Ginsenoside C (BioDeep_00000017284)

Main id: BioDeep_00000403060

 

human metabolite PANOMIX_OTCML-2023 Endogenous


代谢物信息卡片


2-[2-[[3,12-dihydroxy-17-(2-hydroxy-6-methylhept-5-en-2-yl)-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-6-yl]oxy]-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl]oxy-6-methyloxane-3,4,5-triol

化学式: C42H72O13 (784.4972662)
中文名称: 20(R)-人参皂苷 Rg2, 20(R)人参皂苷 Rg2, 20(R)-人参皂苷Rg2, 人参皂甙 Rg2, 20(R)-人参皂苷RG2
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(C)=CCCC(C)(O)C1CCC2(C)C1C(O)CC1C3(C)CCC(O)C(C)(C)C3C(OC3OC(CO)C(O)C(O)C3OC3OC(C)C(O)C(O)C3O)CC12C
InChI: InChI=1S/C42H72O13/c1-20(2)11-10-14-42(9,51)22-12-16-40(7)28(22)23(44)17-26-39(6)15-13-27(45)38(4,5)35(39)24(18-41(26,40)8)53-37-34(32(49)30(47)25(19-43)54-37)55-36-33(50)31(48)29(46)21(3)52-36/h11,21-37,43-51H,10,12-19H2,1-9H3

描述信息

2-[2-[[3,12-dihydroxy-17-(2-hydroxy-6-methylhept-5-en-2-yl)-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-6-yl]oxy]-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl]oxy-6-methyloxane-3,4,5-triol is a natural product found in Panax notoginseng with data available.
Ginsenoside C is found in tea. Ginsenoside C is a constituent of Panax ginseng (ginseng)
Constituent of Panax ginseng (ginseng). Ginsenoside C is found in tea.
20(R)-Ginsenoside Rg2 shows inhibitory effects on lung cancer NCI-H1650 cells. Anti-cancer activities[1].
20(R)-Ginsenoside Rg2 shows inhibitory effects on lung cancer NCI-H1650 cells. Anti-cancer activities[1].
Ginsenoside Rg2 is one of the major active components of ginseng. Ginsenoside Rg2 inhibits VCAM-1 and ICAM-1 expressions stimulated with lipopolysaccharide (LPS). Ginsenoside Rg2 also reduces Aβ1-42 accumulation.
Ginsenoside Rg2 is one of the major active components of ginseng. Ginsenoside Rg2 inhibits VCAM-1 and ICAM-1 expressions stimulated with lipopolysaccharide (LPS). Ginsenoside Rg2 also reduces Aβ1-42 accumulation.

同义名列表

12 个代谢物同义名

2-[2-[[3,12-dihydroxy-17-(2-hydroxy-6-methylhept-5-en-2-yl)-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-6-yl]oxy]-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl]oxy-6-methyloxane-3,4,5-triol; 2-[(2-{[5,16-dihydroxy-14-(2-hydroxy-6-methylhept-5-en-2-yl)-2,6,6,10,11-pentamethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadecan-8-yl]oxy}-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl)oxy]-6-methyloxane-3,4,5-triol; ginsenoside-Rg2, (3beta,6alpha,12beta,20R)-isomer; 20(R)-Ginsenoside Rg2; 20(R)Ginsenoside Rg2; Chikusetsusaponin I; 20(R)-Ginsenoside; ginsenoside-Rg2; Prosapogenin C2; Ginsenoside RG2; Panaxoside Rg2; Ginsenoside C



