(Z)-10-Hydroxyamitriptyline (BioDeep_00000172524)
human metabolite blood metabolite
代谢物信息卡片
化学式: C20H23NO (293.1779548)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CN(C)CCC=C1C2=CC=CC=C2CC(O)C2=CC=CC=C12
InChI: InChI=1S/C20H23NO/c1-21(2)13-7-12-17-16-9-4-3-8-15(16)14-20(22)19-11-6-5-10-18(17)19/h3-6,8-12,20,22H,7,13-14H2,1-2H3
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相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
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1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- K Shimoda, T Noguchi, S Morita, Y Ozeki, M Shibasaki, T Someya, S Takahashi. Interindividual variations of desmethylation and hydroxylation of amitriptyline in a Japanese psychiatric population.
Journal of clinical psychopharmacology.
1995 Jun; 15(3):175-81. doi:
10.1097/00004714-199506000-00005. [PMID: 7635994] - F Coudoré, J Fialip, A Eschalier, J Lavarenne. Mice plasma and brain pharmacokinetics of amitriptyline and its demethylated and hydroxylated metabolites after half-life repeated administration. Comparison with acute administration.
Fundamental & clinical pharmacology.
1994; 8(6):525-31. doi:
10.1111/j.1472-8206.1994.tb00833.x. [PMID: 7721229] - X H Zhang, P Yu, N F Gu, J L Yin, W D Jiang. [Relationship between amitriptyline metabolism and polymorphic debrisoquine hydroxylation in native Chinese volunteers].
Yao xue xue bao = Acta pharmaceutica Sinica.
1993; 28(2):85-91. doi:
NULL. [PMID: 8328289] - U Breyer-Pfaff, B Pfandl, K Nill, E Nusser, C Monney, M Jonzier-Perey, D Baettig, P Baumann. Enantioselective amitriptyline metabolism in patients phenotyped for two cytochrome P450 isozymes.
Clinical pharmacology and therapeutics.
1992 Oct; 52(4):350-8. doi:
10.1038/clpt.1992.155. [PMID: 1424408] - X Zhang. [Serum concentrations of amitriptyline and its metabolites and clinical effect in depressive patients].
Zhonghua shen jing jing shen ke za zhi = Chinese journal of neurology and psychiatry.
1992 Aug; 25(4):196-8, 252. doi:
NULL. [PMID: 1478132] - E Nusser, K Nill, U Breyer-Pfaff. Enantiomer analysis of E- and Z-10-hydroxyamitriptyline in human urine.
Journal of chromatography.
1990 Jun; 528(1):163-71. doi:
10.1016/s0378-4347(00)82371-3. [PMID: 2384550] - P Baumann, M Jonzier-Perey, L Koeb, A Küpfer, D Tinguely, J Schöpf. Amitriptyline pharmacokinetics and clinical response: II. Metabolic polymorphism assessed by hydroxylation of debrisoquine and mephenytoin.
International clinical psychopharmacology.
1986 Apr; 1(2):102-12. doi:
10.1097/00004850-198604000-00002. [PMID: 3571939] - D S Robinson, T B Cooper, D Howard, J Corcella, D Albright. Amitriptyline and hydroxylated metabolite plasma levels in depressed outpatients.
Journal of clinical psychopharmacology.
1985 Apr; 5(2):83-8. doi:
10.1097/00004714-198504000-00005. [PMID: 3988974] - R Ishida, T Ozaki, H Uchida, T Irikura. Gas chromatographic--mass spectrometric determination of amitriptyline and its major metabolites in human serum.
Journal of chromatography.
1984 Jan; 305(1):73-82. doi:
10.1016/s0378-4347(00)83315-0. [PMID: 6707156] - D R Jones, B J Lukey, H E Hurst. Quantification of amitriptyline, nortriptyline, and 10-hydroxy metabolite isomers in plasma by capillary gas chromatography with nitrogen-sensitive detection.
Journal of chromatography.
1983 Dec; 278(2):291-9. doi:
10.1016/s0378-4347(00)84788-x. [PMID: 6668310] - B Mellström, C von Bahr. Demethylation and hydroxylation of amitriptyline, nortriptyline, and 10-hydroxyamitriptyline in human liver microsomes.
Drug metabolism and disposition: the biological fate of chemicals.
1981 Nov; 9(6):565-8. doi:
NULL. [PMID: 6120818]