1-Tert-butyl-3-(4-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine (BioDeep_00000172977)

   

human metabolite blood metabolite


代谢物信息卡片


1-Tert-butyl-3-(4-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

化学式: C15H16ClN5 (301.1094)
中文名称: 3-(4-氯苯基)-1-叔丁基-1H-吡唑并[3,4-d]嘧啶-4-胺
谱图信息: 最多检出来源 Homo sapiens(blood) 15.49%

分子结构信息

SMILES: CC(C)(C)N1C2=NC=NC(=C2C(=N1)C3=CC=C(C=C3)Cl)N
InChI: InChI=1S/C15H16ClN5/c1-15(2,3)21-14-11(13(17)18-8-19-14)12(20-21)9-4-6-10(16)7-5-9/h4-8H,1-3H3,(H2,17,18,19)

描述信息

同义名列表

6 个代谢物同义名

1-Tert-butyl-3-(4-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine; 4-Amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo(3,4-D)pyrimidine; SRC Family kinase inhibitor PP2; PP2 (kinase inhibitor); PP2 CPD; pp2



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Eun Seon Pak, Md Jamal Uddin, Hunjoo Ha. Inhibition of Src Family Kinases Ameliorates LPS-Induced Acute Kidney Injury and Mitochondrial Dysfunction in Mice. International journal of molecular sciences. 2020 Nov; 21(21):. doi: 10.3390/ijms21218246. [PMID: 33153232]
  • Yu-Sen Peng, Jhih-Pu Syu, Sheng-De Wang, Pie-Chun Pan, Hsiu-Ni Kung. BSA-bounded p-cresyl sulfate potentiates the malignancy of bladder carcinoma by triggering cell migration and EMT through the ROS/Src/FAK signaling pathway. Cell biology and toxicology. 2020 08; 36(4):287-300. doi: 10.1007/s10565-019-09509-0. [PMID: 31873818]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Paresh P Chothe, Lindsay C Czuba, Ebehiremen N Ayewoh, Peter W Swaan. Tyrosine Phosphorylation Regulates Plasma Membrane Expression and Stability of the Human Bile Acid Transporter ASBT (SLC10A2). Molecular pharmaceutics. 2019 08; 16(8):3569-3576. doi: 10.1021/acs.molpharmaceut.9b00426. [PMID: 31194565]
  • F Sanarica, P Mantuano, E Conte, A Cozzoli, R F Capogrosso, A Giustino, A Cutrignelli, O Cappellari, J F Rolland, M De Bellis, N Denora, G M Camerino, A De Luca. Proof-of-concept validation of the mechanism of action of Src tyrosine kinase inhibitors in dystrophic mdx mouse muscle: in vivo and in vitro studies. Pharmacological research. 2019 07; 145(?):104260. doi: 10.1016/j.phrs.2019.104260. [PMID: 31059789]
  • Hannah E Steele, Yunxia Guo, Bai-Yan Li, Sungsoo Na. Mechanotransduction of mitochondrial AMPK and its distinct role in flow-induced breast cancer cell migration. Biochemical and biophysical research communications. 2019 06; 514(2):524-529. doi: 10.1016/j.bbrc.2019.04.191. [PMID: 31060777]
  • Dong-Dong Zhang, Yu-Qiu Zhang, Xue-Han Zhang. Prefrontal AMPA receptors are involved in the effect of methylphenidate on response inhibition in rats. Acta pharmacologica Sinica. 2018 Apr; 39(4):607-615. doi: 10.1038/aps.2017.138. [PMID: 29265108]
  • John D Tompkins, Todd A Clason, Thomas R Buttolph, Beatrice M Girard, Anne K Linden, Jean C Hardwick, Laura A Merriam, Victor May, Rodney L Parsons. Src family kinase inhibitors blunt PACAP-induced PAC1 receptor endocytosis, phosphorylation of ERK, and the increase in cardiac neuron excitability. American journal of physiology. Cell physiology. 2018 02; 314(2):C233-C241. doi: 10.1152/ajpcell.00223.2017. [PMID: 29141923]
  • Samantha D Pauls, Arnab Ray, Sen Hou, Andrew T Vaughan, Mark S Cragg, Aaron J Marshall. FcγRIIB-Independent Mechanisms Controlling Membrane Localization of the Inhibitory Phosphatase SHIP in Human B Cells. Journal of immunology (Baltimore, Md. : 1950). 2016 09; 197(5):1587-96. doi: 10.4049/jimmunol.1600105. [PMID: 27456487]
  • Arturo Ponce, Isabel Larre, Aida Castillo, Catalina Flores-Maldonado, Odette Verdejo-Torres, Ruben Gerardo Contreras, Marcelino Cereijido. Ouabain Modulates the Distribution of Connexin 43 in Epithelial Cells. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 2016; 39(4):1329-38. doi: 10.1159/000447837. [PMID: 27606882]
  • Haijiang Wu, Yonghong Shi, Xinna Deng, Ye Su, Chunyang Du, Jinying Wei, Yunzhuo Ren, Ming Wu, Yanjuan Hou, Huijun Duan. Inhibition of c-Src/p38 MAPK pathway ameliorates renal tubular epithelial cells apoptosis in db/db mice. Molecular and cellular endocrinology. 2015 Dec; 417(?):27-35. doi: 10.1016/j.mce.2015.09.008. [PMID: 26363223]
