1,4-Benzodiazepine (BioDeep_00000172459)

   

human metabolite blood metabolite


代谢物信息卡片


1,4-Benzodiazepine-2,5-dione

化学式: C9H8N2 (144.0687448)
中文名称:
谱图信息: 最多检出来源 Danio rerio(blood) 20%

分子结构信息

SMILES: C1=CC=C2C(=C1)C=NC=CN2
InChI: InChI=1S/C9H8N2/c1-2-4-9-8(3-1)7-10-5-6-11-9/h1-7,11H

描述信息

D007155 - Immunologic Factors

同义名列表

3 个代谢物同义名

1,4-Benzodiazepine-2,5-dione; 1H-1,4-benzodiazepine; 1,4-Benzodiazepine



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • M Ia Holovenko, V B Larionov. [Kinetics of hydrolysis of 1,4-benzodiazepine derivative by carboxylesterases in mice organism]. Ukrainian biochemical journal. 2014 Jul; 86(4):150-7. doi: 10.15407/ubj86.04.150. [PMID: 25509194]
  • Nunzio Denora, Tommaso Cassano, Valentino Laquintana, Antonio Lopalco, Adriana Trapani, Concetta Stefania Cimmino, Leonardo Laconca, Andrea Giuffrida, Giuseppe Trapani. Novel codrugs with GABAergic activity for dopamine delivery in the brain. International journal of pharmaceutics. 2012 Nov; 437(1-2):221-31. doi: 10.1016/j.ijpharm.2012.08.023. [PMID: 22940209]
  • Chang-Rui Chen, Xu-Zhao Zhou, Yan-Jia Luo, Zhi-Li Huang, Yoshihiro Urade, Wei-Min Qu. Magnolol, a major bioactive constituent of the bark of Magnolia officinalis, induces sleep via the benzodiazepine site of GABA(A) receptor in mice. Neuropharmacology. 2012 Nov; 63(6):1191-9. doi: 10.1016/j.neuropharm.2012.06.031. [PMID: 22771461]
  • Nina Kämmerer, Tagrid Lemenager, Martin Grosshans, Falk Kiefer, Derik Hermann. [Pregabalin for the reduction of opiate withdrawal symptoms]. Psychiatrische Praxis. 2012 Oct; 39(7):351-2. doi: 10.1055/s-0032-1305042. [PMID: 22689280]
  • Sheng-Chang Wang, Hsiao-Hui Tsou, Chia-Hui Chen, Yu-Ting Chen, Ing-Kang Ho, Chin-Fu Hsiao, Sun-Yuan Chou, Yen-Feng Lin, Kai-Chi Fang, Chieh-Liang Huang, Lien-Wen Su, Yung-Chun Fang, Ming-Lun Liu, Hsiao-Yu Wu, Keh-Ming Lin, Shu Chih Liu, Hsiang-Wei Kuo, I-Chen Chiang, Andrew C H Chen, Jia-Ni Tian, Yu-Li Liu. Genetic polymorphisms in the opioid receptor mu1 gene are associated with changes in libido and insomnia in methadone maintenance patients. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. 2012 Oct; 22(10):695-703. doi: 10.1016/j.euroneuro.2012.02.002. [PMID: 22406240]
  • Nardeli Boufleur, Caren T D Antoniazzi, Camila S Pase, Dalila M Benvegnú, Raquel C S Barcelos, Geisa S Dolci, Verônica T Dias, Katiane Roversi, Karine Roversi, Gessi Koakoskia, João G Rosa, Leonardo J G Barcellos, Marilise E Bürger. Neonatal tactile stimulation changes anxiety-like behavior and improves responsiveness of rats to diazepam. Brain research. 2012 Sep; 1474(?):50-9. doi: 10.1016/j.brainres.2012.08.002. [PMID: 22898153]
  • Stephanie J Marin, Mark Roberts, Michelle Wood, Gwendolyn A McMillin. Sensitive UPLC-MS-MS assay for 21 benzodiazepine drugs and metabolites, zolpidem and zopiclone in serum or plasma. Journal of analytical toxicology. 2012 Sep; 36(7):472-6. doi: 10.1093/jat/bks059. [PMID: 22833647]
  • Germain Sotoing Taïwe, Elisabeth Ngo Bum, Emmanuel Talla, Amadou Dawe, Fleur Clarisse Okomolo Moto, Gwladys Temkou Ngoupaye, Neteydji Sidiki, Bernard Dabole, Paul Désiré Djomeni Dzeufiet, Théophile Dimo, Michel De Waard. Antipsychotic and sedative effects of the leaf extract of Crassocephalum bauchiense (Hutch.) Milne-Redh (Asteraceae) in rodents. Journal of ethnopharmacology. 2012 Aug; 143(1):213-20. doi: 10.1016/j.jep.2012.06.026. [PMID: 22750453]
  • Pablinny Moreira Galdino, Marcus Vinícius Mariano Nascimento, Iziara Ferreira Florentino, Roberta Campos Lino, James Oluwagbamigbe Fajemiroye, Beatriz Abdallah Chaibub, José Realino de Paula, Thereza Christina Monteiro de Lima, Elson Alves Costa. The anxiolytic-like effect of an essential oil derived from Spiranthera odoratissima A. St. Hil. leaves and its major component, β-caryophyllene, in male mice. Progress in neuro-psychopharmacology & biological psychiatry. 2012 Aug; 38(2):276-84. doi: 10.1016/j.pnpbp.2012.04.012. [PMID: 22542869]
  • C Cellai, M Balliu, A Laurenzana, L Guandalini, R Matucci, D Miniati, E Torre, A Nebbioso, V Carafa, L Altucci, M N Romanelli, F Paoletti. The new low-toxic histone deacetylase inhibitor S-(2) induces apoptosis in various acute myeloid leukaemia cells. Journal of cellular and molecular medicine. 2012 Aug; 16(8):1758-65. doi: 10.1111/j.1582-4934.2011.01464.x. [PMID: 22004558]
