2-Aminothiazole (BioDeep_00000173194)

   

human metabolite blood metabolite


代谢物信息卡片


2,3-dihydro-1,3-thiazol-2-imine

化学式: C3H4N2S (100.0095)
中文名称: 2-氨基噻唑
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CSC(=N1)N
InChI: InChI=1S/C3H4N2S/c4-3-5-1-2-6-3/h1-2H,(H2,4,5)

描述信息

C147908 - Hormone Therapy Agent > C547 - Hormone Antagonist > C885 - Antithyroid Agent

同义名列表

13 个代谢物同义名

2,3-dihydro-1,3-thiazol-2-imine; 2-Aminothiazole sulfate (1:1); 2-Aminothiazole mononitrate; 4-Thiazolin-2-onimine; 2-Thiazolylamine; 2-Aminothiazole; Aminothiazolum; 2-Thiazolamine; Aminothiazole; Aminothiazol; Aminotiazol; abadol; 2-Aminothiazole



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Yu-Hang Yan, Ting-Ting Zhang, Rong Li, Si-Yao Wang, Liu-Liu Wei, Xin-Yue Wang, Kai-Rong Zhu, Shan-Rui Li, Guo-Qing Liang, Zeng-Bao Yang, Ling-Ling Yang, Shangshang Qin, Guo-Bo Li. Discovery of 2-Aminothiazole-4-carboxylic Acids as Broad-Spectrum Metallo-β-lactamase Inhibitors by Mimicking Carbapenem Hydrolysate Binding. Journal of medicinal chemistry. 2023 Oct; 66(19):13746-13767. doi: 10.1021/acs.jmedchem.3c01189. [PMID: 37791640]
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  • Muhan Ding, Nan Wu, Qiao Lin, Ya Yan, Yehui Yang, Guangmin Tian, Lian An, Xiaoping Bao. Discovery of Novel Quinazoline-2-Aminothiazole Hybrids Containing a 4-Piperidinylamide Linker as Potential Fungicides against the Phytopathogenic Fungus Rhizoctonia solani. Journal of agricultural and food chemistry. 2022 Aug; 70(33):10100-10110. doi: 10.1021/acs.jafc.1c07706. [PMID: 35960511]
  • Sandra S Jovičić Milić, Verica V Jevtić, Snežana R Radisavljević, Biljana V Petrović, Ivana D Radojević, Ivana R Raković, Đorđe S Petrović, Danijela Lj Stojković, Milena Jurišević, Nevena Gajović, Anđela Petrović, Nebojša Arsenijević, Ivan Jovanović, Olivera R Klisurić, Nenad L Vuković, Milena Vukić, Miroslava Kačániová. Synthesis, characterization, DNA interactions and biological activity of new palladium(II) complexes with some derivatives of 2-aminothiazoles. Journal of inorganic biochemistry. 2022 08; 233(?):111857. doi: 10.1016/j.jinorgbio.2022.111857. [PMID: 35597043]
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  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Pin-Kuei Fu, Chi-Yu Yang, Su-Chin Huang, Yu-Wen Hung, Kee-Ching Jeng, Ying-Pei Huang, Hong Chuang, Nai-Chun Huang, Jui-Ping Li, Ming-Hua Hsu, Jen-Kun Chen. Evaluation of LPS-Induced Acute Lung Injury Attenuation in Rats by Aminothiazole-Paeonol Derivatives. Molecules (Basel, Switzerland). 2017 Sep; 22(10):. doi: 10.3390/molecules22101605. [PMID: 28946699]
  • Wenqian Nong, Anran Zhao, Jinrui Wei, Xiao Lin, Lisheng Wang, Cuiwu Lin. Synthesis and biological evaluation of a new series of cinnamic acid amide derivatives as potent haemostatic agents containing a 2-aminothiazole substructure. Bioorganic & medicinal chemistry letters. 2017 09; 27(18):4506-4511. doi: 10.1016/j.bmcl.2017.07.058. [PMID: 28844387]
  • M S Attia, Najlaa S Al-Radadi. Progress of pancreatitis disease biomarker alpha amylase enzyme by new nano optical sensor. Biosensors & bioelectronics. 2016 Dec; 86(?):413-419. doi: 10.1016/j.bios.2016.06.079. [PMID: 27419907]
  • Simon B M Kretschmer, Stefano Woltersdorf, Carmen B Rödl, Dominik Vogt, Ann-Kathrin Häfner, Dieter Steinhilber, Holger Stark, Bettina Hofmann. Development of novel aminothiazole-comprising 5-LO inhibitors. Future medicinal chemistry. 2016; 8(2):149-64. doi: 10.4155/fmc.15.174. [PMID: 26824797]
  • Nehemiah Cox, Darrell Pilling, Richard H Gomer. DC-SIGN activation mediates the differential effects of SAP and CRP on the innate immune system and inhibits fibrosis in mice. Proceedings of the National Academy of Sciences of the United States of America. 2015 Jul; 112(27):8385-90. doi: 10.1073/pnas.1500956112. [PMID: 26106150]
  • Dominik Vogt, Julia Weber, Katja Ihlefeld, Astrid Brüggerhoff, Ewgenij Proschak, Holger Stark. Design, synthesis and evaluation of 2-aminothiazole derivatives as sphingosine kinase inhibitors. Bioorganic & medicinal chemistry. 2014 Oct; 22(19):5354-67. doi: 10.1016/j.bmc.2014.07.044. [PMID: 25150091]
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  • Ella Meltzer-Mats, Gali Babai-Shani, Lily Pasternak, Neta Uritsky, Tamar Getter, Olga Viskind, Jürgen Eckel, Erol Cerasi, Hanoch Senderowitz, Shlomo Sasson, Arie Gruzman. Synthesis and mechanism of hypoglycemic activity of benzothiazole derivatives. Journal of medicinal chemistry. 2013 Jul; 56(13):5335-50. doi: 10.1021/jm4001488. [PMID: 23750537]
