole in A-431 skin cells. Cutaneous and ocular toxicology. 2008; 27(3):161-72. doi: 10.1080/15569520802092070. [PMID: 18988086]
  • Victor Paromov, Zacharias Suntres, Milton Smith, William L Stone. Sulfur mustard toxicity following dermal exposure: role of oxidative stress, and antioxidant therapy. Journal of burns and wounds. 2007 Oct; 7(?):e7. doi: ". [PMID: 18091984]
  • Shannon D McClintock, Laszlo M Hoesel, Salil K Das, Gerd O Till, Thomas Neff, Robin G Kunkel, Milton G Smith, Peter A Ward. Attenuation of half sulfur mustard gas-induced acute lung injury in rats. Journal of applied toxicology : JAT. 2006 Mar; 26(2):126-31. doi: 10.1002/jat.1115. [PMID: 16252256]
  • Salil K Das, Shyamali Mukherjee, Milton G Smith, Diptendu Chatterjee. Prophylactic protection by N-acetylcysteine against the pulmonary injury induced by 2-chloroethyl ethyl sulfide, a mustard analogue. Journal of biochemical and molecular toxicology. 2003; 17(3):177-84. doi: 10.1002/jbt.10076. [PMID: 12815614]
  • Shannon D McClintock, Gerd O Till, Milton G Smith, Peter A Ward. Protection from half-mustard-gas-induced acute lung injury in the rat. Journal of applied toxicology : JAT. 2002 Jul; 22(4):257-62. doi: 10.1002/jat.856. [PMID: 12210543]
  • N M Mozier, J L Hoffman. Biosynthesis and urinary excretion of methyl sulfonium derivatives of the sulfur mustard analog, 2-chloroethyl ethyl sulfide, and other thioethers. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 1990 Dec; 4(15):3329-33. doi: 10.1096/fasebj.4.15.2253846. [PMID: 2253846]
  • T Fukushima. [Monoamine oxidase (XXXVI). Characteristics of benzylamine oxidase in the dog serum]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. 1975 Jul; 71(5):457-62. doi: . [PMID: 280]