2-(2-Methoxyethoxy)ethanol (BioDeep_00000173095)

   

human metabolite blood metabolite Volatile Flavor Compounds


代谢物信息卡片


Diethylene glycol monomethyl ether

化学式: C5H12O3 (120.0786402)
中文名称: 二乙二醇甲醚, 2-（2-甲氧基乙氧基）乙醇
谱图信息: 最多检出来源 Mus musculus(blood) 84%

分子结构信息

SMILES: COCCOCCO
InChI: InChI=1S/C5H12O3/c1-7-4-5-8-3-2-6/h6H,2-5H2,1H3

描述信息

COVID info from PDB, Protein Data Bank
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS

同义名列表

9 个代谢物同义名

Diethylene glycol monomethyl ether; 2-(2-methoxyethoxy)ethan-1-ol; 2-(2-Methoxyethoxy)ethanol; Diglycol monomethyl ether; Methyl-PEG2-alcohol; Methoxydiglycol; Methylcarbitol; 2-MEE CPD; 2-(2-Methoxyethoxy)ethanol



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

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  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Wendelin Koch, Sara Forcisi, Rainer Lehmann, Philippe Schmitt-Kopplin. Sensitivity improvement in hydrophilic interaction chromatography negative mode electrospray ionization mass spectrometry using 2-(2-methoxyethoxy)ethanol as a post-column modifier for non-targeted metabolomics. Journal of chromatography. A. 2014 Sep; 1361(?):209-16. doi: 10.1016/j.chroma.2014.07.104. [PMID: 25160955]
  • Edward F Krieg, Patricia I Mathias, Christine A Toennis, John C Clark, Kate L Marlow, Clayton B'hymer, Narendra P Singh, Roger L Gibson, Mary Ann Butler. Detection of DNA damage in workers exposed to JP-8 jet fuel. Mutation research. 2012 Sep; 747(2):218-27. doi: 10.1016/j.mrgentox.2012.05.005. [PMID: 22617435]
  • Raymond J Bergeron, Neelam Bharti, Jan Wiegand, James S McManis, Shailendra Singh, Khalil A Abboud. The impact of polyether chain length on the iron clearing efficiency and physiochemical properties of desferrithiocin analogues. Journal of medicinal chemistry. 2010 Apr; 53(7):2843-53. doi: 10.1021/jm9018146. [PMID: 20232803]
  • Clayton B'Hymer, Mary Ann Butler, Kenneth L Cheever. Comparison and evaluation of analysis procedures for the quantification of (2-methoxyethoxy)acetic acid in urine. Analytical and bioanalytical chemistry. 2005 Sep; 383(2):201-9. doi: 10.1007/s00216-005-0048-z. [PMID: 16158298]
  • J Laitinen, J Pulkkinen. Biomonitoring of 2-(2-alkoxyethoxy)ethanols by analysing urinary 2-(2-alkoxyethoxy)acetic acids. Toxicology letters. 2005 Mar; 156(1):117-26. doi: 10.1016/j.toxlet.2003.09.022. [PMID: 15705492]
  • Clayton B'hymer, Deborah E Keil, Kenneth L Cheever. A Test Procedure for the Determination of (2-Methoxyethoxy)acetic Acid in Urine from Jet Fuel-Exposed Mice. Toxicology mechanisms and methods. 2005; 15(5):367-73. doi: 10.1080/153765291009976. [PMID: 20021058]
  • C B'Hymer, K L Cheever, M A Butler, K K Brown. Procedure for the quantification of the biomarker (2-methoxyethoxy)acetic acid in human urine samples. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2003 Sep; 795(1):145-50. doi: 10.1016/s1570-0232(03)00552-x. [PMID: 12957179]
  • J Yamaguchi, M Ohmichi, M Hasegawa, H Yoshida, N Ogawa, S Higuchi. Identification of rat urinary and biliary metabolites of esonarimod, a novel antirheumatic drug, using liquid chromatography/electrospray ionization tandem mass spectrometry with postcolumn addition of 2-(2-methoxyethoxy)ethanol, a signal-enhancing modifier. Drug metabolism and disposition: the biological fate of chemicals. 2001 Jun; 29(6):806-12. doi: NULL. [PMID: 11353748]
  • J Yamaguchi, M Ohmichi, S Jingu, N Ogawa, S Higuchi. Utility of postcolumn addition of 2-(2-methoxyethoxy)ethanol, a signal-enhancing modifier, for metabolite screening with liquid chromatography and negative ion electrospray ionization mass spectrometry. Analytical chemistry. 1999 Dec; 71(23):5386-90. doi: 10.1021/ac990664v. [PMID: 10596216]
  • D W Hobson, A P D'Addario, R H Bruner, D E Uddin. A subchronic dermal exposure study of diethylene glycol monomethyl ether and ethylene glycol monomethyl ether in the male guinea pig. Fundamental and applied toxicology : official journal of the Society of Toxicology. 1986 Feb; 6(2):339-48. doi: 10.1016/0272-0590(86)90249-6. [PMID: 3699323]