Voglibose (BioDeep_00000017300)

human metabolite PANOMIX_OTCML-2023 blood metabolite Chemicals and Drugs

代谢物信息卡片

(1S,2S,3R,4S,5S)-5-{[2-hydroxy-1-(hydroxymethyl)ethyl]amino}-1-(hydroxymethyl)cyclohexane-1,2,3,4-tetrol

化学式: C10H21NO7 (267.1318)
中文名称: 伏格列波糖
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 47.08%

分子结构信息

SMILES: C1C(C(C(C(C1(CO)O)O)O)O)NC(CO)CO
InChI: InChI=1S/C10H21NO7/c12-2-5(3-13)11-6-1-10(18,4-14)9(17)8(16)7(6)15/h5-9,11-18H,1-4H2/t6-,7-,8+,9-,10-/m0/s1

描述信息

Voglibose is only found in individuals that have used or taken this drug. Voglibose (INN and USAN) is an alpha-glucosidase inhibitor used for lowering post-prandial blood glucose levels in people with diabetes mellitus. It is made in India by Ranbaxy Labs and sold under the trade name Volix. [Wikipedia]Alpha-glucosidase inhibitors are saccharides that act as competitive inhibitors of enzymes needed to digest carbohydrates: specifically alpha-glucosidase enzymes in the brush border of the small intestines. The membrane-bound intestinal alpha-glucosidases hydrolyze oligosaccharides, trisaccharides, and disaccharides to glucose and other monosaccharides in the small intestine. Acarbose also blocks pancreatic alpha-amylase in addition to inhibiting membrane-bound alpha-glucosidases. Pancreatic alpha-amylase hydrolyzes complex starches to oligosaccharides in the lumen of the small intestine. Inhibition of these enzyme systems reduces the rate of digestion of complex carbohydrates. Less glucose is absorbed because the carbohydrates are not broken down into glucose molecules. In diabetic patients, the short-term effect of these drugs therapies is to decrease current blood glucose levels: the long term effect is a small reduction in hemoglobin-A1c level. (From Drug Therapy in Nursing, 2nd ed)
Voglibose is an organic molecular entity.
Voglibose is an alpha-glucosidase inhibitor used for lowering post-prandial blood glucose levels in people with diabetes mellitus. It is made in India by Ranbaxy Labs and sold under the trade name Volix.
Voglibose is a valiolamine derivative and inhibitor of alpha-glucosidase with antihyperglycemic activity. Voglibose binds to and inhibits alpha-glucosidase, an enteric enzyme found in the brush border of the small intestines that hydrolyzes oligosaccharides and disaccharides into glucose and other monosaccharides. This prevents the breakdown of larger carbohydrates into glucose and decreases the rise in postprandial blood glucose levels.
A - Alimentary tract and metabolism > A10 - Drugs used in diabetes > A10B - Blood glucose lowering drugs, excl. insulins > A10BF - Alpha glucosidase inhibitors
C78276 - Agent Affecting Digestive System or Metabolism > C29711 - Anti-diabetic Agent
D007004 - Hypoglycemic Agents > D065089 - Glycoside Hydrolase Inhibitors
C471 - Enzyme Inhibitor > C2846 - Glucosidase Inhibitor
D004791 - Enzyme Inhibitors
Voglibose is a derivative of valiolamine, which can inhibit α-glucosidase very well and can act on hyperglycemia.

