3-Chloro-2-hydroxypropanoic acid (BioDeep_00000172975)

   

human metabolite blood metabolite


代谢物信息卡片


3-Chloro-2-hydroxypropanoic acid

化学式: C3H5ClO3 (123.9927)
中文名称: 氯乳酸
谱图信息: 最多检出来源 Homo sapiens(blood) 100%

分子结构信息

SMILES: C(C(C(=O)O)O)Cl
InChI: InChI=1S/C3H5ClO3/c4-1-2(5)3(6)7/h2,5H,1H2,(H,6,7)

描述信息

同义名列表

15 个代谢物同义名

3-Chloro-2-hydroxypropanoic acid; 3-Chloro-2-hydroxypropionic acid; 3-Chlorolactate, (+-)-isomer; 3-Chloro-2-hydroxypropanoate; 3-Chloro-2-hydroxypropionate; 3-Chlorolactate monosodium; beta-Chlorolactic acid; Β-chlorolactic acid; 3-chlorolactic acid; b-Chlorolactic acid; beta-Chlorolactate; 3-Chloro lactate; b-Chlorolactate; Β-chlorolactate; 3-Chlorolactate



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Katharina Schultrich, Fulya Oez, Nick Bergau, Thorsten Buhrke, Albert Braeuning. Absorption and metabolism of 3-MCPD in hepatic and renal cell lines. Toxicology in vitro : an international journal published in association with BIBRA. 2021 Feb; 70(?):105042. doi: 10.1016/j.tiv.2020.105042. [PMID: 33129984]
  • Nick Bergau, Zhiyong Zhao, Klaus Abraham, Bernhard H Monien. Metabolites of 2- and 3-Monochloropropanediol (2- and 3-MCPD) in Humans: Urinary Excretion of 2-Chlorohydracrylic Acid and 3-Chlorolactic Acid after Controlled Exposure to a Single High Dose of Fatty Acid Esters of 2- and 3-MCPD. Molecular nutrition & food research. 2021 02; 65(4):e2000736. doi: 10.1002/mnfr.202000736. [PMID: 33112049]
  • R El Ramy, M Ould Elhkim, S Lezmi, J M Poul. Evaluation of the genotoxic potential of 3-monochloropropane-1,2-diol (3-MCPD) and its metabolites, glycidol and beta-chlorolactic acid, using the single cell gel/comet assay. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2007 Jan; 45(1):41-8. doi: 10.1016/j.fct.2006.07.014. [PMID: 16971032]
  • Rosy El Ramy, Mostafa Ould Elhkim, Martine Poul, Maguelone G Forest, Patrick Leduque, Brigitte Le Magueresse-Battistoni. Lack of effect on rat testicular organogenesis after in utero exposure to 3-monochloropropane-1,2-diol (3-MCPD). Reproductive toxicology (Elmsford, N.Y.). 2006 Oct; 22(3):485-92. doi: 10.1016/j.reprotox.2005.12.008. [PMID: 16472968]
  • A R Jones, C Morin, W Bone, T G Cooper. Lack of antifertility properties of novel halogenated glycolytic inhibitors and the urinary excretion and metabolism of 1,6-dichloro-1,6-dideoxy-D-fructofuranose in the male rat. International journal of andrology. 2002 Jun; 25(3):168-74. doi: 10.1046/j.1365-2605.2002.00345.x. [PMID: 12031045]
  • W Bone, A R Jones, T G Cooper. The effect of (R,S)-ornidazole on the fertility of male mice and the excretion and metabolism of 36Cl-(R,S)-ornidazole and 36Cl-(R,S)-alpha-chlorohydrin in male mice and rats. International journal of andrology. 2002 Apr; 25(2):94-9. doi: 10.1046/j.1365-2605.2002.00331.x. [PMID: 11903658]
  • M S Dobbie, K E Porter, A R Jones. Is the nephrotoxicity of (R)-3-chlorolactate in the rat caused by 3-chloropyruvate?. Xenobiotica; the fate of foreign compounds in biological systems. 1988 Dec; 18(12):1389-99. doi: 10.3109/00498258809042262. [PMID: 3245232]
  • K E Porter, A R Jones. The renal toxicity of (R)-3-chlorolactate in the rat. Chemico-biological interactions. 1987; 62(2):157-66. doi: 10.1016/0009-2797(87)90087-1. [PMID: 3594638]
  • K E Porter, A R Jones. The effect of the isomers of alpha-cholorohydrin and racemic beta-chlorolactate on the rat kidney. Chemico-biological interactions. 1982 Jul; 41(1):95-104. doi: 10.1016/0009-2797(82)90020-5. [PMID: 6807557]