Ginsenoside Rh1 (BioDeep_00000017296)

 

Secondary id: BioDeep_00000622804

human metabolite PANOMIX_OTCML-2023 Endogenous


代谢物信息卡片


(2R,3R,4S,5S,6R)-2-[[(3S,5R,6S,8R,9R,10R,12R,13R,14R,17S)-3,12-dihydroxy-17-[(2S)-2-hydroxy-6-methylhept-5-en-2-yl]-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-6-yl]oxy]-6-(hydroxymethyl)oxane-3,4,5-triol

化学式: C36H62O9 (638.4393602)
中文名称: (20R)-人参皂苷 Rh1, 20(R)-人参皂苷, 人参皂苷 R-Rh1, 人参皂苷R-RH1, 人参皂苷Rh1, 人参皂苷 R-RH1
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(=CCCC(C)(C1CCC2(C1C(CC3C2(CC(C4C3(CCC(C4(C)C)O)C)OC5C(C(C(C(O5)CO)O)O)O)C)O)C)O)C
InChI: InChI=1S/C36H62O9/c1-19(2)10-9-13-36(8,43)20-11-15-34(6)26(20)21(38)16-24-33(5)14-12-25(39)32(3,4)30(33)22(17-35(24,34)7)44-31-29(42)28(41)27(40)23(18-37)45-31/h10,20-31,37-43H,9,11-18H2,1-8H3

描述信息

CID 12855917 is a natural product found in Panax ginseng, Panax notoginseng, and other organisms with data available.
Ginsenoside Rh1 is found in tea. Ginsenoside Rh1 is isolated from Panax species.
Isolated from Panax subspecies Ginsenoside Rh1 is found in tea.
(20R)-Ginsenoside Rh1, the R isomer of Ginsenoside Rh1 isolated from Panax Ginseng, inhibits the thrombin-induced conversion of fibrinogen to fibrin[1].
(20R)-Ginsenoside Rh1, the R isomer of Ginsenoside Rh1 isolated from Panax Ginseng, inhibits the thrombin-induced conversion of fibrinogen to fibrin[1].
Ginsenoside Rh1 (Prosapogenin A2) inhibits the expression of PPAR-γ, TNF-α, IL-6, and IL-1β.
Ginsenoside Rh1 (Prosapogenin A2) inhibits the expression of PPAR-γ, TNF-α, IL-6, and IL-1β.
Ginsenoside Rh1 (Prosapogenin A2) inhibits the expression of PPAR-γ, TNF-α, IL-6, and IL-1β.

同义名列表

16 个代谢物同义名

(2R,3R,4S,5S,6R)-2-[[(3S,5R,6S,8R,9R,10R,12R,13R,14R,17S)-3,12-dihydroxy-17-[(2S)-2-hydroxy-6-methylhept-5-en-2-yl]-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-6-yl]oxy]-6-(hydroxymethyl)oxane-3,4,5-triol; (2R,3R,4S,5S,6R)-2-[[(3S,5R,6S,8R,9R,10R,12R,13R,14R,17S)-3,12-dihydroxy-17-[(2R)-2-hydroxy-6-methylhept-5-en-2-yl]-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-6-yl]oxy]-6-(hydroxymethyl)oxane-3,4,5-triol; 2-[[3,12-Dihydroxy-17-(2-hydroxy-6-methylhept-5-en-2-yl)-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-6-yl]oxy]-6-(hydroxymethyl)oxane-3,4,5-triol; 2-{[5,16-dihydroxy-14-(2-hydroxy-6-methylhept-5-en-2-yl)-2,6,6,10,11-pentamethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadecan-8-yl]oxy}-6-(hydroxymethyl)oxane-3,4,5-triol; 20(R)-Ginsenoside Rh1; (20R)-Ginsenoside Rh1; ginsenoside G-Rh(1); (R)-ginsenoside Rh1; ginsenoside Rh(1); 20(R)-Ginsenoside; Sanchinoside B2; ginsenoside-Rh1; ginsenoside Rh1; CID 12855917; Prosapogenin A2; Sanchinoside Rh1



