2-(Phosphonomethyl)pentanedioic acid (BioDeep_00000173127)

   

human metabolite blood metabolite


代谢物信息卡片


2-(Phosphonomethyl)pentanedioic acid

化学式: C6H11O7P (226.0242)
中文名称: 2-(膦酰基甲基)戊二酸
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C(CC(=O)O)C(CP(=O)(O)O)C(=O)O
InChI: InChI=1S/C6H11O7P/c7-5(8)2-1-4(6(9)10)3-14(11,12)13/h4H,1-3H2,(H,7,8)(H,9,10)(H2,11,12,13)

描述信息

同义名列表

3 个代谢物同义名

2-(Phosphonomethyl)pentanedioic acid; 2-(Phosphonomethyl)pentanedioate; 2-PMPA CPD



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Ruixue Wang, Lianyun Lin, Yiqiang Zheng, Peng Cao, Zhiguang Yuchi, Hui-Yuan Wu. Identification of 2-PMPA as a novel inhibitor of cytosolic carboxypeptidases. Biochemical and biophysical research communications. 2020 12; 533(4):1393-1399. doi: 10.1016/j.bbrc.2020.10.029. [PMID: 33092792]
  • Francesca Borgna, Luisa M Deberle, Susan Cohrs, Roger Schibli, Cristina Müller. Combined Application of Albumin-Binding [177Lu]Lu-PSMA-ALB-56 and Fast-Cleared PSMA Inhibitors: Optimization of the Pharmacokinetics. Molecular pharmaceutics. 2020 06; 17(6):2044-2053. doi: 10.1021/acs.molpharmaceut.0c00199. [PMID: 32383887]
  • Ranjeet P Dash, Tomáš Tichý, Vijayabhaskar Veeravalli, Jenny Lam, Jesse Alt, Ying Wu, Lukáš Tenora, Pavel Majer, Barbara S Slusher, Rana Rais. Enhanced Oral Bioavailability of 2-(Phosphonomethyl)-pentanedioic Acid (2-PMPA) from its (5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl (ODOL)-Based Prodrugs. Molecular pharmaceutics. 2019 10; 16(10):4292-4301. doi: 10.1021/acs.molpharmaceut.9b00637. [PMID: 31503493]
  • Michael Nedelcovych, Ranjeet P Dash, Lukáš Tenora, Sarah C Zimmermann, Alexandra J Gadiano, Caroline Garrett, Jesse Alt, Kristen R Hollinger, Elie Pommier, Andrej Jančařík, Camilo Rojas, Ajit G Thomas, Ying Wu, Krystyna Wozniak, Pavel Majer, Barbara S Slusher, Rana Rais. Enhanced Brain Delivery of 2-(Phosphonomethyl)pentanedioic Acid Following Intranasal Administration of Its γ-Substituted Ester Prodrugs. Molecular pharmaceutics. 2017 10; 14(10):3248-3257. doi: 10.1021/acs.molpharmaceut.7b00231. [PMID: 28763226]
  • Clemens Kratochwil, Frederik L Giesel, Karin Leotta, Matthias Eder, Torsten Hoppe-Tich, Hagop Youssoufian, Klaus Kopka, John W Babich, Uwe Haberkorn. PMPA for nephroprotection in PSMA-targeted radionuclide therapy of prostate cancer. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2015 Feb; 56(2):293-8. doi: 10.2967/jnumed.114.147181. [PMID: 25613537]
  • Rana Rais, Krystyna Wozniak, Ying Wu, Minae Niwa, Marigo Stathis, Jesse Alt, Marc Giroux, Akira Sawa, Camilo Rojas, Barbara S Slusher. Selective CNS Uptake of the GCP-II Inhibitor 2-PMPA following Intranasal Administration. PloS one. 2015; 10(7):e0131861. doi: 10.1371/journal.pone.0131861. [PMID: 26151906]
  • Rana Rais, Camilo Rojas, Krystyna Wozniak, Ying Wu, Ming Zhao, Takashi Tsukamoto, Michelle A Rudek, Barbara S Slusher. Bioanalytical method for evaluating the pharmacokinetics of the GCP-II inhibitor 2-phosphonomethyl pentanedioic acid (2-PMPA). Journal of pharmaceutical and biomedical analysis. 2014 Jan; 88(?):162-9. doi: 10.1016/j.jpba.2013.08.028. [PMID: 24055700]
  • Rana Rais, Randall Hoover, Krystyna Wozniak, Michelle A Rudek, Takashi Tsukamoto, Jesse Alt, Camilo Rojas, Barbara S Slusher. Reversible disulfide formation of the glutamate carboxypeptidase II inhibitor E2072 results in prolonged systemic exposures in vivo. Drug metabolism and disposition: the biological fate of chemicals. 2012 Dec; 40(12):2315-23. doi: 10.1124/dmd.112.046821. [PMID: 22949627]
  • Jarogniew J Luszczki, Mohamed Mohamed, Stanislaw J Czuczwar. 2-phosphonomethyl-pentanedioic acid (glutamate carboxypeptidase II inhibitor) increases threshold for electroconvulsions and enhances the antiseizure action of valproate against maximal electroshock-induced seizures in mice. European journal of pharmacology. 2006 Feb; 531(1-3):66-73. doi: 10.1016/j.ejphar.2005.11.045. [PMID: 16403497]
  • Seung Y Park, Byoung G Ha, Geum H Choi, Wan Lee. N-Acetylated alpha-linked acidic dipeptidase expressed in rat adipocytes is localized in the insulin-responsive glucose transporter (GLUT4) intracellular compartments and involved in the insulin-stimulated GLUT4 recruitment. Archives of biochemistry and biophysics. 2004 Apr; 424(1):11-22. doi: 10.1016/j.abb.2004.01.011. [PMID: 15019832]
  • C Rojas, A G Thomas, P Majer, T Tsukamoto, X M Lu, J J Vornov, K M Wozniak, B S Slusher. Glutamate carboxypeptidase II inhibition as a novel therapeutic target. Advances in experimental medicine and biology. 2003; 524(?):205-13. doi: 10.1007/0-306-47920-6_25. [PMID: 12675241]
  • Dean J Bacich, Epolia Ramadan, Denise S O'Keefe, Noreen Bukhari, Iga Wegorzewska, Olumide Ojeifo, Rafal Olszewski, Craige C Wrenn, Tomasz Bzdega, Barbara Wroblewska, Warren D W Heston, Joseph H Neale. Deletion of the glutamate carboxypeptidase II gene in mice reveals a second enzyme activity that hydrolyzes N-acetylaspartylglutamate. Journal of neurochemistry. 2002 Oct; 83(1):20-9. doi: 10.1046/j.1471-4159.2002.01117.x. [PMID: 12358725]
  • Martin G Pomper, John L Musachio, Jiazhong Zhang, Ursula Scheffel, Yun Zhou, John Hilton, Atul Maini, Robert F Dannals, Dean F Wong, Alan P Kozikowski. 11C-MCG: synthesis, uptake selectivity, and primate PET of a probe for glutamate carboxypeptidase II (NAALADase). Molecular imaging. 2002 Apr; 1(2):96-101. doi: 10.1162/153535002320162750. [PMID: 12920850]
  • C W Tiffany, N S Cai, C Rojas, B S Slusher. Binding of the glutamate carboxypeptidase II (NAALADase) inhibitor 2-PMPA to rat brain membranes. European journal of pharmacology. 2001 Sep; 427(2):91-6. doi: 10.1016/s0014-2999(01)01236-5. [PMID: 11557259]