  • Hsiang-Ruei Liao, Ching-Ru Chien, Jih-Jung Chen, Tzung-Yan Lee, Shinn-Zhi Lin, Ching-Ping Tseng. The anti-inflammatory effect of 2-(4-hydroxy-3-prop-2-enyl-phenyl)-4-prop-2-enyl-phenol by targeting Lyn kinase in human neutrophils. Chemico-biological interactions. 2015 Jul; 236(?):90-101. doi: 10.1016/j.cbi.2015.05.004. [PMID: 25980585]
  • Allison R Prewitt, Sampa Ghose, Andrea L Frump, Arumima Datta, Eric D Austin, Anne K Kenworthy, Mark P de Caestecker. Heterozygous null bone morphogenetic protein receptor type 2 mutations promote SRC kinase-dependent caveolar trafficking defects and endothelial dysfunction in pulmonary arterial hypertension. The Journal of biological chemistry. 2015 Jan; 290(2):960-71. doi: 10.1074/jbc.m114.591057. [PMID: 25411245]
  • Vicky García-Hernández, Catalina Flores-Maldonado, Ruth Rincon-Heredia, Odette Verdejo-Torres, José Bonilla-Delgado, Ivan Meneses-Morales, Patricio Gariglio, Rubén G Contreras. EGF regulates claudin-2 and -4 expression through Src and STAT3 in MDCK cells. Journal of cellular physiology. 2015 Jan; 230(1):105-15. doi: 10.1002/jcp.24687. [PMID: 24909426]
  • Bernardo Nuche-Berenguer, Paola Moreno, R T Jensen. Elucidation of the roles of the Src kinases in pancreatic acinar cell signaling. Journal of cellular biochemistry. 2015 Jan; 116(1):22-36. doi: 10.1002/jcb.24895. [PMID: 25079913]
  • Johanna Congleton, Miaoqing Shen, Robert MacDonald, Fabio Malavasi, Andrew Yen. Phosphorylation of c-Cbl and p85 PI3K driven by all-trans retinoic acid and CD38 depends on Lyn kinase activity. Cellular signalling. 2014 Jul; 26(7):1589-97. doi: 10.1016/j.cellsig.2014.03.021. [PMID: 24686085]
  • Jianying Huang, Yen-Chang Lin, Stan Hileman, Karen H Martin, Robert Hull, Han-Gang Yu. PP2 prevents β-adrenergic stimulation of cardiac pacemaker activity. Journal of cardiovascular pharmacology. 2014 Jun; 63(6):533-43. doi: 10.1097/fjc.0000000000000078. [PMID: 24566462]
  • Rajendra Karki, Yan Zhang, Orisa J Igwe. Activation of c-Src: a hub for exogenous pro-oxidant-mediated activation of Toll-like receptor 4 signaling. Free radical biology & medicine. 2014 Jun; 71(?):256-269. doi: 10.1016/j.freeradbiomed.2014.03.005. [PMID: 24637265]
  • Mei-Chi Chang, Yi-Jane Chen, Hsiao-Hua Chang, Chiu-Po Chan, Chien-Yang Yeh, Yin-Lin Wang, Ru-Hsiu Cheng, Liang-Jiunn Hahn, Jiiang-Huei Jeng. Areca nut components affect COX-2, cyclin B1/cdc25C and keratin expression, PGE2 production in keratinocyte is related to reactive oxygen species, CYP1A1, Src, EGFR and Ras signaling. PloS one. 2014; 9(7):e101959. doi: 10.1371/journal.pone.0101959. [PMID: 25051199]
  • Kota Fujiki, Hisako Inamura, Masato Matsuoka. Phosphorylation of FOXO3a by PI3K/Akt pathway in HK-2 renal proximal tubular epithelial cells exposed to cadmium. Archives of toxicology. 2013 Dec; 87(12):2119-27. doi: 10.1007/s00204-013-1077-6. [PMID: 23673518]
  • Sun-Mi Kim, Hyojung Jang, Yonghae Son, Sae-A Lee, Sun-Sik Bae, Young Chul Park, Seong-Kug Eo, Koanhoi Kim. 27-hydroxycholesterol induces production of tumor necrosis factor-alpha from macrophages. Biochemical and biophysical research communications. 2013 Jan; 430(2):454-9. doi: 10.1016/j.bbrc.2012.12.021. [PMID: 23246833]
  • Robert J Saphirstein, Yuan Z Gao, Mikkel H Jensen, Cynthia M Gallant, Susanne Vetterkind, Jeffrey R Moore, Kathleen G Morgan. The focal adhesion: a regulated component of aortic stiffness. PloS one. 2013; 8(4):e62461. doi: 10.1371/journal.pone.0062461. [PMID: 23626821]
  • Francisco J Arnaud-Batista, Graciana T Costa, Ilana Mara Barbosa de Oliveira, Paula P C Costa, Cláudia F Santos, Manassés C Fonteles, Daniel E Uchôa, Edilberto R Silveira, Bruno A Cardi, Krishnamurti M Carvalho, Luciana S Amaral, Elisa S C Pôças, Luis E M Quintas, François Noël, Nilberto R F Nascimento. Natriuretic effect of bufalin in isolated rat kidneys involves activation of the Na+-K+-ATPase-Src kinase pathway. American journal of physiology. Renal physiology. 2012 Apr; 302(8):F959-66. doi: 10.1152/ajprenal.00130.2011. [PMID: 22237798]