  • Hugh R Wiltshire, Gavin J Kilpatrick, Gary S Tilbrook, Keith M Borkett. A placebo- and midazolam-controlled phase I single ascending-dose study evaluating the safety, pharmacokinetics, and pharmacodynamics of remimazolam (CNS 7056): Part II. Population pharmacokinetic and pharmacodynamic modeling and simulation. Anesthesia and analgesia. 2012 Aug; 115(2):284-96. doi: 10.1213/ane.0b013e318241f68a. [PMID: 22253270]
  • Anita S Kablinger, Marie A Lindner, Stephanie Casso, Franz Hefti, George DeMuth, Barbara S Fox, Lindsay A McNair, Bruce G McCarthy, Nicholas E Goeders. Effects of the combination of metyrapone and oxazepam on cocaine craving and cocaine taking: a double-blind, randomized, placebo-controlled pilot study. Journal of psychopharmacology (Oxford, England). 2012 Jul; 26(7):973-81. doi: 10.1177/0269881111430745. [PMID: 22236504]
  • Sabina Shrestha, Ji-Hae Park, Dae-Young Lee, Jin-Gyeong Cho, Suengmok Cho, Hye-Jin Yang, Hye-Im Yong, Min-Seok Yoon, Dae-Seok Han, Nam-In Baek. Rhus parviflora and its biflavonoid constituent, rhusflavone, induce sleep through the positive allosteric modulation of GABA(A)-benzodiazepine receptors. Journal of ethnopharmacology. 2012 Jun; 142(1):213-20. doi: 10.1016/j.jep.2012.04.047. [PMID: 22579675]
  • James Oluwagbamigbe Fajemiroye, Pablinny Moreira Galdino, Suzana Fereirra Alves, Joelma Abadia Marciano de Paula, José Realino de Paula, Paulo Cesár Ghedini, Elson Alves Costa. Involvement of 5-HT1A in the anxiolytic-like effect of dichloromethane fraction of Pimenta pseudocaryophyllus. Journal of ethnopharmacology. 2012 Jun; 141(3):872-7. doi: 10.1016/j.jep.2012.03.043. [PMID: 22472106]
  • Karen Miotto, Aaron Kaufman, Alexander Kong, Grace Jun, Jeffrey Schwartz. Managing co-occurring substance use and pain disorders. The Psychiatric clinics of North America. 2012 Jun; 35(2):393-409. doi: 10.1016/j.psc.2012.03.006. [PMID: 22640762]
  • Dubravka Švob Štrac, Dorotea Muck-Šeler, Nela Pivac. The involvement of noradrenergic mechanisms in the suppressive effects of diazepam on the hypothalamic-pituitary-adrenal axis activity in female rats. Croatian medical journal. 2012 Jun; 53(3):214-23. doi: 10.3325/cmj.2012.53.214. [PMID: 22661134]
  • J Sarris, A Scholey, I Schweitzer, C Bousman, E Laporte, C Ng, G Murray, C Stough. The acute effects of kava and oxazepam on anxiety, mood, neurocognition; and genetic correlates: a randomized, placebo-controlled, double-blind study. Human psychopharmacology. 2012 May; 27(3):262-9. doi: 10.1002/hup.2216. [PMID: 22311378]
  • L Veenman, M Gavish. The role of 18 kDa mitochondrial translocator protein (TSPO) in programmed cell death, and effects of steroids on TSPO expression. Current molecular medicine. 2012 May; 12(4):398-412. doi: 10.2174/1566524011207040398. [PMID: 22348610]
  • M Hardmeier, R Zimmermann, S Rüegg, M Pflüger, S Deuster, K Suter, M Donzelli, J Drewe, S Krähenbühl, P Fuhr, M Haschke. Intranasal midazolam: pharmacokinetics and pharmacodynamics assessed by quantitative EEG in healthy volunteers. Clinical pharmacology and therapeutics. 2012 May; 91(5):856-62. doi: 10.1038/clpt.2011.316. [PMID: 22453191]
  • Kathrin Arnhard, Rupert Schmid, Uwe Kobold, Roland Thiele. Rapid detection and quantification of 35 benzodiazepines in urine by GC-TOF-MS. Analytical and bioanalytical chemistry. 2012 May; 403(3):755-68. doi: 10.1007/s00216-012-5877-y. [PMID: 22447215]
  • J Bobes, G Rubio, A Terán, G Cervera, V López-Gómez, I Vilardaga, M Pérez. Pregabalin for the discontinuation of long-term benzodiazepines use: an assessment of its effectiveness in daily clinical practice. European psychiatry : the journal of the Association of European Psychiatrists. 2012 May; 27(4):301-7. doi: 10.1016/j.eurpsy.2010.12.004. [PMID: 21334859]
  • S Mukherjee, S K Das. Translocator protein (TSPO) in breast cancer. Current molecular medicine. 2012 May; 12(4):443-57. doi: NULL. [PMID: 22348612]
