4-(5-(4-Chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide (BioDeep_00000172973)
human metabolite blood metabolite
代谢物信息卡片
化学式: C16H11ClF3N3O2S (401.02125720000004)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 50%
分子结构信息
SMILES: C1=CC(=CC=C1C2=CC(=NN2C3=CC=C(C=C3)S(=O)(=O)N)C(F)(F)F)Cl
InChI: InChI=1S/C16H11ClF3N3O2S/c17-11-3-1-10(2-4-11)14-9-15(16(18,19)20)22-23(14)12-5-7-13(8-6-12)26(21,24)25/h1-9H,(H2,21,24,25)
描述信息
D018501 - Antirheumatic Agents > D000894 - Anti-Inflammatory Agents, Non-Steroidal > D016861 - Cyclooxygenase Inhibitors
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
D000893 - Anti-Inflammatory Agents
D004791 - Enzyme Inhibitors
同义名列表
4 个代谢物同义名
4-[5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzene-1-sulfonamide; 4-(5-(4-Chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulphonamide; 4-(5-(4-Chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide; 4-[5-(4-chlorophenyl)-3-(trifluoromethyl)pyrazol-1-yl]benzenesulfonamide
数据库引用编号
6 个数据库交叉引用编号
- PubChem: 9865808
- HMDB: HMDB0244782
- DrugBank: DB14059
- ChEMBL: CHEMBL282093
- chemspider: 8041499
- CAS: 170569-86-5
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Patrick Slattery, Stefanie Frölich, Yannik Schreiber, Rolf M Nüsing. COX-2 gene dosage-dependent defects in kidney development.
American journal of physiology. Renal physiology.
2016 05; 310(10):F1113-22. doi:
10.1152/ajprenal.00430.2015
. [PMID: 26984955] - Ming-Zhi Zhang, Bing Yao, Yinqiu Wang, Shilin Yang, Suwan Wang, Xiaofeng Fan, Raymond C Harris. Inhibition of cyclooxygenase-2 in hematopoietic cells results in salt-sensitive hypertension.
The Journal of clinical investigation.
2015 Nov; 125(11):4281-94. doi:
10.1172/jci81550
. [PMID: 26485285] - Ariel Morales, Wei Gao, Jian Lu, Jihong Xing, Jianhua Li. Muscle cyclo-oxygenase-2 pathway contributes to the exaggerated muscle mechanoreflex in rats with congestive heart failure.
Experimental physiology.
2012 Aug; 97(8):943-54. doi:
10.1113/expphysiol.2012.065425
. [PMID: 22523381] - Michael Scully, Chen Gang, Claire Condron, David Bouchier-Hayes, Anthony J Cunningham. Protective role of cyclooxygenase (COX)-2 in experimental lung injury: evidence of a lipoxin A4-mediated effect.
The Journal of surgical research.
2012 Jun; 175(1):176-84. doi:
10.1016/j.jss.2011.02.020
. [PMID: 21944479] - Kohei Tanaka, Tomoyuki Furuyashiki, Shiho Kitaoka, Yuta Senzai, Yuki Imoto, Eri Segi-Nishida, Yuichi Deguchi, Richard M Breyer, Matthew D Breyer, Shuh Narumiya. Prostaglandin E2-mediated attenuation of mesocortical dopaminergic pathway is critical for susceptibility to repeated social defeat stress in mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2012 Mar; 32(12):4319-29. doi:
10.1523/jneurosci.5952-11.2012
. [PMID: 22442093] - Huifang Cheng, Xiaofeng Fan, Gilbert W Moeckel, Raymond C Harris. Podocyte COX-2 exacerbates diabetic nephropathy by increasing podocyte (pro)renin receptor expression.
Journal of the American Society of Nephrology : JASN.
2011 Jul; 22(7):1240-51. doi:
10.1681/asn.2010111149
. [PMID: 21737546] - J Quilley, M Santos, P Pedraza. Renal protective effect of chronic inhibition of COX-2 with SC-58236 in streptozotocin-diabetic rats.
American journal of physiology. Heart and circulatory physiology.
