Silmitasertib (BioDeep_00000172540)
human metabolite blood metabolite
代谢物信息卡片
5-[(3-chlorophenyl)amino]benzo[c]2,6-naphthyridine-8-carboxylic acid
化学式: C19H12ClN3O2 (349.0618002)
中文名称: 5-[(3-氯苯基)氨基]-苯并[C]-2,6-萘啶-8-羧酸
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC(=CC(=C1)Cl)NC2=NC3=C(C=CC(=C3)C(=O)O)C4=C2C=CN=C4
InChI: InChI=1S/C19H12ClN3O2/c20-12-2-1-3-13(9-12)22-18-15-6-7-21-10-16(15)14-5-4-11(19(24)25)8-17(14)23-18/h1-10H,(H,22,23)(H,24,25)
描述信息
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
C471 - Enzyme Inhibitor > C1404 - Protein Kinase Inhibitor
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
同义名列表
数据库引用编号
7 个数据库交叉引用编号
- PubChem: 24748573
- HMDB: HMDB0244287
- DrugBank: DB15408
- ChEMBL: CHEMBL1230165
- Wikipedia: Silmitasertib
- chemspider: 25057795
- CAS: 1009820-21-6
分类词条
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yanping Luo, Yunxuan Lei, Xin Guo, Dehao Zhu, Haiyang Zhang, Zizhen Guo, Zichong Xu, Hanqing Zhao, Yebin Xi, Xiaochun Peng, Lianbo Xiao, Zhaojun Wang, Xiaoyin Niu, Guangjie Chen. CX-4945 inhibits fibroblast-like synoviocytes functions through the CK2-p53 axis to reduce rheumatoid arthritis disease severity.
International immunopharmacology.
2023 Apr; 119(?):110163. doi:
10.1016/j.intimp.2023.110163. [PMID: 37060808] - Ying-Wen Su, Wen-Yu Huang, Huan-Chau Lin, Po-Nien Liao, Ching-Yung Lin, Xiang-Yu Lin, Sing-Han Huang, Yi-Ting Chen, Pao-Shu Wu. Silmitasertib, a casein kinase 2 inhibitor, induces massive lipid droplet accumulation and nonapoptotic cell death in head and neck cancer cells.
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology.
2022 Oct; ?(?):. doi:
10.1111/jop.13378. [PMID: 36273268] - Anil Kumar Yadav, Byeong-Churl Jang. Anti-adipogenic and Pro-lipolytic Effects on 3T3-L1 Preadipocytes by CX-4945, an Inhibitor of Casein Kinase 2.
International journal of molecular sciences.
2022 Jun; 23(13):. doi:
10.3390/ijms23137274. [PMID: 35806278] - Rico Schwarz, Anna Richter, Elisabeth R D Ito, Hugo Murua Escobar, Christian Junghanß, Burkhard Hinz. Validation of an LC-MS/MS Method for the Quantification of the CK2 Inhibitor Silmitasertib (CX-4945) in Human Plasma.
Molecules (Basel, Switzerland).
2022 Apr; 27(8):. doi:
10.3390/molecules27082394. [PMID: 35458589] - Alexander Becker, Claudia Götz, Mathias Montenarh, Stephan E Philipp. Control of TRPM3 Ion Channels by Protein Kinase CK2-Mediated Phosphorylation in Pancreatic β-Cells of the Line INS-1.
International journal of molecular sciences.
2021 Dec; 22(23):. doi:
10.3390/ijms222313133. [PMID: 34884938] - Eleanor L Atkinson, Jessica Iegre, Paul D Brear, Elizabeth A Zhabina, Marko Hyvönen, David R Spring. Downfalls of Chemical Probes Acting at the Kinase ATP-Site: CK2 as a Case Study.
Molecules (Basel, Switzerland).
