17-AAG (BioDeep_00000172958)
human metabolite blood metabolite
代谢物信息卡片
({13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-19-[(prop-2-en-1-yl)amino]-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl}oxy)methanimidate
化学式: C31H43N3O8 (585.3049998)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 7.31%
分子结构信息
SMILES: COC1CC(C)CC2=C(NCC=C)C(=O)C=C(NC(=O)C(C)=CC=CC(OC)C(OC(N)=O)C(C)=CC(C)C1O)C2=O
InChI: InChI=1S/C31H43N3O8/c1-8-12-33-26-21-13-17(2)14-25(41-7)27(36)19(4)15-20(5)29(42-31(32)39)24(40-6)11-9-10-18(3)30(38)34-22(28(21)37)16-23(26)35/h8-11,15-17,19,24-25,27,29,33,36H,1,12-14H2,2-7H3,(H2,32,39)(H,34,38)
描述信息
同义名列表
19 个代谢物同义名
({13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-19-[(prop-2-en-1-yl)amino]-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl}oxy)methanimidate; 13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-19-[(prop-2-en-1-yl)amino]-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl carbamate; 13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-19-(prop-2-en-1-ylamino)-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl carbamate; 17-Allylamino-17-demethoxygeldanamycin hydroquinone salt; 17-Allylamino-17-demethoxygeldanamycin hydroquinone; 17-(Allylamino)-17-demethoxy-geldanamycin; 17-(Allylamino)-17-demethoxygeldanamycin; 17-Allylamino-17-demethoxygeldanamycin; 17-Allyl-aminogeldanamycin; Retaspimycin hydrochloride; 17-Allylamino-geldanamycin; 17-Allylaminogeldanamycin; Tanespimycin; IPI-493; IPI 493; IPI-504; IPI 504; 17-AAG; 17AAG
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Gui-Sheng Xu, Yu-Ning Lin, Qingzhong Zeng, Zhi-Peng Li, Teng Xiao, Yong-Sheng Ye, Zhen-Yan Li, Xuejuan Gao. HSP90-regulated CHIP/TRIM21/p21 Axis Involves in the Senescence of Osteosarcoma Cells.
Protein and peptide letters.
2023; 30(6):513-519. doi:
10.2174/0929866530666230519101148. [PMID: 37211848] - Zeynep Gizem Todurga Seven, Fatma Kubra Tombulturk, Selim Gokdemir, Sibel Ozyazgan. The Effects of the Heat Shock Protein 90 Inhibitor 17-Allylamino-17-Demethoxygeldanamycin, Cannabinoid Agonist WIN 55,212-2, and Nitric Oxide Synthase Inhibitor Nω-Nitro-L-Arginine Methyl Ester Hydrochloride on the Serotonin and Dry Skin-Induced Itch.
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Virology.
2022 01; 566(?):60-68. doi:
10.1016/j.virol.2021.11.008. [PMID: 34871905] - Ge Li, Chuang Zhang, Wei Liang, Yanbing Zhang, Yunheng Shen, Xinhui Tian. Berberine regulates the Notch1/PTEN/PI3K/AKT/mTOR pathway and acts synergistically with 17-AAG and SAHA in SW480 colon cancer cells.
Pharmaceutical biology.
2021 Dec; 59(1):21-30. doi:
10.1080/13880209.2020.1865407. [PMID: 33417512] - Cun Li, Hin Chu, Xiaojuan Liu, Man Chun Chiu, Xiaoyu Zhao, Dong Wang, Yuxuan Wei, Yuxin Hou, Huiping Shuai, Jianpiao Cai, Jasper Fuk-Woo Chan, Jie Zhou, Kwok Yung Yuen. Human coronavirus dependency on host heat shock protein 90 reveals an antiviral target.
Emerging microbes & infections.
2020 Dec; 9(1):2663-2672. doi:
10.1080/22221751.2020.1850183. [PMID: 33179566] - Vinícius Couto Pires, Carla Pires Magalhães, Marcos Ferrante, Juliana de Souza Rebouças, Paul Nguewa, Patrícia Severino, Aldina Barral, Patrícia Sampaio Tavares Veras, Fabio Rocha Formiga. Solid lipid nanoparticles as a novel formulation approach for tanespimycin (17-AAG) against leishmania infections: Preparation, characterization and macrophage uptake.
Acta tropica.
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Molecular medicine reports.
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Molecular pharmacology.
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European journal of pharmacology.
2019 Jan; 842(?):221-230. doi:
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Cell death & disease.
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Acta biochimica Polonica.
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The Journal of biological chemistry.
2016 09; 291(38):20125-35. doi:
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Oncotarget.
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2016 May; 291(19):10332-46. doi:
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Cancer research.
2016 Mar; 76(5):1044-54. doi:
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Drug development and industrial pharmacy.
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Investigational new drugs.
2015 Aug; 33(4):963-8. doi:
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Pituitary.
2015 Aug; 18(4):542-53. doi:
10.1007/s11102-014-0607-4. [PMID: 25280813] - Swetha Raman, Kaza Suguna. Functional characterization of heat-shock protein 90 from Oryza sativa and crystal structure of its N-terminal domain.
Acta crystallographica. Section F, Structural biology communications.
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Proceedings of the National Academy of Sciences of the United States of America.
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2014 Sep; 8(?):299. doi:
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Acta tropica.
2014 Mar; 131(?):32-6. doi:
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Toxicology and applied pharmacology.
2013 Dec; 273(2):401-9. doi:
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Biochemical and biophysical research communications.
2013 Nov; 441(3):544-9. doi:
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Cancer chemotherapy and pharmacology.
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Experimental cell research.
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Circulation research.
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PloS one.
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International journal of molecular medicine.
2012 Nov; 30(5):1138-44. doi:
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Laboratory investigation; a journal of technical methods and pathology.
2012 Nov; 92(11):1583-96. doi:
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Journal of controlled release : official journal of the Controlled Release Society.
2012 Oct; 163(1):93-9. doi:
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Clinical cancer research : an official journal of the American Association for Cancer Research.
2012 Sep; 18(18):4973-85. doi:
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FEBS letters.
2012 Jul; 586(16):2535-41. doi:
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International journal of oncology.
2012 Jul; 41(1):46-52. doi:
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Clinical cancer research : an official journal of the American Association for Cancer Research.
2012 Apr; 18(7):1888-900. doi:
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PLoS pathogens.
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Clinical cancer research : an official journal of the American Association for Cancer Research.
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Molecular pharmacology.
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Nutrition and cancer.
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The Journal of biological chemistry.
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American journal of physiology. Renal physiology.
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British journal of haematology.
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