2011 Jun; 300(6):H2316-22. doi:
10.1152/ajpheart.01259.2010
. [PMID: 21441310] - Jim C Oates, Perry V Halushka, Florence N Hutchison, Philip Ruiz, Gary S Gilkeson. Selective cyclooxygenase-2 inhibitor suppresses renal thromboxane production but not proliferative lesions in the MRL/lpr murine model of lupus nephritis.
The American journal of the medical sciences.
2011 Feb; 341(2):101-5. doi:
10.1097/maj.0b013e3181f56d2c
. [PMID: 20924284] - Shawna N Greene, José A Ramos-Vara, Bruce A Craig, Steven B Hooser, Cheryl Anderson, Lindsey M Fourez, Brenda M Johnson, Jane C Stewart, Deborah W Knapp. Effects of cyclooxygenase inhibitor treatment on the renal toxicity of cisplatin in rats.
Cancer chemotherapy and pharmacology.
2010 Feb; 65(3):549-56. doi:
10.1007/s00280-009-1061-2
. [PMID: 19629487] - Alexandre A Steiner, John C Hunter, Sean M Phipps, Tatiane B Nucci, Daniela L Oliveira, Jennifer L Roberts, Adrienne C Scheck, Daniel L Simmons, Andrej A Romanovsky. Cyclooxygenase-1 or -2--which one mediates lipopolysaccharide-induced hypothermia?.
American journal of physiology. Regulatory, integrative and comparative physiology.
2009 Aug; 297(2):R485-94. doi:
10.1152/ajpregu.91026.2008
. [PMID: 19515980] - Bing Yao, Jie Xu, Raymond C Harris, Ming-Zhi Zhang. Renal localization and regulation of 15-hydroxyprostaglandin dehydrogenase.
American journal of physiology. Renal physiology.
2008 Feb; 294(2):F433-9. doi:
10.1152/ajprenal.00436.2007
. [PMID: 18057186] - Corina Matzdorf, A Kurtz, Klaus Höcherl. COX-2 activity determines the level of renin expression but is dispensable for acute upregulation of renin expression in rat kidneys.
American journal of physiology. Renal physiology.
2007 Jun; 292(6):F1782-90. doi:
10.1152/ajprenal.00513.2006
. [PMID: 17376760] - Sang-Wan Seo, Won-Seok Jung, Tai-Guang Piao, Seung-Heon Hong, Ki-Jung Yun, Rae-Kil Park, Min-Kyo Shin, Ho-Joon Song, Sung-Joo Park. Selective cyclooxygenase-2 inhibitor ameliorates cholecystokinin-octapeptide-induced acute pancreatitis in rats.
World journal of gastroenterology.
2007 Apr; 13(16):2298-304. doi:
10.3748/wjg.v13.i16.2298
. [PMID: 17511027] - Young-Il Jo, Huifang Cheng, Suwan Wang, Gilbert W Moeckel, Raymond C Harris. Puromycin induces reversible proteinuric injury in transgenic mice expressing cyclooxygenase-2 in podocytes.
Nephron. Experimental nephrology.
2007; 107(3):e87-94. doi:
10.1159/000108653
. [PMID: 17890881] - Johanna Osterberg, Mikael Ljungdahl, Ulf Haglund. Influence of cyclooxygenase inhibitors on gut immune cell distribution and apoptosis rate in experimental sepsis.
Shock (Augusta, Ga.).
2006 Feb; 25(2):147-54. doi:
10.1097/01.shk.0000189843.78729.e2
. [PMID: 16525353] - Reena Rao, Ming-Zhi Zhang, Min Zhao, Hui Cai, Raymond C Harris, Matthew D Breyer, Chuan-Ming Hao. Lithium treatment inhibits renal GSK-3 activity and promotes cyclooxygenase 2-dependent polyuria.
American journal of physiology. Renal physiology.
2005 Apr; 288(4):F642-9. doi:
10.1152/ajprenal.00287.2004
. [PMID: 15585669] - Huifang Cheng, Mingzhi Zhang, Gilbert W Moeckel, Yan Zhao, Suwan Wang, ZhongHua Qi, Matthew D Breyer, Raymond C Harris. Expression of mediators of renal injury in the remnant kidney of ROP mice is attenuated by cyclooxygenase-2 inhibition.
