2-Amino-2-methyl-1-propanol (BioDeep_00000173145)
human metabolite blood metabolite
代谢物信息卡片
化学式: C4H11NO (89.0841)
中文名称: 2-氨基-2-甲基-1-丙醇
谱图信息:
最多检出来源 Mus musculus(blood) 100%
分子结构信息
SMILES: CC(C)(CO)N
InChI: InChI=1S/C4H11NO/c1-4(2,5)3-6/h6H,3,5H2,1-2H3
描述信息
同义名列表
9 个代谢物同义名
2-Amino-2-methyl-1-propanol hydrochloride; 2-Amino-2-methyl-1-propanol nitrate salt; 2-Amino-2-methyl-1-propanol tosylate; 2-Amino-2-methyl-1-propanol mesylate; 2-amino-2-methylpropan-1-ol; 2-Amino-2-methyl-1-propanol; 2-Amino-2-methylpropanol; Aminomethyl propanol; 2-Amino-2-methyl-1-propanol
数据库引用编号
6 个数据库交叉引用编号
- PubChem: 11807
- HMDB: HMDB0244974
- ChEMBL: CHEMBL122588
- Wikipedia: Aminomethyl propanol
- chemspider: 13835861
- CAS: 124-68-5
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
亚细胞结构定位 | 关联基因列表 |
---|
文献列表
- Lindsey Garnick, Christopher Bates, Andrey Massarsky, Pamela Spencer, Priyanka Sura, Andrew D Monnot, Andrew Maier. Dose and exposure route analyses inform relationships between liver steatosis and 2-amino-2-methyl-1-propanol: Implications for hazard characterization.
Journal of applied toxicology : JAT.
2022 12; 42(12):1873-1889. doi:
10.1002/jat.4308
. [PMID: 35199353] - Dorottya Nagy-Szakal, Dinesh K Barupal, Bohyun Lee, Xiaoyu Che, Brent L Williams, Ellie J R Kahn, Joy E Ukaigwe, Lucinda Bateman, Nancy G Klimas, Anthony L Komaroff, Susan Levine, Jose G Montoya, Daniel L Peterson, Bruce Levin, Mady Hornig, Oliver Fiehn, W Ian Lipkin. Insights into myalgic encephalomyelitis/chronic fatigue syndrome phenotypes through comprehensive metabolomics.
Scientific reports.
2018 07; 8(1):10056. doi:
10.1038/s41598-018-28477-9
. [PMID: 29968805] - Fuwei Xie, Yanhao Zhang, Bo Zheng, Feifei Xu, Jianpo Su, Yanyan Lu, Fanya Zeng, Bin Zhang, Yaxiao Guo, Shusheng Zhang. Rapid and sensitive analysis of three polyphenols in tobacco by CE using homemade C(4)D with a mini detection cell.
Electrophoresis.
2012 Aug; 33(15):2433-40. doi:
10.1002/elps.201200057
. [PMID: 22887165] - Vera Sampels, Anne Hartmann, Isabelle Dietrich, Isabelle Coppens, Lilach Sheiner, Boris Striepen, Andreas Herrmann, Richard Lucius, Nishith Gupta. Conditional mutagenesis of a novel choline kinase demonstrates plasticity of phosphatidylcholine biogenesis and gene expression in Toxoplasma gondii.
The Journal of biological chemistry.
2012 May; 287(20):16289-99. doi:
10.1074/jbc.m112.347138
. [PMID: 22451671] - Tawfeeq Shekh-Ahmad, Meir Bialer, Eylon Yavin. Synthesis and anticonvulsant evaluation of dimethylethanolamine analogues of valproic acid and its tetramethylcyclopropyl analogue.
Epilepsy research.
2012 Feb; 98(2-3):238-46. doi:
10.1016/j.eplepsyres.2011.10.005
. [PMID: 22057163] - Xiao-Hong Yu, Richa Rawat, John Shanklin. Characterization and analysis of the cotton cyclopropane fatty acid synthase family and their contribution to cyclopropane fatty acid synthesis.
BMC plant biology.
2011 May; 11(?):97. doi:
10.1186/1471-2229-11-97
. [PMID: 21612656] - Vasily I Svetashev. Mild method for preparation of 4,4-dimethyloxazoline derivatives of polyunsaturated fatty acids for GC-MS.
Lipids.
2011 May; 46(5):463-7. doi:
10.1007/s11745-011-3550-4
. [PMID: 21461869] - Serap Turan, Burcu Topcu, İbrahim Gökçe, Tülay Güran, Zeynep Atay, Anjumanara Omar, Teoman Akçay, Abdullah Bereket. Serum alkaline phosphatase levels in healthy children and evaluation of alkaline phosphatase z-scores in different types of rickets.
Journal of clinical research in pediatric endocrinology.
