4-(3-Phosphonopropyl)piperazine-2-carboxylic acid (BioDeep_00000172539)

   

human metabolite blood metabolite


代谢物信息卡片


3-(2-Carboxypiperazin-4-yl)propyl-1-phosphonic acid

化学式: C8H17N2O5P (252.0875)
中文名称: (±)-CPP
谱图信息: 最多检出来源 Homo sapiens(blood) 66.67%

分子结构信息

SMILES: C1CN(CC(N1)C(=O)O)CCCP(=O)(O)O
InChI: InChI=1S/C8H17N2O5P/c11-8(12)7-6-10(4-2-9-7)3-1-5-16(13,14)15/h7,9H,1-6H2,(H,11,12)(H2,13,14,15)

描述信息

同义名列表

8 个代谢物同义名

3-(2-Carboxypiperazin-4-yl)propyl-1-phosphonic acid; 4-(3-Phosphonopropyl)-2-piperazinecarboxylic acid; 4-(3-Phosphonopropyl)piperazine-2-carboxylic acid; 4-(3-Phosphonopropyl)piperazine-2-carboxylate; Microsomal prolylcarboxypeptidase; (+/-)-2-HYDROXYTRIDECANOICACID; Carboxypeptidase p; 3-2-CPP



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Hannah J Seong, Adam G Carter. D1 receptor modulation of action potential firing in a subpopulation of layer 5 pyramidal neurons in the prefrontal cortex. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2012 Aug; 32(31):10516-21. doi: 10.1523/jneurosci.1367-12.2012. [PMID: 22855801]
  • Alfredo J Garcia, Shakil A Khan, Ganesh K Kumar, Nanduri R Prabhakar, Jan-Marino Ramirez. Hydrogen peroxide differentially affects activity in the pre-Bötzinger complex and hippocampus. Journal of neurophysiology. 2011 Dec; 106(6):3045-55. doi: 10.1152/jn.00550.2010. [PMID: 21849609]
  • Sara Trabulo, Sarah Resina, Sérgio Simões, Bernard Lebleu, Maria C Pedroso de Lima. A non-covalent strategy combining cationic lipids and CPPs to enhance the delivery of splice correcting oligonucleotides. Journal of controlled release : official journal of the Controlled Release Society. 2010 Jul; 145(2):149-58. doi: 10.1016/j.jconrel.2010.03.021. [PMID: 20362021]
  • Jocelyn C Leung, Natalie Ragland, Tara Marphis, Douglas M Silverstein. NMDA agonists and antagonists induce renal culture cell toxicity. Medicinal chemistry (Shariqah (United Arab Emirates)). 2008 Nov; 4(6):565-71. doi: 10.2174/157340608786242034. [PMID: 18991741]
  • J J Rodríguez, H A Davies, A T Silva, I E J De Souza, C J Peddie, F M Colyer, C L Lancashire, A Fine, M L Errington, T V P Bliss, M G Stewart. Long-term potentiation in the rat dentate gyrus is associated with enhanced Arc/Arg3.1 protein expression in spines, dendrites and glia. The European journal of neuroscience. 2005 May; 21(9):2384-96. doi: 10.1111/j.1460-9568.2005.04068.x. [PMID: 15932597]
  • T M Saleh, B J Connell, C Legge, A E Cribb. Estrogen synthesis in the central nucleus of the amygdala following middle cerebral artery occlusion: role in modulating neurotransmission. Neuroscience. 2005; 135(4):1141-53. doi: 10.1016/j.neuroscience.2005.06.061. [PMID: 16165297]
  • Wilhelm Stoffel, Rafael Körner, Dagmar Wachtmann, Bernhard U Keller. Functional analysis of glutamate transporters in excitatory synaptic transmission of GLAST1 and GLAST1/EAAC1 deficient mice. Brain research. Molecular brain research. 2004 Sep; 128(2):170-81. doi: 10.1016/j.molbrainres.2004.06.026. [PMID: 15363892]
  • K I Fritz, S Zanelli, O P Mishra, M Delivoria-Papadopoulos. Effect of graded hypoxia on the high-affinity CPP binding site of the NMDA receptor in the cerebral cortex of newborn piglets. Brain research. 2001 Feb; 891(1-2):266-73. doi: 10.1016/s0006-8993(00)03223-6. [PMID: 11164831]
  • M Bouras, J F Huneau, C Luengo, C Erlanson-Albertsson, D Tomé. Metabolism of enterostatin in rat intestine, brain membranes, and serum: differential involvement of proline-specific peptidases. Peptides. 1995; 16(3):399-405. doi: 10.1016/0196-9781(94)00213-p. [PMID: 7651891]
  • H Ostrowska. Pig platelet acidic carboxypeptidases. Enzyme & protein. 1994 199; 48(5-6):291-7. doi: 10.1159/000475002. [PMID: 8792874]
  • N M Hooper, A J Turner. Ectoenzymes of the kidney microvillar membrane. Aminopeptidase P is anchored by a glycosyl-phosphatidylinositol moiety. FEBS letters. 1988 Mar; 229(2):340-4. doi: 10.1016/0014-5793(88)81152-9. [PMID: 3278935]
  • S Hedeager-Sørensen, A J Kenny. Proteins of the kidney microvillar membrane. Purification and properties of carboxypeptidase P from pig kidneys. The Biochemical journal. 1985 Jul; 229(1):251-7. doi: 10.1042/bj2290251. [PMID: 4038259]
  • R Walter, W H Simmons, T Yoshimoto. Proline specific endo- and exopeptidases. Molecular and cellular biochemistry. 1980 Apr; 30(2):111-27. doi: 10.1007/bf00227927. [PMID: 6991912]