Nephron. Experimental nephrology.
2005; 101(3):e75-85. doi:
10.1159/000086645
. [PMID: 15995341] - Hans Nohl, Natalia Rohr-Udilova, Lars Gille, Werner Bieberschulte, Daniela Jurek, Brigitte Marian, Rolf Schulte-Hermann. Ubiquinol and the papaverine derivative caroverine prevent the expression of tumour- promoting factors in adenoma and carcinoma colon cancer cells induced by dietary fat.
BioFactors (Oxford, England).
2005; 25(1-4):87-95. doi:
10.1002/biof.5520250110
. [PMID: 16873933] - Graham P Pidgeon, Rasa Tamosiuniene, Gang Chen, Irene Leonard, Orina Belton, Aidan Bradford, Desmond J Fitzgerald. Intravascular thrombosis after hypoxia-induced pulmonary hypertension: regulation by cyclooxygenase-2.
Circulation.
2004 Oct; 110(17):2701-7. doi:
10.1161/01.cir.0000145613.01188.0b
. [PMID: 15492320] - Garrett J Gross, Jeannine Moore. Effect of COX-1/COX-2 inhibition versus selective COX-2 inhibition on coronary vasodilator responses to arachidonic acid and acetylcholine.
Pharmacology.
2004 Jul; 71(3):135-42. doi:
10.1159/000077447
. [PMID: 15161995] - Colin G Egan, John C Lockhart, William R Ferrell. Pathophysiology of vascular dysfunction in a rat model of chronic joint inflammation.
The Journal of physiology.
2004 Jun; 557(Pt 2):635-43. doi:
10.1113/jphysiol.2004.062984
. [PMID: 15064324] - Jenny T Mao, Michael D Roth, Kenneth J Serio, Felicita Baratelli, Li Zhu, E Carmack Holmes, Robert M Strieter, Steven M Dubinett. Celecoxib modulates the capacity for prostaglandin E2 and interleukin-10 production in alveolar macrophages from active smokers.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2003 Dec; 9(16 Pt 1):5835-41. doi:
NULL
. [PMID: 14676104] - Hui-Fang Cheng, Sue-Wan Wang, Ming-Zhi Zhang, James A McKanna, Richard Breyer, Raymond C Harris. Prostaglandins that increase renin production in response to ACE inhibition are not derived from cyclooxygenase-1.
American journal of physiology. Regulatory, integrative and comparative physiology.
2002 Sep; 283(3):R638-46. doi:
10.1152/ajpregu.00150.2002
. [PMID: 12184998] - Hui-Fang Cheng, Connie J Wang, Gilbert W Moeckel, Ming-Zhi Zhang, James A McKanna, Raymond C Harris. Cyclooxygenase-2 inhibitor blocks expression of mediators of renal injury in a model of diabetes and hypertension.
Kidney international.
2002 Sep; 62(3):929-39. doi:
10.1046/j.1523-1755.2002.00520.x
. [PMID: 12164875] - Mesut Buluç, Hakan Gürdal, Mehmet Melli. Effect of misoprostol and indomethacin on cyclooxygenase induction and eicosanoid production in carrageenan-induced air pouch inflammation in rats.
Prostaglandins & other lipid mediators.
2002 Sep; 70(1-2):227-39. doi:
10.1016/s0090-6980(02)00112-0
. [PMID: 12428691] - Bao-Ning Su, Muriel Cuendet, Michael E Hawthorne, Leonardus B S Kardono, Soedarsono Riswan, Harry H S Fong, Rajendra G Mehta, John M Pezzuto, A Douglas Kinghorn. Constituents of the bark and twigs of Artocarpus dadah with cyclooxygenase inhibitory activity.
Journal of natural products.
2002 Feb; 65(2):163-9. doi:
10.1021/np010451c
. [PMID: 11858749] - M Devrim Dogan, Haluk Ataoglu, Eyup S Akarsu. Effects of selective cyclooxygenase enzyme inhibitors on lipopolysaccharide-induced dual thermoregulatory changes in rats.
