1,4-Dihydropyridine (BioDeep_00000172473)

   

human metabolite blood metabolite


代谢物信息卡片


1,4-Dihydropyridine

化学式: C5H7N (81.0578462)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 100%

分子结构信息

SMILES: C1C=CNC=C1
InChI: InChI=1S/C5H7N/c1-2-4-6-5-3-1/h2-6H,1H2

描述信息

D002317 - Cardiovascular Agents > D002121 - Calcium Channel Blockers
D000077264 - Calcium-Regulating Hormones and Agents
D049990 - Membrane Transport Modulators

同义名列表

3 个代谢物同义名

1,4-Dihydropyridine; Dihydropyridine; Lemildipine



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Tamer Z Attia, Mahmoud A Abdelmajed, Mahmoud A Omar, Khalid M Badr El-Din. Selective Spectrofluorimetric Protocol for Determination of Commonly Used Gram-negative Bactericidal Drug in Combined Pharmaceutical Dosage Forms and Human Plasma. Journal of fluorescence. 2022 Mar; 32(2):603-612. doi: 10.1007/s10895-021-02862-6. [PMID: 35013853]
  • Kristīne Dišlere, Evita Rostoka, Egils Bisenieks, Gunars Duburs, Natalia Paramonova, Nikolajs Sjakste. 1,4-dihydropyridine derivatives increase mRNA expression of Psma3, Psmb5, and Psmc6 in rats. Arhiv za higijenu rada i toksikologiju. 2021 Jun; 72(3):148-156. doi: 10.2478/aiht-2021-72-3422. [PMID: 34187104]
  • Oluwafemi Ezekiel Kale, Miyase Gözde Gündüz, Babafemi Tosin Ogunbiyi, Temitope Funmi Ogundare, Martins Ekor, Olufunsho Awodele. M3, a 1,4-Dihydropyridine Derivative and Mixed L-/T-Type Calcium Channel Blocker, Attenuates Isoproterenol-Induced Toxicity in Male Wistar Rats. Cardiovascular toxicology. 2020 12; 20(6):627-640. doi: 10.1007/s12012-020-09587-1. [PMID: 32671560]
  • George A Mugendi, Florence M Mutua, Patrizia Natale, Tonya M Esterhuizen, Giovanni Fm Strippoli. Calcium channel blockers for people with chronic kidney disease requiring dialysis. The Cochrane database of systematic reviews. 2020 Oct; 10(?):CD011064. doi: 10.1002/14651858.cd011064.pub2. [PMID: 33000470]
  • Nele Seemann, Andrea Welling, Ingo Rustenbeck. The inhibitor of connexin Cx36 channels, mefloquine, inhibits voltage-dependent Ca2+ channels and insulin secretion. Molecular and cellular endocrinology. 2018 09; 472(?):97-106. doi: 10.1016/j.mce.2017.11.024. [PMID: 29208420]
  • Minghua Yang, Fang Zhang, Yuting Hou, Yue Su, Yinlong Guo. Screening of illegally adulterated 1,4-dihydropyridine calcium antagonists in traditional Chinese medicines by a high-performance liquid chromatography electrospray ionization in-source collision-induced dissociation triple quadrupole mass spectrometric method. Rapid communications in mass spectrometry : RCM. 2018 04; 32(8):672-676. doi: 10.1002/rcm.8076. [PMID: 29420846]
  • Takayuki Hori, Motoshi Ouchi, Naoyuki Otani, Masakatsu Nohara, Asuka Morita, Yusuke Otsuka, Promsuk Jutabha, Ikuko Shibasaki, Yasushi Matsushita, Tomoe Fujita, Hirotsugu Fukuda, Naohiko Anzai. The uricosuric effects of dihydropyridine calcium channel blockers in vivo using urate under-excretion animal models. Journal of pharmacological sciences. 2018 Apr; 136(4):196-202. doi: 10.1016/j.jphs.2017.11.011. [PMID: 29656005]
  • Manasa Kongot, Neha Maurya, Neeraj Dohare, Mehraj Ud Din Parray, Jitendra Kumar Maurya, Amit Kumar, Rajan Patel. Enthalpy-driven interaction between dihydropyrimidine compound and bovine serum albumin: a spectroscopic and computational approach. Journal of biomolecular structure & dynamics. 2018 04; 36(5):1161-1170. doi: 10.1080/07391102.2017.1314834. [PMID: 28399704]
