L-Threo-Sphingosine C-18 (BioDeep_00000173186)

   

human metabolite blood metabolite


代谢物信息卡片


2-Aminooctadec-4-ene-1,3-diols

化学式: C18H37NO2 (299.2824)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 87.8%

分子结构信息

SMILES: CCCCCCCCCCCCCC=CC(O)C(N)CO
InChI: InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h14-15,17-18,20-21H,2-13,16,19H2,1H3

描述信息

同义名列表

3 个代谢物同义名

2-Aminooctadec-4-ene-1,3-diols; 2-aminooctadec-4-ene-1,3-diol; L-threo-Sphingosine C-18



数据库引用编号

3 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Weihua Liu, Tian Lan, Xi Xie, Kaipeng Huang, Jing Peng, Juan Huang, Xiaoyan Shen, Peiqing Liu, Heqing Huang. S1P2 receptor mediates sphingosine-1-phosphate-induced fibronectin expression via MAPK signaling pathway in mesangial cells under high glucose condition. Experimental cell research. 2012 May; 318(8):936-43. doi: 10.1016/j.yexcr.2012.02.020. [PMID: 22406263]
  • Keith S Mascall, Gary R Small, George Gibson, Graeme F Nixon. Sphingosine-1-phosphate-induced release of TIMP-2 from vascular smooth muscle cells inhibits angiogenesis. Journal of cell science. 2012 May; 125(Pt 9):2267-75. doi: 10.1242/jcs.099044. [PMID: 22344262]
  • Daniela Küllenberg, Lenka A Taylor, Michael Schneider, Ulrich Massing. Health effects of dietary phospholipids. Lipids in health and disease. 2012 Jan; 11(?):3. doi: 10.1186/1476-511x-11-3. [PMID: 22221489]
  • Kelley M Argraves, Amar A Sethi, Patrick J Gazzolo, Brent A Wilkerson, Alan T Remaley, Anne Tybjaerg-Hansen, Børge G Nordestgaard, Sharon D Yeatts, Katherine S Nicholas, Jeremy L Barth, W Scott Argraves. S1P, dihydro-S1P and C24:1-ceramide levels in the HDL-containing fraction of serum inversely correlate with occurrence of ischemic heart disease. Lipids in health and disease. 2011 May; 10(?):70. doi: 10.1186/1476-511x-10-70. [PMID: 21554699]
  • Alvaro Yogi, Glaucia E Callera, Anna B Aranha, Tayze T Antunes, Delyth Graham, Martin McBride, Anna Dominiczak, Rhian M Touyz. Sphingosine-1-phosphate-induced inflammation involves receptor tyrosine kinase transactivation in vascular cells: upregulation in hypertension. Hypertension (Dallas, Tex. : 1979). 2011 Apr; 57(4):809-18. doi: 10.1161/hypertensionaha.110.162719. [PMID: 21383307]
  • Sébastien Proulx-Bonneau, Borhane Annabi. The primary cilium as a biomarker in the hypoxic adaptation of bone marrow-derived mesenchymal stromal cells: a role for the secreted frizzled-related proteins. Biomarker insights. 2011; 6(?):107-18. doi: 10.4137/bmi.s8247. [PMID: 22084569]
  • Mariana Bertea, Markus F Rütti, Alaa Othman, Jaqueline Marti-Jaun, Martin Hersberger, Arnold von Eckardstein, Thorsten Hornemann. Deoxysphingoid bases as plasma markers in diabetes mellitus. Lipids in health and disease. 2010 Aug; 9(?):84. doi: 10.1186/1476-511x-9-84. [PMID: 20712864]
  • Agnieszka Chrobak, Urszula Sieradzka, Rafał Sozański, Anna Chełmońska-Soyta, Marian Gabryś, Małgorzata Jerzak. Ectopic and eutopic stromal endometriotic cells have a damaged ceramide signaling pathway to apoptosis. Fertility and sterility. 2009 Dec; 92(6):1834-43. doi: 10.1016/j.fertnstert.2008.09.035. [PMID: 19019359]
  • Akira Tokumura, Laura D Carbone, Yasuko Yoshioka, Junichi Morishige, Masaki Kikuchi, Arnold Postlethwaite, Mitchell A Watsky. Elevated serum levels of arachidonoyl-lysophosphatidic acid and sphingosine 1-phosphate in systemic sclerosis. International journal of medical sciences. 2009 Jun; 6(4):168-76. doi: 10.7150/ijms.6.168. [PMID: 19521548]
  • Susan Pyne, Sue Chin Lee, Jaclyn Long, Nigel J Pyne. Role of sphingosine kinases and lipid phosphate phosphatases in regulating spatial sphingosine 1-phosphate signalling in health and disease. Cellular signalling. 2009 Jan; 21(1):14-21. doi: 10.1016/j.cellsig.2008.08.008. [PMID: 18768158]
  • Gergana S Nikolova, Günter Haufe. Stereoselective synthesis of (2S,3S,4Z)-4-fluoro-1,3-dihydroxy-2-(octadecanoylamino)octadec-4-ene, [(Z)-4-fluoroceramide], and its phase behavior at the air/water interface. Beilstein journal of organic chemistry. 2008; 4(?):12. doi: 10.3762/bjoc.4.12. [PMID: 18941484]