数据库引用编号

15 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

23 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Jingqi Zhao, Yuan Liang, Ziyi Zhu, Yingyi Wang, Tianzhu Guan, Jie Zhang, Tiehua Zhang. Complexation mechanism between 20(R, S)-ginsenoside Rh1 and serum albumin: Multi-spectroscopy, in vitro cytotoxicity, and in silico investigations. Journal of food science. 2022 Mar; 87(3):929-938. doi: 10.1111/1750-3841.16053. [PMID: 35106766]
  • Qiang Li, Chunmiao Zhai, Guodong Wang, Jia Zhou, Weiguang Li, Liquan Xie, Zhanli Shi. Ginsenoside Rh1 attenuates ovalbumin-induced asthma by regulating Th1/Th2 cytokines balance. Bioscience, biotechnology, and biochemistry. 2021 Jul; 85(8):1809-1817. doi: 10.1093/bbb/zbab099. [PMID: 34057179]
  • Wen-Ya Su, Ying Li, Xuan Chen, Xin Li, Heng Wei, Zhi Liu, Qiong Shen, Chen Chen, Ying-Ping Wang, Wei Li. Ginsenoside Rh1 Improves Type 2 Diabetic Nephropathy through AMPK/PI3K/Akt-Mediated Inflammation and Apoptosis Signaling Pathway. The American journal of Chinese medicine. 2021; 49(5):1215-1233. doi: 10.1142/s0192415x21500580. [PMID: 34049473]
  • Diem Thi Ngoc Huynh, Naehwan Baek, Sohyun Sim, Chang-Seon Myung, Kyung-Sun Heo. Minor Ginsenoside Rg2 and Rh1 Attenuates LPS-Induced Acute Liver and Kidney Damages via Downregulating Activation of TLR4-STAT1 and Inflammatory Cytokine Production in Macrophages. International journal of molecular sciences. 2020 Sep; 21(18):. doi: 10.3390/ijms21186656. [PMID: 32932915]
  • Li-Yuan Ma, Qi-Le Zhou, Xiu-Wei Yang. New SIRT1 activator from alkaline hydrolysate of total saponins in the stems-leaves of Panax ginseng. Bioorganic & medicinal chemistry letters. 2015 Nov; 25(22):5321-5. doi: 10.1016/j.bmcl.2015.09.039. [PMID: 26420067]
  • Cheng-Zhen Gu, Jun-Jiang Lv, Xiao-Xia Zhang, Yi-Jun Qiao, Hui Yan, Yan Li, Dong Wang, Hong-Tao Zhu, Huai-Rong Luo, Chong-Ren Yang, Min Xu, Ying-Jun Zhang. Triterpenoids with Promoting Effects on the Differentiation of PC12 Cells from the Steamed Roots of Panax notoginseng. Journal of natural products. 2015 Aug; 78(8):1829-40. doi: 10.1021/acs.jnatprod.5b00027. [PMID: 26200131]
  • Wan Gu, Kyung-Ah Kim, Dong-Hyun Kim. Ginsenoside Rh1 ameliorates high fat diet-induced obesity in mice by inhibiting adipocyte differentiation. Biological & pharmaceutical bulletin. 2013; 36(1):102-7. doi: 10.1248/bpb.b12-00558. [PMID: 23302642]
  • Yusheng Gai, Zhigang Ma, Xiaofeng Yu, Shaochun Qu, Dayuan Sui. Effect of ginsenoside Rh1 on myocardial injury and heart function in isoproterenol-induced cardiotoxicity in rats. Toxicology mechanisms and methods. 2012 Oct; 22(8):584-91. doi: 10.3109/15376516.2012.702798. [PMID: 22694660]
  • Se-Eun Jang, Il-Hoon Jung, Eun-Ha Joh, Myung Joo Han, Dong-Hyun Kim. Antibiotics attenuate anti-scratching behavioral effect of ginsenoside Re in mice. Journal of ethnopharmacology. 2012 Jun; 142(1):105-112. doi: 10.1016/j.jep.2012.04.022. [PMID: 22855946]
  • Liang Feng, Chang-Jiang Hu, Ling-Ying Yu. [Pharmacokinetics of ginsenosides Rg1 and its metabolites in rats]. Yao xue xue bao = Acta pharmaceutica Sinica. 2010 May; 45(5):636-40. doi: NULL. [PMID: 20931768]
  • Li Lai, Haiping Hao, Yitong Liu, Chaonan Zheng, Qiong Wang, Guangji Wang, Xijin Chen. Characterization of pharmacokinetic profiles and metabolic pathways of 20(S)-ginsenoside Rh1 in vivo and in vitro. Planta medica. 2009 Jun; 75(8):797-802. doi: 10.1055/s-0029-1185400. [PMID: 19266426]
  • Li Lai, Yitong Liu, Haiping Hao, Guangji Wang, Xijing Chen, Hongcan Ren. Determination of 20(S)-ginsenoside Rh1 and its aglycone 20(S)-protopanaxatriol in rat plasma by sensitive LC-APCI-MS method and its application to pharmacokinetic study. European journal of mass spectrometry (Chichester, England). 2009; 15(1):57-65. doi: 10.1255/ejms.974. [PMID: 19174594]
  • Jianguo Sun, Guangji Wang, Xie Haitang, Li Hao, Pan Guoyu, Ian Tucker. Simultaneous rapid quantification of ginsenoside Rg1 and its secondary glycoside Rh1 and aglycone protopanaxatriol in rat plasma by liquid chromatography-mass spectrometry after solid-phase extraction. Journal of pharmaceutical and biomedical analysis. 2005 Jun; 38(1):126-32. doi: 10.1016/j.jpba.2004.12.007. [PMID: 15907630]
  • Mona Abdel Tawab, Ute Bahr, Michael Karas, Mario Wurglics, Manfred Schubert-Zsilavecz. Degradation of ginsenosides in humans after oral administration. Drug metabolism and disposition: the biological fate of chemicals. 2003 Aug; 31(8):1065-71. doi: 10.1124/dmd.31.8.1065. [PMID: 12867496]