同义名列表

35 个代谢物同义名

(1S,2S,3R,4S,5S)-5-{[2-hydroxy-1-(hydroxymethyl)ethyl]amino}-1-(hydroxymethyl)cyclohexane-1,2,3,4-tetrol; (1S,2S,3R,4S,5S)-5-((1,3-dihydroxypropan-2-yl)amino)-1-(hydroxymethyl)cyclohexane-1,2,3,4-tetraol; (1S,2S,3R,4S,5S)-5-[(1,3-dihydroxypropan-2-yl)amino]-1-(hydroxymethyl)cyclohexane-1,2,3,4-tetrol; (1S,2S,3R,4S,5S)-5-(1,3-dihydroxypropan-2-ylamino)-1-(hydroxymethyl)cyclohexane-1,2,3,4-tetraol; (1R,2R,3S,4R,5R)-5-(1,3-dihydroxypropan-2-ylamino)-1-(hydroxymethyl)cyclohexane-1,2,3,4-tetraol; (1S,2S,3R,4S,5S)-5-(1,3-dihydroxypropan-2-ylamino)-1-(hydroxymethyl)cyclohexane-1,2,3,4-tetrol; D-epi-Inositol, 3,4-dideoxy-4-((2-hydroxy-1-(hydroxymethyl)ethyl)amino)-2-C-(hydroxymethyl)-; 3,4-Dideoxy-4-[[2-hydroxy-1-(hydroxymethyl)ethyl]amino]-2-C-(hydroxymethyl)-D-epi-inositol; 3,4-dideoxy-4-((2-hydroxy-1-(hydroxymethyl)ethyl)amino)-2-C-(hydroxymethyl)-D-epi-inositol; 3,4-DIDEOXY-4-[[2-HYDROXY-1-(HYDROXYMETHYL)ETHYL]AMINO]-2-C-(HYDROXYMETHYL)-D-EPINOSITOL; N-(1,3-dihydroxy-2-propyl)valiolamine; FZNCGRZWXLXZSZ-CIQUZCHMSA-N; Voglibose (JP17/USAN/INN); Voglibose, >=97.0\\% (TLC); Voglibosa [INN-Spanish]; Voglibosum [INN-Latin]; Voglibose [USAN:INN]; VOGLIBOSE [WHO-DD]; VOGLIBOSE [MART.]; Voglibose- Bio-X; VOGLIBOSE [USAN]; Voglibose [INN]; VOGLIBOSE [JAN]; UNII-S77P977AG8; VOGLIBOSE [MI]; Tox21_112220_1; Tox21_112220; S77P977AG8; Basen (TN); Voglibosum; Voglibose; Basen OD; Glustat; Basen; VOG

数据库引用编号

13 个数据库交叉引用编号

ChEBI: CHEBI:32300
KEGGdrug: D01665
PubChem: 444020
HMDB: HMDB0015598
DrugBank: DB04878
ChEMBL: CHEMBL476960
Wikipedia: Voglibose
MeSH: voglibose
ChemIDplus: 0083480299
chemspider: 392046
CAS: 112653-29-9
CAS: 83480-29-9
medchemexpress: HY-B0025

