p-MPPF (BioDeep_00000172906)

   

human metabolite blood metabolite


代谢物信息卡片


4-fluoro-N-{2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl}-N-(pyridin-2-yl)benzamide

化学式: C25H27FN4O2 (434.2117934)
中文名称: 4-氟-N-(2-[4-(2-甲氧苯基)1-哌嗪基]乙基)-N-(2-吡啶基)苯酰胺二盐酸
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: COC1=CC=CC=C1N1CCN(CCN(C(=O)C2=CC=C(F)C=C2)C2=CC=CC=N2)CC1
InChI: InChI=1S/C25H27FN4O2/c1-32-23-7-3-2-6-22(23)29-17-14-28(15-18-29)16-19-30(24-8-4-5-13-27-24)25(31)20-9-11-21(26)12-10-20/h2-13H,14-19H2,1H3

描述信息

同义名列表

6 个代谢物同义名

4-fluoro-N-{2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl}-N-(pyridin-2-yl)benzamide; 4-fluoro-n-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-n-pyridin-2-ylbenzamide; 4-(2 Methoxyphenyl)-1-(2-(N-(2-pyridinyl)-4-fluorobenzamido)ethyl)piperazine; 4-MPPF; p-MPPF; MPPF



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

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COVID-19 Disease Map(0)

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1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • F Lecomte, J Aerts, A Plenevaux, C Defraiteur, F Chapuis-Hugon, E Rozet, P Chiap, A Luxen, V Pichon, Ph Hubert, C Hubert. Performance evaluation of a MIP for the MISPE-LC determination of p-[18F]MPPF and a potential metabolite in human plasma. Journal of pharmaceutical and biomedical analysis. 2020 Feb; 180(?):113015. doi: 10.1016/j.jpba.2019.113015. [PMID: 31865206]
  • G Aditya Kumar, Parijat Sarkar, Md Jafurulla, Shishu Pal Singh, Gunda Srinivas, Gopal Pande, Amitabha Chattopadhyay. Exploring Endocytosis and Intracellular Trafficking of the Human Serotonin1A Receptor. Biochemistry. 2019 06; 58(22):2628-2641. doi: 10.1021/acs.biochem.9b00033. [PMID: 30896156]
  • Patrícia de Souza Villa, José Vanderlei Menani, Gabriela Maria Pavan de Arruda Camargo, Luiz Antônio de Arruda Camargo, Wilson Abrão Saad. Activation of the serotonergic 5-HT1A receptor in the paraventricular nucleus of the hypothalamus inhibits water intake and increases urinary excretion in water-deprived rats. Regulatory peptides. 2008 Oct; 150(1-3):14-20. doi: 10.1016/j.regpep.2008.05.003. [PMID: 18556076]
  • Caroline Defraiteur, Christian Lemaire, André Luxen, Alain Plenevaux. Radiochemical synthesis and tissue distribution of p-[18F]DMPPF, a new 5-HT1A ligand for PET, in rats. Nuclear medicine and biology. 2006 Jul; 33(5):667-75. doi: 10.1016/j.nucmedbio.2006.03.010. [PMID: 16843842]
  • Thomas J Pucadyil, Amitabha Chattopadhyay. Cholesterol modulates the antagonist-binding function of hippocampal serotonin1A receptors. Biochimica et biophysica acta. 2005 Aug; 1714(1):35-42. doi: 10.1016/j.bbamem.2005.06.005. [PMID: 16005846]
  • Nicole Praschak-Rieder, Douglas Hussey, Alan A Wilson, Anna Carella, Maggie Lee, Edward Dunn, Matthäus Willeit, R Michael Bagby, Sylvain Houle, Jeffrey H Meyer. Tryptophan depletion and serotonin loss in selective serotonin reuptake inhibitor-treated depression: an [(18)F] MPPF positron emission tomography study. Biological psychiatry. 2004 Oct; 56(8):587-91. doi: 10.1016/j.biopsych.2004.07.018. [PMID: 15476688]
  • Nicolas Costes, Isabelle Merlet, Luc Zimmer, Franck Lavenne, Luc Cinotti, Jacques Delforge, André Luxen, Jean-François Pujol, Didier Le Bars. Modeling [18 F]MPPF positron emission tomography kinetics for the determination of 5-hydroxytryptamine(1A) receptor concentration with multiinjection. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2002 Jun; 22(6):753-65. doi: 10.1097/00004647-200206000-00014. [PMID: 12045674]
  • Sandra M Sanabria-Bohórquez, Francoise Biver, Philippe Damhaut, David Wikler, Claude Veraart, Serge Goldman. Quantification of 5-HT(1A) receptors in human brain using p-MPPF kinetic modelling and PET. European journal of nuclear medicine and molecular imaging. 2002 Jan; 29(1):76-81. doi: 10.1007/s00259-001-0684-2. [PMID: 11807610]
  • J Passchier, A van Waarde, W Vaalburg, A T Willemsen. On the quantification of [18F]MPPF binding to 5-HT1A receptors in the human brain. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2001 Jul; 42(7):1025-31. doi: NULL. [PMID: 11438622]
  • J Passchier, A van Waarde, P Doze, P H Elsinga, W Vaalburg. Influence of P-glycoprotein on brain uptake of [18F]MPPF in rats. European journal of pharmacology. 2000 Nov; 407(3):273-80. doi: 10.1016/s0014-2999(00)00752-4. [PMID: 11068023]
  • A Plenevaux, D Weissmann, J Aerts, C Lemaire, C Brihaye, C Degueldre, D Le Bars, D Comar, J Pujol, A Luxen. Tissue distribution, autoradiography, and metabolism of 4-(2'-methoxyphenyl)-1-[2' -[N-2'-pyridinyl)-p-[(18)F]fluorobenzamido]ethyl]piperazine (p-[(18)F]MPPF), a new serotonin 5-HT(1A) antagonist for positron emission tomography: An In vivo study in rats. Journal of neurochemistry. 2000 Aug; 75(2):803-11. doi: 10.1046/j.1471-4159.2000.0750803.x. [PMID: 10899958]
  • J Passchier, A van Waarde, R M Pieterman, P H Elsinga, J Pruim, H N Hendrikse, A T Willemsen, W Vaalburg. Quantitative imaging of 5-HT(1A) receptor binding in healthy volunteers with [(18)f]p-MPPF. Nuclear medicine and biology. 2000 Jul; 27(5):473-6. doi: 10.1016/s0969-8051(00)00114-1. [PMID: 10962253]
  • C Y Shiue, G G Shiue, P D Mozley, M P Kung, Z P Zhuang, H J Kim, H F Kung. P-[18F]-MPPF: a potential radioligand for PET studies of 5-HT1A receptors in humans. Synapse (New York, N.Y.). 1997 Feb; 25(2):147-54. doi: 10.1002/(sici)1098-2396(199702)25:2<147::aid-syn5>3.0.co;2-c. [PMID: 9021895]