  • Ayano Fukuhara, Hidemitsu Nakajima, Yuya Miyamoto, Katsuaki Inoue, Satoshi Kume, Young-Ho Lee, Masanori Noda, Susumu Uchiyama, Shigeru Shimamoto, Shigenori Nishimura, Tadayasu Ohkubo, Yuji Goto, Tadayoshi Takeuchi, Takashi Inui. Drug delivery system for poorly water-soluble compounds using lipocalin-type prostaglandin D synthase. Journal of controlled release : official journal of the Controlled Release Society. 2012 Apr; 159(1):143-50. doi: 10.1016/j.jconrel.2011.12.020. [PMID: 22226778]
  • Werner J Heinz, Anna Grau, Anne Ulrich, Annegret Helle-Beyersdorf, Janina Zirkel, Diana Schirmer, Ulrike Lenker, Hermann Einsele, Hartwig Klinker. Impact of benzodiazepines on posaconazole serum concentrations. A population-based pharmacokinetic study on drug interaction. Current medical research and opinion. 2012 Apr; 28(4):551-7. doi: 10.1185/03007995.2012.664123. [PMID: 22303909]
  • Chia-Hung Kao, Li-Min Sun, Kuan-Pin Su, Shih-Ni Chang, Fung-Chang Sung, Chih-Hsin Muo, Ji-An Liang. Benzodiazepine use possibly increases cancer risk: a population-based retrospective cohort study in Taiwan. The Journal of clinical psychiatry. 2012 Apr; 73(4):e555-60. doi: 10.4088/jcp.11m07333. [PMID: 22579162]
  • Patrick B Kyle, Kathryn B Brown, Alyssa P Bailey, John L Stevenson. Reactivity of commercial benzodiazepine immunoassays to phenazepam. Journal of analytical toxicology. 2012 Apr; 36(3):207-9. doi: 10.1093/jat/bks008. [PMID: 22417837]
  • Rudra Prosad Goswami, Swati Mondal, Subrata Basu, Partha Sarathi Karmakar, Alakendu Ghosh. A sound sleep. Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine. 2012 Apr; 16(2):106-8. doi: 10.4103/0972-5229.99128. [PMID: 22988366]
  • Juan Carlos Perazzo, Silvina Tallis, Amalia Delfante, Pablo Andrés Souto, Abraham Lemberg, Francisco Xavier Eizayaga, Salvador Romay. Hepatic encephalopathy: An approach to its multiple pathophysiological features. World journal of hepatology. 2012 Mar; 4(3):50-65. doi: 10.4254/wjh.v4.i3.50. [PMID: 22489256]
  • Lieve Desbonnet, Orna Tighe, Maria Karayiorgou, Joseph A Gogos, John L Waddington, Colm M P O'Tuathaigh. Physiological and behavioural responsivity to stress and anxiogenic stimuli in COMT-deficient mice. Behavioural brain research. 2012 Mar; 228(2):351-8. doi: 10.1016/j.bbr.2011.12.014. [PMID: 22192380]
  • Einat Peles, Shaul Schreiber, Miki Bloch, Shaul Dollberg, Miriam Adelson. Duration of methadone maintenance treatment during pregnancy and pregnancy outcome parameters in women with opiate addiction. Journal of addiction medicine. 2012 Mar; 6(1):18-23. doi: 10.1097/adm.0b013e318229bb25. [PMID: 21817914]
  • A M Quílez, M T Saenz, M D García. Uncaria tomentosa (Willd. ex. Roem. & Schult.) DC. and Eucalyptus globulus Labill. interactions when administered with diazepam. Phytotherapy research : PTR. 2012 Mar; 26(3):458-61. doi: 10.1002/ptr.3593. [PMID: 21928376]
  • Judith Singhuber, Igor Baburin, Sophia Khom, Martin Zehl, Ernst Urban, Steffen Hering, Brigitte Kopp. GABA(A) receptor modulators from the Chinese herbal drug Junci Medulla--the pith of Juncus effusus. Planta medica. 2012 Mar; 78(5):455-8. doi: 10.1055/s-0031-1298174. [PMID: 22271080]
  • Charles Mikel, Amadeo Pesce, Cameron West. 3 things to consider before relying solely on point of care tests for determining benzodiazepine use in chronic pain. Pain physician. 2012 Mar; 15(2):E154-5; author reply E155. doi: NULL. [PMID: 22430663]
  • Jobin Mathew, Savitha Balakrishnan, Sherin Antony, Pretty Mary Abraham, C S Paulose. Decreased GABA receptor in the cerebral cortex of epileptic rats: effect of Bacopa monnieri and Bacoside-A. Journal of biomedical science. 2012 Feb; 19(?):25. doi: 10.1186/1423-0127-19-25. [PMID: 22364254]
  • Judith Singhuber, Igor Baburin, Hanspeter Kählig, Ernst Urban, Brigitte Kopp, Steffen Hering. GABA(A) receptor modulators from Chinese herbal medicines traditionally applied against insomnia and anxiety. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2012 Feb; 19(3-4):334-40. doi: 10.1016/j.phymed.2011.10.009. [PMID: 22118921]
  • A W Jones, A Holmgren, J Ahlner. Concentrations of free-morphine in peripheral blood after recent use of heroin in overdose deaths and in apprehended drivers. Forensic science international. 2012 Feb; 215(1-3):18-24. doi: 10.1016/j.forsciint.2011.01.043. [PMID: 21353406]