分类词条

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

9606 - Homo sapiens: -

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位		关联基因列表

文献列表

Kentaro Ejiri, Toru Miyoshi, Hajime Kihara, Yoshiki Hata, Toshihiko Nagano, Atsushi Takaishi, Hironobu Toda, Seiji Namba, Yoichi Nakamura, Satoshi Akagi, Satoru Sakuragi, Taro Minagawa, Yusuke Kawai, Nobuhiro Nishii, Soichiro Fuke, Masaki Yoshikawa, Kazufumi Nakamura, Hiroshi Ito. Effects of luseogliflozin and voglibose on high-risk lipid profiles and inflammatory markers in diabetes patients with heart failure. Scientific reports. 2022 09; 12(1):15449. doi: 10.1038/s41598-022-19371-6. [PMID: 36104378]
Vishal Chavda, Pooja Shah, Snehal S Patel, Shraddha Bhadada. Pre-exposure of voglibose exerts cerebroprotective effects through attenuating activation of the polyol pathway and inflammation. The European journal of neuroscience. 2021 04; 53(8):2541-2552. doi: 10.1111/ejn.15151. [PMID: 33608957]
Selvam Kasthuri, Subramani Poongothai, Ranjit Mohan Anjana, Jayvel Selvakumar, Subramaniam Muthukumar, Sengottuevel Kayalvizhi, Syed Tariq, Evangelin Honey, Prasanna Kumar Gupta, Ulagamathesan Venkatesan, Viswanathan Mohan. Comparison of Glycemic Excursion Using Flash Continuous Glucose Monitoring in Patients with Type 2 Diabetes Mellitus Before and After Treatment with Voglibose. Diabetes technology & therapeutics. 2021 03; 23(3):213-220. doi: 10.1089/dia.2019.0484. [PMID: 32916063]
Peyman Nowrouzi-Sohrabi, Reza Tabrizi, Shahla Rezaei, Fatemeh Jafari, Kamran Hessami, Mehdi Abedi, Mohammad Jalali, Pedram Keshavarzi, Saeed Shahabi, Ali Asghar Kolahi, Kristin Carson-Chahhoud, Amirhossein Sahebkar, Saeid Safiri. The effect of voglibose on metabolic profiles in patients with type 2 diabetes mellitus: A systematic review and meta-analysis of clinical trials. Pharmacological research. 2020 09; 159(?):104988. doi: 10.1016/j.phrs.2020.104988. [PMID: 32504833]
Pooja Shah, Vishal Chavda, Snehal Patel, Shraddha Bhadada, Ghulam Md Ashraf. Promising Anti-stroke Signature of Voglibose: Investigation through In- Silico Molecular Docking and Virtual Screening in In-Vivo Animal Studies. Current gene therapy. 2020; 20(3):223-235. doi: 10.2174/1566523220999200726225457. [PMID: 33054705]
Soo Jin Yang, Hyun Ju Do, Youngae Jung, Geum-Sook Hwang, Min-Jeong Shin. Voglibose-mediated alterations in neurometabolomic profiles in the hypothalamus of high-fat diet-fed mice. Nutritional neuroscience. 2019 Nov; 22(11):760-767. doi: 10.1080/1028415x.2018.1443995. [PMID: 29495953]
Tae Jung Oh, Jae Myung Yu, Kyung Wan Min, Hyun Shik Son, Moon Kyu Lee, Kun Ho Yoon, Young Duk Song, Joong Yeol Park, In Kyung Jeong, Bong Soo Cha, Yong Seong Kim, Sei Hyun Baik, In Joo Kim, Doo Man Kim, Sung Rae Kim, Kwan Woo Lee, Jeong Hyung Park, In Kyu Lee, Tae Sun Park, Sung Hee Choi, Sung Woo Park. Efficacy and Safety of Voglibose Plus Metformin in Patients with Type 2 Diabetes Mellitus: A Randomized Controlled Trial. Diabetes & metabolism journal. 2019 06; 43(3):276-286. doi: 10.4093/dmj.2018.0051. [PMID: 30604594]