2021 Mar; 26(7):. doi:
10.3390/molecules26071977. [PMID: 33807474] - Bo Zhong, Olivia Campagne, Ralph Salloum, Teresa Purzner, Clinton F Stewart. LC-MS/MS method for quantitation of the CK2 inhibitor silmitasertib (CX-4945) in human plasma, CSF, and brain tissue, and application to a clinical pharmacokinetic study in children with brain tumors.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2020 Sep; 1152(?):122254. doi:
10.1016/j.jchromb.2020.122254. [PMID: 32615532] - Anna Richter, Sina Sender, Annemarie Lenz, Rico Schwarz, Burkhard Hinz, Gudrun Knuebel, Anett Sekora, Hugo Murua Escobar, Christian Junghanss, Catrin Roolf. Influence of Casein kinase II inhibitor CX-4945 on BCL6-mediated apoptotic signaling in B-ALL in vitro and in vivo.
BMC cancer.
2020 Mar; 20(1):184. doi:
10.1186/s12885-020-6650-9. [PMID: 32131762] - Estefania Alcaraz, Jordi Vilardell, Christian Borgo, Eduard Sarró, Maria Plana, Oriano Marin, Lorenzo A Pinna, José R Bayascas, Anna Meseguer, Mauro Salvi, Emilio Itarte, Maria Ruzzene. Effects of CK2β subunit down-regulation on Akt signalling in HK-2 renal cells.
PloS one.
2020; 15(1):e0227340. doi:
10.1371/journal.pone.0227340. [PMID: 31910234] - Jung-Il Jung, Se Young Kim, Kyeong-Yong Park, Kongmany Sydara, Sang Woo Lee, Soon Ae Kim, Jiyeon Kim. In vitro combinatorial anti-proliferative and immunosuppressive effects of Brucea javanica extract with CX-4945 and imatinib in human T-cell acute lymphoblastic leukemia cells.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2018 Oct; 106(?):403-410. doi:
10.1016/j.biopha.2018.06.164. [PMID: 29966986] - Maj Rabjerg. Identification and validation of novel prognostic markers in Renal Cell Carcinoma.
Danish medical journal.
2017 Oct; 64(10):. doi:
. [PMID: 28975890] - Maj Rabjerg, Barbara Guerra, Aida Oliván-Viguera, Minne Line Nedergaard Mikkelsen, Ralf Köhler, Olaf-Georg Issinger, Niels Marcussen. Nuclear localization of the CK2α-subunit correlates with poor prognosis in clear cell renal cell carcinoma.
Oncotarget.
2017 Jan; 8(1):1613-1627. doi:
10.18632/oncotarget.13693. [PMID: 27906674] - Mario Rossi, Inigo Ruiz de Azua, Luiz F Barella, Wataru Sakamoto, Lu Zhu, Yinghong Cui, Huiyan Lu, Heike Rebholz, Franz M Matschinsky, Nicolai M Doliba, Adrian J Butcher, Andrew B Tobin, Jürgen Wess. CK2 acts as a potent negative regulator of receptor-mediated insulin release in vitro and in vivo.
Proceedings of the National Academy of Sciences of the United States of America.
2015 Dec; 112(49):E6818-24. doi:
10.1073/pnas.1519430112. [PMID: 26598688] - You Hwa Son, Jin Sook Song, Seong Hwan Kim, Jiyeon Kim. Pharmacokinetic characterization of CK2 inhibitor CX-4945.
Archives of pharmacal research.
2013 Jul; 36(7):840-5. doi:
10.1007/s12272-013-0103-9. [PMID: 23543629] - Tania Tahtouh, Jonathan M Elkins, Panagis Filippakopoulos, Meera Soundararajan, Guillaume Burgy, Emilie Durieu, Claude Cochet, Ralf S Schmid, Donald C Lo, Florent Delhommel, Anselm E Oberholzer, Laurence H Pearl, François Carreaux, Jean-Pierre Bazureau, Stefan Knapp, Laurent Meijer. Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B.
Journal of medicinal chemistry.
2012 Nov; 55(21):9312-30. doi:
10.1021/jm301034u. [PMID: 22998443] - Denis Drygin, Caroline B Ho, Mayuko Omori, Joshua Bliesath, Chris Proffitt, Rachel Rice, Adam Siddiqui-Jain, Sean O'Brien, Claire Padgett, John K C Lim, Kenna Anderes, William G Rice, David Ryckman. Protein kinase CK2 modulates IL-6 expression in inflammatory breast cancer.
Biochemical and biophysical research communications.
2011 Nov; 415(1):163-7. doi:
10.1016/j.bbrc.2011.10.046. [PMID: 22027148] - . .
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