  • B Michael Silber, Satish Rao, Kimberly L Fife, Alejandra Gallardo-Godoy, Adam R Renslo, Deepak K Dalvie, Kurt Giles, Yevgeniy Freyman, Manuel Elepano, Joel R Gever, Zhe Li, Matthew P Jacobson, Yong Huang, Leslie Z Benet, Stanley B Prusiner. Pharmacokinetics and metabolism of 2-aminothiazoles with antiprion activity in mice. Pharmaceutical research. 2013 Apr; 30(4):932-50. doi: 10.1007/s11095-012-0912-4. [PMID: 23417511]
  • Sugunadevi Sakkiah, Chandrasekaran Meganathan, Young-Sik Sohn, Sundaraganesan Namadevan, Keun Woo Lee. Identification of important chemical features of 11β-hydroxysteroid dehydrogenase type1 inhibitors: application of ligand based virtual screening and density functional theory. International journal of molecular sciences. 2012; 13(4):5138-5162. doi: 10.3390/ijms13045138. [PMID: 22606035]
  • Strayo De, Thomas P A Devasagayam. Protective effect of an aminothiazole compound against γ-radiation induced oxidative damage. Free radical research. 2011 Nov; 45(11-12):1342-53. doi: 10.3109/10715762.2011.623836. [PMID: 21923621]
  • Milan Mladenović, Mirjana Mihailović, Desanka Bogojević, Sanja Matić, Neda Nićiforović, Vladimir Mihailović, Nenad Vuković, Slobodan Sukdolak, Slavica Solujić. In vitro antioxidant activity of selected 4-hydroxy-chromene-2-one derivatives-SAR, QSAR and DFT studies. International journal of molecular sciences. 2011; 12(5):2822-41. doi: 10.3390/ijms12052822. [PMID: 21686153]
  • K B Kalpana, N Devipriya, K Thayalan, Venugopal P Menon. Protection against X-ray radiation-induced cellular damage of human peripheral blood lymphocytes by an aminothiazole derivative of dendrodoine. Chemico-biological interactions. 2010 Aug; 186(3):267-74. doi: 10.1016/j.cbi.2010.05.003. [PMID: 20465993]
  • Hiroshi Hirai, Toshiyasu Shimomura, Makiko Kobayashi, Tomohiro Eguchi, Eri Taniguchi, Kazuhiro Fukasawa, Takumitsu Machida, Hiroko Oki, Tsuyoshi Arai, Koji Ichikawa, Shinichi Hasako, Kyosuke Haze, Tsutomu Kodera, Nobuhiko Kawanishi, Ikuko Takahashi-Suziki, Yoko Nakatsuru, Hidehito Kotani, Yoshikazu Iwasawa. Biological characterization of 2-aminothiazole-derived Cdk4/6 selective inhibitor in vitro and in vivo. Cell cycle (Georgetown, Tex.). 2010 Apr; 9(8):1590-600. doi: 10.4161/cc.9.8.11306. [PMID: 20372067]
  • Andrew C Kotze, Steven R Kopp. The potential impact of density dependent fecundity on the use of the faecal egg count reduction test for detecting drug resistance in human hookworms. PLoS neglected tropical diseases. 2008 Oct; 2(10):e297. doi: 10.1371/journal.pntd.0000297. [PMID: 18827883]
  • K B Kalpana, M Srinivasan, Venugopal P Menon. Antioxidant potential of aminothiazole derivative and its protective effect on H(2)O(2)-induced oxidative damage on pBR322 DNA and RBC cellular membrane. Molecular and cellular biochemistry. 2008 Jul; 314(1-2):95-103. doi: 10.1007/s11010-008-9769-6. [PMID: 18437532]
  • Strayo De, S Adhikari, J Tilak-Jain, V P Menon, T P A Devasagayam. Antioxidant activity of an aminothiazole compound: possible mechanisms. Chemico-biological interactions. 2008 Jun; 173(3):215-23. doi: 10.1016/j.cbi.2008.03.011. [PMID: 18466888]
  • Günter Pappenberger, Tanja Schulz-Gasch, Eric Kusznir, Francis Müller, Michael Hennig. Structure-assisted discovery of an aminothiazole derivative as a lead molecule for inhibition of bacterial fatty-acid synthesis. Acta crystallographica. Section D, Biological crystallography. 2007 Dec; 63(Pt 12):1208-16. doi: 10.1107/s0907444907049852. [PMID: 18084068]
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  • Aruna Kode, Rukkumani Rajagopalan, Suresh Varma Penumastha, Venugopal P Menon. Role of an aminothiazole derivative on ethanol-induced toxicity. Toxicology mechanisms and methods. 2007; 17(1):33-40. doi: 10.1080/15376510600970026. [PMID: 20020985]
  • Kode Aruna, Rajagopalan Rukkumani, Penumathsa Suresh, Venugopal P Menon. Expression pattern of matrix metalloproteinases in alcohol- and thermally oxidized sunflower oil-induced toxicity: protective role of an aminothiazole derivative. Journal of medicinal food. 2005; 8(2):242-5. doi: 10.1089/jmf.2005.8.242. [PMID: 16117618]
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