2011; 3(1):7-11. doi:
10.4274/jcrpe.v3i1.02
. [PMID: 21448327] - Amina Ibrahim, Anna-Lena Schütz, Jean-Marie Galano, Cornelia Herrfurth, Kirstin Feussner, Thierry Durand, Florian Brodhun, Ivo Feussner. The Alphabet of Galactolipids in Arabidopsis thaliana.
Frontiers in plant science.
2011; 2(?):95. doi:
10.3389/fpls.2011.00095
. [PMID: 22639619] - Giampaolo Cattozzo, Chiara Albeni, Carlo Franzini. Harmonization of values for serum alkaline phosphatase catalytic activity concentration employing commutable calibration materials.
Clinica chimica acta; international journal of clinical chemistry.
2010 Jun; 411(11-12):882-5. doi:
10.1016/j.cca.2010.03.008
. [PMID: 20226776] - Vinay Saluja, Jean P Amorij, Maarten L van Roosmalen, Kees Leenhouts, Anke Huckriede, Wouter L J Hinrichs, Henderik W Frijlink. Intranasal delivery of influenza subunit vaccine formulated with GEM particles as an adjuvant.
The AAPS journal.
2010 Jun; 12(2):109-16. doi:
10.1208/s12248-009-9168-2
. [PMID: 20058113] - David Melzer, Neil E Rice, Ceri Lewis, William E Henley, Tamara S Galloway. Association of urinary bisphenol a concentration with heart disease: evidence from NHANES 2003/06.
PloS one.
2010 Jan; 5(1):e8673. doi:
10.1371/journal.pone.0008673
. [PMID: 20084273] - Xiao-Rong Li, Lu Wang, Yong-Ling Ruan. Developmental and molecular physiological evidence for the role of phosphoenolpyruvate carboxylase in rapid cotton fibre elongation.
Journal of experimental botany.
2010; 61(1):287-95. doi:
10.1093/jxb/erp299
. [PMID: 19815688] - Binod B Sahu, Birendra P Shaw. Isolation, identification and expression analysis of salt-induced genes in Suaeda maritima, a natural halophyte, using PCR-based suppression subtractive hybridization.
BMC plant biology.
2009 Jun; 9(?):69. doi:
10.1186/1471-2229-9-69
. [PMID: 19497134] - Su-Hsia Lin, Kuo-Lun Tung, Hao-Wei Chang, Kueir-Rarn Lee. Influence of fluorocarbon flat-membrane hydrophobicity on carbon dioxide recovery.
Chemosphere.
2009 Jun; 75(10):1410-6. doi:
10.1016/j.chemosphere.2009.02.027
. [PMID: 19289246] - Shakil A Saghir, Amy J Clark, E Lynn McClymont, Jennifer L Staley. Pharmacokinetics of aminomethylpropanol in rats following oral and a novel dermal study design.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2008 Feb; 46(2):678-87. doi:
10.1016/j.fct.2007.09.091
. [PMID: 17961896] - Sontaya Limmatvapirat, Chutima Limmatvapirat, Satit Puttipipatkhachorn, Jurairat Nuntanid, Manee Luangtana-Anan. Enhanced enteric properties and stability of shellac films through composite salts formation.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
2007 Nov; 67(3):690-8. doi:
10.1016/j.ejpb.2007.04.008
. [PMID: 17576057] - Makoto Matsushita, Tsutomu Irino, Kiyoshi Kamiyama, Yoshimi Muramoto, Takeshi Kawaguchi, Takanari Nakano, Tsugikazu Komoda. Evaluation of a method for measuring tissue non-specific alkaline phosphatase activity in healthy subjects.
Annals of clinical biochemistry.
2007 Nov; 44(Pt 6):544-8. doi:
10.1258/000456307782268165
. [PMID: 17961309] - Deepa Jethwaney, Md Rafiqul Islam, Kevin G Leidal, Daniel Beltran-Valero de Bernabe, Kevin P Campbell, William M Nauseef, Bradford W Gibson. Proteomic analysis of plasma membrane and secretory vesicles from human neutrophils.
Proteome science.
2007 Aug; 5(?):12. doi:
10.1186/1477-5956-5-12
. [PMID: 17692124] - Chengyong Liao, Russell A Nicholson. Ethanolamine and related amino alcohols increase basal and evoked release of [3H]-D-aspartic acid from synaptosomes by enhancing the filling of synaptic vesicles.
European journal of pharmacology.
2007 Jul; 566(1-3):103-12. doi:
10.1016/j.ejphar.2007.03.020
. [PMID: 17448462] - Nishith Gupta, Matthew M Zahn, Isabelle Coppens, Keith A Joiner, Dennis R Voelker. Selective disruption of phosphatidylcholine metabolism of the intracellular parasite Toxoplasma gondii arrests its growth.
The Journal of biological chemistry.