  • Petra Baumann, Wilko Thiele, Natascha Cremers, Santoshi Muppala, Justyna Krachulec, Markus Diefenbacher, Olivier Kassel, Giridhar Mudduluru, Heike Allgayer, Margaret Frame, Jonathan P Sleeman. CD24 interacts with and promotes the activity of c-src within lipid rafts in breast cancer cells, thereby increasing integrin-dependent adhesion. Cellular and molecular life sciences : CMLS. 2012 Feb; 69(3):435-48. doi: 10.1007/s00018-011-0756-9. [PMID: 21710320]
  • Cristiana Caliceti, Laura Zambonin, Cecilia Prata, Francesco Vieceli Dalla Sega, Gabriele Hakim, Silvana Hrelia, Diana Fiorentini. Effect of plasma membrane cholesterol depletion on glucose transport regulation in leukemia cells. PloS one. 2012; 7(7):e41246. doi: 10.1371/journal.pone.0041246. [PMID: 22859971]
  • Yong-Chao Ma, Chong Shi, Yao-Nan Zhang, Lan-Ge Wang, Hao Liu, Hong-Ti Jia, Yu-Xiang Zhang, Fazlul H Sarkar, Ze-Sheng Wang. The tyrosine kinase c-Src directly mediates growth factor-induced Notch-1 and Furin interaction and Notch-1 activation in pancreatic cancer cells. PloS one. 2012; 7(3):e33414. doi: 10.1371/journal.pone.0033414. [PMID: 22479394]
  • Galyna Kleveta, Kinga Borzęcka, Mykola Zdioruk, Maciej Czerkies, Hanna Kuberczyk, Natalia Sybirna, Andrzej Sobota, Katarzyna Kwiatkowska. LPS induces phosphorylation of actin-regulatory proteins leading to actin reassembly and macrophage motility. Journal of cellular biochemistry. 2012 Jan; 113(1):80-92. doi: 10.1002/jcb.23330. [PMID: 21898535]
  • Keri A Seymour, Benjamin Sadowitz, Jeffrey J Stein, Jack Lawler, Kristopher G Maier, Vivian Gahtan. Vascular smooth muscle cell migration induced by domains of thrombospondin-1 is differentially regulated. American journal of surgery. 2011 Nov; 202(5):553-7. doi: 10.1016/j.amjsurg.2011.06.025. [PMID: 21906719]
  • Anh-Nguyet T Nguyen, Kyle Jansson, Gladis Sánchez, Madhulika Sharma, Gail A Reif, Darren P Wallace, Gustavo Blanco. Ouabain activates the Na-K-ATPase signalosome to induce autosomal dominant polycystic kidney disease cell proliferation. American journal of physiology. Renal physiology. 2011 Oct; 301(4):F897-906. doi: 10.1152/ajprenal.00095.2011. [PMID: 21697238]
  • Navjotsingh Pabla, Guie Dong, Man Jiang, Shuang Huang, M Vijay Kumar, Robert O Messing, Zheng Dong. Inhibition of PKCδ reduces cisplatin-induced nephrotoxicity without blocking chemotherapeutic efficacy in mouse models of cancer. The Journal of clinical investigation. 2011 Jul; 121(7):2709-22. doi: 10.1172/jci45586. [PMID: 21633170]
  • Ying Han, Ning Yuan, Shu-Juan Zhang, Juan Gao, Zhen Shi, Ye-Bo Zhou, Xing-Ya Gao, Guo-Qing Zhu. c-Src in paraventricular nucleus modulates sympathetic activity and cardiac sympathetic afferent reflex in renovascular hypertensive rats. Pflugers Archiv : European journal of physiology. 2011 Apr; 461(4):437-46. doi: 10.1007/s00424-011-0932-7. [PMID: 21340460]
  • Hui Liu, Shao-En Ong, Kwabena Badu-Nkansah, Jeffrey Schindler, Forest M White, Richard O Hynes. CUB-domain-containing protein 1 (CDCP1) activates Src to promote melanoma metastasis. Proceedings of the National Academy of Sciences of the United States of America. 2011 Jan; 108(4):1379-84. doi: 10.1073/pnas.1017228108. [PMID: 21220330]
  • Subhashree Pradhan, Nawaf Alrehani, Vimal Patel, Tanvir Khatlani, K Vinod Vijayan. Cross-talk between serine/threonine protein phosphatase 2A and protein tyrosine phosphatase 1B regulates Src activation and adhesion of integrin αIIbβ3 to fibrinogen. The Journal of biological chemistry. 2010 Sep; 285(38):29059-68. doi: 10.1074/jbc.m109.085167. [PMID: 20615878]
  • Su-Jung Yang, Shi-Chuan Chang, Hui-Chin Wen, Ching-Yu Chen, Jyh-Fei Liao, Chung-Ho Chang. Plumbagin activates ERK1/2 and Akt via superoxide, Src and PI3-kinase in 3T3-L1 cells. European journal of pharmacology. 2010 Jul; 638(1-3):21-8. doi: 10.1016/j.ejphar.2010.04.016. [PMID: 20420821]