Satoko Tsuchiya, Shojiro Sawada, Kana Takeda, Kenji Takahashi, Takeko Nakajima, Masato Kohata, Satoko Kurosawa, Chihiro Satake, Junta Imai, Katsuko Kikuchi, Setsuya Aiba, Hideki Katagiri. Eruptive xanthomas in a patient with soft-drink diabetic ketosis and apolipoprotein E4/2. Endocrine journal. 2019 Jan; 66(1):107-114. doi: 10.1507/endocrj.ej18-0356. [PMID: 30393272]
Chunhong Shi, Ru Zhang, Ran Bai, Dan Liu, Yongbo Wang, Xueyang Zhang, Hao Wang, Jianling Du. Efficacy and safety of sitagliptin added to metformin and insulin compared with voglibose in patients with newly diagnosed type 2 diabetes. Clinics (Sao Paulo, Brazil). 2019; 74(?):e736. doi: 10.6061/clinics/2019/e736. [PMID: 31038562]
Ho-Sook Kim, Minkyung Oh, Eun Ji Kim, Geun Seog Song, Eun-Young Kim, Jae-Gook Shin. Pharmacodynamic effects of voglibose administered alone, administered with metformin, and administered with metformin in a fixed-dose combination in healthy Korean subjects . International journal of clinical pharmacology and therapeutics. 2018 Nov; 56(11):544-550. doi: 10.5414/cp203146. [PMID: 30178742]
Taku Koyama, Atsushi Tanaka, Hisako Yoshida, Jun-Ichi Oyama, Shigeru Toyoda, Masashi Sakuma, Teruo Inoue, Yoritaka Otsuka, Koichi Node. Comparison of the effects of linagliptin and voglibose on endothelial function in patients with type 2 diabetes and coronary artery disease: a prospective, randomized, pilot study (EFFORT). Heart and vessels. 2018 Aug; 33(8):958-964. doi: 10.1007/s00380-018-1136-2. [PMID: 29427024]
Keishi Moriwaki, Tetsushiro Takeuchi, Naoki Fujimoto, Toshiki Sawai, Yuichi Sato, Naoto Kumagai, Jun Masuda, Shiro Nakamori, Masaki Ishida, Norikazu Yamada, Mashio Nakamura, Hajime Sakuma, Masaaki Ito, Kaoru Dohi. Effect of Sitagliptin on Coronary Flow Reserve Assessed by Magnetic Resonance Imaging in Type 2 Diabetic Patients With Coronary Artery Disease. Circulation journal : official journal of the Japanese Circulation Society. 2018 07; 82(8):2119-2127. doi: 10.1253/circj.cj-18-0083. [PMID: 29760346]
Xiaodan Liu, Jianan Feng, Yan Li. Preparation of carbon-functionalized magnetic graphene/mesoporous silica composites for selective extraction of miglitol and voglibose in rat plasma. Talanta. 2018 May; 182(?):405-413. doi: 10.1016/j.talanta.2018.01.079. [PMID: 29501171]
Akira Kurozumi, Yosuke Okada, Hiroaki Satoh, Ikuo Inoue, Hiroko Chimori, Etsuko Akita, Toshihiko Shiraiwa, Yoshio Fujitani, Tomoya Mita, Masahiko Gosho, Hirotaka Watada. Effects of linagliptin monotherapy compared with voglibose on postprandial lipid profiles in Japanese patients with type 2 diabetes: linagliptin study of effects on postprandial blood glucose (L-STEP) sub-study 1. Endocrine journal. 2018 Apr; 65(4):415-425. doi: 10.1507/endocrj.ej17-0386. [PMID: 29367471]
Man Wang, Ping Ma, Xiaonan Xi, Lei Liu, Yabin Wen, Kangning Liu, Liang Sun, Yaxin Lu, Zheng Yin. Online solid phase extraction and liquid chromatography-mass spectrometric determination of nucleoside drugs in plasma. Talanta. 2016 Dec; 161(?):278-287. doi: 10.1016/j.talanta.2016.08.050. [PMID: 27769407]
Yoshio Fujitani, Shimpei Fujimoto, Kiyohito Takahashi, Hiroaki Satoh, Takahisa Hirose, Toru Hiyoshi, Masumi Ai, Yosuke Okada, Masahiko Gosho, Tomoya Mita, Hirotaka Watada. Effects of linagliptin monotherapy compared with voglibose on postprandial blood glucose responses in Japanese patients with type 2 diabetes: Linagliptin Study of Effects on Postprandial blood glucose (L-STEP). Diabetes research and clinical practice. 2016 Nov; 121(?):146-156. doi: 10.1016/j.diabres.2016.09.014. [PMID: 27710821]