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Yu-Shun Lu, Zheng-Bo Liu, Yan-Yang Xu, Ji-Yue Sha, Di Qu, Yin-Shi Sun. Uptake and accumulation of di(2-ethylhexyl) phthalate (DEHP) in a soil-ginseng system and toxicological mechanisms on ginseng (Panax ginseng C.A. Meyer). The Science of the total environment. 2024 Mar; 914(?):170040. doi: 10.1016/j.scitotenv.2024.170040. [PMID: 38215853]
  • Silu Liu, Weijia Chen, Yan Zhao, Ying Zong, Jianming Li, Zhongmei He. Research Progress on Effects of Ginsenoside Rg2 and Rh1 on Nervous System and Related Mechanisms. Molecules (Basel, Switzerland). 2023 Dec; 28(23):. doi: 10.3390/molecules28237935. [PMID: 38067664]
  • Haijian Sun, Yunke Guo, Haidan Wang, Ailing Yin, Jing Hu, Tianjie Yuan, Shuxin Zhou, Weichen Xu, Peng Wei, Shusheng Yin, Panru Liu, Xi Guo, Yizhao Tang, Yujiao Yan, Zichen Luo, Majie Wang, Qingqing Liang, Peng Wu, Aifeng Zhang, Zhuxiu Zhou, Yueyue Chen, Yongming Li, Jing Li, Jinjun Shan, Wei Zhou. Gut commensal Parabacteroides distasonis alleviates inflammatory arthritis. Gut. 2023 Jan; ?(?):. doi: 10.1136/gutjnl-2022-327756. [PMID: 36604114]
  • Ziwei He, Siyu Chen, Tingting Pan, Ao Li, Kangyu Wang, Zhuofeng Lin, Wei Liu, Yi Wang, Yanfang Wang. Ginsenoside Rg2 Ameliorating CDAHFD-Induced Hepatic Fibrosis by Regulating AKT/mTOR-Mediated Autophagy. Journal of agricultural and food chemistry. 2022 Feb; 70(6):1911-1922. doi: 10.1021/acs.jafc.1c07578. [PMID: 35104139]
  • Liying Cai, Feifei Hu, Wenwen Fu, Xiaofeng Yu, Weijie Zhong, Fangcong Liu, Tian Wang, Dayuan Sui. Ginsenoside Rg2 Ameliorates Brain Injury After Intracerebral Hemorrhage in a Rat Model of Preeclampsia. Reproductive sciences (Thousand Oaks, Calif.). 2021 12; 28(12):3431-3439. doi: 10.1007/s43032-021-00692-2. [PMID: 34270001]
  • Xianghai Li, Ning Xiang, Zhengrong Wang. Ginsenoside Rg2 attenuates myocardial fibrosis and improves cardiac function after myocardial infarction via AKT signaling pathway. Bioscience, biotechnology, and biochemistry. 2020 Nov; 84(11):2199-2206. doi: 10.1080/09168451.2020.1793292. [PMID: 32706304]
  • Yi-Ju Hsu, Chao-Yun Wang, Mon-Chien Lee, Chi-Chang Huang. Hepatoprotection by Traditional Essence of Ginseng against Carbon Tetrachloride-Induced Liver Damage. Nutrients. 2020 Oct; 12(10):. doi: 10.3390/nu12103214. [PMID: 33096694]
  • Diem Thi Ngoc Huynh, Naehwan Baek, Sohyun Sim, Chang-Seon Myung, Kyung-Sun Heo. Minor Ginsenoside Rg2 and Rh1 Attenuates LPS-Induced Acute Liver and Kidney Damages via Downregulating Activation of TLR4-STAT1 and Inflammatory Cytokine Production in Macrophages. International journal of molecular sciences. 2020 Sep; 21(18):. doi: 10.3390/ijms21186656. [PMID: 32932915]
  • Bo Cheng, Weihang Gao, Xiaojie Wu, Mingxuan Zheng, Yuanyuan Yu, Chunhui Song, Wei Miao, Zehong Yang, Yuqing He, Changhui Liu, Wangyin Yang, Xiaoying Yang, Yanwu Li, Fang Zhang, Yong Gao. Ginsenoside Rg2 Ameliorates High-Fat Diet-Induced Metabolic Disease through SIRT1. Journal of agricultural and food chemistry. 2020 Apr; 68(14):4215-4226. doi: 10.1021/acs.jafc.0c00833. [PMID: 32181656]
  • Zhuo-Wei Gao, Rong-Le Ju, Min Luo, Shu-Lian Wu, Wen-Tong Zhang. The anxiolytic-like effects of ginsenoside Rg2 on an animal model of PTSD. Psychiatry research. 2019 09; 279(?):130-137. doi: 10.1016/j.psychres.2018.12.034. [PMID: 31103345]
  • Tanya Biswas, A K Mathur, Archana Mathur. A literature update elucidating production of Panax ginsenosides with a special focus on strategies enriching the anti-neoplastic minor ginsenosides in ginseng preparations. Applied microbiology and biotechnology. 2017 May; 101(10):4009-4032. doi: 10.1007/s00253-017-8279-4. [PMID: 28411325]
  • Ming-shan Pi, Qin Ru, Xiao-kang Gong, Ri-hui Wu, Xiang Tian, Xiong Qi, Chao-ying Li. [Effect of Ginsenoside Rg2 and Its Stereoisomers on Oxygen-Glucose Deprivation and Reperfusion Induced Cortical Neuronal Injury Model]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine. 2016 Mar; 36(3):333-8. doi: ". [PMID: 27236892]
  • Atsushi Kawase, Ayano Yamada, Yuko Gamou, Chika Tahara, Fumiaki Takeshita, Kazuya Murata, Hideaki Matsuda, Keiichi Samukawa, Masahiro Iwaki. Effects of ginsenosides on the expression of cytochrome P450s and transporters involved in cholesterol metabolism. Journal of natural medicines. 2014 Apr; 68(2):395-401. doi: 10.1007/s11418-013-0791-y. [PMID: 23835644]
