3-[1-(Dimethylamino)ethyl]phenol (BioDeep_00000172568)
human metabolite blood metabolite
代谢物信息卡片
化学式: C10H15NO (165.1154)
中文名称: 3-[1-(二甲基氨基)乙基]苯酚
谱图信息:
最多检出来源 Homo sapiens(blood) 3.48%
分子结构信息
SMILES: CC(C1=CC(=CC=C1)O)N(C)C
InChI: InChI=1S/C10H15NO/c1-8(11(2)3)9-5-4-6-10(12)7-9/h4-8,12H,1-3H3
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Ping-Song Chou, Kai-Ming Jhang, Ling-Chun Huang, Wen-Fu Wang, Yuan-Han Yang. Skinfold thickness for rivastigmine patch application in Alzheimer's disease.
Psychopharmacology.
2019 Apr; 236(4):1255-1260. doi:
10.1007/s00213-018-5135-x. [PMID: 30645680] - Gilbert Lefèvre, Francesca Callegari, Sandro Gsteiger, Yuan Xiong. Effects of Renal Impairment on Steady-State Plasma Concentrations of Rivastigmine: A Population Pharmacokinetic Analysis of Capsule and Patch Formulations in Patients with Alzheimer's Disease.
Drugs & aging.
2016 10; 33(10):725-736. doi:
10.1007/s40266-016-0405-y. [PMID: 27681702] - Muriel Noetzli, Nicolas Ansermot, Maria Dobrinas, Chin B Eap. Simultaneous determination of antidementia drugs in human plasma: procedure transfer from HPLC-MS to UPLC-MS/MS.
Journal of pharmaceutical and biomedical analysis.
2012 May; 64-65(?):16-25. doi:
10.1016/j.jpba.2012.02.008. [PMID: 22410501] - Mei-Chuan Chou, Chun-Hung Chen, Ching-Kuan Liu, Su-Hwei Chen, Shyh-Jong Wu, Yuan-Han Yang. Concentrations of rivastigmine and NAP 226-90 and the cognitive response in Taiwanese Alzheimer's disease patients.
Journal of Alzheimer's disease : JAD.
2012; 31(4):857-64. doi:
10.3233/jad-2012-120109. [PMID: 22751168] - Ya-Hui Hsieh, Yuan-Han Yang, Hsin-Hua Yeh, Ping-Chih Lin, Su-Hwei Chen. Simultaneous determination of galantamine, rivastigmine and NAP 226-90 in plasma by MEKC and its application in Alzheimer's disease.
Electrophoresis.
2009 Feb; 30(4):644-53. doi:
10.1002/elps.200800559. [PMID: 19170055] - G Lefèvre, G Sedek, S S Jhee, M T Leibowitz, H-La Huang, A Enz, S Maton, L Ereshefsky, F Pommier, H Schmidli, S Appel-Dingemanse. Pharmacokinetics and pharmacodynamics of the novel daily rivastigmine transdermal patch compared with twice-daily capsules in Alzheimer's disease patients.
Clinical pharmacology and therapeutics.
2008 Jan; 83(1):106-14. doi:
10.1038/sj.clpt.6100242. [PMID: 17522596] - Joshua Shua-Haim, Juanita Smith, Franck Picard, Greg Sedek, Sandeep Athalye, Françoise Pommier, Gilbert Lefèvre. Steady-state pharmacokinetics of rivastigmine in patients with mild to moderate Alzheimer's disease not affected by co-administration of memantine: an open-label, crossover, single-centre study.
Clinical drug investigation.
2008; 28(6):361-74. doi:
10.2165/00044011-200828060-00004. [PMID: 18479178] - Suzanne V Frankfort, Mariët Ouwehand, Maria J van Maanen, Hilde Rosing, Linda R Tulner, Jos H Beijnen. A simple and sensitive assay for the quantitative analysis of rivastigmine and its metabolite NAP 226-90 in human EDTA plasma using coupled liquid chromatography and tandem mass spectrometry.
Rapid communications in mass spectrometry : RCM.
2006; 20(22):3330-6. doi:
10.1002/rcm.2737. [PMID: 17044120] - Albert Enz, Alain Chappuis, Andre Dattler. A simple, rapid and sensitive method for simultaneous determination of rivastigmine and its major metabolite NAP 226-90 in rat brain and plasma by reversed-phase liquid chromatography coupled to electrospray ionization mass spectrometry.
Biomedical chromatography : BMC.
2004 Apr; 18(3):160-6. doi:
10.1002/bmc.304. [PMID: 15103701]
