11,12-Epoxyeicosantrienoic acid (BioDeep_00000172611)
human metabolite blood metabolite
代谢物信息卡片
10-(3-octyloxiran-2-yl)deca-2,4,6-trienoic acid
化学式: C20H32O3 (320.23513219999995)
中文名称:
谱图信息:
最多检出来源 Mus musculus(blood) 50%
分子结构信息
SMILES: CCCCCCCCC1OC1CCCC=CC=CC=CC(O)=O
InChI: InChI=1S/C20H32O3/c1-2-3-4-5-9-12-15-18-19(23-18)16-13-10-7-6-8-11-14-17-20(21)22/h6-8,11,14,17-19H,2-5,9-10,12-13,15-16H2,1H3,(H,21,22)
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Peng Sun, Joseph Antoun, Dao-Hong Lin, Peng Yue, Katherine H Gotlinger, Jorge Capdevila, Wen-Hui Wang. Cyp2c44 epoxygenase is essential for preventing the renal sodium absorption during increasing dietary potassium intake.
Hypertension (Dallas, Tex. : 1979).
2012 Feb; 59(2):339-47. doi:
10.1161/hypertensionaha.111.178475. [PMID: 22184322] - Annemarieke E Loot, Isabelle Moneke, Benjamin Keserü, Matthias Oelze, Tetyana Syzonenko, Andreas Daiber, Ingrid Fleming. 11,12-EET stimulates the association of BK channel α and β(1) subunits in mitochondria to induce pulmonary vasoconstriction.
PloS one.
2012; 7(9):e46065. doi:
10.1371/journal.pone.0046065. [PMID: 23029390] - Moritz Schmelzle, Levent Dizdar, Hanno Matthaei, Stephan E Baldus, Judith Wolters, Nina Lindenlauf, Ingmar Bruns, Ron-Patrick Cadeddu, Feride Kröpil, Stefan A Topp, Jan Schulte am Esch, Claus F Eisenberger, Wolfram T Knoefel, Nikolas H Stoecklein. Esophageal cancer proliferation is mediated by cytochrome P450 2C9 (CYP2C9).
Prostaglandins & other lipid mediators.
2011 Feb; 94(1-2):25-33. doi:
10.1016/j.prostaglandins.2010.12.001. [PMID: 21167292] - Peng Sun, Dao-Hong Lin, Peng Yue, Houli Jiang, Katherine H Gotlinger, Michal L Schwartzman, John R Falck, Mohan Goli, Wen-Hui Wang. High potassium intake enhances the inhibitory effect of 11,12-EET on ENaC.
Journal of the American Society of Nephrology : JASN.
2010 Oct; 21(10):1667-77. doi:
10.1681/asn.2009111110. [PMID: 20595684] - Peng Sun, Wen Liu, Dao-Hong Lin, Peng Yue, Rowena Kemp, Lisa M Satlin, Wen-Hui Wang. Epoxyeicosatrienoic acid activates BK channels in the cortical collecting duct.
Journal of the American Society of Nephrology : JASN.
2009 Mar; 20(3):513-23. doi:
10.1681/asn.2008040427. [PMID: 19073823] - Su Wang, Fei Meng, Jingyuan Xu, Yuchun Gu. Effects of lipids on ENaC activity in cultured mouse cortical collecting duct cells.
The Journal of membrane biology.
2009 Jan; 227(2):77-85. doi:
10.1007/s00232-008-9145-1. [PMID: 19122972] - Jian Cao, George Drummond, Kazuyoshi Inoue, Komal Sodhi, Xiao Y Li, Shinji Omura. Upregulation of heme oxygenase-1 combined with increased adiponectin lowers blood pressure in diabetic spontaneously hypertensive rats through a reduction in endothelial cell dysfunction, apoptosis and oxidative stress.
International journal of molecular sciences.
