Vorozole (BioDeep_00000172669)
human metabolite blood metabolite
代谢物信息卡片
化学式: C16H13ClN6 (324.089)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CN1C2=C(C=CC(=C2)C(C3=CC=C(C=C3)Cl)N4C=NC=N4)N=N1
InChI: InChI=1S/C16H13ClN6/c1-22-15-8-12(4-7-14(15)20-21-22)16(23-10-18-9-19-23)11-2-5-13(17)6-3-11/h2-10,16H,1H3
描述信息
L - Antineoplastic and immunomodulating agents > L02 - Endocrine therapy > L02B - Hormone antagonists and related agents > L02BG - Aromatase inhibitors
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006727 - Hormone Antagonists > D065088 - Steroid Synthesis Inhibitors
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006727 - Hormone Antagonists > D004965 - Estrogen Antagonists
D004791 - Enzyme Inhibitors > D065088 - Steroid Synthesis Inhibitors > D047072 - Aromatase Inhibitors
D000970 - Antineoplastic Agents
同义名列表
数据库引用编号
6 个数据库交叉引用编号
- PubChem: 60796
- HMDB: HMDB0244433
- ChEMBL: CHEMBL100749
- Wikipedia: Vorozole
- chemspider: 54791
- CAS: 118949-22-7
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
亚细胞结构定位 | 关联基因列表 |
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文献列表
- Jean Logan, Sung Won Kim, Deborah Pareto, Frank Telang, Gene-Jack Wang, Joanna S Fowler, Anat Biegon. Kinetic analysis of [11C]vorozole binding in the human brain with positron emission tomography.
Molecular imaging.
2014; 13(?):1-12. doi:
NULL
. [PMID: 24824855] - Deborah Pareto, Anat Biegon, David Alexoff, Pauline Carter, Coreen Shea, Lisa Muench, Youwen Xu, Joanna S Fowler, Sunny W Kim, Jean Logan. In vivo imaging of brain aromatase in female baboons: [11C]vorozole kinetics and effect of the menstrual cycle.
Molecular imaging.
2013 Nov; 12(8):. doi:
10.2310/7290.2013.00068
. [PMID: 24447618] - Mari Miyajima, Hiroyuki Kusuhara, Kayo Takahashi, Tadayuki Takashima, Takamitsu Hosoya, Yasuyoshi Watanabe, Yuichi Sugiyama. Investigation of the effect of active efflux at the blood-brain barrier on the distribution of nonsteroidal aromatase inhibitors in the central nervous system.
Journal of pharmaceutical sciences.
2013 Sep; 102(9):3309-19. doi:
10.1002/jps.23600
. [PMID: 23712697] - Anat Biegon, Sung Won Kim, David L Alexoff, Millard Jayne, Pauline Carter, Barbara Hubbard, Payton King, Jean Logan, Lisa Muench, Deborah Pareto, David Schlyer, Colleen Shea, Frank Telang, Gene-Jack Wang, Youwen Xu, Joanna S Fowler. Unique distribution of aromatase in the human brain: in vivo studies with PET and [N-methyl-11C]vorozole.
Synapse (New York, N.Y.).
2010 Nov; 64(11):801-7. doi:
10.1002/syn.20791
. [PMID: 20842717] - Anat Biegon, Sung-Won Kim, Jean Logan, Jacob M Hooker, Lisa Muench, Joanna S Fowler. Nicotine blocks brain estrogen synthase (aromatase): in vivo positron emission tomography studies in female baboons.
Biological psychiatry.
2010 Apr; 67(8):774-7. doi:
10.1016/j.biopsych.2010.01.004
. [PMID: 20188349] - Silvia Diani-Moore, Fotini Papachristou, Erin Labitzke, Arleen B Rifkind. Induction of CYP1A and cyp2-mediated arachidonic acid epoxygenation and suppression of 20-hydroxyeicosatetraenoic acid by imidazole derivatives including the aromatase inhibitor vorozole.
Drug metabolism and disposition: the biological fate of chemicals.
2006 Aug; 34(8):1376-85. doi:
10.1124/dmd.106.009498
. [PMID: 16714371] - Dmitrijus Kirilovas, Tord Naessen, Mats Bergström, Elizabeth Bergström-Petterman, Kjell Carlström, Bengt Långström. Characterization of [11C]vorozole binding in ovarian tissue in rats throughout estrous cycle in association with conversion of androgens to estrogens in vivo and in vitro.
Steroids.