  • Honghong Yao, Yanjing Yang, Kee Jun Kim, Crystal Bethel-Brown, Nan Gong, Keiko Funa, Howard E Gendelman, Tsung-Ping Su, John Q Wang, Shilpa Buch. Molecular mechanisms involving sigma receptor-mediated induction of MCP-1: implication for increased monocyte transmigration. Blood. 2010 Jun; 115(23):4951-62. doi: 10.1182/blood-2010-01-266221. [PMID: 20354174]
  • Robert X-D Song, Yuchai Chen, Zhenguo Zhang, Yongde Bao, Wei Yue, Ji-Ping Wang, Ping Fan, Richard J Santen. Estrogen utilization of IGF-1-R and EGF-R to signal in breast cancer cells. The Journal of steroid biochemistry and molecular biology. 2010 Feb; 118(4-5):219-30. doi: 10.1016/j.jsbmb.2009.09.018. [PMID: 19815064]
  • Bin Dong, Noriko Nishimura, Christoph F Vogel, Chiharu Tohyama, Fumio Matsumura. TCDD-induced cyclooxygenase-2 expression is mediated by the nongenomic pathway in mouse MMDD1 macula densa cells and kidneys. Biochemical pharmacology. 2010 Feb; 79(3):487-97. doi: 10.1016/j.bcp.2009.08.031. [PMID: 19782052]
  • Mamiko Hatta, Tomoko Matsuzaki, Yoko Morioka, Yoko Yoshida, Makoto Noda. Density- and serum-dependent regulation of the Reck tumor suppressor in mouse embryo fibroblasts. Cellular signalling. 2009 Dec; 21(12):1885-93. doi: 10.1016/j.cellsig.2009.08.005. [PMID: 19720143]
  • Tun-Hui Chung, Seu-Mei Wang, Jyun-Yan Liang, Shih-Hung Yang, Jiahn-Chun Wu. The interaction of estrogen receptor alpha and caveolin-3 regulates connexin43 phosphorylation in metabolic inhibition-treated rat cardiomyocytes. The international journal of biochemistry & cell biology. 2009 Nov; 41(11):2323-33. doi: 10.1016/j.biocel.2009.06.001. [PMID: 19523531]
  • Sung Yong Eum, Ibolya Andras, Bernhard Hennig, Michal Toborek. NADPH oxidase and lipid raft-associated redox signaling are required for PCB153-induced upregulation of cell adhesion molecules in human brain endothelial cells. Toxicology and applied pharmacology. 2009 Oct; 240(2):299-305. doi: 10.1016/j.taap.2009.07.022. [PMID: 19632255]
  • Roberta Palumbo, Francesco De Marchis, Tobias Pusterla, Antonio Conti, Massimo Alessio, Marco E Bianchi. Src family kinases are necessary for cell migration induced by extracellular HMGB1. Journal of leukocyte biology. 2009 Sep; 86(3):617-23. doi: 10.1189/jlb.0908581. [PMID: 19401391]
  • P Gamas, S Marchetti, A Puissant, S Grosso, A Jacquel, P Colosetti, J-M Pasquet, F-X Mahon, J-P Cassuto, P Auberger. Inhibition of imatinib-mediated apoptosis by the caspase-cleaved form of the tyrosine kinase Lyn in chronic myelogenous leukemia cells. Leukemia. 2009 Aug; 23(8):1500-6. doi: 10.1038/leu.2009.60. [PMID: 19340007]
  • Takuya Watanabe, Masumi Tsuda, Yoshinori Makino, Tassos Konstantinou, Hiroshi Nishihara, Tokifumi Majima, Akio Minami, Stephan M Feller, Shinya Tanaka. Crk adaptor protein-induced phosphorylation of Gab1 on tyrosine 307 via Src is important for organization of focal adhesions and enhanced cell migration. Cell research. 2009 May; 19(5):638-50. doi: 10.1038/cr.2009.40. [PMID: 19350053]
  • Marpadga A Reddy, Saurabh Sahar, Louisa M Villeneuve, Linda Lanting, Rama Natarajan. Role of Src tyrosine kinase in the atherogenic effects of the 12/15-lipoxygenase pathway in vascular smooth muscle cells. Arteriosclerosis, thrombosis, and vascular biology. 2009 Mar; 29(3):387-93. doi: 10.1161/atvbaha.108.179150. [PMID: 19095999]
  • Daniel Sagan, Friederike Eckardt-Schupp, Hedda Eichholtz-Wirth. Reduced expression of SRC family kinases decreases PI3K activity in NBS1-/- lymphoblasts. Biochemical and biophysical research communications. 2008 Dec; 377(1):181-6. doi: 10.1016/j.bbrc.2008.09.098. [PMID: 18835245]
  • G Daoud, F Le bellego, J Lafond. PP2 regulates human trophoblast cells differentiation by activating p38 and ERK1/2 and inhibiting FAK activation. Placenta. 2008 Oct; 29(10):862-70. doi: 10.1016/j.placenta.2008.07.011. [PMID: 18783823]
  • Lei Jin, Paul M Waterman, Karen R Jonscher, Cindy M Short, Nichole A Reisdorph, John C Cambier. MPYS, a novel membrane tetraspanner, is associated with major histocompatibility complex class II and mediates transduction of apoptotic signals. Molecular and cellular biology. 2008 Aug; 28(16):5014-26. doi: 10.1128/mcb.00640-08. [PMID: 18559423]