  • C T Li, H B Wang, B J Xu. A comparative study on anticoagulant activities of three Chinese herbal medicines from the genus Panax and anticoagulant activities of ginsenosides Rg1 and Rg2. Pharmaceutical biology. 2013 Aug; 51(8):1077-80. doi: 10.3109/13880209.2013.775164. [PMID: 23742679]
  • Lin-Fang Huang, Feng-Mei Suo, Jing-Yuan Song, Mei-Jia Wen, Guang-Lin Jia, Cai-Xiang Xie, Shi-Lin Chen. [Quality variation and ecotype division of Panax quinquefolium in China]. Yao xue xue bao = Acta pharmaceutica Sinica. 2013 Apr; 48(4):580-9. doi: ". [PMID: 23833949]
  • Xiuwei Yang, Fangjin Gui, Yan Song, Weiqing Zhang, Jianming Tian, Longyun Li. [Study on excretion of ginsenoside Rg2 in rats]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2009 May; 34(10):1281-4. doi: NULL. [PMID: 19673396]
  • Jun-Ling Cao, Zu-Lun Li, Xiao-He Xiao. [Effects of 3 genosides on bio-thermodynamic expression of splenic lymphocyte in mice]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine. 2008 Jan; 28(1):54-7. doi: ". [PMID: 18418972]
  • Guangtong Chen, Min Yang, Zhiqiang Lu, Jinqiang Zhang, Huilian Huang, Yan Liang, Shuhong Guan, Yan Song, Lijun Wu, De-an Guo. Microbial transformation of 20(S)-protopanaxatriol-type saponins by Absidia coerulea. Journal of natural products. 2007 Jul; 70(7):1203-6. doi: 10.1021/np070053v. [PMID: 17629326]
  • Na Li, Bin Liu, Dean E Dluzen, Yi Jin. Protective effects of ginsenoside Rg2 against glutamate-induced neurotoxicity in PC12 cells. Journal of ethnopharmacology. 2007 May; 111(3):458-63. doi: 10.1016/j.jep.2006.12.015. [PMID: 17257792]
  • Fang-Jin Gui, Xiu-Wei Yang, Long-Yun Li, Jian-Ming Tian. Simultaneous enantiomer determination of 20 (R)- and 20 (S)-ginsenoside-Rg2 in rat plasma after intravenous administration using HPLC method. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2007 May; 850(1-2):1-6. doi: 10.1016/j.jchromb.2006.11.008. [PMID: 17113840]
  • Jian-ming Tian, Hao Li, Jin-mei Ye, Wei-fang Guo, Lon-yun Li, Li-ping Wang. [Effect of ginsenoside Rg2 on chemical myocardial ischemia in rats]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2003 Dec; 28(12):1191-2. doi: ". [PMID: 15617510]
  • Jun-Ho Lee, Sang Min Jeong, Byung-Hwan Lee, Dong-Hyun Kim, Jong-Hoon Kim, Jai-Il Kim, Sang-Mok Lee, Seung-Yeol Nah. Differential effect of bovine serum albumin on ginsenoside metabolite-induced inhibition of alpha3beta4 nicotinic acetylcholine receptor expressed in Xenopus oocytes. Archives of pharmacal research. 2003 Oct; 26(10):868-73. doi: 10.1007/bf02980034. [PMID: 14609137]
  • Sung-Ryong Ko, Kang-Ju Choi, Kei Suzuki, Yukio Suzuki. Enzymatic preparation of ginsenosides Rg2, Rh1, and F1. Chemical & pharmaceutical bulletin. 2003 Apr; 51(4):404-8. doi: 10.1248/cpb.51.404. [PMID: 12672992]
  • Sung-Ryong Ko, Kang-Ju Choi, Kei Uchida, Yukio Suzuki. Enzymatic preparation of ginsenosides Rg2, Rh1, and F1 from protopanaxatriol-type ginseng saponin mixture. Planta medica. 2003 Mar; 69(3):285-6. doi: 10.1055/s-2003-38476. [PMID: 12677539]
  • E Tachikawa, K Kudo, M Nunokawa, T Kashimoto, E Takahashi, S Kitagawa. Characterization of ginseng saponin ginsenoside-Rg(3) inhibition of catecholamine secretion in bovine adrenal chromaffin cells. Biochemical pharmacology. 2001 Oct; 62(7):943-51. doi: 10.1016/s0006-2952(01)00743-2. [PMID: 11543730]
  • J Lu, W W Lu, J M Tian, L Y Li. [Effect of Rg2 on hemodynamics of hemorrhagic shock and its antioxidation in dogs]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2001 Aug; 26(8):556-8. doi: NULL. [PMID: 12776372]
  • S R Yoon, J J Nah, S K Kim, S C Kim, K Y Nam, D W Jung, S Y Nah. Determination of ginsenoside Rf and Rg2 from Panax ginseng using enzyme immunoassay. Chemical & pharmaceutical bulletin. 1998 Jul; 46(7):1144-7. doi: 10.1248/cpb.46.1144. [PMID: 9692222]
  • K Kudo, E Tachikawa, T Kashimoto, E Takahashi. Properties of ginseng saponin inhibition of catecholamine secretion in bovine adrenal chromaffin cells. European journal of pharmacology. 1998 Jan; 341(2-3):139-44. doi: 10.1016/s0014-2999(97)01350-2. [PMID: 9543231]
  • H X Kuang. [Rhizoma ginseng (III)--Isolation and identification of saponins E1 and E2]. Zhong yao tong bao (Beijing, China : 1981). 1986 Mar; 11(3):39-40, 38. doi: ". [PMID: 2943490]