Brain research bulletin.
2002 Jan; 57(2):179-85. doi:
10.1016/s0361-9230(01)00739-0
. [PMID: 11849824] - N P Dowd, M Scully, S R Adderley, A J Cunningham, D J Fitzgerald. Inhibition of cyclooxygenase-2 aggravates doxorubicin-mediated cardiac injury in vivo.
The Journal of clinical investigation.
2001 Aug; 108(4):585-90. doi:
10.1172/jci11334
. [PMID: 11518732] - C M Hao, F Yull, T Blackwell, M Kömhoff, L S Davis, M D Breyer. Dehydration activates an NF-kappaB-driven, COX2-dependent survival mechanism in renal medullary interstitial cells.
The Journal of clinical investigation.
2000 Oct; 106(8):973-82. doi:
10.1172/jci9956
. [PMID: 11032857] - J L Wang, H F Cheng, S Shappell, R C Harris. A selective cyclooxygenase-2 inhibitor decreases proteinuria and retards progressive renal injury in rats.
Kidney international.
2000 Jun; 57(6):2334-42. doi:
10.1046/j.1523-1755.2000.00093.x
. [PMID: 10844603] - M Kömhoff, J L Wang, H F Cheng, R Langenbach, J A McKanna, R C Harris, M D Breyer. Cyclooxygenase-2-selective inhibitors impair glomerulogenesis and renal cortical development.
Kidney international.
2000 Feb; 57(2):414-22. doi:
10.1046/j.1523-1755.2000.00861.x
. [PMID: 10652018] - F Karmeli, P Cohen, D Rachmilewitz. Cyclo-oxygenase-2 inhibitors ameliorate the severity of experimental colitis in rats.
European journal of gastroenterology & hepatology.
2000 Feb; 12(2):223-31. doi:
10.1097/00042737-200012020-00015
. [PMID: 10741939] - R Gust, J K Kozlowski, A H Stephenson, D P Schuster. Role of cyclooxygenase-2 in oleic acid-induced acute lung injury.
American journal of respiratory and critical care medicine.
1999 Oct; 160(4):1165-70. doi:
10.1164/ajrccm.160.4.9811073
. [PMID: 10508803] - C M Hao, M Kömhoff, Y Guan, R Redha, M D Breyer. Selective targeting of cyclooxygenase-2 reveals its role in renal medullary interstitial cell survival.
The American journal of physiology.
1999 09; 277(3):F352-9. doi:
10.1152/ajprenal.1999.277.3.f352
. [PMID: 10484518] - M Bosch-Marcè, J Clària, E Titos, J L Masferrer, R Altuna, J L Poo, W Jiménez, V Arroyo, F Rivera, J Rodés. Selective inhibition of cyclooxygenase 2 spares renal function and prostaglandin synthesis in cirrhotic rats with ascites.
Gastroenterology.
1999 May; 116(5):1167-75. doi:
10.1016/s0016-5085(99)70020-x
. [PMID: 10220509] - T D Penning, J J Talley, S R Bertenshaw, J S Carter, P W Collins, S Docter, M J Graneto, L F Lee, J W Malecha, J M Miyashiro, R S Rogers, D J Rogier, S S Yu, AndersonGD, E G Burton, J N Cogburn, S A Gregory, C M Koboldt, W E Perkins, K Seibert, A W Veenhuizen, Y Y Zhang, P C Isakson. Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benze nesulfonamide (SC-58635, celecoxib).
Journal of medicinal chemistry.
1997 Apr; 40(9):1347-65. doi:
10.1021/jm960803q
. [PMID: 9135032] - J K Gierse, J J McDonald, S D Hauser, S H Rangwala, C M Koboldt, K Seibert. A single amino acid difference between cyclooxygenase-1 (COX-1) and -2 (COX-2) reverses the selectivity of COX-2 specific inhibitors.
The Journal of biological chemistry.
1996 Jun; 271(26):15810-4. doi:
10.1074/jbc.271.26.15810
. [PMID: 8663121]