Magainin II (GIGKFLHSAKKFGKAFVGEIMNS-acid) (BioDeep_00000172578)

   

human metabolite blood metabolite


代谢物信息卡片


4-{[2-({2-[(2-{[2-({6-amino-2-[(2-{[2-({6-amino-2-[(6-amino-2-{[2-({2-[(2-{[2-({2-[(6-amino-2-{[2-({2-[(2-amino-1-hydroxyethylidene)amino]-1-hydroxy-3-methylpentylidene}amino)-1-hydroxyethylidene]amino}-1-hydroxyhexylidene)amino]-1-hydroxy-3-phenylpropylidene}amino)-1-hydroxy-4-methylpentylidene]amino}-1-hydroxy-3-(1H-imidazol-5-yl)propylidene)amino]-1,3-dihydroxypropylidene}amino)-1-hydroxypropylidene]amino}-1-hydroxyhexylidene)amino]-1-hydroxyhexylidene}amino)-1-hydroxy-3-phenylpropylidene]amino}-1-hydroxyethylidene)amino]-1-hydroxyhexylidene}amino)-1-hydroxypropylidene]amino}-1-hydroxy-3-phenylpropylidene)amino]-1-hydroxy-3-methylbutylidene}amino)-1-hydroxyethylidene]amino}-4-[(1-{[1-({1-[(1-carboxy-2-hydroxyethyl)-C-hydroxycarbonimidoyl]-2-(C-hydroxycarbonimidoyl)ethyl}-C-hydroxycarbonimidoyl)-3-(methylsulphanyl)propyl]-C-hydroxycarbonimidoyl}-2-methylbutyl)-C-hydroxycarbonimidoyl]butanoic acid

化学式: C114H180N30O29S (2465.325255)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCC(C)C(NC(=O)CN)C(=O)NCC(=O)NC(CCCCN)C(=O)NC(CC1=CC=CC=C1)C(=O)NC(CC(C)C)C(=O)NC(CC1=CNC=N1)C(=O)NC(CO)C(=O)NC(C)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CC1=CC=CC=C1)C(=O)NCC(=O)NC(CCCCN)C(=O)NC(C)C(=O)NC(CC1=CC=CC=C1)C(=O)NC(C(C)C)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(C(C)CC)C(=O)NC(CCSC)C(=O)NC(CC(N)=O)C(=O)NC(CO)C(O)=O
InChI: InChI=1S/C114H180N30O29S/c1-12-65(7)94(142-88(148)55-119)112(170)124-59-90(150)129-74(38-24-28-45-116)100(158)137-81(51-70-33-19-15-20-34-70)106(164)135-79(49-63(3)4)105(163)138-83(53-72-56-121-62-125-72)107(165)140-85(60-145)110(168)127-67(9)96(154)131-75(39-25-29-46-117)101(159)132-76(40-26-30-47-118)102(160)136-80(50-69-31-17-14-18-32-69)98(156)122-57-89(149)128-73(37-23-27-44-115)99(157)126-68(10)97(155)134-82(52-71-35-21-16-22-36-71)109(167)143-93(64(5)6)111(169)123-58-91(151)130-77(41-42-92(152)153)104(162)144-95(66(8)13-2)113(171)133-78(43-48-174-11)103(161)139-84(54-87(120)147)108(166)141-86(61-146)114(172)173/h14-22,31-36,56,62-68,73-86,93-95,145-146H,12-13,23-30,37-55,57-61,115-119H2,1-11H3,(H2,120,147)(H,121,125)(H,122,156)(H,123,169)(H,124,170)(H,126,157)(H,127,168)(H,128,149)(H,129,150)(H,130,151)(H,131,154)(H,132,159)(H,133,171)(H,134,155)(H,135,164)(H,136,160)(H,137,158)(H,138,163)(H,139,161)(H,140,165)(H,141,166)(H,142,148)(H,143,167)(H,144,162)(H,152,153)(H,172,173)

