2-(2-Chlorophenyl)-4-(3-(dimethylamino)phenyl)-5-methyl-1H-pyrazolo[4,3-c]pyridine-3,6(2H,5H)-dione (BioDeep_00000172696)

   

human metabolite blood metabolite


代谢物信息卡片


2-(2-chlorophenyl)-4-[3-(dimethylamino)phenyl]-5-methyl-1H,2H,3H,5H,6H-pyrazolo[4,3-c]pyridine-3,6-dione

化学式: C21H19ClN4O2 (394.1196464)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CN(C)C1=CC=CC(=C1)C1=C2C(NN(C2=O)C2=CC=CC=C2Cl)=CC(=O)N1C
InChI: InChI=1S/C21H19ClN4O2/c1-24(2)14-8-6-7-13(11-14)20-19-16(12-18(27)25(20)3)23-26(21(19)28)17-10-5-4-9-15(17)22/h4-12,23H,1-3H3

描述信息

C471 - Enzyme Inhibitor
Setanaxib (GKT137831) is a selective NADPH oxidase (NOX1/4) inhibitor with Kis of 140 and 110 nM, respectively.

同义名列表

8 个代谢物同义名

2-(2-chlorophenyl)-4-[3-(dimethylamino)phenyl]-5-methyl-1H,2H,3H,5H,6H-pyrazolo[4,3-c]pyridine-3,6-dione; 2-(2-Chlorophenyl)-4-(3-(dimethylamino)phenyl)-5-methyl-1H-pyrazolo(4,3-c)pyridine-3,6(2H,5H)-dione; 2-(2-Chlorophenyl)-4-(3-(dimethylamino)phenyl)-5-methyl-1H-pyrazolo[4,3-c]pyridine-3,6(2H,5H)-dione; 2-(2-chlorophenyl)-4-[3-(dimethylamino)phenyl]-5-methyl-1H-pyrazolo[4,3-c]pyridine-3,6-dione; Setanaxib; GKT-831; GKT137831; GKT831



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

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PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

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BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