  • T Kosjek, S Perko, M Zupanc, M Zanoški Hren, T Landeka Dragičević, D Zigon, B Kompare, E Heath. Environmental occurrence, fate and transformation of benzodiazepines in water treatment. Water research. 2012 Feb; 46(2):355-68. doi: 10.1016/j.watres.2011.10.056. [PMID: 22115636]
  • Yi Shen, A Kerstin Lindemeyer, Claudia Gonzalez, Xuesi M Shao, Igor Spigelman, Richard W Olsen, Jing Liang. Dihydromyricetin as a novel anti-alcohol intoxication medication. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2012 Jan; 32(1):390-401. doi: 10.1523/jneurosci.4639-11.2012. [PMID: 22219299]
  • Chung-Hsiang Liu, Yi-Wen Lin, Nou-Ying Tang, Hsu-Jan Liu, Ching-Liang Hsieh. Neuroprotective Effect of Uncaria rhynchophylla in Kainic Acid-Induced Epileptic Seizures by Modulating Hippocampal Mossy Fiber Sprouting, Neuron Survival, Astrocyte Proliferation, and S100B Expression. Evidence-based complementary and alternative medicine : eCAM. 2012; 2012(?):194790. doi: 10.1155/2012/194790. [PMID: 21837247]
  • Victor J Valdes, Alejandro Athie, Laura S Salinas, Rosa E Navarro, Luis Vaca. CUP-1 is a novel protein involved in dietary cholesterol uptake in Caenorhabditis elegans. PloS one. 2012; 7(3):e33962. doi: 10.1371/journal.pone.0033962. [PMID: 22479487]
  • Gisela Skopp, Gisela Zimmer. [Pregabalin--a drug with abuse potential?]. Archiv fur Kriminologie. 2012 Jan; 229(1-2):44-54. doi: NULL. [PMID: 22448469]
  • Cory D Champagne, Dorian S Houser, Daniel P Costa, Daniel E Crocker. The effects of handling and anesthetic agents on the stress response and carbohydrate metabolism in northern elephant seals. PloS one. 2012; 7(5):e38442. doi: 10.1371/journal.pone.0038442. [PMID: 22693622]
  • Wesley Anderson, Mark Barrows, Fernando Lopez, Sara Rogers, Adriana Ortiz-Coffie, David Norman, Jonathan Hodges, Keith McDonald, Devon Barnes, Suzanne McCall, Johnson Arthur Don, Thomas E Ceremuga. Investigation of the anxiolytic effects of naringenin, a component of Mentha aquatica, in the male Sprague-Dawley rat. Holistic nursing practice. 2012 Jan; 26(1):52-7. doi: 10.1097/hnp.0b013e31823c003a. [PMID: 22157509]
  • W Gordon Frankle, Raymond Y Cho, N Scott Mason, Chi-Min Chen, Michael Himes, Christopher Walker, David A Lewis, Chester A Mathis, Rajesh Narendran. [11C]flumazenil binding is increased in a dose-dependent manner with tiagabine-induced elevations in GABA levels. PloS one. 2012; 7(2):e32443. doi: 10.1371/journal.pone.0032443. [PMID: 22384252]
  • Anderson Marques de Oliveira, Lucia M Conserva, Jamylle N De Souza Ferro, Fabíola de Almeida Brito, Rosângela P Lyra Lemos, Emiliano Barreto. Antinociceptive and anti-inflammatory effects of octacosanol from the leaves of Sabicea grisea var. grisea in mice. International journal of molecular sciences. 2012; 13(2):1598-1611. doi: 10.3390/ijms13021598. [PMID: 22408410]
  • Anna M Arroyo Plasencia, Lynn M Ballentine, James B Mowry, Louise W Kao. Benzodiazepine-associated atrioventricular block. American journal of therapeutics. 2012 Jan; 19(1):e48-52. doi: 10.1097/mjt.0b013e3181dcf572. [PMID: 20535011]
  • S B Sartori, N Whittle, A Hetzenauer, N Singewald. Magnesium deficiency induces anxiety and HPA axis dysregulation: modulation by therapeutic drug treatment. Neuropharmacology. 2012 Jan; 62(1):304-12. doi: 10.1016/j.neuropharm.2011.07.027. [PMID: 21835188]
  • Emanuel Calenoff. Interplaying factors that effect multiple sclerosis causation and sustenance. ISRN neurology. 2012; 2012(?):851541. doi: 10.5402/2012/851541. [PMID: 22462023]
  • Rachad Alnamer, Katim Alaoui, El Houcine Bouidida, Abdelaziz Benjouad, Yahia Cherrah. Sedative and Hypnotic Activities of the Methanolic and Aqueous Extracts of Lavandula officinalis from Morocco. Advances in pharmacological sciences. 2012; 2012(?):270824. doi: 10.1155/2012/270824. [PMID: 22162677]
  • Laurence Desrues, Thomas Lefebvre, Céline Lecointre, Marie-Thérèse Schouft, Jérôme Leprince, Vincent Compère, Fabrice Morin, François Proust, Pierrick Gandolfo, Marie-Christine Tonon, Hélène Castel. Down-regulation of GABA(A) receptor via promiscuity with the vasoactive peptide urotensin II receptor. Potential involvement in astrocyte plasticity. PloS one. 2012; 7(5):e36319. doi: 10.1371/journal.pone.0036319. [PMID: 22563490]