  • Renata Nishida Goto, Lays Martin Sobral, Lucas Oliveira Sousa, Cristiana Bernadelli Garcia, Norberto Peporine Lopes, Javier Marín-Prida, Estael Ochoa-Rodríguez, Yamila Verdecia-Reyes, Gilberto Lázaro Pardo-Andreu, Carlos Curti, Andréia Machado Leopoldino. Anti-cancer activity of a new dihydropyridine derivative, VdiE-2N, in head and neck squamous cell carcinoma. European journal of pharmacology. 2018 Jan; 819(?):198-206. doi: 10.1016/j.ejphar.2017.12.009. [PMID: 29221949]
  • Christine M Murphy, Cliff Williams, Michael E Quinn, Brian Nicholson, Thomas Shoe, Michael C Beuhler, William P Kerns. Pilot Trial of Intravenous Lipid Emulsion Treatment for Severe Nifedipine-Induced Shock. Journal of medical toxicology : official journal of the American College of Medical Toxicology. 2016 12; 12(4):380-385. doi: 10.1007/s13181-016-0572-6. [PMID: 27501853]
  • Elina Leonova, Jelizaveta Sokolovska, Jean-Luc Boucher, Sergejs Isajevs, Evita Rostoka, Larisa Baumane, Tatjana Sjakste, Nikolajs Sjakste. New 1,4-Dihydropyridines Down-regulate Nitric Oxide in Animals with Streptozotocin-induced Diabetes Mellitus and Protect Deoxyribonucleic Acid against Peroxynitrite Action. Basic & clinical pharmacology & toxicology. 2016 Jul; 119(1):19-31. doi: 10.1111/bcpt.12542. [PMID: 26663724]
  • Kristīne Ošiņa, Evita Rostoka, Jelizaveta Sokolovska, Natalia Paramonova, Egils Bisenieks, Gunars Duburs, Nikolajs Sjakste, Tatjana Sjakste. 1,4-Dihydropyridine derivatives without Ca2+-antagonist activity up-regulate Psma6 mRNA expression in kidneys of intact and diabetic rats. Cell biochemistry and function. 2016 Jan; 34(1):3-6. doi: 10.1002/cbf.3160. [PMID: 26634809]
  • James B Wetmore, Jonathan D Mahnken, Milind A Phadnis, Edward F Ellerbeck, Theresa I Shireman. Relationship between calcium channel blocker class and mortality in dialysis. Pharmacoepidemiology and drug safety. 2015 Dec; 24(12):1249-58. doi: 10.1002/pds.3869. [PMID: 26371369]
  • J K Hwang, M Erkhembaatar, D R Gu, S H Lee, C H Lee, D M Shin, Y R Lee, M S Kim. Glechoma hederacea Suppresses RANKL-mediated Osteoclastogenesis. Journal of dental research. 2014 Jul; 93(7):685-90. doi: 10.1177/0022034514536579. [PMID: 24850617]
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  • Andreas Krämer, Torben Mentrup, Bertrand Kleizen, Eric Rivera-Milla, Daniela Reichenbach, Christoph Enzensperger, Richard Nohl, Eric Täuscher, Helmar Görls, Aspasia Ploubidou, Christoph Englert, Oliver Werz, Hans-Dieter Arndt, Christoph Kaether. Small molecules intercept Notch signaling and the early secretory pathway. Nature chemical biology. 2013 Nov; 9(11):731-8. doi: 10.1038/nchembio.1356. [PMID: 24077179]
  • Takanori Yasu, Mayumi Kobayashi, Akiko Mutoh, Ken Yamakawa, Shin-ichi Momomura, Shinichiro Ueda. Dihydropyridine calcium channel blockers inhibit non-esterified-fatty-acid-induced endothelial and rheological dysfunction. Clinical science (London, England : 1979). 2013 Sep; 125(5):247-55. doi: 10.1042/cs20120311. [PMID: 23535137]
  • Itsuro Kazama, Yoshio Maruyama, Mitsunobu Matsubara. Benidipine persistently inhibits delayed rectifier K(+)-channel currents in murine thymocytes. Immunopharmacology and immunotoxicology. 2013 Feb; 35(1):28-33. doi: 10.3109/08923973.2012.723011. [PMID: 22978806]
  • Raquel Gómez-Pliego, Jaime Gómez-Zamudio, Benjamín Velasco-Bejarano, Maximiliano Ibarra-Barajas, Rafael Villalobos-Molina. Effect of bis-1,4-dihydropyridine in the kidney of diabetic rats. Journal of pharmacological sciences. 2013; 122(3):184-92. doi: 10.1254/jphs.12248fp. [PMID: 23823933]