  • Letizia Mattii, Barbara Battolla, Stefania Moscato, Rita Fazzi, Sara Galimberti, Nunzia Bernardini, Amelio Dolfi, Mario Petrini. The small peptide OGP(10-14) acts through Src kinases and RhoA pathways in Mo-7e cells: morphologic and immunologic evaluation. Medical science monitor : international medical journal of experimental and clinical research. 2008 Jun; 14(6):BR103-108. doi: . [PMID: 18509267]
  • Naoto Ichihara, Yoshitsugu Kubota, Akira Kitanaka, Terukazu Tanaka, Tomohiko Taminato. Inhibition of Src reduces gemcitabine-induced cytotoxicity in human pancreatic cancer cell lines. Cancer letters. 2008 Feb; 260(1-2):155-62. doi: 10.1016/j.canlet.2007.10.035. [PMID: 18078709]
  • Klaudia Giehl, Angela Graness, Margarete Goppelt-Struebe. The small GTPase Rac-1 is a regulator of mesangial cell morphology and thrombospondin-1 expression. American journal of physiology. Renal physiology. 2008 Feb; 294(2):F407-13. doi: 10.1152/ajprenal.00093.2007. [PMID: 18045834]
  • Olga A Akimova, Pavel Hamet, Sergei N Orlov. [Na+]i/[K+]i -independent death of ouabain-treated renal epithelial cells is not mediated by Na+,K+ -ATPase internalization and de novo gene expression. Pflugers Archiv : European journal of physiology. 2008 Jan; 455(4):711-9. doi: 10.1007/s00424-007-0283-6. [PMID: 17622553]
  • Katherine A Price, Gulay Filiz, Aphrodite Caragounis, Tai Du, Katrina M Laughton, Colin L Masters, Robyn A Sharples, Andrew F Hill, Qiao-Xin Li, Paul S Donnelly, Kevin J Barnham, Peter J Crouch, Anthony R White. Activation of epidermal growth factor receptor by metal-ligand complexes decreases levels of extracellular amyloid beta peptide. The international journal of biochemistry & cell biology. 2008; 40(9):1901-17. doi: 10.1016/j.biocel.2008.01.033. [PMID: 18346929]
  • Lakshmi C Wijeyewickrema, Elizabeth E Gardiner, Masaaki Moroi, Michael C Berndt, Robert K Andrews. Snake venom metalloproteinases, crotarhagin and alborhagin, induce ectodomain shedding of the platelet collagen receptor, glycoprotein VI. Thrombosis and haemostasis. 2007 Dec; 98(6):1285-90. doi: . [PMID: 18064326]
  • I-Ju Chen, Hung-Lin Chen, Michael Demetriou. Lateral compartmentalization of T cell receptor versus CD45 by galectin-N-glycan binding and microfilaments coordinate basal and activation signaling. The Journal of biological chemistry. 2007 Nov; 282(48):35361-72. doi: 10.1074/jbc.m706923200. [PMID: 17897956]
  • Yaohong Wang, Alok Tomar, Sudeep P George, Seema Khurana. Obligatory role for phospholipase C-gamma(1) in villin-induced epithelial cell migration. American journal of physiology. Cell physiology. 2007 May; 292(5):C1775-86. doi: 10.1152/ajpcell.00420.2006. [PMID: 17229814]
  • Wenyi Zhang, Qin Tong, Kathleen Conrad, Jocelyn Wozney, Joseph Y Cheung, Barbara A Miller. Regulation of TRP channel TRPM2 by the tyrosine phosphatase PTPL1. American journal of physiology. Cell physiology. 2007 May; 292(5):C1746-58. doi: 10.1152/ajpcell.00569.2006. [PMID: 17251321]
  • Jing Cheng, Simon C Watkins, William H Walker. Testosterone activates mitogen-activated protein kinase via Src kinase and the epidermal growth factor receptor in sertoli cells. Endocrinology. 2007 May; 148(5):2066-74. doi: 10.1210/en.2006-1465. [PMID: 17272394]
  • M T Harper, S O Sage. PAR-1-dependent pp60src activation is dependent on protein kinase C and increased [Ca2+]: evidence that pp60src does not regulate PAR-1-dependent Ca2+ entry in human platelets. Journal of thrombosis and haemostasis : JTH. 2006 Dec; 4(12):2695-703. doi: 10.1111/j.1538-7836.2006.02207.x. [PMID: 16965542]
  • Sheeja Joy, Richard C M Siow, David J Rowlands, Marko Becker, Amanda W Wyatt, Philip I Aaronson, Clive W Coen, Imre Kallo, Ron Jacob, Giovanni E Mann. The isoflavone Equol mediates rapid vascular relaxation: Ca2+-independent activation of endothelial nitric-oxide synthase/Hsp90 involving ERK1/2 and Akt phosphorylation in human endothelial cells. The Journal of biological chemistry. 2006 Sep; 281(37):27335-45. doi: 10.1074/jbc.m602803200. [PMID: 16840783]
