1H-Indol-2-amine (BioDeep_00000173062)

   

human metabolite blood metabolite


代谢物信息卡片


1H-indol-2-amine

化学式: C8H8N2 (132.0687)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 33.33%

分子结构信息

SMILES: C1=CC=C2C(=C1)C=C(N2)N
InChI: InChI=1S/C8H8N2/c9-8-5-6-3-1-2-4-7(6)10-8/h1-5,10H,9H2

描述信息

同义名列表

2 个代谢物同义名

1H-indol-2-amine; Indolamine



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Ahmet Özer Şehirli, Serkan Sayıner. Daylight is critical to preserve 5-methoxytryptophol levels in suspected and confirmed COVID-19 patients. Medical hypotheses. 2021 Feb; 147(?):110504. doi: 10.1016/j.mehy.2021.110504. [PMID: 33485026]
  • R Ramakrishnan. Brain signalling systems: A target for treating type I diabetes mellitus. Brain research bulletin. 2019 10; 152(?):191-201. doi: 10.1016/j.brainresbull.2019.07.017. [PMID: 31325597]
  • Alma Rus, Francisco Molina, María Luisa Del Moral, María Jesús Ramírez-Expósito, José Manuel Martínez-Martos. Catecholamine and Indolamine Pathway: A Case-Control Study in Fibromyalgia. Biological research for nursing. 2018 10; 20(5):577-586. doi: 10.1177/1099800418787672. [PMID: 30009619]
  • Andy J Liedtke, Brenda C Crews, Cristina M Daniel, Anna L Blobaum, Philip J Kingsley, Kebreab Ghebreselasie, Lawrence J Marnett. Cyclooxygenase-1-selective inhibitors based on the (E)-2'-des-methyl-sulindac sulfide scaffold. Journal of medicinal chemistry. 2012 Mar; 55(5):2287-300. doi: 10.1021/jm201528b. [PMID: 22263894]
  • Mari Gabrielsen, Aina Westrheim Ravna, Kurt Kristiansen, Ingebrigt Sylte. Substrate binding and translocation of the serotonin transporter studied by docking and molecular dynamics simulations. Journal of molecular modeling. 2012 Mar; 18(3):1073-85. doi: 10.1007/s00894-011-1133-1. [PMID: 21670993]
  • J Furuzawa-Carballeda, G Lima, J Alberú, D Palafox, N Uribe-Uribe, L E Morales-Buenrostro, R Reyes Acevedo, G Mondragón, A Chevaile, L Llorente. Infiltrating cellular pattern in kidney graft biopsies translates into forkhead box protein 3 up-regulation and p16INK4α senescence protein down-regulation in patients treated with belatacept compared to cyclosporin A. Clinical and experimental immunology. 2012 Feb; 167(2):330-7. doi: 10.1111/j.1365-2249.2011.04504.x. [PMID: 22236010]
  • Nicola A G Meenan, Graeme Ball, Krystyna Bromek, Dušan Uhrín, Alan Cooper, Malcolm W Kennedy, Brian O Smith. Solution structure of a repeated unit of the ABA-1 nematode polyprotein allergen of Ascaris reveals a novel fold and two discrete lipid-binding sites. PLoS neglected tropical diseases. 2011 Apr; 5(4):e1040. doi: 10.1371/journal.pntd.0001040. [PMID: 21526216]
  • Kutti R Vinothkumar. Structure of rhomboid protease in a lipid environment. Journal of molecular biology. 2011 Mar; 407(2):232-47. doi: 10.1016/j.jmb.2011.01.029. [PMID: 21256137]
  • Guoqiang Dong, Chunquan Sheng, Shengzheng Wang, Zhenyuan Miao, Jianzhong Yao, Wannian Zhang. Selection of evodiamine as a novel topoisomerase I inhibitor by structure-based virtual screening and hit optimization of evodiamine derivatives as antitumor agents. Journal of medicinal chemistry. 2010 Nov; 53(21):7521-31. doi: 10.1021/jm100387d. [PMID: 20942490]
  • Hsin-Pin Wu, Cheng-Ju Yu, Chin-Yu Lin, Yen-Hsiu Lin, Wei-Lung Tseng. Gold nanoparticles as assisted matrices for the detection of biomolecules in a high-salt solution through laser desorption/ionization mass spectrometry. Journal of the American Society for Mass Spectrometry. 2009 May; 20(5):875-82. doi: 10.1016/j.jasms.2009.01.002. [PMID: 19211262]
  • Kristian W Kaufmann, Eric S Dawson, L Keith Henry, Julie R Field, Randy D Blakely, Jens Meiler. Structural determinants of species-selective substrate recognition in human and Drosophila serotonin transporters revealed through computational docking studies. Proteins. 2009 Feb; 74(3):630-42. doi: 10.1002/prot.22178. [PMID: 18704946]
  • Arneh Babakhani, Alemayehu A Gorfe, Judy E Kim, J Andrew McCammon. Thermodynamics of peptide insertion and aggregation in a lipid bilayer. The journal of physical chemistry. B. 2008 Aug; 112(34):10528-34. doi: 10.1021/jp804710v. [PMID: 18681475]