  • Ahmed A Omran, Abdel-Aziz El-Sayed, Ahmed Shehata. Binding of benzodiazepine drugs to bovine serum albumin: a second derivative spectrophotometric study. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2011 Dec; 83(1):362-7. doi: 10.1016/j.saa.2011.08.047. [PMID: 21930425]
  • Derek J Roberts, Richard I Hall, Andreas H Kramer, Helen Lee Robertson, Clare N Gallagher, David A Zygun. Sedation for critically ill adults with severe traumatic brain injury: a systematic review of randomized controlled trials. Critical care medicine. 2011 Dec; 39(12):2743-51. doi: 10.1097/ccm.0b013e318228236f. [PMID: 22094498]
  • Tarun Dua, Corrado Barbui, Nicolas Clark, Alexandra Fleischmann, Vladimir Poznyak, Mark van Ommeren, M Taghi Yasamy, Jose Luis Ayuso-Mateos, Gretchen L Birbeck, Colin Drummond, Melvyn Freeman, Panteleimon Giannakopoulos, Itzhak Levav, Isidore S Obot, Olayinka Omigbodun, Vikram Patel, Michael Phillips, Martin Prince, Afarin Rahimi-Movaghar, Atif Rahman, Josemir W Sander, John B Saunders, Chiara Servili, Thara Rangaswamy, Jürgen Unützer, Peter Ventevogel, Lakshmi Vijayakumar, Graham Thornicroft, Shekhar Saxena. Evidence-based guidelines for mental, neurological, and substance use disorders in low- and middle-income countries: summary of WHO recommendations. PLoS medicine. 2011 Nov; 8(11):e1001122. doi: 10.1371/journal.pmed.1001122. [PMID: 22110406]
  • Akihiro Takano, Balázs Gulyás, Andrea Varrone, Per Karlsson, Nils Sjoholm, Stig Larsson, Cathrine Jonsson, Richard Odh, Richard Sparks, Nabil Al Tawil, Anja Hoffmann, Torsten Zimmermann, Andrea Thiele, Christer Halldin. Biodistribution and radiation dosimetry of the 18 kDa translocator protein (TSPO) radioligand [18F]FEDAA1106: a human whole-body PET study. European journal of nuclear medicine and molecular imaging. 2011 Nov; 38(11):2058-65. doi: 10.1007/s00259-011-1864-3. [PMID: 21732107]
  • Keisuke Migita, Masahiko Tomiyama, Junko Yamada, Masashi Fukuzawa, Takashi Kanematsu, Masato Hirata, Shinya Ueno. Phenotypes of pain behavior in phospholipase C-related but catalytically inactive protein type 1 knockout mice. Molecular pain. 2011 Oct; 7(?):79. doi: 10.1186/1744-8069-7-79. [PMID: 22008183]
  • Detlef Degner, Michael A Nitsche, Frank Bias, Eckart Rüther, Udo Reulbach. EEG alterations during treatment with olanzapine. European archives of psychiatry and clinical neuroscience. 2011 Oct; 261(7):483-8. doi: 10.1007/s00406-011-0208-4. [PMID: 21431467]
  • Steve Wiseman, Jith K Thomas, Eric Higley, Olesya Hursky, Michael Pietrock, Jason C Raine, John P Giesy, David M Janz, Markus Hecker. Chronic exposure to dietary selenomethionine increases gonadal steroidogenesis in female rainbow trout. Aquatic toxicology (Amsterdam, Netherlands). 2011 Oct; 105(3-4):218-26. doi: 10.1016/j.aquatox.2011.06.012. [PMID: 21762653]
  • Beena Parikh, Jyotsna Maliwad, Veena R Shah. Preventive analgesia: Effect of small dose of ketamine on morphine requirement after renal surgery. Journal of anaesthesiology, clinical pharmacology. 2011 Oct; 27(4):485-8. doi: 10.4103/0970-9185.86592. [PMID: 22096281]
  • Steve Wiseman, Jith K Thomas, Landon McPhee, Olesya Hursky, Jason C Raine, Michael Pietrock, John P Giesy, Markus Hecker, David M Janz. Attenuation of the cortisol response to stress in female rainbow trout chronically exposed to dietary selenomethionine. Aquatic toxicology (Amsterdam, Netherlands). 2011 Oct; 105(3-4):643-51. doi: 10.1016/j.aquatox.2011.09.002. [PMID: 21963595]
  • J Vasantha, P Soundararajan, N Vanitharani, G Kannan, P Thennarasu, G Neenu, C Umamaheswara Reddy. Safety and efficacy of nicotinamide in the management of hyperphosphatemia in patients on hemodialysis. Indian journal of nephrology. 2011 Oct; 21(4):245-9. doi: 10.4103/0971-4065.83735. [PMID: 22022084]
  • Janelle M Ward, Brett D Gartrell, Jesse R Conklin, Phil F Battley. Midazolam as an adjunctive therapy for capture myopathy in Bar-tailed Godwits (Limosa lapponica baueri) with prognostic indicators. Journal of wildlife diseases. 2011 Oct; 47(4):925-35. doi: 10.7589/0090-3558-47.4.925. [PMID: 22102663]