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PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Alysha M De Livera, Anne Reutens, Mark Cooper, Merlin Thomas, Karin Jandeleit-Dahm, Jonathan E Shaw, Agus Salim. Evaluating the efficacy and safety of GKT137831 in adults with type 1 diabetes and persistently elevated urinary albumin excretion: a statistical analysis plan. Trials. 2020 Jun; 21(1):459. doi: 10.1186/s13063-020-04404-0. [PMID: 32493401]
  • Anne T Reutens, Karin Jandeleit-Dahm, Merlin Thomas, Agus Salim, Alysha M De Livera, Leon A Bach, Peter G Colman, Timothy M E Davis, Elif I Ekinci, Greg Fulcher, Peter Shane Hamblin, Mark A Kotowicz, Richard J MacIsaac, Claire Morbey, David Simmons, Georgia Soldatos, Gary Wittert, Ted Wu, Mark E Cooper, Jonathan E Shaw. A physician-initiated double-blind, randomised, placebo-controlled, phase 2 study evaluating the efficacy and safety of inhibition of NADPH oxidase with the first-in-class Nox-1/4 inhibitor, GKT137831, in adults with type 1 diabetes and persistently elevated urinary albumin excretion: Protocol and statistical considerations. Contemporary clinical trials. 2020 03; 90(?):105892. doi: 10.1016/j.cct.2019.105892. [PMID: 31740428]
  • Jasmin Dächert, Vanessa Ehrenfeld, Karoline Habermann, Nadezda Dolgikh, Simone Fulda. Targeting ferroptosis in rhabdomyosarcoma cells. International journal of cancer. 2020 01; 146(2):510-520. doi: 10.1002/ijc.32496. [PMID: 31173656]
  • Yihang Li, Guoxu Ma, Yana Lv, Jing Su, Guang Li, Xi Chen. Efficacy of Obcordata A from Aspidopterys obcordata on Kidney Stones by Inhibiting NOX4 Expression. Molecules (Basel, Switzerland). 2019 May; 24(10):. doi: 10.3390/molecules24101957. [PMID: 31117291]
  • Sungkwon Cho, Seong-Lan Yu, Jaeku Kang, Bo Young Jeong, Hoi Young Lee, Chang Gyo Park, Young-Bin Yu, Dong-Chan Jin, Won-Min Hwang, Sung-Ro Yun, Ho Seung Song, Moon Hyang Park, Se-Hee Yoon. NADPH oxidase 4 mediates TGF-β1/Smad signaling pathway induced acute kidney injury in hypoxia. PloS one. 2019; 14(7):e0219483. doi: 10.1371/journal.pone.0219483. [PMID: 31318905]
  • Wasan Abdulmahdi, May M Rabadi, Edson Jules, Yara Marghani, Noor Marji, Jessica Leung, Frank Zhang, Avi Siani, Tamar Siskind, Kiara Vedovino, Nazrul Chowdhury, Miroslav Sekulic, Brian B Ratliff. Kidney dysfunction in the low-birth weight murine adult: implications of oxidative stress. American journal of physiology. Renal physiology. 2018 09; 315(3):F583-F594. doi: 10.1152/ajprenal.00164.2018. [PMID: 29846114]
  • Jia-Fu Ji, Wan-Zhen Jiao, Yan Cheng, Hua Yan, Fan Su, Li-Li Chi. ShenFu Preparation Protects AML12 Cells Against Palmitic Acid-Induced Injury Through Inhibition of Both JNK/Nox4 and JNK/NFκB Pathways. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 2018; 45(4):1617-1630. doi: 10.1159/000487728. [PMID: 29486473]
  • Jin Joo Cha, Hye Sook Min, Ki Tae Kim, Jung Eun Kim, Jung Yeon Ghee, Hyun Wook Kim, Ji Eun Lee, Jee Young Han, Gayoung Lee, Hun Joo Ha, Yun Soo Bae, Sae Rom Lee, Sung Hwan Moon, Sung Chan Lee, Ganghyun Kim, Young Sun Kang, Dae Ryong Cha. APX-115, a first-in-class pan-NADPH oxidase (Nox) inhibitor, protects db/db mice from renal injury. Laboratory investigation; a journal of technical methods and pathology. 2017 04; 97(4):419-431. doi: 10.1038/labinvest.2017.2. [PMID: 28165467]
  • Qian Sun, Wenliang Zhang, Wei Zhong, Xinguo Sun, Zhanxiang Zhou. Pharmacological inhibition of NOX4 ameliorates alcohol-induced liver injury in mice through improving oxidative stress and mitochondrial function. Biochimica et biophysica acta. General subjects. 2017 Jan; 1861(1 Pt A):2912-2921. doi: 10.1016/j.bbagen.2016.09.009. [PMID: 27634671]
  • Jong-Seok Moon, Kiichi Nakahira, Kuei-Pin Chung, Gina M DeNicola, Michael Jakun Koo, Maria A Pabón, Kristen T Rooney, Joo-Heon Yoon, Stefan W Ryter, Heather Stout-Delgado, Augustine M K Choi. NOX4-dependent fatty acid oxidation promotes NLRP3 inflammasome activation in macrophages. Nature medicine. 2016 09; 22(9):1002-12. doi: 10.1038/nm.4153. [PMID: 27455510]
  • Ahmed Bettaieb, Joy X Jiang, Yu Sasaki, Tzu-I Chao, Zsofia Kiss, Xiangling Chen, Jijing Tian, Masato Katsuyama, Chihiro Yabe-Nishimura, Yannan Xi, Cedric Szyndralewiez, Kathrin Schröder, Ajay Shah, Ralph P Brandes, Fawaz G Haj, Natalie J Török. Hepatocyte Nicotinamide Adenine Dinucleotide Phosphate Reduced Oxidase 4 Regulates Stress Signaling, Fibrosis, and Insulin Sensitivity During Development of Steatohepatitis in Mice. Gastroenterology. 2015 Aug; 149(2):468-80.e10. doi: 10.1053/j.gastro.2015.04.009. [PMID: 25888330]
  • Yves Gorin, Rita C Cavaglieri, Khaled Khazim, Doug-Yoon Lee, Francesca Bruno, Sachin Thakur, Paolo Fanti, Cédric Szyndralewiez, Jeffrey L Barnes, Karen Block, Hanna E Abboud. Targeting NADPH oxidase with a novel dual Nox1/Nox4 inhibitor attenuates renal pathology in type 1 diabetes. American journal of physiology. Renal physiology. 2015 Jun; 308(11):F1276-87. doi: 10.1152/ajprenal.00396.2014. [PMID: 25656366]
  • Francisco J Rios, Karla B Neves, Aurelie Nguyen Dinh Cat, Sarah Even, Roberto Palacios, Augusto C Montezano, Rhian M Touyz. Cholesteryl ester-transfer protein inhibitors stimulate aldosterone biosynthesis in adipocytes through Nox-dependent processes. The Journal of pharmacology and experimental therapeutics. 2015 Apr; 353(1):27-34. doi: 10.1124/jpet.114.221002. [PMID: 25617244]
  • Tian Lan, Tatiana Kisseleva, David A Brenner. Deficiency of NOX1 or NOX4 Prevents Liver Inflammation and Fibrosis in Mice through Inhibition of Hepatic Stellate Cell Activation. PloS one. 2015; 10(7):e0129743. doi: 10.1371/journal.pone.0129743. [PMID: 26222337]
  • Jay C Jha, Stephen P Gray, David Barit, Jun Okabe, Assam El-Osta, Tamehachi Namikoshi, Vicki Thallas-Bonke, Kirstin Wingler, Cedric Szyndralewiez, Freddy Heitz, Rhian M Touyz, Mark E Cooper, Harald H H W Schmidt, Karin A Jandeleit-Dahm. Genetic targeting or pharmacologic inhibition of NADPH oxidase nox4 provides renoprotection in long-term diabetic nephropathy. Journal of the American Society of Nephrology : JASN. 2014 Jun; 25(6):1237-54. doi: 10.1681/asn.2013070810. [PMID: 24511132]