2003 Dec; 68(14):1139-46. doi:
10.1016/j.steroids.2003.08.013
. [PMID: 14643875] - Catherine L Harper-Wynne, Nigel P M Sacks, Karyn Shenton, Fiona A MacNeill, Paul Sauven, Ian J Laidlaw, Zen Rayter, Stephanie Miall, Angela Howes, Janine Salter, Margaret J Hills, Frances M Lowe, Roger A'Hern, Nazar Nasiri, Debbie Doody, Jhangir Iqbal, Mitchell Dowsett. Comparison of the systemic and intratumoral effects of tamoxifen and the aromatase inhibitor vorozole in postmenopausal patients with primary breast cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
2002 Feb; 20(4):1026-35. doi:
10.1200/jco.2002.20.4.1026
. [PMID: 11844826] - D Vanderschueren, S Boonen, A G Ederveen, R de Coster, E Van Herck, K Moermans, L Vandenput, A Verstuyf, R Bouillon. Skeletal effects of estrogen deficiency as induced by an aromatase inhibitor in an aged male rat model.
Bone.
2000 Nov; 27(5):611-7. doi:
10.1016/s8756-3282(00)00363-x
. [PMID: 11062346] - K Christov, A Shilkaitis, A Green, R G Mehta, C Grubbs, G Kelloff, R Lubet. Cellular responses of mammary carcinomas to aromatase inhibitors: effects of vorozole.
Breast cancer research and treatment.
2000 Mar; 60(2):117-28. doi:
10.1023/a:1006384026252
. [PMID: 10845274] - M Dowsett, D Doody, S Miall, A Howes, J English, R C Coombes. Vorozole results in greater oestrogen suppression than formestane in postmenopausal women and when added to goserelin in premenopausal women with advanced breast cancer.
Breast cancer research and treatment.
1999 Jul; 56(1):25-34. doi:
10.1023/a:1006289811540
. [PMID: 10517340] - G C Panzica, C Castagna, C Viglietti-Panzica, C Russo, O Tlemçani, J Balthazart. Organizational effects of estrogens on brain vasotocin and sexual behavior in quail.
Journal of neurobiology.
1998 Dec; 37(4):684-99. doi:
10.1002/(sici)1097-4695(199812)37:4<684::aid-neu15>3.0.co;2-u
. [PMID: 9858268] - R A Lubet, V E Steele, R DeCoster, C Bowden, M You, M M Juliana, I Eto, G J Kelloff, C J Grubbs. Chemopreventive effects of the aromatase inhibitor vorozole (R 83842) in the methylnitrosourea-induced mammary cancer model.
Carcinogenesis.
1998 Aug; 19(8):1345-51. doi:
10.1093/carcin/19.8.1345
. [PMID: 9744527] - P F Bruning, J M Bonfrer, R Paridaens, M Nooij, J G Klijn, L V Beex, J Bruynseels, M J Piccart. Vorozole (R83842) in the treatment of postmenopausal advanced breast cancer: relationship of serum levels of vorozole and clinical results (a study of the EORTC Breast Cancer Cooperative Group).
Anti-cancer drugs.
1998 Jun; 9(5):419-25. doi:
10.1097/00001813-199806000-00008
. [PMID: 9660539] - E Dewil, J Buyse, J D Veldhuis, J Mast, R De Coster, E Decuypere. In ovo treatment with an aromatase inhibitor masculinizes postnatal hormone levels, abdominal fat pad content, and GH pulsatility in broiler chickens.
Domestic animal endocrinology.
1998 Mar; 15(2):115-27. doi:
10.1016/s0739-7240(97)00084-2
. [PMID: 9532425] - V K Piotrovsky, M L Huang, A Van Peer, C Langenaecken. Effects of demographic variables on vorozole pharmacokinetics in healthy volunteers and in breast cancer patients.
Cancer chemotherapy and pharmacology.
1998; 42(3):221-8. doi:
10.1007/s002800050808
. [PMID: 9685057] - L R Wiseman, C M Spencer. Vorozole.
Drugs & aging.
1997 Sep; 11(3):245-50; discussion 251. doi:
10.2165/00002512-199711030-00007
. [PMID: 9303282] - D Vanderschueren, E van Herck, J Nijs, A G Ederveen, R De Coster, R Bouillon. Aromatase inhibition impairs skeletal modeling and decreases bone mineral density in growing male rats.
Endocrinology.
1997 Jun; 138(6):2301-7. doi:
10.1210/endo.138.6.5216
. [PMID: 9165015] - D Vanderschueren, E Van Herck, R De Coster, R Bouillon. Aromatization of androgens is important for skeletal maintenance of aged male rats.
Calcified tissue international.
1996 Sep; 59(3):179-83. doi:
10.1007/s002239900106
. [PMID: 8694895] - E F Rissman, N Harada, C E Roselli. Effect of vorozole, an aromatase enzyme inhibitor, on sexual behavior, aromatase activity and neural immunoreactivity.
Journal of neuroendocrinology.
