6-Chloro-5-(4-(1-hydroxycyclobutyl)phenyl)-1H-indole-3-carboxylic acid (BioDeep_00000172860)

   

human metabolite blood metabolite


代谢物信息卡片


6-chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1H-indole-3-carboxylic acid

化学式: C19H16ClNO3 (341.0818656)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1CC(C1)(C2=CC=C(C=C2)C3=C(C=C4C(=C3)C(=CN4)C(=O)O)Cl)O
InChI: InChI=1S/C19H16ClNO3/c20-16-9-17-14(15(10-21-17)18(22)23)8-13(16)11-2-4-12(5-3-11)19(24)6-1-7-19/h2-5,8-10,21,24H,1,6-7H2,(H,22,23)

描述信息

PF-06409577 is a potent and selective allosteric activator of AMPK α1β1γ1 isoform with an EC50 of 7 nM.

同义名列表

4 个代谢物同义名

6-chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1H-indole-3-carboxylic acid; 6-Chloro-5-(4-(1-hydroxycyclobutyl)phenyl)-1H-indole-3-carboxylic acid; 6-Chloro-5-(4-(1-hydroxycyclobutyl)phenyl)-1H-indole-3-carboxylate; PF-06409577



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • F Anthony Romero, Christopher T Jones, Yingzi Xu, Martijn Fenaux, Randall L Halcomb. The Race to Bash NASH: Emerging Targets and Drug Development in a Complex Liver Disease. Journal of medicinal chemistry. 2020 05; 63(10):5031-5073. doi: 10.1021/acs.jmedchem.9b01701. [PMID: 31930920]
  • Kimberly Lapham, Jian Lin, Jonathan Novak, Christine Orozco, Mark Niosi, Li Di, Theunis C Goosen, Sangwoo Ryu, Keith Riccardi, Heather Eng, Kimberly O Cameron, Amit S Kalgutkar. 6-Chloro-5-[4-(1-Hydroxycyclobutyl)Phenyl]-1H-Indole-3-Carboxylic Acid is a Highly Selective Substrate for Glucuronidation by UGT1A1, Relative to β-Estradiol. Drug metabolism and disposition: the biological fate of chemicals. 2018 12; 46(12):1836-1846. doi: 10.1124/dmd.118.083709. [PMID: 30194276]
  • Nereida Jiménez de Oya, Ana-Belén Blázquez, Josefina Casas, Juan-Carlos Saiz, Miguel A Martín-Acebes. Direct Activation of Adenosine Monophosphate-Activated Protein Kinase (AMPK) by PF-06409577 Inhibits Flavivirus Infection through Modification of Host Cell Lipid Metabolism. Antimicrobial agents and chemotherapy. 2018 07; 62(7):. doi: 10.1128/aac.00360-18. [PMID: 29712653]
  • Xiao-Feng Li, Xiu-Ming Liu, Da-Rui Huang, Hai-Jing Cao, Jun-Ying Wang. PF-06409577 activates AMPK signaling to protect retinal pigment epithelium cells from UV radiation. Biochemical and biophysical research communications. 2018 06; 501(1):293-299. doi: 10.1016/j.bbrc.2018.05.003. [PMID: 29733844]
  • Marc Foretz, Benoit Viollet. Activation of AMPK for a Break in Hepatic Lipid Accumulation and Circulating Cholesterol. EBioMedicine. 2018 05; 31(?):15-16. doi: 10.1016/j.ebiom.2018.05.009. [PMID: 29754882]
  • Ryan M Esquejo, Christopher T Salatto, Jake Delmore, Bina Albuquerque, Allan Reyes, Yuji Shi, Rob Moccia, Emily Cokorinos, Matthew Peloquin, Mara Monetti, Jason Barricklow, Eliza Bollinger, Brennan K Smith, Emily A Day, Chuong Nguyen, Kieran F Geoghegan, John M Kreeger, Alan Opsahl, Jessica Ward, Amit S Kalgutkar, David Tess, Lynne Butler, Norimitsu Shirai, Timothy F Osborne, Gregory R Steinberg, Morris J Birnbaum, Kimberly O Cameron, Russell A Miller. Activation of Liver AMPK with PF-06409577 Corrects NAFLD and Lowers Cholesterol in Rodent and Primate Preclinical Models. EBioMedicine. 2018 May; 31(?):122-132. doi: 10.1016/j.ebiom.2018.04.009. [PMID: 29673898]
  • David J Edmonds, Daniel W Kung, Amit S Kalgutkar, Kevin J Filipski, David C Ebner, Shawn Cabral, Aaron C Smith, Gary E Aspnes, Samit K Bhattacharya, Kris A Borzilleri, Janice A Brown, Matthew F Calabrese, Nicole L Caspers, Emily C Cokorinos, Edward L Conn, Matthew S Dowling, Heather Eng, Bo Feng, Dilinie P Fernando, Nathan E Genung, Michael Herr, Ravi G Kurumbail, Sophie Y Lavergne, Esther C-Y Lee, Qifang Li, Sumathy Mathialagan, Russell A Miller, Jane Panteleev, Jana Polivkova, Francis Rajamohan, Allan R Reyes, Christopher T Salatto, Andre Shavnya, Benjamin A Thuma, Meihua Tu, Jessica Ward, Jane M Withka, Jun Xiao, Kimberly O Cameron. Optimization of Metabolic and Renal Clearance in a Series of Indole Acid Direct Activators of 5'-Adenosine Monophosphate-Activated Protein Kinase (AMPK). Journal of medicinal chemistry. 2018 03; 61(6):2372-2383. doi: 10.1021/acs.jmedchem.7b01641. [PMID: 29466005]
  • Christopher T Salatto, Russell A Miller, Kimberly O Cameron, Emily Cokorinos, Allan Reyes, Jessica Ward, Matthew F Calabrese, Ravi G Kurumbail, Francis Rajamohan, Amit S Kalgutkar, David A Tess, Andre Shavnya, Nathan E Genung, David J Edmonds, Aditi Jatkar, Benjamin S Maciejewski, Marina Amaro, Harmeet Gandhok, Mara Monetti, Katherine Cialdea, Eliza Bollinger, John M Kreeger, Timothy M Coskran, Alan C Opsahl, Germaine G Boucher, Morris J Birnbaum, Paul DaSilva-Jardine, Tim Rolph. Selective Activation of AMPK β1-Containing Isoforms Improves Kidney Function in a Rat Model of Diabetic Nephropathy. The Journal of pharmacology and experimental therapeutics. 2017 05; 361(2):303-311. doi: 10.1124/jpet.116.237925. [PMID: 28289077]