  • Yuehan Zhou, Patrice Bouyer, Walter F Boron. Role of a tyrosine kinase in the CO2-induced stimulation of HCO3- reabsorption by rabbit S2 proximal tubules. American journal of physiology. Renal physiology. 2006 Aug; 291(2):F358-67. doi: 10.1152/ajprenal.00520.2005. [PMID: 16705143]
  • Toshiaki Suguro, Takuya Watanabe, Tomoko Kanome, Syuusuke Kodate, Tsutomu Hirano, Akira Miyazaki, Mitsuru Adachi. Serotonin acts as an up-regulator of acyl-coenzyme A:cholesterol acyltransferase-1 in human monocyte-macrophages. Atherosclerosis. 2006 Jun; 186(2):275-81. doi: 10.1016/j.atherosclerosis.2005.08.007. [PMID: 16157345]
  • Ju Suk Lee, Su Yung Kim, Chae Hwa Kwon, Yong Keun Kim. EGFR-dependent ERK activation triggers hydrogen peroxide-induced apoptosis in OK renal epithelial cells. Archives of toxicology. 2006 Jun; 80(6):337-46. doi: 10.1007/s00204-005-0052-2. [PMID: 16341693]
  • L D Alexander, Y Ding, S Alagarsamy, X-L Cui, J G Douglas. Arachidonic acid induces ERK activation via Src SH2 domain association with the epidermal growth factor receptor. Kidney international. 2006 May; 69(10):1823-32. doi: 10.1038/sj.ki.5000363. [PMID: 16598196]
  • Thomais Markou, Chee Shin Yong, Peter H Sugden, Angela Clerk. Regulation of protein kinase C delta by phorbol ester, endothelin-1, and platelet-derived growth factor in cardiac myocytes. The Journal of biological chemistry. 2006 Mar; 281(13):8321-31. doi: 10.1074/jbc.m508398200. [PMID: 16361709]
  • Ellen J Tisdale, Cristina R Artalejo. Src-dependent aprotein kinase C iota/lambda (aPKCiota/lambda) tyrosine phosphorylation is required for aPKCiota/lambda association with Rab2 and glyceraldehyde-3-phosphate dehydrogenase on pre-golgi intermediates. The Journal of biological chemistry. 2006 Mar; 281(13):8436-42. doi: 10.1074/jbc.m513031200. [PMID: 16452474]
  • Miguel A Sanjuan, Navin Rao, Kuei-Tai A Lai, Yin Gu, Siquan Sun, Anja Fuchs, Wai-Ping Fung-Leung, Marco Colonna, Lars Karlsson. CpG-induced tyrosine phosphorylation occurs via a TLR9-independent mechanism and is required for cytokine secretion. The Journal of cell biology. 2006 Mar; 172(7):1057-68. doi: 10.1083/jcb.200508058. [PMID: 16567503]
  • H Shankar, A Garcia, J Prabhakar, S Kim, S P Kunapuli. P2Y12 receptor-mediated potentiation of thrombin-induced thromboxane A2 generation in platelets occurs through regulation of Erk1/2 activation. Journal of thrombosis and haemostasis : JTH. 2006 Mar; 4(3):638-47. doi: 10.1111/j.1538-7836.2006.01789.x. [PMID: 16460446]
  • Yoshiko Fujita, Masanori Yoshizumi, Yuki Izawa, Nermin Ali, Hideki Ohnishi, Yasuhisa Kanematsu, Keisuke Ishizawa, Koichiro Tsuchiya, Toshiaki Tamaki. Transactivation of fetal liver kinase-1/kinase-insert domain-containing receptor by lysophosphatidylcholine induces vascular endothelial cell proliferation. Endocrinology. 2006 Mar; 147(3):1377-85. doi: 10.1210/en.2005-0644. [PMID: 16322069]
  • Tzeng-Horng Leu, Suparat Charoenfuprasert, Chia-Kuang Yen, Chiung-Wen Fan, Ming-Chei Maa. Lipopolysaccharide-induced c-Src expression plays a role in nitric oxide and TNFalpha secretion in macrophages. Molecular immunology. 2006 Feb; 43(4):308-16. doi: 10.1016/j.molimm.2005.03.015. [PMID: 15869794]
  • Timothy P Newsome, Ina Weisswange, Friedrich Frischknecht, Michael Way. Abl collaborates with Src family kinases to stimulate actin-based motility of vaccinia virus. Cellular microbiology. 2006 Feb; 8(2):233-41. doi: 10.1111/j.1462-5822.2005.00613.x. [PMID: 16441434]
  • Alec J Hirsch, Guruprasad R Medigeshi, Heather L Meyers, Victor DeFilippis, Klaus Früh, Thomas Briese, W Ian Lipkin, Jay A Nelson. The Src family kinase c-Yes is required for maturation of West Nile virus particles. Journal of virology. 2005 Sep; 79(18):11943-51. doi: 10.1128/jvi.79.18.11943-11951.2005. [PMID: 16140770]
  • Yun Yong Wang, Anders E Myhre, Solveig J Pettersen, Maria K Dahle, Simon J Foster, Christoph Thiemermann, Kristin Bjørnland, Ansgar O Aasen, Jacob E Wang. Peptidoglycan of Staphylococcus aureus induces enhanced levels of matrix metalloproteinase-9 in human blood originating from neutrophils. Shock (Augusta, Ga.). 2005 Sep; 24(3):214-8. doi: 10.1097/01.shk.0000174935.13786.6c. [PMID: 16135959]
