1,4-Benzothiazepine (BioDeep_00000172461)
human metabolite blood metabolite
代谢物信息卡片
化学式: C9H7NS (161.0299)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 99.17%
分子结构信息
SMILES: C1=CC=C2C(=C1)C=NC=CS2
InChI: InChI=1S/C9H7NS/c1-2-4-9-8(3-1)7-10-5-6-11-9/h1-7H
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- U Deniz Dincer. Cardiac ryanodine receptor in metabolic syndrome: is JTV519 (K201) future therapy?.
Diabetes, metabolic syndrome and obesity : targets and therapy.
2012; 5(?):89-99. doi:
10.2147/dmso.s30005. [PMID: 22563249] - W Boehmerle, M Endres. Salinomycin induces calpain and cytochrome c-mediated neuronal cell death.
Cell death & disease.
2011 Jun; 2(?):e168. doi:
10.1038/cddis.2011.46. [PMID: 21633391] - Saskia Koene, Jan Smeitink. Metabolic manipulators: a well founded strategy to combat mitochondrial dysfunction.
Journal of inherited metabolic disease.
2011 Apr; 34(2):315-25. doi:
10.1007/s10545-010-9162-y. [PMID: 20668944] - S Beuck, W Schänzer, M Thevis. Investigation of the in vitro metabolism of the emerging drug candidate S107 for doping-preventive purposes.
Journal of mass spectrometry : JMS.
2011 Feb; 46(2):112-30. doi:
10.1002/jms.1878. [PMID: 21254313] - Mario Thevis, Simon Beuck, Andreas Thomas, Gregor Fusshöller, Gerg Sigmund, Nils Schlörer, Grigory Rodchenkov, Mathias Schäfer, Wilhelm Schänzer. Electron ionization mass spectrometry of the ryanodine receptor-based Ca(2+)-channel stabilizer S-107 and its implementation into routine doping control.
Rapid communications in mass spectrometry : RCM.
2009 Aug; 23(15):2363-70. doi:
10.1002/rcm.4161. [PMID: 19575395] - Yoichi Miwa, Hiroyuki Masai, Masatoshi Shimizu. Differential effects of calcium-channel blockers on vascular endothelial function in patients with coronary spastic angina.
Circulation journal : official journal of the Japanese Circulation Society.
2009 Apr; 73(4):713-7. doi:
10.1253/circj.cj-08-0188. [PMID: 19225210] - Mario Thevis, Simon Beuck, Andreas Thomas, Maxie Kohler, Nils Schlörer, Ileana Vajiala, Wilhelm Schänzer. Screening for the calstabin-ryanodine receptor complex stabilizers JTV-519 and S-107 in doping control analysis.
Drug testing and analysis.
2009 Jan; 1(1):32-42. doi:
10.1002/dta.13. [PMID: 20355157] - Donald J Hunt, Peter P Jones, Ruiwu Wang, Wenqian Chen, Jeff Bolstad, Keyun Chen, Yakhin Shimoni, S R Wayne Chen. K201 (JTV519) suppresses spontaneous Ca2+ release and [3H]ryanodine binding to RyR2 irrespective of FKBP12.6 association.
The Biochemical journal.
2007 Jun; 404(3):431-8. doi:
10.1042/bj20070135. [PMID: 17313373] - Kozo Yao, Hiroshi Maeda, Yasuhiro Ina, Miwa Sato, Kazuhiro Fujita, Takashi Kuwabara, Hiroyuki Kobayashi, Shiro Shirakura. Combined effects of benidipine and diltiazem on cardiohemodynamics in anesthetized dogs.
Biological & pharmaceutical bulletin.
2006 Apr; 29(4):730-4. doi:
10.1248/bpb.29.730. [PMID: 16595908] - Ondrej Lisy, John C Burnett. New cardioprotective agent K201 is natriuretic and glomerular filtration rate enhancing.
Circulation.
2006 Jan; 113(2):246-51. doi:
10.1161/circulationaha.105.558213. [PMID: 16401775] - David Cia, Agnès Bordais, Carolina Varela, Valérie Forster, José A Sahel, Alvaro Rendon, Serge Picaud. Voltage-gated channels and calcium homeostasis in mammalian rod photoreceptors.
Journal of neurophysiology.
2005 Mar; 93(3):1468-75. doi:
10.1152/jn.00874.2004. [PMID: 15483058] - Norifumi Shimizu, Shiroh Kishioka, Takehiko Maeda, Yohji Fukazawa, Chizuko Yamamoto, Masanobu Ozaki, Hiroyuki Yamamoto. Role of pharmacokinetic effects in the potentiation of morphine analgesia by L-type calcium channel blockers in mice.
Journal of pharmacological sciences.
2004 Mar; 94(3):240-5. doi:
10.1254/jphs.94.240. [PMID: 15037808] - S Hallén, A Björquist, A M Ostlund-Lindqvist, G Sachs. Identification of a region of the ileal-type sodium/bile acid cotransporter interacting with a competitive bile acid transport inhibitor.
Biochemistry.
2002 Dec; 41(50):14916-24. doi:
10.1021/bi0205404. [PMID: 12475240]