描述信息

同义名列表

5 个代谢物同义名

4-{[2-({2-[(2-{[2-({6-amino-2-[(2-{[2-({6-amino-2-[(6-amino-2-{[2-({2-[(2-{[2-({2-[(6-amino-2-{[2-({2-[(2-amino-1-hydroxyethylidene)amino]-1-hydroxy-3-methylpentylidene}amino)-1-hydroxyethylidene]amino}-1-hydroxyhexylidene)amino]-1-hydroxy-3-phenylpropylidene}amino)-1-hydroxy-4-methylpentylidene]amino}-1-hydroxy-3-(1H-imidazol-5-yl)propylidene)amino]-1,3-dihydroxypropylidene}amino)-1-hydroxypropylidene]amino}-1-hydroxyhexylidene)amino]-1-hydroxyhexylidene}amino)-1-hydroxy-3-phenylpropylidene]amino}-1-hydroxyethylidene)amino]-1-hydroxyhexylidene}amino)-1-hydroxypropylidene]amino}-1-hydroxy-3-phenylpropylidene)amino]-1-hydroxy-3-methylbutylidene}amino)-1-hydroxyethylidene]amino}-4-[(1-{[1-({1-[(1-carboxy-2-hydroxyethyl)-C-hydroxycarbonimidoyl]-2-(C-hydroxycarbonimidoyl)ethyl}-C-hydroxycarbonimidoyl)-3-(methylsulphanyl)propyl]-C-hydroxycarbonimidoyl}-2-methylbutyl)-C-hydroxycarbonimidoyl]butanoic acid; 4-{[2-({2-[(2-{[2-({6-amino-2-[(2-{[2-({6-amino-2-[(6-amino-2-{[2-({2-[(2-{[2-({2-[(6-amino-2-{[2-({2-[(2-amino-1-hydroxyethylidene)amino]-1-hydroxy-3-methylpentylidene}amino)-1-hydroxyethylidene]amino}-1-hydroxyhexylidene)amino]-1-hydroxy-3-phenylpropylidene}amino)-1-hydroxy-4-methylpentylidene]amino}-1-hydroxy-3-(1H-imidazol-5-yl)propylidene)amino]-1,3-dihydroxypropylidene}amino)-1-hydroxypropylidene]amino}-1-hydroxyhexylidene)amino]-1-hydroxyhexylidene}amino)-1-hydroxy-3-phenylpropylidene]amino}-1-hydroxyethylidene)amino]-1-hydroxyhexylidene}amino)-1-hydroxypropylidene]amino}-1-hydroxy-3-phenylpropylidene)amino]-1-hydroxy-3-methylbutylidene}amino)-1-hydroxyethylidene]amino}-4-[(1-{[1-({1-[(1-carboxy-2-hydroxyethyl)-C-hydroxycarbonimidoyl]-2-(C-hydroxycarbonimidoyl)ethyl}-C-hydroxycarbonimidoyl)-3-(methylsulphanyl)propyl]-C-hydroxycarbonimidoyl}-2-methylbutyl)-C-hydroxycarbonimidoyl]butanoate; 4-{[2-({2-[(2-{[2-({6-amino-2-[(2-{[2-({6-amino-2-[(6-amino-2-{[2-({2-[(2-{[2-({2-[(6-amino-2-{[2-({2-[(2-amino-1-hydroxyethylidene)amino]-1-hydroxy-3-methylpentylidene}amino)-1-hydroxyethylidene]amino}-1-hydroxyhexylidene)amino]-1-hydroxy-3-phenylpropylidene}amino)-1-hydroxy-4-methylpentylidene]amino}-1-hydroxy-3-(1H-imidazol-5-yl)propylidene)amino]-1,3-dihydroxypropylidene}amino)-1-hydroxypropylidene]amino}-1-hydroxyhexylidene)amino]-1-hydroxyhexylidene}amino)-1-hydroxy-3-phenylpropylidene]amino}-1-hydroxyethylidene)amino]-1-hydroxyhexylidene}amino)-1-hydroxypropylidene]amino}-1-hydroxy-3-phenylpropylidene)amino]-1-hydroxy-3-methylbutylidene}amino)-1-hydroxyethylidene]amino}-4-[(1-{[1-({1-[(1-carboxy-2-hydroxyethyl)-C-hydroxycarbonimidoyl]-2-(C-hydroxycarbonimidoyl)ethyl}-C-hydroxycarbonimidoyl)-3-(methylsulfanyl)propyl]-C-hydroxycarbonimidoyl}-2-methylbutyl)-C-hydroxycarbonimidoyl]butanoate; 4-{2-[2-(2-{2-[6-amino-2-(2-{2-[6-amino-2-(6-amino-2-{2-[2-(2-{2-[2-(6-amino-2-{2-[2-(2-aminoacetamido)-3-methylpentanamido]acetamido}hexanamido)-3-phenylpropanamido]-4-methylpentanamido}-3-(1H-imidazol-4-yl)propanamido)-3-hydroxypropanamido]propanamido}hexanamido)hexanamido]-3-phenylpropanamido}acetamido)hexanamido]propanamido}-3-phenylpropanamido)-3-methylbutanamido]acetamido}-4-[(1-{[1-({2-carbamoyl-1-[(1-carboxy-2-hydroxyethyl)carbamoyl]ethyl}carbamoyl)-3-(methylsulfanyl)propyl]carbamoyl}-2-methylbutyl)carbamoyl]butanoic acid; Magainin II (GIGKFLHSAKKFGKAFVGEIMNS-acid)