2008 Dec; 9(12):2388-406. doi:
10.3390/ijms9122388. [PMID: 19330083] - ZhiJian Wang, Yuan Wei, John R Falck, Krishnam Raju Atcha, Wen-Hui Wang. Arachidonic acid inhibits basolateral K channels in the cortical collecting duct via cytochrome P-450 epoxygenase-dependent metabolic pathways.
American journal of physiology. Renal physiology.
2008 Jun; 294(6):F1441-7. doi:
10.1152/ajprenal.00038.2008. [PMID: 18417544] - Christiana Dimitropoulou, Lashondra West, Mary B Field, Richard E White, L Manmohan Reddy, John R Falck, John D Imig. Protein phosphatase 2A and Ca2+-activated K+ channels contribute to 11,12-epoxyeicosatrienoic acid analog mediated mesenteric arterial relaxation.
Prostaglandins & other lipid mediators.
2007 Feb; 83(1-2):50-61. doi:
10.1016/j.prostaglandins.2006.09.008. [PMID: 17259072] - David Sacerdoti, Claudia Colombrita, Marco Di Pascoli, Michal L Schwartzman, Massimo Bolognesi, John R Falck, Angelo Gatta, Nader G Abraham. 11,12-epoxyeicosatrienoic acid stimulates heme-oxygenase-1 in endothelial cells.
Prostaglandins & other lipid mediators.
2007 Jan; 82(1-4):155-61. doi:
10.1016/j.prostaglandins.2006.07.001. [PMID: 17164143] - Peng Sun, Dao-Hong Lin, Tong Wang, Elisa Babilonia, Zhijian Wang, Yan Jin, Rowena Kemp, Alberto Nasjletti, Wen-Hui Wang. Low Na intake suppresses expression of CYP2C23 and arachidonic acid-induced inhibition of ENaC.
American journal of physiology. Renal physiology.
2006 Dec; 291(6):F1192-200. doi:
10.1152/ajprenal.00112.2006. [PMID: 16849695] - Yuan Wei, Peng Sun, Zhijian Wang, Baofeng Yang, Mairead A Carroll, Wen-Hui Wang. Adenosine inhibits ENaC via cytochrome P-450 epoxygenase-dependent metabolites of arachidonic acid.
American journal of physiology. Renal physiology.
2006 May; 290(5):F1163-8. doi:
10.1152/ajprenal.00301.2005. [PMID: 16234312] - Dominik N Muller, Juergen Theuer, Erdenechimeg Shagdarsuren, Eva Kaergel, Horst Honeck, Joon-Keun Park, Marija Markovic, Eduardo Barbosa-Sicard, Ralf Dechend, Maren Wellner, Torsten Kirsch, Anette Fiebeler, Michael Rothe, Hermann Haller, Friedrich C Luft, Wolf-Hagen Schunck. A peroxisome proliferator-activated receptor-alpha activator induces renal CYP2C23 activity and protects from angiotensin II-induced renal injury.
The American journal of pathology.
2004 Feb; 164(2):521-32. doi:
10.1016/s0002-9440(10)63142-2. [PMID: 14742258] - Pasi Jolma, Peeter Kööbi, Jarkko Kalliovalkama, Heikki Saha, Meng Fan, Jarkko Jokihaara, Eeva Moilanen, Ilkka Tikkanen, Ilkka Pörsti. Treatment of secondary hyperparathyroidism by high calcium diet is associated with enhanced resistance artery relaxation in experimental renal failure.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2003 Dec; 18(12):2560-9. doi:
10.1093/ndt/gfg374. [PMID: 14605278] - J D Imig, X Zhao, J R Falck, S Wei, J H Capdevila. Enhanced renal microvascular reactivity to angiotensin II in hypertension is ameliorated by the sulfonimide analog of 11,12-epoxyeicosatrienoic acid.
Journal of hypertension.
2001 May; 19(5):983-92. doi:
10.1097/00004872-200105000-00020. [PMID: 11393683]