Hyun Ju Do, Youn Sue Lee, Min Jin Ha, Yoonsu Cho, Hana Yi, Yu-Jin Hwang, Geum-Sook Hwang, Min-Jeong Shin. Beneficial effects of voglibose administration on body weight and lipid metabolism via gastrointestinal bile acid modification. Endocrine journal. 2016 Aug; 63(8):691-702. doi: 10.1507/endocrj.ej15-0747. [PMID: 27349182]
Praful A Talaviya, Banshi D Saboo, Hardik G Dodiya, Shaival K Rao, Shashank R Joshi, Vipul B Modh, Sneha V Ghadiya. Retrospective comparison of voglibose or acarbose as an add-on therapy to sulfonylureas in Western Indian patients with uncontrolled overweight/obese type 2 diabetes. Diabetes & metabolic syndrome. 2016 Apr; 10(2):88-91. doi: 10.1016/j.dsx.2015.09.021. [PMID: 26777258]
N Kasahara, H Fukase, Y Ohba, T Saito, K Miyata, S Iida, Y Takano, S Ikeda, M Harigai, K Terao. A Pharmacokinetic/Pharmacodynamic Drug-Drug Interaction Study of Tofogliflozin (a New SGLT2 Inhibitor) and Selected Anti-Type 2 Diabetes Mellitus Drugs. Drug research. 2016 Feb; 66(2):74-81. doi: 10.1055/s-0035-1549967. [PMID: 26158794]
S Tani, K Nagao, A Hirayama. Differences between Mitiglinide/Voglibose Fixed-dose Combination and Glimepiride in Modifying Low-density Lipoprotein Heterogeneity in Japanese Type-2 Diabetic Patients: A Pilot Study. Drug research. 2016 Feb; 66(2):94-9. doi: 10.1055/s-0035-1549993. [PMID: 26011816]
Hiroki Oe, Kazufumi Nakamura, Hajime Kihara, Kenei Shimada, Shota Fukuda, Tsutomu Takagi, Toru Miyoshi, Kumiko Hirata, Junichi Yoshikawa, Hiroshi Ito. Comparison of effects of sitagliptin and voglibose on left ventricular diastolic dysfunction in patients with type 2 diabetes: results of the 3D trial. Cardiovascular diabetology. 2015 Jun; 14(?):83. doi: 10.1186/s12933-015-0242-z. [PMID: 26084668]
Hyang-Ki Choi, Minkyung Oh, Eun Ji Kim, Geun Seog Song, Jong-Lyul Ghim, Ji-Hong Shon, Ho-Sook Kim, Jae-Gook Shin. Pharmacokinetic study of metformin to compare voglibose/metformin fixed-dose combination with coadministered voglibose and metformin. International journal of clinical pharmacology and therapeutics. 2015 Feb; 53(2):147-53. doi: 10.5414/cp202197. [PMID: 25546164]
Jang-Won Son, In-Kyu Lee, Jeong-taek Woo, Sei Hyun Baik, Hak Chul Jang, Kwan Woo Lee, Bong Soo Cha, Yeon-Ah Sung, Tae Sun Park, Soon-Jib Yoo, Kun-Ho Yoon. A prospective, randomized, multicenter trial comparing the efficacy and safety of the concurrent use of long-acting insulin with mitiglinide or voglibose in patients with type 2 diabetes. Endocrine journal. 2015; 62(12):1049-57. doi: 10.1507/endocrj.ej15-0325. [PMID: 26411328]
Ho-Sook Kim, Minkyung Oh, Eun Ji Kim, Geun Seog Song, Jong-Lyul Ghim, Ji-Hong Shon, Dong-Hyun Kim, Jae-Gook Shin. Effect of voglibose on the pharmacokinetics of metformin in healthy Korean subjects. International journal of clinical pharmacology and therapeutics. 2014 Nov; 52(11):1005-11. doi: 10.5414/cp202160. [PMID: 25161160]