  • O Petrichenko, K Erglis, A Cēbers, A Plotniece, K Pajuste, G Béalle, Ch Ménager, E Dubois, R Perzynski. Bilayer properties of giant magnetic liposomes formed by cationic pyridine amphiphile and probed by active deformation under magnetic forces. The European physical journal. E, Soft matter. 2013 Jan; 36(1):9. doi: 10.1140/epje/i2013-13009-0. [PMID: 23359032]
  • Zanna Hyvönen, Vesa Hämäläinen, Marika Ruponen, Bart Lucas, Joanna Rejman, Dries Vercauteren, Jo Demeester, Stefaan De Smedt, Kevin Braeckmans. Elucidating the pre- and post-nuclear intracellular processing of 1,4-dihydropyridine based gene delivery carriers. Journal of controlled release : official journal of the Controlled Release Society. 2012 Aug; 162(1):167-75. doi: 10.1016/j.jconrel.2012.06.013. [PMID: 22709591]
  • R Ram, G Swarnalatha, Bh Santhosh Pai, C Shyam Sunder Rao, K V Dakshinamurty. Cloudy peritoneal fluid attributable to non-dihydropyridine calcium channel blocker. Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis. 2012 Jan; 32(1):110-1. doi: 10.3747/pdi.2010.00277. [PMID: 22302929]
  • Göknur Aktay, Memet Hanifi Emre, Alaadin Polat. Influence of dihydropyridine calcium antagonist nitrendipine on benzo(a)pyrene-induced oxidative stress. Archives of pharmacal research. 2011 Jul; 34(7):1171-5. doi: 10.1007/s12272-011-0715-x. [PMID: 21811924]
  • Atsushi Inayoshi, Yoshiyuki Sugimoto, Jun Funahashi, Saori Takahashi, Masahiro Matsubara, Hideaki Kusaka. Mechanism underlying the block of human Cav3.2 T-type Ca2+ channels by benidipine, a dihydropyridine Ca2+ channel blocker. Life sciences. 2011 May; 88(19-20):898-907. doi: 10.1016/j.lfs.2011.03.019. [PMID: 21466810]
  • Miguel A Piñeros, Mark Tester. Calcium inhibits dihydropyridine-stimulated increases in opening and unitary conductance of a plant Ca²+ channel. The Journal of membrane biology. 2011 Mar; 240(1):13-20. doi: 10.1007/s00232-011-9338-x. [PMID: 21274523]
  • Tomislava Lovaković, Marija Poljak-Blazi, Gunars Duburs, Ana Cipak, Marina Cindrić, Brigita Vigante, Egils Bisenieks, Morana Jaganjac, Lidija Mrakovcić, Azra Dedić, Neven Zarković. Growth modulation of human cells in vitro by mild oxidative stress and 1,4-dihydropyridine derivative antioxidants. Collegium antropologicum. 2011 Mar; 35(1):137-41. doi: ". [PMID: 21661362]
  • E Melendez, M Bidet, J L Reyes, S Martial, O Barbier, M Tauc, E Sanchez, P Poujeol. New evidence of a dihydropyridine-activated cationic channel in the MDCK cell line. Nephron. Physiology. 2011; 118(4):p73-81. doi: 10.1159/000325467. [PMID: 21502768]
  • Jaime N Guzman, Javier Sanchez-Padilla, David Wokosin, Jyothisri Kondapalli, Ema Ilijic, Paul T Schumacker, D James Surmeier. Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1. Nature. 2010 Dec; 468(7324):696-700. doi: 10.1038/nature09536. [PMID: 21068725]
  • Agnieszka Augustyniak, Grzegorz Bartosz, Ana Cipak, Gunars Duburs, L'ubica Horáková, Wojciech Luczaj, Magdalena Majekova, Andreani D Odysseos, Lucia Rackova, Elzbieta Skrzydlewska, Milan Stefek, Miriam Strosová, Gunars Tirzitis, Petras Rimantas Venskutonis, Jana Viskupicova, Panagiota S Vraka, Neven Zarković. Natural and synthetic antioxidants: an updated overview. Free radical research. 2010 Oct; 44(10):1216-62. doi: 10.3109/10715762.2010.508495. [PMID: 20836663]
  • Atul Kumar, Ram Awatar Maurya, Siddharth Sharma, Mukesh Kumar, Gitika Bhatia. Synthesis and biological evaluation of N-aryl-1,4-dihydropyridines as novel antidyslipidemic and antioxidant agents. European journal of medicinal chemistry. 2010 Feb; 45(2):501-9. doi: 10.1016/j.ejmech.2009.10.036. [PMID: 19962217]