  • Tiago Rodrigues, Rui Moreira, Rita C Guedes, Jim Iley, Francisca Lopes. Unanticipated acyloxymethylation of sumatriptan indole nitrogen atom and its implications in prodrug design. Archiv der Pharmazie. 2008 Jun; 341(6):344-50. doi: 10.1002/ardp.200700250. [PMID: 18442019]
  • Wei-Lung Tseng, Sheng-Min Chen, Chih-Yao Hsu, Ming-Mu Hsieh. On-line concentration and separation of indolamines, catecholamines, and metanephrines in capillary electrophoresis using high concentration of poly(diallyldimethylammonium chloride). Analytica chimica acta. 2008 Apr; 613(1):108-15. doi: 10.1016/j.aca.2008.02.049. [PMID: 18374708]
  • K Nawrot-Porabka, J Jaworek, A Leja-Szpak, J Szklarczyk, M Kot, M Mitis-Musioł, S J Konturek, W W Pawlik. Involvement of vagal nerves in the pancreatostimulatory effects of luminal melatonin, or its precursor L-tryptophan. Study in the rats. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. 2007 Dec; 58 Suppl 6(?):81-95. doi: . [PMID: 18212402]
  • M Soledade C Pedras, Mohammad Hossain. Design, synthesis, and evaluation of potential inhibitors of brassinin glucosyltransferase, a phytoalexin detoxifying enzyme from Sclerotinia sclerotiorum. Bioorganic & medicinal chemistry. 2007 Sep; 15(17):5981-96. doi: 10.1016/j.bmc.2007.05.072. [PMID: 17590338]
  • Darrell Desveaux, Alex U Singer, Ai-Jiuan Wu, Brian C McNulty, Laura Musselwhite, Zachary Nimchuk, John Sondek, Jeffery L Dangl. Type III effector activation via nucleotide binding, phosphorylation, and host target interaction. PLoS pathogens. 2007 Mar; 3(3):e48. doi: 10.1371/journal.ppat.0030048. [PMID: 17397263]
  • Fabienne Peyrot, Bernadette O Fernandez, Nathan S Bryan, Martin Feelisch, Claire Ducrocq. N-Nitroso products from the reaction of indoles with Angeli's salt. Chemical research in toxicology. 2006 Jan; 19(1):58-67. doi: 10.1021/tx050253b. [PMID: 16411657]
  • Victor Kulik, Elisabeth Hartmann, Michael Weyand, Monika Frey, Alfons Gierl, Dimitri Niks, Michael F Dunn, Ilme Schlichting. On the structural basis of the catalytic mechanism and the regulation of the alpha subunit of tryptophan synthase from Salmonella typhimurium and BX1 from maize, two evolutionarily related enzymes. Journal of molecular biology. 2005 Sep; 352(3):608-20. doi: 10.1016/j.jmb.2005.07.014. [PMID: 16120446]
  • Christian Albers, Matthias Lehr, Justus Beike, Helga Köhler, Bernd Brinkmann. Synthesis of a psilocin hapten and a protein-hapten conjugate. The Journal of pharmacy and pharmacology. 2002 Sep; 54(9):1265-70. doi: 10.1211/002235702320402116. [PMID: 12356281]
  • E M Adkins, E L Barker, R D Blakely. Interactions of tryptamine derivatives with serotonin transporter species variants implicate transmembrane domain I in substrate recognition. Molecular pharmacology. 2001 Mar; 59(3):514-23. doi: 10.1124/mol.59.3.514. [PMID: 11179447]
  • L Givalois, H Becq, P Siaud, G Ixart, I Assenmacher, G Barbanel. Serotoninergic and suprachiasmatic nucleus involvement in the corticotropic response to systemic endotoxin challenge in rats. Journal of neuroendocrinology. 1999 Aug; 11(8):629-36. doi: 10.1046/j.1365-2826.1999.00374.x. [PMID: 10447801]
  • S R Thomas, P K Witting, R Stocker. 3-Hydroxyanthranilic acid is an efficient, cell-derived co-antioxidant for alpha-tocopherol, inhibiting human low density lipoprotein and plasma lipid peroxidation. The Journal of biological chemistry. 1996 Dec; 271(51):32714-21. doi: 10.1074/jbc.271.51.32714. [PMID: 8955104]
  • M C Okomo-Assoumou, M Geffard, S Daulouede, C Chaugier, J L Lemesre, P Vincendeau. Circulating antibodies directed against tryptophan-like epitopes in sera of patients with human African trypanosomiasis. The American journal of tropical medicine and hygiene. 1995 May; 52(5):461-7. doi: 10.4269/ajtmh.1995.52.461. [PMID: 7539598]
  • A J Dunn, S L Vickers. Neurochemical and neuroendocrine responses to Newcastle disease virus administration in mice. Brain research. 1994 May; 645(1-2):103-12. doi: 10.1016/0006-8993(94)91643-8. [PMID: 8062073]
  • A J Dunn, H E Chuluyan. Endotoxin elicits normal tryptophan and indolamine responses but impaired catecholamine and pituitary-adrenal responses in endotoxin-resistant mice. Life sciences. 1994; 54(13):847-53. doi: 10.1016/0024-3205(94)00621-0. [PMID: 8139374]