Natsuyo Hariya, Kazuki Mochizuki, Seiya Inoue, Miyoko Saito, Masahiro Fuchigami, Toshinao Goda, Takeshi Osonoi. Switching α-glucosidase inhibitors to miglitol reduced glucose fluctuations and circulating cardiovascular disease risk factors in type 2 diabetic Japanese patients. Drugs in R&D. 2014 Sep; 14(3):177-84. doi: 10.1007/s40268-014-0055-7. [PMID: 25079671]
Kazufumi Nakamura, Hiroki Oe, Hajime Kihara, Kenei Shimada, Shota Fukuda, Kyoko Watanabe, Tsutomu Takagi, Kei Yunoki, Toru Miyoshi, Kumiko Hirata, Junichi Yoshikawa, Hiroshi Ito. DPP-4 inhibitor and alpha-glucosidase inhibitor equally improve endothelial function in patients with type 2 diabetes: EDGE study. Cardiovascular diabetology. 2014 Jul; 13(?):110. doi: 10.1186/s12933-014-0110-2. [PMID: 25074318]
Takeshi Osonoi, Miyoko Saito, Atsuko Tamasawa, Hidenori Ishida, Yusuke Osonoi. Effects of sitagliptin or mitiglinide as an add-on to acarbose on daily blood glucose fluctuations measured by 72 h subcutaneous continuous glucose monitoring in Japanese patients with type 2 diabetes: a prospective randomized study. Expert opinion on pharmacotherapy. 2014 Jul; 15(10):1325-35. doi: 10.1517/14656566.2014.920323. [PMID: 24866329]
Robert B Jones, Steven P Vickers, Sharon C Cheetham, Katie R Headland, Michael Mark, Thomas Klein. Effect of linagliptin, alone and in combination with voglibose or exendin-4, on glucose control in male ZDF rats. European journal of pharmacology. 2014 Apr; 729(?):59-66. doi: 10.1016/j.ejphar.2014.02.004. [PMID: 24530555]
Hideo Otsuki, Takeo Kosaka, Kenzo Nakamura, Fumihiko Shimomura, Yoshitaka Kuwahara, Takuji Tsukamoto. Safety and efficacy of teneligliptin: a novel DPP-4 inhibitor for hemodialysis patients with type 2 diabetes. International urology and nephrology. 2014 Feb; 46(2):427-32. doi: 10.1007/s11255-013-0552-6. [PMID: 24014134]
Hyun Ju Do, Taeon Jin, Ji Hyung Chung, Ji Won Hwang, Min-Jeong Shin. Voglibose administration regulates body weight and energy intake in high fat-induced obese mice. Biochemical and biophysical research communications. 2014 Jan; 443(3):1110-7. doi: 10.1016/j.bbrc.2013.12.120. [PMID: 24388987]
Mi Young Lee, Dong Seop Choi, Moon Kyu Lee, Hyoung Woo Lee, Tae Sun Park, Doo Man Kim, Choon Hee Chung, Duk Kyu Kim, In Joo Kim, Hak Chul Jang, Yong Soo Park, Hyuk Sang Kwon, Seung Hun Lee, Hee Kang Shin. Comparison of acarbose and voglibose in diabetes patients who are inadequately controlled with basal insulin treatment: randomized, parallel, open-label, active-controlled study. Journal of Korean medical science. 2014 Jan; 29(1):90-7. doi: 10.3346/jkms.2014.29.1.90. [PMID: 24431911]
Masayuki Yamaguchi, Takami Saji, Sachiko Mita, Kenneth Kulmatycki, Yan-Ling He, Kenichi Furihata, Kaneo Sekiguchi. Pharmacokinetic and pharmacodynamic interaction of vildagliptin and voglibose in Japanese patients with Type 2 diabetes. International journal of clinical pharmacology and therapeutics. 2013 Aug; 51(8):641-51. doi: 10.5414/cp201902. [PMID: 23782587]
Masahiro Inoue. Tighter control of postprandial hyperglycemia with mitiglinide/voglibose fixed-dose combination in Japanese patients with type 2 diabetes mellitus. Expert opinion on pharmacotherapy. 2012 Nov; 13(16):2257-68. doi: 10.1517/14656566.2012.726614. [PMID: 22994875]