  • Maria A S Fernandes, Maria S Santos, António J M Moreno, Laura Chernova, Aivars Krauze, Gunars Duburs, Joaquim A F Vicente. Effects of 5-acetyl(carbamoyl)-6-methylsulfanyl-1,4-dihydropyridine-5-carbonitriles on rat liver mitochondrial function. Toxicology in vitro : an international journal published in association with BIBRA. 2009 Oct; 23(7):1333-41. doi: 10.1016/j.tiv.2009.07.002. [PMID: 19596436]
  • Helena M Viola, Peter G Arthur, Livia C Hool. Evidence for regulation of mitochondrial function by the L-type Ca2+ channel in ventricular myocytes. Journal of molecular and cellular cardiology. 2009 Jun; 46(6):1016-26. doi: 10.1016/j.yjmcc.2008.12.015. [PMID: 19166857]
  • Masayuki Abe, Yoshihiko Ito, Asahi Suzuki, Satomi Onoue, Hiroshi Noguchi, Shizuo Yamada. Isolation and pharmacological characterization of fatty acids from saw palmetto extract. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry. 2009 Apr; 25(4):553-7. doi: 10.2116/analsci.25.553. [PMID: 19359798]
  • Helga Engi. [Perspectives of inhibition of multidrug resistance during cancer chemotherapy, in vitro and in vivo experiments]. Orvosi hetilap. 2009 Mar; 150(13):607-14. doi: 10.1556/oh.2009.28358. [PMID: 19293063]
  • Eun Joo Roh, Jason M Keller, Zoltan Olah, Michael J Iadarola, Kenneth A Jacobson. Structure-activity relationships of 1,4-dihydropyridines that act as enhancers of the vanilloid receptor 1 (TRPV1). Bioorganic & medicinal chemistry. 2008 Oct; 16(20):9349-58. doi: 10.1016/j.bmc.2008.08.048. [PMID: 18809334]
  • Yoshihiro Uesawa, Kiminori Mohri. Relationship between lipophilicities of 1,4-dihydropyridine derivatives and pharmacokinetic interaction strengths with grapefruit juice. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 2008 Jan; 128(1):117-22. doi: 10.1248/yakushi.128.117. [PMID: 18176062]
  • Alberto S Pereira, Beatriz Bicalho, Jaime O Ilha, Gilberto De Nucci. Analysis of dihydropyridine calcium channel blockers using negative ion photoionization mass spectrometry. Journal of chromatographic science. 2008 Jan; 46(1):35-41. doi: 10.1093/chromsci/46.1.35. [PMID: 18218186]
  • Julián Segura, José A García-Donaire, Luis M Ruilope. Are differences in calcium antagonists relevant across all stages of nephropathy or only proteinuric nephropathy?. Current opinion in nephrology and hypertension. 2007 Sep; 16(5):422-6. doi: 10.1097/mnh.0b013e328285dfc4. [PMID: 17693756]
  • Stavroula Ziakka, Nikolaos Kaperonis, Eleftheria Ferentinou, Filippos Karakasis, George Ntatsis, Christine Kourvelou, Nikolaos Papagalanis. Calcium channels blockers and progression of kidney disease. Renal failure. 2007; 29(8):1003-12. doi: 10.1080/08860220701643559. [PMID: 18067048]
  • Katayoun Javidnia, Ramin Miri, Azadeh Jamalian. HPLC method for analysis of a new 1,4-dihydropyridine: application to pharmacokinetic study in rabbit. Journal of pharmaceutical and biomedical analysis. 2006 Feb; 40(2):438-42. doi: 10.1016/j.jpba.2005.07.027. [PMID: 16144752]
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  • Maria A S Fernandes, Amália S Jurado, Romeu A Videira, Maria S Santos, António J M Moreno, Astrida Velena, Gunars Duburs, Catarina R Oliveira, Joaquim A F Vicente. Cerebrocrast promotes the cotransport of H+ and Cl- in rat liver mitochondria. Mitochondrion. 2005 Oct; 5(5):341-51. doi: 10.1016/j.mito.2005.06.004. [PMID: 16099223]
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