  • Suzanna M Zick, Benjamin D Wright, Ananda Sen, J Todd Arnedt. Preliminary examination of the efficacy and safety of a standardized chamomile extract for chronic primary insomnia: a randomized placebo-controlled pilot study. BMC complementary and alternative medicine. 2011 Sep; 11(?):78. doi: 10.1186/1472-6882-11-78. [PMID: 21939549]
  • Simone Patergnani, Jan M Suski, Chiara Agnoletto, Angela Bononi, Massimo Bonora, Elena De Marchi, Carlotta Giorgi, Saverio Marchi, Sonia Missiroli, Federica Poletti, Alessandro Rimessi, Jerzy Duszynski, Mariusz R Wieckowski, Paolo Pinton. Calcium signaling around Mitochondria Associated Membranes (MAMs). Cell communication and signaling : CCS. 2011 Sep; 9(?):19. doi: 10.1186/1478-811x-9-19. [PMID: 21939514]
  • Yufei Li, Doni Hikmat Ramdhan, Hisao Naito, Nozomi Yamagishi, Yuki Ito, Yumi Hayashi, Yukie Yanagiba, Ai Okamura, Hazuki Tamada, Frank J Gonzalez, Tamie Nakajima. Ammonium perfluorooctanoate may cause testosterone reduction by adversely affecting testis in relation to PPARα. Toxicology letters. 2011 Sep; 205(3):265-72. doi: 10.1016/j.toxlet.2011.06.015. [PMID: 21712084]
  • R Parrish Waters, Ronald E See. Chronic cocaine self-administration attenuates the anxiogenic-like and stress potentiating effects of the benzodiazepine inverse agonist, FG 7142. Pharmacology, biochemistry, and behavior. 2011 Sep; 99(3):408-13. doi: 10.1016/j.pbb.2011.05.021. [PMID: 21635914]
  • Daniel B Hawcutt, Sunil Sampath, Alison Timmis, Veronica Newland, Paul Newland, Richard Appleton. Serum phenytoin concentrations in paediatric patients following intravenous loading. Archives of disease in childhood. 2011 Sep; 96(9):883-4. doi: 10.1136/adc.2011.215269. [PMID: 21596726]
  • Einat Peles, Shaul Schreiber, Vera Rados, Miriam Adelson. Low risk for hepatitis C seroconversion in methadone maintenance treatment. Journal of addiction medicine. 2011 Sep; 5(3):214-20. doi: 10.1097/adm.0b013e31820e13dd. [PMID: 21844836]
  • Celso A Rodrigues de Almeida Costa, Daniele Oliveira Kohn, Valéria Martins de Lima, André Costa Gargano, Jorge Camilo Flório, Mirtes Costa. The GABAergic system contributes to the anxiolytic-like effect of essential oil from Cymbopogon citratus (lemongrass). Journal of ethnopharmacology. 2011 Sep; 137(1):828-36. doi: 10.1016/j.jep.2011.07.003. [PMID: 21767622]
  • Poonam Mahendra, Shradha Bisht. Anti-anxiety activity of Coriandrum sativum assessed using different experimental anxiety models. Indian journal of pharmacology. 2011 Sep; 43(5):574-7. doi: 10.4103/0253-7613.84975. [PMID: 22022003]
  • A V Turina, G J Quinteros, B Caruso, E L Moyano, M A Perillo. Surface active benzodiazepine-bromo-alkyl conjugate for potential GABAA-receptor purification. Organic & biomolecular chemistry. 2011 Aug; 9(16):5737-47. doi: 10.1039/c1ob05210a. [PMID: 21717023]
  • Ismene A Dontas, Katerina A Marinou, Dimitrios Iliopoulos, Nektaria Tsantila, George Agrogiannis, Apostolos Papalois, Theodore Karatzas. Changes of blood biochemistry in the rabbit animal model in atherosclerosis research; a time- or stress-effect. Lipids in health and disease. 2011 Aug; 10(?):139. doi: 10.1186/1476-511x-10-139. [PMID: 21838924]
  • Nicholas J Doperalski, Christopher J Martyniuk, Melinda S Prucha, Kevin J Kroll, Nancy D Denslow, David S Barber. Cloning and expression of the translocator protein (18 kDa), voltage-dependent anion channel, and diazepam binding inhibitor in the gonad of largemouth bass (Micropterus salmoides) across the reproductive cycle. General and comparative endocrinology. 2011 Aug; 173(1):86-95. doi: 10.1016/j.ygcen.2011.04.027. [PMID: 21600210]
  • Caroline Drake, Hervé Boutin, Matthew S Jones, Adam Denes, Barry W McColl, Johann R Selvarajah, Sharon Hulme, Rachel F Georgiou, Rainer Hinz, Alexander Gerhard, Andy Vail, Christian Prenant, Peter Julyan, Renaud Maroy, Gavin Brown, Alison Smigova, Karl Herholz, Michael Kassiou, David Crossman, Sheila Francis, Spencer D Proctor, James C Russell, Stephen J Hopkins, Pippa J Tyrrell, Nancy J Rothwell, Stuart M Allan. Brain inflammation is induced by co-morbidities and risk factors for stroke. Brain, behavior, and immunity. 2011 Aug; 25(6):1113-22. doi: 10.1016/j.bbi.2011.02.008. [PMID: 21356305]