  • Liat Abovich Gilad, Tali Bresler, Julia Gnainsky, Patricia Smirnoff, Betty Schwartz. Regulation of vitamin D receptor expression via estrogen-induced activation of the ERK 1/2 signaling pathway in colon and breast cancer cells. The Journal of endocrinology. 2005 Jun; 185(3):577-92. doi: 10.1677/joe.1.05770. [PMID: 15930183]
  • Carolyn M Klinge, Kristy A Blankenship, Kelly E Risinger, Shephali Bhatnagar, Edouard L Noisin, Wasana K Sumanasekera, Lei Zhao, Darren M Brey, Robert S Keynton. Resveratrol and estradiol rapidly activate MAPK signaling through estrogen receptors alpha and beta in endothelial cells. The Journal of biological chemistry. 2005 Mar; 280(9):7460-8. doi: 10.1074/jbc.m411565200. [PMID: 15615701]
  • Kyung-Ok Nam, Hyun Kang, Su-Mi Shin, Kwang-Hyun Cho, Byoungsuk Kwon, Byoung S Kwon, Sung-Jin Kim, Hyeon-Woo Lee. Cross-linking of 4-1BB activates TCR-signaling pathways in CD8+ T lymphocytes. Journal of immunology (Baltimore, Md. : 1950). 2005 Feb; 174(4):1898-905. doi: 10.4049/jimmunol.174.4.1898. [PMID: 15699116]
  • Catherine M Waters, Michelle C Connell, Susan Pyne, Nigel J Pyne. c-Src is involved in regulating signal transmission from PDGFbeta receptor-GPCR(s) complexes in mammalian cells. Cellular signalling. 2005 Feb; 17(2):263-77. doi: 10.1016/j.cellsig.2004.07.011. [PMID: 15494217]
  • Laura Lynch, Pavel I Vodyanik, David Boettiger, Marina A Guvakova. Insulin-like growth factor I controls adhesion strength mediated by alpha5beta1 integrins in motile carcinoma cells. Molecular biology of the cell. 2005 Jan; 16(1):51-63. doi: 10.1091/mbc.e04-05-0399. [PMID: 15509657]
  • Michael Lee, Ji-Young Kim, Wayne B Anderson. Src tyrosine kinase inhibitor PP2 markedly enhances Ras-independent activation of Raf-1 protein kinase by phorbol myristate acetate and H2O2. The Journal of biological chemistry. 2004 Nov; 279(47):48692-701. doi: 10.1074/jbc.m403132200. [PMID: 15356004]
  • Emmanuelle Rollet-Labelle, Sébastien Marois, Kathy Barbeau, Stephen E Malawista, Paul H Naccache. Recruitment of the cross-linked opsonic receptor CD32A (FcgammaRIIA) to high-density detergent-resistant membrane domains in human neutrophils. The Biochemical journal. 2004 Aug; 381(Pt 3):919-28. doi: 10.1042/bj20031808. [PMID: 15130090]
  • Deepak K Sharma, Jennifer C Brown, Amit Choudhury, Timothy E Peterson, Eileen Holicky, David L Marks, Robert Simari, Robert G Parton, Richard E Pagano. Selective stimulation of caveolar endocytosis by glycosphingolipids and cholesterol. Molecular biology of the cell. 2004 Jul; 15(7):3114-22. doi: 10.1091/mbc.e04-03-0189. [PMID: 15107466]
  • Valerie J Collett, Graham L Collingridge. Interactions between NMDA receptors and mGlu5 receptors expressed in HEK293 cells. British journal of pharmacology. 2004 Jul; 142(6):991-1001. doi: 10.1038/sj.bjp.0705861. [PMID: 15210575]
  • Marcello Maggiolini, Adele Vivacqua, Giovanna Fasanella, Anna Grazia Recchia, Diego Sisci, Vincenzo Pezzi, Daniela Montanaro, Anna Maria Musti, Didier Picard, Sebastiano Andò. The G protein-coupled receptor GPR30 mediates c-fos up-regulation by 17beta-estradiol and phytoestrogens in breast cancer cells. The Journal of biological chemistry. 2004 Jun; 279(26):27008-16. doi: 10.1074/jbc.m403588200. [PMID: 15090535]
  • Trevor R Walker, Marie-Helene Ruchaud-Sparagano, Sarah R McMeekin, Ian Dransfield. A critical 'threshold' of beta 2-integrin engagement regulates augmentation of cytokine-mediated superoxide anion release. British journal of pharmacology. 2004 Apr; 141(7):1131-40. doi: 10.1038/sj.bjp.0705715. [PMID: 15006901]
  • Sung Jae Kim, Myeong Yoon Kim, Eun Jin Lee, Young Soo Ahn, Ja-Hyun Baik. Distinct regulation of internalization and mitogen-activated protein kinase activation by two isoforms of the dopamine D2 receptor. Molecular endocrinology (Baltimore, Md.). 2004 Mar; 18(3):640-52. doi: 10.1210/me.2003-0066. [PMID: 14684845]
