3-(6-(Dimethylamino)-4-methylpyridin-3-yl)-2,5-dimethyl-N,N-dipropylpyrazolo[1,5-a]pyrimidin-7-amine (BioDeep_00000173028)

   

human metabolite blood metabolite


代谢物信息卡片


3-(6-(Dimethylamino)-4-methylpyridin-3-yl)-2,5-dimethyl-N,N-dipropylpyrazolo[1,5-a]pyrimidin-7-amine

化学式: C22H32N6 (380.26883119999997)
中文名称: R121919
谱图信息: 最多检出来源 Homo sapiens(blood) 88.89%

分子结构信息

SMILES: CCCN(CCC)C1=CC(=NC2=C(C(=NN12)C)C3=CN=C(C=C3C)N(C)C)C
InChI: InChI=1S/C22H32N6/c1-8-10-27(11-9-2)20-13-16(4)24-22-21(17(5)25-28(20)22)18-14-23-19(26(6)7)12-15(18)3/h12-14H,8-11H2,1-7H3

描述信息

同义名列表

3 个代谢物同义名

3-(6-(Dimethylamino)-4-methylpyridin-3-yl)-2,5-dimethyl-N,N-dipropylpyrazolo[1,5-a]pyrimidin-7-amine; 5-[7-(dipropylamino)-2,5-dimethylpyrazolo[1,5-a]pyrimidin-3-yl]-N,N,4-trimethylpyridin-2-amine; R-121919



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

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PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Cheng Zhang, Robert A Rissman. Corticotropin-releasing factor receptor-1 modulates biomarkers of DNA oxidation in Alzheimer's disease mice. PloS one. 2017; 12(7):e0181367. doi: 10.1371/journal.pone.0181367. [PMID: 28750017]
  • Hongxin Dong, Shirlene Wang, Ziling Zeng, Fei Li, Janitza Montalvo-Ortiz, Christopher Tucker, Shahzad Akhtar, Jingshan Shi, Herbert Y Meltzer, Kenner C Rice, John G Csernansky. Effects of corticotrophin-releasing factor receptor 1 antagonists on amyloid-β and behavior in Tg2576 mice. Psychopharmacology. 2014 Dec; 231(24):4711-22. doi: 10.1007/s00213-014-3629-8. [PMID: 24862368]
  • Susan K Wood, Kile McFadden, Tagan Griffin, John H Wolfe, Stephen Zderic, Rita J Valentino. A corticotropin-releasing factor receptor antagonist improves urodynamic dysfunction produced by social stress or partial bladder outlet obstruction in male rats. American journal of physiology. Regulatory, integrative and comparative physiology. 2013 Jun; 304(11):R940-50. doi: 10.1152/ajpregu.00257.2012. [PMID: 23552576]
  • Yoshinori Takahashi, Minako Hashizume, Kogyoku Shin, Taro Terauchi, Kunitoshi Takeda, Shigeki Hibi, Kaoru Murata-Tai, Masae Fujisawa, Kodo Shikata, Ryota Taguchi, Mitsuhiro Ino, Hisashi Shibata, Masahiro Yonaga. Design, synthesis, and structure-activity relationships of novel pyrazolo[5,1-b]thiazole derivatives as potent and orally active corticotropin-releasing factor 1 receptor antagonists. Journal of medicinal chemistry. 2012 Oct; 55(19):8450-63. doi: 10.1021/jm300864p. [PMID: 22971011]
  • Georgette M Gafford, Ji-Dong Guo, Elizabeth I Flandreau, Rimi Hazra, Donald G Rainnie, Kerry J Ressler. Cell-type specific deletion of GABA(A)α1 in corticotropin-releasing factor-containing neurons enhances anxiety and disrupts fear extinction. Proceedings of the National Academy of Sciences of the United States of America. 2012 Oct; 109(40):16330-5. doi: 10.1073/pnas.1119261109. [PMID: 22992651]
  • Kelly H Skelton, Dana Oren, David A Gutman, Keith Easterling, Stephen G Holtzman, Charles B Nemeroff, Michael J Owens. The CRF1 receptor antagonist, R121919, attenuates the severity of precipitated morphine withdrawal. European journal of pharmacology. 2007 Sep; 571(1):17-24. doi: 10.1016/j.ejphar.2007.05.041. [PMID: 17610870]
  • Kristina A Fenoglio, Kristen L Brunson, Sarit Avishai-Eliner, Blake A Stone, Bhumika J Kapadia, Tallie Z Baram. Enduring, handling-evoked enhancement of hippocampal memory function and glucocorticoid receptor expression involves activation of the corticotropin-releasing factor type 1 receptor. Endocrinology. 2005 Sep; 146(9):4090-6. doi: 10.1210/en.2004-1285. [PMID: 15932935]
  • Brian Dyck, Dimitri E Grigoriadis, Raymond S Gross, Zhiqiang Guo, Mustapha Haddach, Dragan Marinkovic, James R McCarthy, Manisha Moorjani, Collin F Regan, John Saunders, Michael K Schwaebe, Tomas Szabo, John P Williams, Xiaohu Zhang, Haig Bozigian, Ta Kung Chen. Potent, orally active corticotropin-releasing factor receptor-1 antagonists containing a tricyclic pyrrolopyridine or pyrazolopyridine core. Journal of medicinal chemistry. 2005 Jun; 48(12):4100-10. doi: 10.1021/jm050070m. [PMID: 15943483]
  • Heike E Künzel, Marcus Ising, Astrid W Zobel, Thomas Nickel, Nibal Ackl, Annette Sonntag, Florian Holsboer, Manfred Uhr. Treatment with a CRH-1-receptor antagonist (R121919) does not affect weight or plasma leptin concentration in patients with major depression. Journal of psychiatric research. 2005 Mar; 39(2):173-7. doi: 10.1016/j.jpsychires.2004.06.006. [PMID: 15589565]
  • Heike E Künzel, Astrid W Zobel, Thomas Nickel, Nibal Ackl, Manfred Uhr, Annette Sonntag, Marcus Ising, Florian Holsboer. Treatment of depression with the CRH-1-receptor antagonist R121919: endocrine changes and side effects. Journal of psychiatric research. 2003 Nov; 37(6):525-33. doi: 10.1016/s0022-3956(03)00070-0. [PMID: 14563384]
  • David A Gutman, Michael J Owens, Kelly H Skelton, K V Thrivikraman, Charles B Nemeroff. The corticotropin-releasing factor1 receptor antagonist R121919 attenuates the behavioral and endocrine responses to stress. The Journal of pharmacology and experimental therapeutics. 2003 Feb; 304(2):874-80. doi: 10.1124/jpet.102.042788. [PMID: 12538845]
  • M E Keck, T Welt, M B Müller, R Landgraf, F Holsboer. The high-affinity non-peptide CRH1 receptor antagonist R121919 attenuates stress-induced alterations in plasma oxytocin, prolactin, and testosterone secretion in rats. Pharmacopsychiatry. 2003 Jan; 36(1):27-31. doi: 10.1055/s-2003-38092. [PMID: 12649771]
  • A W Zobel, T Nickel, H E Künzel, N Ackl, A Sonntag, M Ising, F Holsboer. Effects of the high-affinity corticotropin-releasing hormone receptor 1 antagonist R121919 in major depression: the first 20 patients treated. Journal of psychiatric research. 2000 May; 34(3):171-81. doi: 10.1016/s0022-3956(00)00016-9. [PMID: 10867111]