  • J Braudeau, B Delatour, A Duchon, P Lopes Pereira, L Dauphinot, F de Chaumont, J-C Olivo-Marin, R H Dodd, Y Hérault, M-C Potier. Specific targeting of the GABA-A receptor α5 subtype by a selective inverse agonist restores cognitive deficits in Down syndrome mice. Journal of psychopharmacology (Oxford, England). 2011 Aug; 25(8):1030-42. doi: 10.1177/0269881111405366. [PMID: 21693554]
  • Herman Henkes, Michael Franz, Orin Kendall, Jacqueline Monroe, Anna Legaspi, Joann LeDoux, Christopher Haese, Daniel Williams, Suzanne McCall, Arthur Don Johnson, Thomas E Ceremuga. Evaluation of the anxiolytic properties of tetrahydropalmatine, a Corydalis yanhusuo compound, in the male Sprague-Dawley rat. AANA journal. 2011 Aug; 79(4 Suppl):S75-80. doi: ". [PMID: 22403971]
  • Fatemeh Emadi, Narguess Yassa, Abbas Hadjiakhoondi, Cordian Beyer, Mohammad Sharifzadeh. Sedative effects of Iranian Artemisia annua in mice: possible benzodiazepine receptors involvement. Pharmaceutical biology. 2011 Aug; 49(8):784-8. doi: 10.3109/13880209.2010.548389. [PMID: 21554148]
  • M Rabbani, S E Sajjadi, S Khalili. A Lack of tolerance to the anxiolytic action of Echium amoenum. Research in pharmaceutical sciences. 2011 Jul; 6(2):101-6. doi: ". [PMID: 22224093]
  • Shilan Mozaffari, Hadi Esmaily, Roja Rahimi, Maryam Baeeri, Yara Sanei, Azar Asadi-Shahmirzadi, Mohammad-Hossein Salehi-Surmaghi, Mohammad Abdollahi. Effects of Hypericum perforatum extract on rat irritable bowel syndrome. Pharmacognosy magazine. 2011 Jul; 7(27):213-23. doi: 10.4103/0973-1296.84235. [PMID: 21969792]
  • Kumaresan P Thirupathy, Asish Tulshkar, C Vijaya. Neuropharmacological activity of Lippia nodiflora Linn. Pharmacognosy research. 2011 Jul; 3(3):194-200. doi: 10.4103/0974-8490.85007. [PMID: 22022169]
  • Huishan Han, Jae Kyung Jung, Sang Bae Han, Sang Yoon Nam, Ki Wan Oh, Jin Tae Hong. Anxiolytic-like effects of 4-O-methylhonokiol isolated from Magnolia officinalis through enhancement of GABAergic transmission and chloride influx. Journal of medicinal food. 2011 Jul; 14(7-8):724-31. doi: 10.1089/jmf.2010.1111. [PMID: 21501091]
  • Boby Varkey Maramattom, Anu Jacob. N-methyl D-aspartate receptor encephalitis: A new addition to the spectrum of autoimmune encephalitis. Annals of Indian Academy of Neurology. 2011 Jul; 14(3):153-7. doi: 10.4103/0972-2327.85872. [PMID: 22028524]
  • Masahito Shimizu, Yoichi Yasuda, Hiroyasu Sakai, Masaya Kubota, Daishi Terakura, Atsushi Baba, Tomohiko Ohno, Takahiro Kochi, Hisashi Tsurumi, Takuji Tanaka, Hisataka Moriwaki. Pitavastatin suppresses diethylnitrosamine-induced liver preneoplasms in male C57BL/KsJ-db/db obese mice. BMC cancer. 2011 Jun; 11(?):281. doi: 10.1186/1471-2407-11-281. [PMID: 21711565]
  • Emilia Balsemão-Pires, Yvon Jaillais, Bradley J S C Olson, Leonardo R Andrade, James G Umen, Joanne Chory, Gilberto Sachetto-Martins. The Arabidopsis translocator protein (AtTSPO) is regulated at multiple levels in response to salt stress and perturbations in tetrapyrrole metabolism. BMC plant biology. 2011 Jun; 11(?):108. doi: 10.1186/1471-2229-11-108. [PMID: 21689410]
  • René Robert, Daniel Aiham Ghazali, Frédéric Favreau, Gérard Mauco, Thierry Hauet, Jean-Michel Goujon. Gender difference and sex hormone production in rodent renal ischemia reperfusion injury and repair. Journal of inflammation (London, England). 2011 Jun; 8(?):14. doi: 10.1186/1476-9255-8-14. [PMID: 21658244]
  • Sora Han, Ki Sook Oh, Yoosik Yoon, Jeong Su Park, Yun Sun Park, Jeong Hye Han, Ae Lee Jeong, Sunyi Lee, Miyoung Park, Yeon A Choi, Jong Seok Lim, Young Yang. Herbal extract THI improves metabolic abnormality in mice fed a high-fat diet. Nutrition research and practice. 2011 Jun; 5(3):198-204. doi: 10.4162/nrp.2011.5.3.198. [PMID: 21779522]
  • Marc Verleye, Sylvie Dumas, Isabelle Heulard, Nicolas Krafft, Jean-Marie Gillardin. Differential effects of etifoxine on anxiety-like behaviour and convulsions in BALB/cByJ and C57BL/6J mice: any relation to overexpression of central GABAA receptor beta2 subunits?. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. 2011 Jun; 21(6):457-70. doi: 10.1016/j.euroneuro.2010.09.008. [PMID: 20943351]