2005 Apr; 280(16):16345-53. doi:
10.1074/jbc.m501523200
. [PMID: 15708856] - Peter Kämpfer, Hans-Jürgen Busse, Ramon Rosséllo-Mora, Eva Kjellin, Enevold Falsen. Rhodovarius lipocyclicus gen. nov. sp. nov., a new genus of the alpha-1 subclass of the Proteobacteria.
Systematic and applied microbiology.
2004 Sep; 27(5):511-6. doi:
10.1078/0723202041748235
. [PMID: 15490551] - Kristin A Waite, Dennis E Vance. Dimethylethanolamine does not prevent liver failure in phosphatidylethanolamine N-methyltransferase-deficient mice fed a choline-deficient diet.
Biochimica et biophysica acta.
2004 Mar; 1636(2-3):175-82. doi:
10.1016/j.bbalip.2003.10.014
. [PMID: 15164765] - Makoto Matsushita, Tsutomu Irino, Takeshi Kawaguchi, Tsugikazu Komoda. The effect of different buffers and amounts of intestinal alkaline phosphatase isoforms on total alkaline phosphatase activity.
Clinica chimica acta; international journal of clinical chemistry.
2002 May; 319(1):49-55. doi:
10.1016/s0009-8981(02)00008-6
. [PMID: 11922923] - T Tozawa, M Hashimoto. [Influences of uncommon isoenzymes on determination of alkaline phosphatase activity by dry-chemistry analyzers].
Rinsho byori. The Japanese journal of clinical pathology.
2001 Apr; 49(4):389-94. doi:
NULL
. [PMID: 11391954] - G Schumann, H C Dominick, D Hellmann, R Klauke, M Möckesch, H Stekel, H von Schenck, M Kraft, R Nagel, E Hänseler. Alkaline phosphatase activity: new assay for the Reflotron system. Results of the evaluation in eight clinical laboratories.
Clinical chemistry and laboratory medicine.
2001 Jan; 39(1):71-8. doi:
10.1515/cclm.2001.015
. [PMID: 11256805] - K Lewandrowski, E Lee-Lewandrowski, G N Bowers, R B McComb. Investigation of N-methyl-D-glucamine buffer for assay of alkaline phosphatase in serum.
Clinical chemistry.
1992 Nov; 38(11):2286-94. doi:
10.1093/clinchem/38.11.2286
. [PMID: 1424126] - N W Tietz, C A Burtis, P Duncan, K Ervin, C J Petitclerc, A D Rinker, D Shuey, E R Zygowicz. A reference method for measurement of alkaline phosphatase activity in human serum.
Clinical chemistry.
1983 May; 29(5):751-61. doi:
10.1093/clinchem/29.5.751
. [PMID: 6404566] - M A Koupparis, E P Diamandis, H V Malmstadt. Total calcium and magnesium determined in serum with an automated stopped-flow analyzer.
Clinical chemistry.
1982 Oct; 28(10):2149-52. doi:
10.1093/clinchem/28.10.2149
. [PMID: 7127745] - H J Derks, V Borrias-van Tongeren, J B Terlingen, J C Koedam. Elimination of inhibitors of alkaline phosphatase from 2-amino-2-methyl-1-propanol.
Clinical chemistry.
1981 Feb; 27(2):318-21. doi:
10.1093/clinchem/27.2.318
. [PMID: 7460285] - W J LONGMORE, D J MULFORD. The effect of 2-amino-2-methylpropanol on rat liver phospholipid metabolism.
The Journal of biological chemistry.
1962 Mar; 237(?):694-8. doi:
10.1016/s0021-9258(18)60357-6
. [PMID: 14466506] - W J LONGMORE, D J MULFORD. Evidence for the in vivo incorporation of 2-amino-2-methylpropanol into rat liver phospholipid.
Biochemical and biophysical research communications.
1960 Nov; 3(?):566-9. doi:
10.1016/0006-291x(60)90176-5
. [PMID: 13763368] - C E OUTLAND, E H MEALEY, W J LONGMORE, D J MULFORD. The effect of ethanolamine and its N-methyl derivatives on kidney hemorrhagic degeneration in rats due to 2-amino-2-methyl-1-propanol.
The Journal of nutrition.
1959 Apr; 67(4):655-63. doi:
10.1093/jn/67.4.655
. [PMID: 13642154] - D J MULFORD, C E OUTLAND. The effect of 2-amino-2-methyl-1-propanol on the incidence of kidney lesions in male rats of different ages fed diets low in choline.
The Journal of nutrition.
1957 Mar; 61(3):381-8. doi:
10.1093/jn/61.3.381
. [PMID: 13416962] - D J MULFORD. Betaine and methionine on renal hemorrhagic degeneration in rats receiving 2-amino-2-methyl propanol-1.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.).
1955 Jul; 89(3):471-3. doi:
10.3181/00379727-89-21848
. [PMID: 13254798] - . .
.
. doi:
. [PMID: 22345606]