  • R A Sabbadini. Targeting sphingosine-1-phosphate for cancer therapy. British journal of cancer. 2006 Nov; 95(9):1131-5. doi: 10.1038/sj.bjc.6603400. [PMID: 17024123]
  • Mayya Meriane, Stéphanie Duhamel, Laurence Lejeune, Jacques Galipeau, Borhane Annabi. Cooperation of matrix metalloproteinases with the RhoA/Rho kinase and mitogen-activated protein kinase kinase-1/extracellular signal-regulated kinase signaling pathways is required for the sphingosine-1-phosphate-induced mobilization of marrow-derived stromal cells. Stem cells (Dayton, Ohio). 2006 Nov; 24(11):2557-65. doi: 10.1634/stemcells.2006-0209. [PMID: 16931773]
  • Caylib A Durand, Jens Westendorf, Kathy W K Tse, Michael R Gold. The Rap GTPases mediate CXCL13- and sphingosine1-phosphate-induced chemotaxis, adhesion, and Pyk2 tyrosine phosphorylation in B lymphocytes. European journal of immunology. 2006 Aug; 36(8):2235-49. doi: 10.1002/eji.200535004. [PMID: 16821235]
  • Nicolas Garmy, Nadira Taïeb, Nouara Yahi, Jacques Fantini. Apical uptake and transepithelial transport of sphingosine monomers through intact human intestinal epithelial cells: physicochemical and molecular modeling studies. Archives of biochemistry and biophysics. 2005 Aug; 440(1):91-100. doi: 10.1016/j.abb.2005.06.001. [PMID: 16009329]
  • Jens-Michael Jensen, Michael Förl, Supandi Winoto-Morbach, Sophie Seite, Michael Schunck, Ehrhardt Proksch, Stefan Schütze. Acid and neutral sphingomyelinase, ceramide synthase, and acid ceramidase activities in cutaneous aging. Experimental dermatology. 2005 Aug; 14(8):609-18. doi: 10.1111/j.0906-6705.2005.00342.x. [PMID: 16026583]
  • Josefina Edsbagge, Jenny K Johansson, Farzad Esni, Yang Luo, Glenn L Radice, Henrik Semb. Vascular function and sphingosine-1-phosphate regulate development of the dorsal pancreatic mesenchyme. Development (Cambridge, England). 2005 Mar; 132(5):1085-92. doi: 10.1242/dev.01643. [PMID: 15689381]
  • William J Tanski, Suzanne M Nicholl, Dong Kim, Allison J Fegley, Elisa Roztocil, Mark G Davies. Sphingosine-1-phosphate-induced smooth muscle cell migration involves the mammalian target of rapamycin. Journal of vascular surgery. 2005 Jan; 41(1):91-8. doi: 10.1016/j.jvs.2004.08.058. [PMID: 15696050]
  • Eva M Schmelz. Sphingolipids in the chemoprevention of colon cancer. Frontiers in bioscience : a journal and virtual library. 2004 Sep; 9(?):2632-9. doi: 10.2741/1422. [PMID: 15358586]
  • Anke Niedernberg, Sorin Tunaru, Andree Blaukat, Bruce Harris, Evi Kostenis. Comparative analysis of functional assays for characterization of agonist ligands at G protein-coupled receptors. Journal of biomolecular screening. 2003 Oct; 8(5):500-10. doi: 10.1177/1087057103257555. [PMID: 14567777]
  • Shin-ichiro Miura, Hiroyuki Tanigawa, Yoshino Matsuo, Masahiro Fujino, Akira Kawamura, Keijiro Saku. Ras/Raf1-dependent signal in sphingosine-1-phosphate-induced tube formation in human coronary artery endothelial cells. Biochemical and biophysical research communications. 2003 Jul; 306(4):924-9. doi: 10.1016/s0006-291x(03)01065-9. [PMID: 12821130]
  • G Wu, Z H Lu, X Xie, L Li, R W Ledeen. Mutant NG108-15 cells (NG-CR72) deficient in GM1 synthase respond aberrantly to axonogenic stimuli and are vulnerable to calcium-induced apoptosis: they are rescued with LIGA-20. Journal of neurochemistry. 2001 Feb; 76(3):690-702. doi: 10.1046/j.1471-4159.2001.00036.x. [PMID: 11158239]
  • K Tamama, J Kon, K Sato, H Tomura, A Kuwabara, T Kimura, T Kanda, H Ohta, M Ui, I Kobayashi, F Okajima. Extracellular mechanism through the Edg family of receptors might be responsible for sphingosine-1-phosphate-induced regulation of DNA synthesis and migration of rat aortic smooth-muscle cells. The Biochemical journal. 2001 Jan; 353(Pt 1):139-146. doi: . [PMID: 11115407]