1996 Mar; 8(3):199-210. doi:
10.1046/j.1365-2826.1996.04505.x
. [PMID: 8730654] - P E Goss, R M Clark, U Ambus, H A Weizel, N A Wadden, M Crump, D Walde, L M Tye, R De Coster, J Bruynseels. Phase II study of vorozole (R83842), a new aromatase inhibitor, in postmenopausal women with advanced breast cancer in progression on tamoxifen.
Clinical cancer research : an official journal of the American Association for Cancer Research.
1995 Mar; 1(3):287-94. doi:
NULL
. [PMID: 9815984] - W Wouters, E Snoeck, R De Coster. Vorozole, a specific non-steroidal aromatase inhibitor.
Breast cancer research and treatment.
1994; 30(1):89-94. doi:
10.1007/bf00682743
. [PMID: 7726994] - E van der Wall, T H Donker, E de Frankrijker, H W Nortier, J H Thijssen, M A Blankenstein. Inhibition of the in vivo conversion of androstenedione to estrone by the aromatase inhibitor vorozole in healthy postmenopausal women.
Cancer research.
1993 Oct; 53(19):4563-6. doi:
NULL
. [PMID: 8402628] - L Rombauts, L R Berghman, D Vanmontfort, E Decuypere, G Verhoeven. Changes in immunoreactive FSH and inhibin in developing chicken embryos and the effects of estradiol and the aromatase inhibitor R76713.
Biology of reproduction.
1993 Sep; 49(3):549-54. doi:
10.1095/biolreprod49.3.549
. [PMID: 8399849] - W Wouters, R Van Ginckel, M Krekels, C Bowden, R De Coster. Pharmacology of vorozole.
The Journal of steroid biochemistry and molecular biology.
1993 Mar; 44(4-6):617-21. doi:
10.1016/0960-0760(93)90268-2
. [PMID: 8386540] - R De Coster, R F Van Ginckel, M J Callens, N K Goeminne, B L Janssens. Antitumoral and endocrine effects of (+)-vorozole in rats bearing dimethylbenzanthracene-induced mammary tumors.
Cancer research.
1992 Mar; 52(5):1240-4. doi:
NULL
. [PMID: 1737385] - R W Tuman, D M Morris, N H Wallace, C R Bowden. Inhibition of peripheral aromatization in the male cynomolgus monkey by a novel nonsteroidal aromatase inhibitor (R 76713).
The Journal of clinical endocrinology and metabolism.
1991 Apr; 72(4):755-60. doi:
10.1210/jcem-72-4-755
. [PMID: 2005200] - W Wouters, R De Coster, J van Dun, M D Krekels, A Dillen, A Raeymaekers, E Freyne, J Van Gelder, G Sanz, M Venet. Comparative effects of the aromatase inhibitor R76713 and of its enantiomers R83839 and R83842 on steroid biosynthesis in vitro and in vivo.
The Journal of steroid biochemistry and molecular biology.
1990 Dec; 37(6):1049-54. doi:
10.1016/0960-0760(90)90464-v
. [PMID: 2178362] - R De Coster, W Wouters, C R Bowden, H Vanden Bossche, J Bruynseels, R W Tuman, R Van Ginckel, E Snoeck, A Van Peer, P A Janssen. New non-steroidal aromatase inhibitors: focus on R76713.
The Journal of steroid biochemistry and molecular biology.
1990 Nov; 37(3):335-41. doi:
10.1016/0960-0760(90)90482-z
. [PMID: 2257238] - M D Krekels, W Wouters, R De Coster. Aromatase inhibition by R 76 713: a kinetic analysis in rat ovarian homogenates.
Steroids.
1990 Feb; 55(2):69-73. doi:
10.1016/0039-128x(90)90027-9
. [PMID: 2326830] - R De Coster, R Van Ginckel, W Wouters, N Goeminne, W Vanherck, M Byloos. Endocrine and antitumoral effects of R76713 in rats.
Journal of enzyme inhibition.
1990; 4(2):159-67. doi:
10.3109/14756369009040738
. [PMID: 2098522] - W Wouters, R De Coster, M Krekels, J van Dun, D Beerens, C Haelterman, A Raeymaekers, E Freyne, J Van Gelder, M Venet. R 76713, a new specific non-steroidal aromatase inhibitor.
Journal of steroid biochemistry.
1989 Jun; 32(6):781-8. doi:
10.1016/0022-4731(89)90453-6
. [PMID: 2755126] - W Wouters, R De Coster, R W Tuman, C R Bowden, J Bruynseels, H Vanderpas, P Van Rooy, W K Amery, P A Janssen. Aromatase inhibition by R 76713: experimental and clinical pharmacology.
Journal of steroid biochemistry.
1989; 34(1-6):427-30. doi:
10.1016/0022-4731(89)90121-0
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