4-Tert-butyl-N-[6-(2-hydroxyethoxy)-5-(3-methoxyphenoxy)pyrimidin-4-yl]benzenesulfonamide (BioDeep_00000172888)

   

human metabolite blood metabolite


代谢物信息卡片


4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(3-methoxyphenoxy)pyrimidin-4-yl]benzene-1-sulfonamide

化学式: C23H27N3O6S (473.1620482000001)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(C)(C)C1=CC=C(C=C1)S(=O)(=O)NC2=C(C(=NC=N2)OCCO)OC3=CC=CC(=C3)OC
InChI: InChI=1S/C23H27N3O6S/c1-23(2,3)16-8-10-19(11-9-16)33(28,29)26-21-20(22(25-15-24-21)31-13-12-27)32-18-7-5-6-17(14-18)30-4/h5-11,14-15,27H,12-13H2,1-4H3,(H,24,25,26)

描述信息

D065128 - Endothelin Receptor Antagonists
Ro 46-2005 is a novel synthetic non-peptide endothelin receptor antagonist, inhibits the specific binding of 125I-ET-1 to human vascular smooth muscle cells (ETA receptor) with IC50 of 220 nM. IC50 value: 220 nM (ETA) [2] Target: Endothelin in vitro: Ro 46-2005 proves to be equipotent (IC50 200-500 nM) for inhibition of [125I]ET-1 binding on the two known ET receptor subtypes (ETA and ETB). Ro 46-2005 also inhibits the functional consequences of ET-1 stimulation: the ET-l-induced release of arachidonic acid from rat mesangial cells was inhibited with an IC50 of 1.8 μM.[1]

同义名列表

5 个代谢物同义名

4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(3-methoxyphenoxy)pyrimidin-4-yl]benzene-1-sulfonamide; 4-Tert-butyl-N-[6-(2-hydroxyethoxy)-5-(3-methoxyphenoxy)pyrimidin-4-yl]benzenesulphonamide; 4-Tert-butyl-N-(6-(2-hydroxyethoxy)-5-(3-methoxyphenoxy)-4-pyrimidinyl)benzenesulfonamide; 4-Tert-butyl-N-[6-(2-hydroxyethoxy)-5-(3-methoxyphenoxy)pyrimidin-4-yl]benzenesulfonamide; Ro 46-2005



数据库引用编号

7 个数据库交叉引用编号

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相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • M Clozel, C Qiu, R Osterwalder, A Roeckel, P Bruneval, D Heudes, J P Clozel. Effects of nonpeptide endothelin receptor antagonists in rats with reduced renal mass. Journal of cardiovascular pharmacology. 1999 Apr; 33(4):611-8. doi: 10.1097/00005344-199904000-00014. [PMID: 10218732]
  • A V Nabokov, K Amann, S Wessels, K Münter, J Wagner, E Ritz. Endothelin receptor antagonists influence cardiovascular morphology in uremic rats. Kidney international. 1999 Feb; 55(2):512-9. doi: 10.1046/j.1523-1755.1999.00290.x. [PMID: 9987075]
  • A Nabokov, K Amann, J Wagner, F Gehlen, K Münter, E Ritz. Influence of specific and non-specific endothelin receptor antagonists on renal morphology in rats with surgical renal ablation. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 1996 Mar; 11(3):514-20. doi: 10.1093/oxfordjournals.ndt.a027320. [PMID: 8671823]
  • B M Löffler, V Breu, M Clozel. Effect of different endothelin receptor antagonists and of the novel non-peptide antagonist Ro 46-2005 on endothelin levels in rat plasma. FEBS letters. 1993 Oct; 333(1-2):108-10. doi: 10.1016/0014-5793(93)80384-7. [PMID: 8224145]
  • M Clozel, V Breu, K Burri, J M Cassal, W Fischli, G A Gray, G Hirth, B M Löffler, M Müller, W Neidhart. Pathophysiological role of endothelin revealed by the first orally active endothelin receptor antagonist. Nature. 1993 Oct; 365(6448):759-61. doi: 10.1038/365759a0. [PMID: 8413655]