  • Einat Peles, Shaul Schreiber, Rachel Bar Hamburger, Miriam Adelson. No change of sleep after 6 and 12 months of methadone maintenance treatment. Journal of addiction medicine. 2011 Jun; 5(2):141-7. doi: 10.1097/adm.0b013e3181e8b6c4. [PMID: 21769060]
  • Vittorio Coiro, Riccardo Volpi, Amos Casti, Maria Ludovica Maffei, Adriano Stella, Elio Volta, Paolo Chiodera. Naloxone decreases the inhibitory effect of alprazolam on the release of adrenocorticotropin/cortisol induced by physical exercise in man. British journal of clinical pharmacology. 2011 Jun; 71(6):951-5. doi: 10.1111/j.1365-2125.2010.03900.x. [PMID: 21564163]
  • Herbert Bosshart. Withdrawal-induced delirium associated with a benzodiazepine switch: a case report. Journal of medical case reports. 2011 May; 5(?):207. doi: 10.1186/1752-1947-5-207. [PMID: 21615891]
  • Elisa Torres, Maria D Gutierrez-Lopez, Andrea Mayado, Ana Rubio, Esther O'Shea, Maria I Colado. Changes in interleukin-1 signal modulators induced by 3,4-methylenedioxymethamphetamine (MDMA): regulation by CB2 receptors and implications for neurotoxicity. Journal of neuroinflammation. 2011 May; 8(?):53. doi: 10.1186/1742-2094-8-53. [PMID: 21595923]
  • Liansheng Liu, Qian Li, Robert Sapolsky, Min Liao, Kshama Mehta, Aditi Bhargava, Pankaj J Pasricha. Transient gastric irritation in the neonatal rats leads to changes in hypothalamic CRF expression, depression- and anxiety-like behavior as adults. PloS one. 2011 May; 6(5):e19498. doi: 10.1371/journal.pone.0019498. [PMID: 21589865]
  • Toni-Lee Sterley, Fleur M Howells, Vivienne A Russell. Effects of early life trauma are dependent on genetic predisposition: a rat study. Behavioral and brain functions : BBF. 2011 May; 7(?):11. doi: 10.1186/1744-9081-7-11. [PMID: 21548935]
  • Laxmaiah Manchikanti, Yogesh Malla, Bradley W Wargo, Bert Fellows. Comparative evaluation of the accuracy of benzodiazepine testing in chronic pain patients utilizing immunoassay with liquid chromatography tandem mass spectrometry (LC/MS/MS) of urine drug testing. Pain physician. 2011 May; 14(3):259-70. doi: NULL. [PMID: 21587329]
  • Kyoko Makise, Gaku Inagawa, Koui Ka. [Anesthetic management in a patient with trifunctional protein deficiency]. Masui. The Japanese journal of anesthesiology. 2011 May; 60(5):628-30. doi: ". [PMID: 21626870]
  • Pablo R Moya, Meredith A Fox, Catherine L Jensen, Justin L Laporte, Helen T French, Jens R Wendland, Dennis L Murphy. Altered 5-HT2C receptor agonist-induced responses and 5-HT2C receptor RNA editing in the amygdala of serotonin transporter knockout mice. BMC pharmacology. 2011 Apr; 11(?):3. doi: 10.1186/1471-2210-11-3. [PMID: 21473759]
  • Andrzej Banyś, Jakub Kaźmierski, Ryszard Jaszewski. Psychiatric manifestations in a patient after surgical management of aortic stenosis of systemic lupus erythematosus. Archives of medical science : AMS. 2011 Apr; 7(2):342-4. doi: 10.5114/aoms.2011.22089. [PMID: 22291778]
  • Cristina Wasowski, Mariel Marder. Central nervous system activities of two diterpenes isolated from Aloysia virgata. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2011 Mar; 18(5):393-401. doi: 10.1016/j.phymed.2010.08.017. [PMID: 21036579]
  • José Del Carmen Rejón-Orantes, Alma Rosa González-Esquinca, Miguel Pérez de la Mora, Gabriel Roldan Roldan, Diego Cortes. Annomontine, an alkaloid isolated from Annona purpurea, has anxiolytic-like effects in the elevated plus-maze. Planta medica. 2011 Mar; 77(4):322-7. doi: 10.1055/s-0030-1250406. [PMID: 20890807]
  • J R Atack, K A Wafford, L J Street, G R Dawson, S Tye, K Van Laere, G Bormans, S M Sanabria-Bohórquez, I De Lepeleire, J N de Hoon, A Van Hecken, H D Burns, R M McKernan, M G Murphy, R J Hargreaves. MRK-409 (MK-0343), a GABAA receptor subtype-selective partial agonist, is a non-sedating anxiolytic in preclinical species but causes sedation in humans. Journal of psychopharmacology (Oxford, England). 2011 Mar; 25(3):314-28. doi: 10.1177/0269881109354927. [PMID: 20147571]