  • Nataliya N Bulayeva, Bahiru Gametchu, Cheryl S Watson. Quantitative measurement of estrogen-induced ERK 1 and 2 activation via multiple membrane-initiated signaling pathways. Steroids. 2004 Mar; 69(3):181-92. doi: 10.1016/j.steroids.2003.12.003. [PMID: 15072920]
  • Jun Liu, Zhongji Liao, Jean Camden, Korey D Griffin, Richard C Garrad, Laura I Santiago-Pérez, Fernando A González, Cheikh I Seye, Gary A Weisman, Laurie Erb. Src homology 3 binding sites in the P2Y2 nucleotide receptor interact with Src and regulate activities of Src, proline-rich tyrosine kinase 2, and growth factor receptors. The Journal of biological chemistry. 2004 Feb; 279(9):8212-8. doi: 10.1074/jbc.m312230200. [PMID: 14670955]
  • Hideyuki Takahashi, Kingo Suzuki, Hideo Namiki. Pervanadate-induced reverse translocation and tyrosine phosphorylation of phorbol ester-stimulated protein kinase C betaII are mediated by Src-family tyrosine kinases in porcine neutrophils. Biochemical and biophysical research communications. 2004 Feb; 314(3):830-7. doi: 10.1016/j.bbrc.2003.12.163. [PMID: 14741711]
  • Chellappa Vasant, Rama Rajaram, Thirumalachari Ramasami. Apoptosis of lymphocytes induced by chromium(VI/V) is through ROS-mediated activation of Src-family kinases and caspase-3. Free radical biology & medicine. 2003 Nov; 35(9):1082-100. doi: 10.1016/s0891-5849(03)00471-4. [PMID: 14572611]
  • Baharia Mograbi, Elisabeth Corcelle, Norah Defamie, Michel Samson, Marielle Nebout, Dominique Segretain, Patrick Fénichel, Georges Pointis. Aberrant Connexin 43 endocytosis by the carcinogen lindane involves activation of the ERK/mitogen-activated protein kinase pathway. Carcinogenesis. 2003 Aug; 24(8):1415-23. doi: 10.1093/carcin/bgg093. [PMID: 12807735]
  • Gabriella Gruden, Shawanna Araf, Silvia Zonca, Davina Burt, Stephen Thomas, Luigi Gnudi, Giancarlo Viberti. IGF-I induces vascular endothelial growth factor in human mesangial cells via a Src-dependent mechanism. Kidney international. 2003 Apr; 63(4):1249-55. doi: 10.1046/j.1523-1755.2003.00857.x. [PMID: 12631341]
  • Francesca Carlomagno, Donata Vitagliano, Teresa Guida, Fulvio Basolo, Maria Domenica Castellone, Rosa Marina Melillo, Alfredo Fusco, Massimo Santoro. Efficient inhibition of RET/papillary thyroid carcinoma oncogenic kinases by 4-amino-5-(4-chloro-phenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine (PP2). The Journal of clinical endocrinology and metabolism. 2003 Apr; 88(4):1897-902. doi: 10.1210/jc.2002-021278. [PMID: 12679489]
  • Martin Baumgartner, Pavla Angelisová, Niclas Setterblad, Nuala Mooney, Dirk Werling, Václav Horejsí, Gordon Langsley. Constitutive exclusion of Csk from Hck-positive membrane microdomains permits Src kinase-dependent proliferation of Theileria-transformed B lymphocytes. Blood. 2003 Mar; 101(5):1874-81. doi: 10.1182/blood-2002-02-0456. [PMID: 12411311]
  • Diviya Sinha, Zhiyong Wang, Valerie R Price, John H Schwartz, Wilfred Lieberthal. Chemical anoxia of tubular cells induces activation of c-Src and its translocation to the zonula adherens. American journal of physiology. Renal physiology. 2003 Mar; 284(3):F488-97. doi: 10.1152/ajprenal.00172.2002. [PMID: 12419774]
  • Jacqueline Friedman, Bonita Babu, Richard B Clark. Beta(2)-adrenergic receptor lacking the cyclic AMP-dependent protein kinase consensus sites fully activates extracellular signal-regulated kinase 1/2 in human embryonic kidney 293 cells: lack of evidence for G(s)/G(i) switching. Molecular pharmacology. 2002 Nov; 62(5):1094-102. doi: 10.1124/mol.62.5.1094. [PMID: 12391272]
  • Elena Gubina, Trina Chen, Lei Zhang, Elaine F Lizzio, Steven Kozlowski. CD43 polarization in unprimed T cells can be dissociated from raft coalescence by inhibition of HMG CoA reductase. Blood. 2002 Apr; 99(7):2518-25. doi: 10.1182/blood.v99.7.2518. [PMID: 11895788]
  • J M Fredriksson, J M Lindquist, G E Bronnikov, J Nedergaard. Norepinephrine induces vascular endothelial growth factor gene expression in brown adipocytes through a beta -adrenoreceptor/cAMP/protein kinase A pathway involving Src but independently of Erk1/2. The Journal of biological chemistry. 2000 May; 275(18):13802-11. doi: 10.1074/jbc.275.18.13802. [PMID: 10788502]