1,3,5-Trioxane (BioDeep_00000172452)

   

human metabolite blood metabolite Volatile Flavor Compounds


代谢物信息卡片


1,3,5-Trioxacyclohexane

化学式: C3H6O3 (90.0316926)
中文名称: 三聚甲醛, 1,3,5-三恶烷
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1OCOCO1
InChI: InChI=1S/C3H6O3/c1-4-2-6-3-5-1/h1-3H2

描述信息

同义名列表

10 个代谢物同义名

1,3,5-Trioxacyclohexane; Formaldehyde, trimer; Metaformaldehyde; Trioxymethylene; 1,3,5-trioxane; 1,3,5-Trioxan; Sym-trioxane; S-Trioxane; trioxane; 1,3,5-Trioxane



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • H N Kushwaha, N Gautam, A Misra, B Singh, S Kumar, H H Siddiqui, S K Singh. Intersex effect of lamotrigine on the pharmacokinetic parameters of CDRI-97/78, a novel trioxane antimalarial compound, in rats. Arzneimittel-Forschung. 2012 Jun; 62(6):274-9. doi: 10.1055/s-0032-1306317. [PMID: 22508175]
  • Hari Narayan Kushwaha, Nagsen Gautam, Shio Kumar Singh. Liquid chromatographic tandem mass spectrometric assay for simultaneous quantification of compound 97/78 and its in vivo metabolite 97/63, a novel trioxane antimalarial, in human plasma and its application to a protein binding study. Arzneimittel-Forschung. 2011; 61(7):425-32. doi: 10.1055/s-0031-1296222. [PMID: 21899212]
  • Rajendra Pratap Singh, S Sabarinath, Nagsen Gautam, Ram Chandra Gupta, Shio Kumar Singh. Pharmacokinetic study of the novel, synthetic trioxane antimalarial compound 97-78 in rats using an LC-MS/MS method for quantification. Arzneimittel-Forschung. 2011; 61(2):120-5. doi: 10.1055/s-0031-1296177. [PMID: 21428247]
  • N Kumar, M Sharma, D S Rawat. Medicinal chemistry perspectives of trioxanes and tetraoxanes. Current medicinal chemistry. 2011; 18(25):3889-928. doi: 10.2174/092986711803414340. [PMID: 21824099]
  • Rajendra Pratap Singh, Ram Chandra Gupta, Shio Kumar Singh. Interspecies comparison of the pharmacokinetics and oral bioavailability of 99-357, a potent synthetic trioxane antimalarial compound. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2010 Oct; 41(2):312-9. doi: 10.1016/j.ejps.2010.06.013. [PMID: 20599503]
  • Naokazu Kumura, Hirotaka Furukawa, Arnold N Onyango, Minoru Izumi, Shuhei Nakajima, Hideyuki Ito, Tsutomu Hatano, Hye-Sook Kim, Yusuke Wataya, Naomichi Baba. Different behavior of artemisinin and tetraoxane in the oxidative degradation of phospholipid. Chemistry and physics of lipids. 2009 Aug; 160(2):114-20. doi: 10.1016/j.chemphyslip.2009.04.005. [PMID: 19426722]
  • R P Singh, S Sabarinath, N Gautam, R C Gupta, S K Singh. Liquid chromatographic tandem mass spectrometric assay for quantification of 97/78 and its metabolite 97/63: a promising trioxane antimalarial in monkey plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2009 Jul; 877(22):2074-80. doi: 10.1016/j.jchromb.2009.05.044. [PMID: 19520624]
  • Wichit Nosoongnoen, Jaturong Pratuangdejkul, Korbtham Sathirakul, Alexandre Jacob, Marc Conti, Sylvain Loric, Jean-Marie Launay, Philippe Manivet. Elucidation of the natural artemisinin decomposition route upon iron interaction: a fine electronic redistribution promotes reactivity. Physical chemistry chemical physics : PCCP. 2008 Sep; 10(33):5083-93. doi: 10.1039/b804516j. [PMID: 18701956]
  • Rajendra Pratap Singh, S Sabarinath, Shio Kumar Singh, Ram Chandra Gupta. A sensitive and selective liquid chromatographic tandem mass spectrometric assay for simultaneous quantification of novel trioxane antimalarials in different biomatrices using sample-pooling approach for high throughput pharmacokinetic studies. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2008 Mar; 864(1-2):52-60. doi: 10.1016/j.jchromb.2008.01.054. [PMID: 18316253]
  • Jean-Marie Kindermans, Jacques Pilloy, Piero Olliaro, Melba Gomes. Ensuring sustained ACT production and reliable artemisinin supply. Malaria journal. 2007 Sep; 6(?):125. doi: 10.1186/1475-2875-6-125. [PMID: 17868471]
  • Rajendra Pratap Singh, S K Singh, R C Gupta. A high throughput approach for simultaneous estimation of multiple synthetic trioxane derivatives using sample pooling for pharmacokinetic studies. Journal of pharmaceutical and biomedical analysis. 2005 Feb; 37(1):127-33. doi: 10.1016/j.jpba.2004.09.038. [PMID: 15664752]
  • S K Singh, Rajendra Pratap Singh, R C Gupta. HPLC-UV method for assaying 99/357, a synthetic trioxane antimalarial derivative in rat and rabbit serum. Journal of pharmaceutical and biomedical analysis. 2004 Oct; 36(2):371-6. doi: 10.1016/j.jpba.2004.07.001. [PMID: 15496331]
  • Kevin T Batty, Kenneth F Ilett, Timothy M E Davis. Protein binding and alpha : beta anomer ratio of dihydroartemisinin in vivo. British journal of clinical pharmacology. 2004 Apr; 57(4):529-33. doi: 10.1046/j.1365-2125.2003.02045.x. [PMID: 15025754]
  • K Sitarek, B Barański, A Sapota. Distribution and binding of 1, 3, 5 [U14C]-trioxane in maternal and fetal rats. Polish journal of occupational medicine. 1990; 3(1):83-94. doi: NULL. [PMID: 2132938]