2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one (BioDeep_00000172948)
human metabolite blood metabolite
代谢物信息卡片
2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one
化学式: C16H13NO3 (267.0895)
中文名称: 2-(2-氨基-3-甲氧苯基)色酮
谱图信息:
最多检出来源 Homo sapiens(endogenous) 17.5%
分子结构信息
SMILES: COC1=CC=CC(=C1N)C1=CC(=O)C2=CC=CC=C2O1
InChI: InChI=1S/C16H13NO3/c1-19-14-8-4-6-11(16(14)17)15-9-12(18)10-5-2-3-7-13(10)20-15/h2-9H,17H2,1H3
描述信息
C274 - Antineoplastic Agent > C163758 - Targeted Therapy Agent > C69145 - Mitogen-Activated Protein Kinase Kinase Inhibitor
C274 - Antineoplastic Agent > C163758 - Targeted Therapy Agent > C2149 - Mitogen-Activated Protein Kinase Inhibitor
C471 - Enzyme Inhibitor > C1404 - Protein Kinase Inhibitor > C61074 - Serine/Threonine Kinase Inhibitor
D004791 - Enzyme Inhibitors > D047428 - Protein Kinase Inhibitors
PD98059 is a potent and selective MEK inhibitor with an IC50 of 5 μM. PD98059 binds to the inactive form of MEK, thereby preventing the activation of MEK1 (IC50 of 2-7 μM) and MEK2 (IC50 of 50 μM) by upstream kinases. PD98059 is a ERK1/2 signaling inhibitor. PD98059 is a ligand for the aryl hydrocarbon receptor (AHR), and suppresses TCDD binding (IC50 of 4 μM) and AHR transformation (IC50 of 1 μM). PD98059 also inhibits Mycobacterium bovis Bacillus CalmetteGuerin (BCG)-induced autophagy[1][2][3].
同义名列表
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:77954
- PubChem: 4713
- HMDB: HMDB0244751
- ChEMBL: CHEMBL35482
- chemspider: 4551
- CAS: 167869-21-8
- medchemexpress: HY-12028
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
|---|
文献列表
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International journal of molecular sciences.
2021 Sep; 22(19):. doi:
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Hepatology (Baltimore, Md.).
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The Journal of membrane biology.
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Journal of lipid research.
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Molecular neurobiology.
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Nutrients.
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The Journal of biological chemistry.
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Cellular signalling.
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Bioscience, biotechnology, and biochemistry.
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Nutrients.
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Toxicology and applied pharmacology.
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Biochemical and biophysical research communications.
2017 Jan; 482(4):727-734. doi:
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Mediators of inflammation.
2017; 2017(?):2086840. doi:
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Chinese journal of integrative medicine.
2017 Jan; 23(1):40-47. doi:
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American journal of physiology. Endocrinology and metabolism.
2017 01; 312(1):E27-E36. doi:
10.1152/ajpendo.00203.2016. [PMID: 27827806] - Yoolhee Yang, Hee Jung Kim, Kyong-Je Woo, Daeho Cho, Sa Ik Bang. Lipo-PGE1 suppresses collagen production in human dermal fibroblasts via the ERK/Ets-1 signaling pathway.
PloS one.
2017; 12(6):e0179614. doi:
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PloS one.
2017; 12(5):e0177862. doi:
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PloS one.
2017; 12(7):e0181085. doi:
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Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2017; 43(6):2353-2366. doi:
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Acta pharmacologica Sinica.
2017 Jan; 38(1):29-40. doi:
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Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2017; 41(5):1957-1969. doi:
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Protoplasma.
2016 Nov; 253(6):1541-1556. doi:
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Journal of tissue engineering and regenerative medicine.
2016 10; 10(10):E537-E545. doi:
10.1002/term.1864. [PMID: 24634418] - Guanmin Meng, Kequn Chai, Xinda Li, Yongqiang Zhu, Weihua Huang. Luteolin exerts pro-apoptotic effect and anti-migration effects on A549 lung adenocarcinoma cells through the activation of MEK/ERK signaling pathway.
Chemico-biological interactions.
2016 Sep; 257(?):26-34. doi:
10.1016/j.cbi.2016.07.028. [PMID: 27474067] - Gwang Hun Park, Hun Min Song, Jin Boo Jeong. The coffee diterpene kahweol suppresses the cell proliferation by inducing cyclin D1 proteasomal degradation via ERK1/2, JNK and GKS3β-dependent threonine-286 phosphorylation in human colorectal cancer cells.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2016 Sep; 95(?):142-8. doi:
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Journal of ethnopharmacology.
2016 Jul; 187(?):28-41. doi:
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Angiogenesis.
2016 07; 19(3):311-24. doi:
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Biochemical and biophysical research communications.
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Proceedings of the National Academy of Sciences of the United States of America.
2016 Apr; 113(17):4759-64. doi:
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International journal of oncology.
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Chemico-biological interactions.
2016 Feb; 245(?):110-21. doi:
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International journal of molecular sciences.
2016 Jan; 17(1):. doi:
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Toxicology.
2016 Jan; 339(?):40-50. doi:
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Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2016; 39(4):1329-38. doi:
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Molecular medicine reports.
2016 Jan; 13(1):433-40. doi:
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Genetics and molecular research : GMR.
2015 Dec; 14(4):18325-33. doi:
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Molecular medicine reports.
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Arthritis & rheumatology (Hoboken, N.J.).
2015 Sep; 67(9):2383-93. doi:
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Plant biology (Stuttgart, Germany).
2015 Sep; 17(5):946-52. doi:
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International immunopharmacology.
2015 Sep; 28(1):531-9. doi:
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Chemico-biological interactions.
2015 Aug; 238(?):66-73. doi:
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Molecular medicine reports.
2015 Aug; 12(2):2643-9. doi:
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Molecular medicine reports.
2015 Jul; 12(1):696-704. doi:
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Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine.
2015 Jul; 35(7):847-53. doi:
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Experimental and therapeutic medicine.
2015 Jun; 9(6):2072-2080. doi:
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Biochemical and biophysical research communications.
2015 Apr; 459(3):379-86. doi:
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Food & function.
2015 Apr; 6(4):1331-44. doi:
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Canadian journal of diabetes.
2015 Apr; 39(2):123-7. doi:
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International journal of molecular medicine.
2015 Apr; 35(4):1042-50. doi:
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Toxicology in vitro : an international journal published in association with BIBRA.
2015 Mar; 29(2):380-8. doi:
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Experimental cell research.
2015 Mar; 332(1):116-27. doi:
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Journal of cellular and molecular medicine.
2015 Mar; 19(3):630-41. doi:
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Basic & clinical pharmacology & toxicology.
2015 Feb; 116(2):96-109. doi:
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Tsitologiia.
2015; 57(4):269-77. doi:
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Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2015; 36(6):2418-32. doi:
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