Deoxyaminopteroic acid (BioDeep_00000173032)
human metabolite blood metabolite
代谢物信息卡片
化学式: C15H15N7O2 (325.128717)
中文名称: 4-氨基-4-脱氧-10-甲基蝶酸
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)O
InChI: InChI=1S/C15H15N7O2/c1-22(10-4-2-8(3-5-10)14(23)24)7-9-6-18-13-11(19-9)12(16)20-15(17)21-13/h2-6H,7H2,1H3,(H,23,24)(H4,16,17,18,20,21)
描述信息
同义名列表
12 个代谢物同义名
4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)amino}benzoic acid; 4-(((2,4-Diamino-6-pteridinyl)methyl)methylamino)benzoic acid; 4-Amino-4-deoxy-N-10-methylpteroic acid hydrochloride (2:1); 4-Deoxy-4-amino-N(10)-methylpteroic acid; 4-Amino-4-deoxy-N-10-methylpteroic acid; 4-Amino-4-deoxy-N 10-methylpteroic acid; 4-Amino-4-deoxy-10-methylpteroic acid; 2,4-Diamino-N(10)-methylpteroic acid; N-10-Methyl-4-deoxy-4-aminopteroate; 2,4-Diamino-N10-methylpteroic acid; Deoxyaminopteroic acid; Deoxyaminopteroate
数据库引用编号
6 个数据库交叉引用编号
- KEGG: C90286
- PubChem: 72441
- HMDB: HMDB0244853
- ChEMBL: CHEMBL3544676
- chemspider: 65368
- CAS: 19741-14-1
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Shenghui Mei, Yong Cui, Dongjie Zhang, Chun Zeng, Xiaohui Ren, Kefu Yu, Song Lin, Zhigang Zhao. Simultaneous Determination of Urine Methotrexate, 7-Hydroxy Methotrexate, Deoxyaminopteroic Acid, and 7-Hydroxy Deoxyaminopteroic Acid by UHPLC-MS/MS in Patients Receiving High-dose Methotrexate Therapy.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry.
2020 Dec; 36(12):1479-1486. doi:
10.2116/analsci.19p481. [PMID: 32801284] - Francisco Berga, Pablo Luna, Clara Martorell, Juan Rey, Isabel Gomila, Sandra Gimenez, Antonia Costa-Bauza, Miguel Ángel Elorza, Iolanda Sánchez, Félix Grases, Bernardino Barceló. 2,4-Diamino-N10-methylpteroic acid (DAMPA) crystalluria in a patient with osteosarcoma treated with carboxypeptidase-G2 rescue after high-dose methotrexate-induced nephrotoxicity.
Clinica chimica acta; international journal of clinical chemistry.
2018 Dec; 487(?):1-5. doi:
10.1016/j.cca.2018.09.006. [PMID: 30205081] - Ryan C Schofield, Lakshmi V Ramanathan, Kazunori Murata, Marie Grace, Martin Fleisher, Melissa S Pessin, Dean C Carlow. Development and validation of a turbulent flow chromatography and tandem mass spectrometry method for the quantitation of methotrexate and its metabolites 7-hydroxy methotrexate and DAMPA in serum.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2015 Oct; 1002(?):169-75. doi:
10.1016/j.jchromb.2015.08.025. [PMID: 26322588] - Masanobu Uchiyama, Takanori Matsumoto, Taichi Matsumoto, Shiro Jimi, Yasushi Takamatsu, Kazuo Tamura, Shuuji Hara. Simple and sensitive HPLC method for the fluorometric determination of methotrexate and its major metabolites in human plasma by post-column photochemical reaction.
Biomedical chromatography : BMC.
2012 Jan; 26(1):76-80. doi:
10.1002/bmc.1628. [PMID: 21437923] - Michael C Milone. Commentary.
Clinical chemistry.
2010 Dec; 56(12):1795-6. doi:
10.1373/clinchem.2010.153619. [PMID: 21119036] - Elizabeth Fox, Frank M Balis. Commentary.
Clinical chemistry.
2010 Dec; 56(12):1795. doi:
10.1373/clinchem.2010.153601. [PMID: 21119037] - B C Widemann, E Sung, L Anderson, W L Salzer, F M Balis, K S Monitjo, C McCully, M Hawkins, P C Adamson. Pharmacokinetics and metabolism of the methotrexate metabolite 2, 4-diamino-N(10)-methylpteroic acid.
The Journal of pharmacology and experimental therapeutics.
2000 Sep; 294(3):894-901. doi:
NULL. [PMID: 10945838] - L M DeAngelis, W P Tong, S Lin, M Fleisher, J R Bertino. Carboxypeptidase G2 rescue after high-dose methotrexate.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
1996 Jul; 14(7):2145-9. doi:
10.1200/jco.1996.14.7.2145. [PMID: 8683248] - M C Broughton, S F Queener. Pneumocystis carinii dihydrofolate reductase used to screen potential antipneumocystis drugs.
Antimicrobial agents and chemotherapy.
1991 Jul; 35(7):1348-55. doi:
10.1128/aac.35.7.1348. [PMID: 1929292] - H N Alkaysi, A M Gharaibeh, M A Salem. High-performance liquid chromatographic determination of methotrexate in plasma.
Therapeutic drug monitoring.
1990 Mar; 12(2):191-4. doi:
10.1097/00007691-199003000-00014. [PMID: 2315976] - C Wolfrom, R Hepp, R Hartmann, H Breithaupt, G Henze. Pharmacokinetic study of methotrexate, folinic acid and their serum metabolites in children treated with high-dose methotrexate and leucovorin rescue.
European journal of clinical pharmacology.
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10.1007/bf00315414. [PMID: 2076721] - B Nuernberg, M Kohlbrenner, R Faulkner, D E Furst. Rapid quantitation of methotrexate and its metabolites in human serum, urine and bile, using solid-phase extraction and high-performance liquid chromatography.
Journal of chromatography.
1989 Feb; 487(2):476-82. doi:
10.1016/s0378-4347(00)83058-3. [PMID: 2723014] - J Salamoun, J Frantisek. Determination of methotrexate and its metabolites 7-hydroxymethotrexate and 2,4-diamino-N10-methylpteroic acid in biological fluids by liquid chromatography with fluorimetric detection.
Journal of chromatography.
1986 May; 378(1):173-81. doi:
NULL. [PMID: 3733970] - D A Cairnes, W E Evans. High-performance liquid chromatographic assay of methotrexate, 7-hydroxymethortrexate, 4-deoxy-4-amino-N10-methylpteroic acid and sulfamethoxazole in serum, urine and cerebrospinal fluid.
Journal of chromatography.
1982 Aug; 231(1):103-10. doi:
10.1016/s0378-4347(00)80513-7. [PMID: 7119052] - H Breithaupt, E Küenzlen, G Goebel. Rapid high-pressure liquid chromatographic determination of methotrexate and its metabolites 7-hydroxymethotrexate and 2,4-diamino-N(10)-methylpteroic acid in biological fluids.
Analytical biochemistry.
1982 Mar; 121(1):103-13. doi:
10.1016/0003-2697(82)90562-0. [PMID: 7091670] - R G Smith, J C Pegues, D Farquhar, T L Loo, Y M Wang. Mass spectrometry of permethylated folic acid analogs.
Biomedical mass spectrometry.
1981 Apr; 8(4):144-8. doi:
10.1002/bms.1200080403. [PMID: 7236861] - J W Paxton. Interference of 4-amino-4-deoxy-N10-methylpteroic acid with the radioimmunoassay of methotrexate.
Clinical chemistry.
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10.1093/clinchem/25.3.491. [PMID: 262195]