数据库引用编号

3 个数据库交叉引用编号

分类词条

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代谢反应

0 个相关的代谢反应过程信息。

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1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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文献列表

  • Shan Liu, Hao Yang, Lin Wan, Jingqiu Cheng, Xiaofeng Lu. Penetratin-mediated delivery enhances the antitumor activity of the cationic antimicrobial peptide Magainin II. Cancer biotherapy & radiopharmaceuticals. 2013 May; 28(4):289-97. doi: 10.1089/cbr.2012.1328. [PMID: 23286306]
  • Oscar Cirioni, Carmela Silvestri, Roberto Ghiselli, Fiorenza Orlando, Alessandra Riva, Federico Mocchegiani, Leonardo Chiodi, Sefora Castelletti, Eleonora Gabrielli, Vittorio Saba, Giorgio Scalise, Andrea Giacometti. Protective effects of the combination of alpha-helical antimicrobial peptides and rifampicin in three rat models of Pseudomonas aeruginosa infection. The Journal of antimicrobial chemotherapy. 2008 Dec; 62(6):1332-8. doi: 10.1093/jac/dkn393. [PMID: 18799470]
  • A M Speranza, A R Taddei, E Ovidi. In vitro toxicity towards kiwifruit pollen of the antimicrobial peptides magainins 1 and 2. Plant biology (Stuttgart, Germany). 2007 Nov; 9(6):800-6. doi: 10.1055/s-2007-965119. [PMID: 17564946]
  • Andrea Giacometti, Oscar Cirioni, Roberto Ghiselli, Federico Mocchegiani, Carmela Silvestri, Fiorenza Orlando, Wojciech Kamysz, Alberto Licci, Elzbieta Kamysz, Jerzy Lukasiak, Vittorio Saba, Giorgio Scalise. Amphibian peptides prevent endotoxemia and bacterial translocation in bile duct-ligated rats. Critical care medicine. 2006 Sep; 34(9):2415-20. doi: 10.1097/01.ccm.0000231879.11963.eb. [PMID: 16791114]
  • Yoonkyung Park, Dong Gun Lee, Kyung-Soo Hahm. HP(2-9)-magainin 2(1-12), a synthetic hybrid peptide, exerts its antifungal effect on Candida albicans by damaging the plasma membrane. Journal of peptide science : an official publication of the European Peptide Society. 2004 Apr; 10(4):204-9. doi: 10.1002/psc.489. [PMID: 15119592]
  • Dong Gun Lee, Yoonkyung Park, Pyoung Il Kim, Hye Gwang Jeong, Eun-Rhan Woo, Kyung-Soo Hahm. Influence on the plasma membrane of Candida albicans by HP (2-9)-magainin 2 (1-12) hybrid peptide. Biochemical and biophysical research communications. 2002 Oct; 297(4):885-9. doi: 10.1016/s0006-291x(02)02230-1. [PMID: 12359236]
