2-(Allylthio)pyrazine (BioDeep_00000173110)
human metabolite blood metabolite
代谢物信息卡片
2-(prop-2-en-1-ylsulfanyl)pyrazine
化学式: C7H8N2S (152.0408)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 100%
分子结构信息
SMILES: C=CCSC1=NC=CN=C1
InChI: InChI=1S/C7H8N2S/c1-2-5-10-7-6-8-3-4-9-7/h2-4,6H,1,5H2
描述信息
D004791 - Enzyme Inhibitors > D065607 - Cytochrome P-450 Enzyme Inhibitors > D065691 - Cytochrome P-450 CYP2E1 Inhibitors
同义名列表
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Jun-Hee Jang, Chong-Kook Kim, Han-Gon Choi, Jung Hoon Sung. Preparation and evaluation of 2-(allylthio)pyrazine-loaded lipid emulsion with enhanced stability and liver targeting.
Drug development and industrial pharmacy.
2009 Mar; 35(3):363-8. doi:
10.1080/03639040802363696. [PMID: 19016100] - Eun J Lee, Eun J Kim, Yoon G Kim, Hye C Chung, So H Kim, Dong H Kim, Inchul Lees, Sang G Kim, Myung G Lee. Effects of acute renal failure induced by uranyl nitrate on the pharmacokinetics of 2-(allylthio) pyrazine, a chemoprotective agent, in rats: the role of CYP3A23 induction.
Research communications in molecular pathology and pharmacology.
2004; 115-116(?):111-21. doi:
NULL. [PMID: 17564310] - Yoon Gyoon Yim, Min Kyung Cho, Jong Won Kwon, Dong-Hyun Kim, Sang Geon Kim, Myung Gull Lee. Effects of cysteine on the pharmacokinetics of intravenous 2-(allylthio)pyrazine, a new chemoprotective agent, in rats with protein-calorie malnutrition.
International journal of pharmaceutics.
2003 Apr; 255(1-2):1-11. doi:
10.1016/s0378-5173(03)00054-1. [PMID: 12672597] - Eun J Lee, Eun J Kim, Yoon G Kim, Hye C Chung, So H Kim, Dong H Kim, Inchul Lee, Sang G Kim, Myung G Lee. Pharmacokinetic changes of intravenous 2-(allylthio) pyrazine, a chemoprotective agent, in rats with acute renal failure induced by uranyl nitrate.
Research communications in molecular pathology and pharmacology.
2002; 111(5-6):225-36. doi:
NULL. [PMID: 15244038] - K W Kang, J R Ha, C W Kim, N D Kim, S G Kim. 2-(Allylthio)pyrazine, a cancer chemopreventive agent, inhibits liver fibrosis induced by dimethylnitrosamine in rats: role of inhibition of transforming growth factor-beta1 expression.
Pharmacology & toxicology.
2001 Jul; 89(1):23-9. doi:
10.1034/j.1600-0773.2001.d01-131.x. [PMID: 11484906] - S Bu, Y Kim, S Kim, M Lee. Effects of enzyme inducers and inhibitor on the pharmacokinetics of intravenous 2-(allylthio)pyrazine, a new chemoprotective agent, in rats.
Biopharmaceutics & drug disposition.
2000 May; 21(4):157-64. doi:
10.1002/1099-081x(200005)21:4<157::aid-bdd226>3.0.co;2-c. [PMID: 11180194] - K S Han, M G Lee. Effect of a new chemoprotective agent, 2-(allylthio)pyrazine, on the pharmacokinetics of intravenous theophylline in rats.
International journal of pharmaceutics.
1999 Jul; 184(2):237-42. doi:
10.1016/s0378-5173(99)00111-8. [PMID: 10387953] - T G Ha, J J Jang, S G Kim, N D Kim. 2-(Allylthio)pyrazine inhibition of aflatoxin B1-induced hepatocarcinogenesis in rats.
Chemico-biological interactions.
1999 Jul; 121(2):209-22. doi:
10.1016/s0009-2797(99)00094-0. [PMID: 10418965] - K S Han, M G Lee. Pharmacokinetics of a chemoprotective agent, 2-(allylthio)pyrazine, after intravenous and oral administration to rats: hepatic and gastric first-pass effects.
Drug metabolism and disposition: the biological fate of chemicals.
1999 Feb; 27(2):221-6. doi:
NULL. [PMID: 9929506] - T G Ha, N D Kim. 2-(allylthio)pyrazine inhibition of aflatoxin B1-induced hepatotoxicity in rats: inhibition of cytochrome P450 2B- and 3A2-mediated bioactivation.
Research communications in molecular pathology and pharmacology.
1998 Oct; 102(1):69-78. doi:
NULL. [PMID: 9920347] - K S Han, S J Woo, C H Koo, M G Lee. Stability, blood partition, and protein binding of a chemoprotective agent, 2-(allylthio)pyrazine.
Research communications in molecular pathology and pharmacology.
1998 Aug; 101(2):171-8. doi:
NULL. [PMID: 9821213] - Y J Surh, S G Kim, K K Park, Y Sohn, J M Lee, N D Kim, J A Miller. Chemopreventive effects of 2-(allylthio)pyrazine on hepatic lesion, mutagenesis and tumorigenesis induced by vinyl carbamate or vinyl carbamate epoxide.
Carcinogenesis.
1998 Jul; 19(7):1263-7. doi:
10.1093/carcin/19.7.1263. [PMID: 9683187] - K S Han, S J Woo, C H Koo, M G Lee. Determination of a chemoprotective agent, 2-(allylthio)pyrazine, in plasma, urine and tissue homogenates by high-performance liquid chromatography.
Journal of chromatography. B, Biomedical sciences and applications.
1998 Jun; 710(1-2):239-42. doi:
10.1016/s0378-4347(98)00097-8. [PMID: 9686894] - K S Han, S J Woo, C H Koo, M G Lee. Pharmacokinetics of a chemoprotective agent, 2-(allylthio)pyrazine, after intravenous administration to rabbits.
Research communications in molecular pathology and pharmacology.
1998 Apr; 100(1):29-34. doi:
NULL. [PMID: 9644716] - S G Kim, A K Lee, N D Kim. Partial hepatoprotective effects of allylthiobenzimidazole in the absence of cytochrome P4502E1 suppression: effects on epoxide hydrolase, rGSTA2, rGSTA3/5, rGSTM1 and rGSTM2 expression.
Xenobiotica; the fate of foreign compounds in biological systems.
1998 Mar; 28(3):323-36. doi:
10.1080/004982598239605. [PMID: 9574820] - N D Kim, K W Kang, S G Kim, V B Schini-Kerth. Inhibition of inducible nitric oxide synthase expression and stimulation of the endothelial formation of nitric oxide most likely accounts for the protective effect of 2-(allylthio)pyrazine in a murine model of endotoxemia.
Biochemical and biophysical research communications.
1997 Oct; 239(1):310-5. doi:
10.1006/bbrc.1997.7406. [PMID: 9345316] - N D Kim, M K Kwak, S G Kim. Inhibition of cytochrome P450 2E1 expression by 2-(allylthio)pyrazine, a potential chemoprotective agent: hepatoprotective effects.
Biochemical pharmacology.
1997 Feb; 53(3):261-9. doi:
10.1016/s0006-2952(96)00647-8. [PMID: 9065729]