Tomoko Kimura, Jinya Suzuki, Mai Ichikawa, Michiko Imagawa, Satsuki Sato, Miki Fujii, Yasuo Zenimaru, Satoru Inaba, Sadao Takahashi, Tadashi Konoshita, Isamu Miyamori. Differential effects of α-glucosidase inhibitors on postprandial plasma glucose and lipid profile in patients with type 2 diabetes under control with insulin lispro mix 50/50. Diabetes technology & therapeutics. 2012 Jul; 14(7):545-51. doi: 10.1089/dia.2012.0015. [PMID: 22519736]
Hwang Eui Cho, Su Youn Ahn, In Seop Son, Sangwhan In, Ran Seon Hong, Dong Woo Kim, Sang Hee Woo, Dong Cheul Moon, Suncheun Kim. Determination and validation of tetrodotoxin in human whole blood using hydrophilic interaction liquid chromatography-tandem mass spectroscopy and its application. Forensic science international. 2012 Apr; 217(1-3):76-80. doi: 10.1016/j.forsciint.2011.10.026. [PMID: 22019394]
Ruchita V Kumar, Vivek Ranjan Sinha. Newer insights into the drug delivery approaches of α-glucosidase inhibitors. Expert opinion on drug delivery. 2012 Apr; 9(4):403-16. doi: 10.1517/17425247.2012.663080. [PMID: 22364261]
T Narita, H Yokoyama, R Yamashita, T Sato, M Hosoba, T Morii, H Fujita, K Tsukiyama, Y Yamada. Comparisons of the effects of 12-week administration of miglitol and voglibose on the responses of plasma incretins after a mixed meal in Japanese type 2 diabetic patients. Diabetes, obesity & metabolism. 2012 Mar; 14(3):283-7. doi: 10.1111/j.1463-1326.2011.01526.x. [PMID: 22051162]
Takuo Emoto, Takahiro Sawada, Megumi Hashimoto, Hiroko Kageyama, Daisuke Terashita, Taiji Mizoguchi, Takao Mizuguchi, Yoshiki Motodi, Masamichi Iwasaki, Kazuki Taira, Hiroshi Okamoto, Yosuke Matsuo, Sushi-ku Kim, Akira Takarada, Mitsuhiro Yokoyama. Effect of 3-month repeated administration of miglitol on vascular endothelial function in patients with diabetes mellitus and coronary artery disease. The American journal of cardiology. 2012 Jan; 109(1):42-6. doi: 10.1016/j.amjcard.2011.08.005. [PMID: 21944671]
Nalinee Poolsup, Naeti Suksomboon, Wanwaree Setwiwattanakul. Efficacy of various antidiabetic agents as add-on treatments to metformin in type 2 diabetes mellitus: systematic review and meta-analysis. ISRN endocrinology. 2012; 2012(?):798146. doi: 10.5402/2012/798146. [PMID: 22619731]
Miyako Kishimoto, Mitsuhiko Noda. A pilot study of the efficacy of miglitol and sitagliptin for type 2 diabetes with a continuous glucose monitoring system and incretin-related markers. Cardiovascular diabetology. 2011 Dec; 10(?):115. doi: 10.1186/1475-2840-10-115. [PMID: 22189184]
Yutaka Seino, Tetsuya Fujita, Shinzo Hiroi, Masashi Hirayama, Kohei Kaku. Alogliptin plus voglibose in Japanese patients with type 2 diabetes: a randomized, double-blind, placebo-controlled trial with an open-label, long-term extension. Current medical research and opinion. 2011 Nov; 27 Suppl 3(?):21-9. doi: 10.1185/03007995.2011.614936. [PMID: 22106975]
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Felipe Cabezas, Jonathan Lagos, Carlos Céspedes, Carlos P Vio, Miguel Bronfman, María-Paz Marzolo. Megalin/LRP2 expression is induced by peroxisome proliferator-activated receptor -alpha and -gamma: implications for PPARs' roles in renal function. PloS one. 2011 Feb; 6(2):e16794. doi: 10.1371/journal.pone.0016794. [PMID: 21311715]
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