  • Oscar Cirioni, Andrea Giacometti, Roberto Ghiselli, Federico Mocchegiani, Anna Fineo, Fiorenza Orlando, Maria Simona Del Prete, Marco Rocchi, Vittorio Saba, Giorgio Scalise. Single-dose intraperitoneal magainins improve survival in a gram-negative-pathogen septic shock rat model. Antimicrobial agents and chemotherapy. 2002 Jan; 46(1):101-4. doi: 10.1128/aac.46.1.101-104.2002. [PMID: 11751118]
  • E T Mystkowska, A Niemierko, A Komar, W Sawicki. Embryotoxicity of magainin-2-amide and its enhancement by cyclodextrin, albumin, hydrogen peroxide and acidification. Human reproduction (Oxford, England). 2001 Jul; 16(7):1457-63. doi: 10.1093/humrep/16.7.1457. [PMID: 11425829]
  • A Giacometti, O Cirioni, F Barchiesi, M Fortuna, G Scalise. In-vitro activity of cationic peptides alone and in combination with clinically used antimicrobial agents against Pseudomonas aeruginosa. The Journal of antimicrobial chemotherapy. 1999 Nov; 44(5):641-5. doi: 10.1093/jac/44.5.641. [PMID: 10552980]
  • D A Devine, P D Marsh, R S Percival, M Rangarajan, M A Curtis. Modulation of antibacterial peptide activity by products of Porphyromonas gingivalis and Prevotella spp. Microbiology (Reading, England). 1999 Apr; 145 ( Pt 4)(?):965-971. doi: 10.1099/13500872-145-4-965. [PMID: 10220176]
  • K T Miyasaki, R Iofel, A Oren, T Huynh, R I Lehrer. Killing of Fusobacterium nucleatum, Porphyromonas gingivalis and Prevotella intermedia by protegrins. Journal of periodontal research. 1998 Feb; 33(2):91-8. doi: 10.1111/j.1600-0765.1998.tb02297.x. [PMID: 9553868]
  • R P Darveau, M D Cunningham, C L Seachord, L Cassiano-Clough, W L Cosand, J Blake, C S Watkins. Beta-lactam antibiotics potentiate magainin 2 antimicrobial activity in vitro and in vivo. Antimicrobial agents and chemotherapy. 1991 Jun; 35(6):1153-9. doi: 10.1128/aac.35.6.1153. [PMID: 1929257]
  • F R Rana, C M Sultany, J Blazyk. Interactions between Salmonella typhimurium lipopolysaccharide and the antimicrobial peptide, magainin 2 amide. FEBS letters. 1990 Feb; 261(2):464-7. doi: 10.1016/0014-5793(90)80616-q. [PMID: 2178981]
  • H V Westerhoff, D Juretić, R W Hendler, M Zasloff. Magainins and the disruption of membrane-linked free-energy transduction. Proceedings of the National Academy of Sciences of the United States of America. 1989 Sep; 86(17):6597-601. doi: 10.1073/pnas.86.17.6597. [PMID: 2671997]
  • D Marion, M Zasloff, A Bax. A two-dimensional NMR study of the antimicrobial peptide magainin 2. FEBS letters. 1988 Jan; 227(1):21-6. doi: 10.1016/0014-5793(88)81405-4. [PMID: 3338566]